{"id":"https://openalex.org/W1970988228","doi":"https://doi.org/10.1371/journal.pcbi.1001046","title":"Decrypting the Sequence of Structural Events during the Gating Transition of Pentameric Ligand-Gated Ion Channels Based on an Interpolated Elastic Network Model","display_name":"Decrypting the Sequence of Structural Events during the Gating Transition of Pentameric Ligand-Gated Ion Channels Based on an Interpolated Elastic Network Model","publication_year":2011,"publication_date":"2011-01-06","ids":{"openalex":"https://openalex.org/W1970988228","doi":"https://doi.org/10.1371/journal.pcbi.1001046","mag":"1970988228","pmid":"https://pubmed.ncbi.nlm.nih.gov/21253563"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1001046","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1001046","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1001046&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1001046&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049050864","display_name":"Wenjun Zheng","orcid":"https://orcid.org/0000-0002-6236-9765"},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wenjun Zheng","raw_affiliation_strings":["Department of Physics, University at Buffalo, Buffalo, New York, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Physics, University at Buffalo, Buffalo, New York, United States of America","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064835126","display_name":"Anthony Auerbach","orcid":"https://orcid.org/0000-0003-0921-4358"},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony Auerbach","raw_affiliation_strings":["Department of Physiology and Biophysics, University at Buffalo, Buffalo, New York, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, University at Buffalo, Buffalo, New York, United States of America","institution_ids":["https://openalex.org/I63190737"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5049050864"],"corresponding_institution_ids":["https://openalex.org/I63190737"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.8016,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":{"value":0.90700979,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"7","issue":"1","first_page":"e1001046","last_page":"e1001046"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.994700014591217,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gating","display_name":"Gating","score":0.7419006824493408},{"id":"https://openalex.org/keywords/transmembrane-domain","display_name":"Transmembrane domain","score":0.7126936316490173},{"id":"https://openalex.org/keywords/ligand-gated-ion-channel","display_name":"Ligand-gated ion channel","score":0.611477792263031},{"id":"https://openalex.org/keywords/ion-channel","display_name":"Ion channel","score":0.6078798174858093},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.5100567936897278},{"id":"https://openalex.org/keywords/transmembrane-protein","display_name":"Transmembrane protein","score":0.5016312599182129},{"id":"https://openalex.org/keywords/protein-subunit","display_name":"Protein subunit","score":0.46283459663391113},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.42695823311805725},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.42407816648483276},{"id":"https://openalex.org/keywords/crystallography","display_name":"Crystallography","score":0.3296734690666199},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2527579963207245},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.15293070673942566},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1261824071407318}],"concepts":[{"id":"https://openalex.org/C194544171","wikidata":"https://www.wikidata.org/wiki/Q21105679","display_name":"Gating","level":2,"score":0.7419006824493408},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.7126936316490173},{"id":"https://openalex.org/C82617044","wikidata":"https://www.wikidata.org/wiki/Q418536","display_name":"Ligand-gated ion channel","level":4,"score":0.611477792263031},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.6078798174858093},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5100567936897278},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.5016312599182129},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.46283459663391113},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42695823311805725},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.42407816648483276},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3296734690666199},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2527579963207245},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15293070673942566},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1261824071407318},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1001046","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1001046","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1001046&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:21253563","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21253563","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.292.5721","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.292.5721","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/1c/86/PLoS_Comput_Biol_2011_Jan_6_7(1)_e1001046.tar.gz","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1001046","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1001046","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:702f89df6c2a4ac1a0d2c0bd2ece739d","is_oa":true,"landing_page_url":"https://doaj.org/article/702f89df6c2a4ac1a0d2c0bd2ece739d","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 7, Iss 1, p e1001046 (2011)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/139660","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Decrypting_the_Sequence_of_Structural_Events_during_the_Gating_Transition_of_Pentameric_Ligand_Gated_Ion_Channels_Based_on_an_Interpolated_Elastic_Network_Model/139660","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:3017109","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3017109","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1001046","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1001046","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1001046&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2460934748","display_name":null,"funder_award_id":"NS-23513","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8500489669","display_name":null,"funder_award_id":"0835292N","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1970988228.pdf","grobid_xml":"https://content.openalex.org/works/W1970988228.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W161216184","https://openalex.org/W1788430178","https://openalex.org/W1843549281","https://openalex.org/W1968407616","https://openalex.org/W1969208014","https://openalex.org/W1969231606","https://openalex.org/W1969593771","https://openalex.org/W1971422019","https://openalex.org/W1974558307","https://openalex.org/W1977242895","https://openalex.org/W1981857440","https://openalex.org/W1985074986","https://openalex.org/W1986084361","https://openalex.org/W1997486650","https://openalex.org/W1999569420","https://openalex.org/W2003468829","https://openalex.org/W2005843451","https://openalex.org/W2008051946","https://openalex.org/W2009084960","https://openalex.org/W2012080882","https://openalex.org/W2020843872","https://openalex.org/W2023680003","https://openalex.org/W2026385696","https://openalex.org/W2032233949","https://openalex.org/W2032892621","https://openalex.org/W2033894997","https://openalex.org/W2036173433","https://openalex.org/W2041720100","https://openalex.org/W2042485714","https://openalex.org/W2043901383","https://openalex.org/W2050347178","https://openalex.org/W2050352579","https://openalex.org/W2051893115","https://openalex.org/W2056305953","https://openalex.org/W2056837297","https://openalex.org/W2059230624","https://openalex.org/W2060432517","https://openalex.org/W2067763399","https://openalex.org/W2069777230","https://openalex.org/W2071222366","https://openalex.org/W2074698050","https://openalex.org/W2080944192","https://openalex.org/W2081556250","https://openalex.org/W2082028745","https://openalex.org/W2083685628","https://openalex.org/W2085913208","https://openalex.org/W2088330478","https://openalex.org/W2091485628","https://openalex.org/W2094929016","https://openalex.org/W2100158730","https://openalex.org/W2101887667","https://openalex.org/W2106948759","https://openalex.org/W2113994268","https://openalex.org/W2115380324","https://openalex.org/W2120781005","https://openalex.org/W2122328845","https://openalex.org/W2126984090","https://openalex.org/W2129931931","https://openalex.org/W2133552860","https://openalex.org/W2137955461","https://openalex.org/W2140889378","https://openalex.org/W2142694980","https://openalex.org/W2142872962","https://openalex.org/W2143014450","https://openalex.org/W2148421905","https://openalex.org/W2149744037","https://openalex.org/W2152326664","https://openalex.org/W2155782989","https://openalex.org/W2159163399","https://openalex.org/W2160251618","https://openalex.org/W2166138676","https://openalex.org/W2166619667","https://openalex.org/W2170963483","https://openalex.org/W2170993363","https://openalex.org/W2172010590"],"related_works":["https://openalex.org/W3099772455","https://openalex.org/W3172198228","https://openalex.org/W1986078734","https://openalex.org/W2129301794","https://openalex.org/W1540599686","https://openalex.org/W2016396528","https://openalex.org/W2909437011","https://openalex.org/W1979645639","https://openalex.org/W2060293073","https://openalex.org/W2064457055"],"abstract_inverted_index":{"Despite":[0],"many":[1],"experimental":[2],"and":[3,82,94,103,113,119,171],"computational":[4],"studies":[5],"of":[6,10,19,55,63,73,88,108,116,129,140,143,168,179],"the":[7,16,49,52,60,79,86,98,101,106,109,123,137,165,176],"gating":[8,26],"transition":[9,46],"pentameric":[11],"ligand-gated":[12,155],"ion":[13],"channels":[14],"(pLGICs),":[15],"structural":[17,74,130],"basis":[18],"how":[20],"ligand":[21],"binding":[22],"couples":[23],"to":[24,42,51],"channel":[25,156],"remains":[27],"unknown.":[28],"By":[29],"using":[30],"a":[31,44,71,150],"newly":[32],"developed":[33],"interpolated":[34],"elastic":[35],"network":[36],"model":[37],"(iENM),":[38],"we":[39],"have":[40],"attempted":[41],"compute":[43],"likely":[45],"pathway":[47,69],"from":[48],"closed-":[50],"open-channel":[53],"conformation":[54],"pLGICs":[56],"as":[57],"captured":[58],"by":[59,85],"crystal":[61],"structures":[62],"two":[64,89],"prokaryotic":[65],"pLGICs.":[66,159],"The":[67,126],"iENM":[68],"predicts":[70],"sequence":[72,178],"events":[75,131],"that":[76],"begins":[77],"at":[78,97],"ligand-binding":[80],"loops":[81,91],"is":[83,132],"followed":[84],"displacements":[87],"key":[90],"(loop":[92],"2":[93],"loop":[95],"7)":[96],"interface":[99],"between":[100],"extracellular":[102],"transmembrane":[104,124],"domain,":[105],"tilting/bending":[107],"pore-lining":[110],"M2":[111],"helix,":[112],"subsequent":[114],"movements":[115],"M4,":[117],"M3":[118],"M1":[120],"helices":[121],"in":[122,133,158,174],"domain.":[125],"predicted":[127],"order":[128],"broad":[134],"agreement":[135],"with":[136],"\u03a6-value":[138],"analysis":[139,162],"\u03b1":[141],"subunit":[142],"nicotinic":[144],"acetylcholine":[145],"receptor":[146],"mutants,":[147],"which":[148],"supports":[149],"conserved":[151],"core":[152],"mechanism":[153],"for":[154],"opening":[157],"Further":[160],"perturbation":[161],"has":[163],"supported":[164],"critical":[166],"role":[167],"certain":[169],"intra-subunit":[170],"inter-subunit":[172],"interactions":[173],"dictating":[175],"above":[177],"events.":[180]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":6}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
