{"id":"https://openalex.org/W2044162698","doi":"https://doi.org/10.1371/journal.pcbi.1001027","title":"Sequence-Based Prediction for Vaccine Strain Selection and Identification of Antigenic Variability in Foot-and-Mouth Disease Virus","display_name":"Sequence-Based Prediction for Vaccine Strain Selection and Identification of Antigenic Variability in Foot-and-Mouth Disease Virus","publication_year":2010,"publication_date":"2010-12-09","ids":{"openalex":"https://openalex.org/W2044162698","doi":"https://doi.org/10.1371/journal.pcbi.1001027","mag":"2044162698","pmid":"https://pubmed.ncbi.nlm.nih.gov/21151576"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1001027","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1001027","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1001027&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1001027&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027685288","display_name":"Richard Reeve","orcid":"https://orcid.org/0000-0003-2589-8091"},"institutions":[{"id":"https://openalex.org/I4210155983","display_name":"Glasgow Centre for Population Health","ror":"https://ror.org/04j2yny21","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210155983"]},{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Richard Reeve","raw_affiliation_strings":["Boyd Orr Centre for Population and Ecosystem Health, University of Glasgow, Glasgow, United Kingdom. richard.reeve@glasgow.ac.uk","Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom","Boyd Orr Centre for Population and Ecosystem Health, University of Glasgow, Glasgow, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Boyd Orr Centre for Population and Ecosystem Health, University of Glasgow, Glasgow, United Kingdom. richard.reeve@glasgow.ac.uk","institution_ids":["https://openalex.org/I4210155983"]},{"raw_affiliation_string":"Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I7882870"]},{"raw_affiliation_string":"Boyd Orr Centre for Population and Ecosystem Health, University of Glasgow, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I4210155983","https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026290009","display_name":"Belinda Blignaut","orcid":"https://orcid.org/0000-0002-7989-3301"},"institutions":[{"id":"https://openalex.org/I69552723","display_name":"University of Pretoria","ror":"https://ror.org/00g0p6g84","country_code":"ZA","type":"education","lineage":["https://openalex.org/I69552723"]},{"id":"https://openalex.org/I4210146252","display_name":"Onderstepoort Veterinary Institute","ror":"https://ror.org/05dqm7k77","country_code":"ZA","type":"facility","lineage":["https://openalex.org/I4210146252","https://openalex.org/I4210151505"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Belinda Blignaut","raw_affiliation_strings":["Department of Microbiology and Plant Pathology, University of Pretoria, Pretoria, South Africa","Transboundary Animal Diseases Programme, Onderstepoort Veterinary Institute, Agricultural Research Council, Onderstepoort, South Africa"],"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Plant Pathology, University of Pretoria, Pretoria, South Africa","institution_ids":["https://openalex.org/I69552723"]},{"raw_affiliation_string":"Transboundary Animal Diseases Programme, Onderstepoort Veterinary Institute, Agricultural Research Council, Onderstepoort, South Africa","institution_ids":["https://openalex.org/I4210146252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006736184","display_name":"J J Esterhuysen","orcid":null},"institutions":[{"id":"https://openalex.org/I4210146252","display_name":"Onderstepoort Veterinary Institute","ror":"https://ror.org/05dqm7k77","country_code":"ZA","type":"facility","lineage":["https://openalex.org/I4210146252","https://openalex.org/I4210151505"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Jan J. Esterhuysen","raw_affiliation_strings":["Transboundary Animal Diseases Programme, Onderstepoort Veterinary Institute, Agricultural Research Council, Onderstepoort, South Africa"],"affiliations":[{"raw_affiliation_string":"Transboundary Animal Diseases Programme, Onderstepoort Veterinary Institute, Agricultural Research Council, Onderstepoort, South Africa","institution_ids":["https://openalex.org/I4210146252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016533281","display_name":"Pamela Opperman","orcid":"https://orcid.org/0000-0003-2313-520X"},"institutions":[{"id":"https://openalex.org/I69552723","display_name":"University of Pretoria","ror":"https://ror.org/00g0p6g84","country_code":"ZA","type":"education","lineage":["https://openalex.org/I69552723"]},{"id":"https://openalex.org/I4210146252","display_name":"Onderstepoort Veterinary Institute","ror":"https://ror.org/05dqm7k77","country_code":"ZA","type":"facility","lineage":["https://openalex.org/I4210146252","https://openalex.org/I4210151505"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Pamela Opperman","raw_affiliation_strings":["Department of Microbiology and Plant Pathology, University of Pretoria, Pretoria, South Africa","Transboundary Animal Diseases Programme, Onderstepoort Veterinary Institute, Agricultural Research Council, Onderstepoort, South Africa"],"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Plant Pathology, University of Pretoria, Pretoria, South Africa","institution_ids":["https://openalex.org/I69552723"]},{"raw_affiliation_string":"Transboundary Animal Diseases Programme, Onderstepoort Veterinary Institute, Agricultural Research Council, Onderstepoort, South Africa","institution_ids":["https://openalex.org/I4210146252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074071953","display_name":"Louise Matthews","orcid":"https://orcid.org/0000-0003-4420-8367"},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]},{"id":"https://openalex.org/I4210155983","display_name":"Glasgow Centre for Population Health","ror":"https://ror.org/04j2yny21","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210155983"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Louise Matthews","raw_affiliation_strings":["Boyd Orr Centre for Population and Ecosystem Health, University of Glasgow, Glasgow, United Kingdom","Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Boyd Orr Centre for Population and Ecosystem Health, University of Glasgow, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I4210155983","https://openalex.org/I7882870"]},{"raw_affiliation_string":"Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078717593","display_name":"Elizabeth E. Fry","orcid":"https://orcid.org/0000-0001-9754-5303"},"institutions":[{"id":"https://openalex.org/I1336263701","display_name":"Centre for Human Genetics","ror":"https://ror.org/01rjnta51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elizabeth E. Fry","raw_affiliation_strings":["Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, Headington, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, Headington, United Kingdom","institution_ids":["https://openalex.org/I1336263701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034259396","display_name":"Tjaart de Beer","orcid":"https://orcid.org/0000-0001-5966-6091"},"institutions":[{"id":"https://openalex.org/I69552723","display_name":"University of Pretoria","ror":"https://ror.org/00g0p6g84","country_code":"ZA","type":"education","lineage":["https://openalex.org/I69552723"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Tjaart A. P. de Beer","raw_affiliation_strings":["Bioinformatics and Computational Biology Unit, University of Pretoria, Pretoria, South Africa"],"affiliations":[{"raw_affiliation_string":"Bioinformatics and Computational Biology Unit, University of Pretoria, Pretoria, South Africa","institution_ids":["https://openalex.org/I69552723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002990635","display_name":"Jacques Theron","orcid":"https://orcid.org/0000-0001-9091-3898"},"institutions":[{"id":"https://openalex.org/I69552723","display_name":"University of Pretoria","ror":"https://ror.org/00g0p6g84","country_code":"ZA","type":"education","lineage":["https://openalex.org/I69552723"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Jacques Theron","raw_affiliation_strings":["Department of Microbiology and Plant Pathology, University of Pretoria, Pretoria, South Africa"],"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Plant Pathology, University of Pretoria, Pretoria, South Africa","institution_ids":["https://openalex.org/I69552723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074343525","display_name":"Elizabeth Rieder","orcid":"https://orcid.org/0000-0003-3211-1170"},"institutions":[{"id":"https://openalex.org/I1336096307","display_name":"United States Department of Agriculture","ror":"https://ror.org/01na82s61","country_code":"US","type":"government","lineage":["https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I4210120146","display_name":"Plum Island Animal Disease Center","ror":"https://ror.org/02dtaqq02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210120146","https://openalex.org/I4210138094"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Rieder","raw_affiliation_strings":["Foreign Animal Disease Research Unit, United States Department of Agriculture, Agricultural Research Service, Plum Island Animal Disease Center, Greenport, New York, United States of America"],"affiliations":[{"raw_affiliation_string":"Foreign Animal Disease Research Unit, United States Department of Agriculture, Agricultural Research Service, Plum Island Animal Disease Center, Greenport, New York, United States of America","institution_ids":["https://openalex.org/I4210120146","https://openalex.org/I1336096307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002774542","display_name":"Wilna Vosloo","orcid":"https://orcid.org/0000-0003-3262-0135"},"institutions":[{"id":"https://openalex.org/I4210146252","display_name":"Onderstepoort Veterinary Institute","ror":"https://ror.org/05dqm7k77","country_code":"ZA","type":"facility","lineage":["https://openalex.org/I4210146252","https://openalex.org/I4210151505"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Wilna Vosloo","raw_affiliation_strings":["Transboundary Animal Diseases Programme, Onderstepoort Veterinary Institute, Agricultural Research Council, Onderstepoort, South Africa"],"affiliations":[{"raw_affiliation_string":"Transboundary Animal Diseases Programme, Onderstepoort Veterinary Institute, Agricultural Research Council, Onderstepoort, South Africa","institution_ids":["https://openalex.org/I4210146252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076387327","display_name":"Hester G. O\u2019Neill","orcid":"https://orcid.org/0000-0002-5044-6081"},"institutions":[{"id":"https://openalex.org/I27765905","display_name":"North-West University","ror":"https://ror.org/010f1sq29","country_code":"ZA","type":"education","lineage":["https://openalex.org/I27765905"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Hester G. O'Neill","raw_affiliation_strings":["Biochemistry Division, North-West University, Potchefstroom, South Africa"],"affiliations":[{"raw_affiliation_string":"Biochemistry Division, North-West University, Potchefstroom, South Africa","institution_ids":["https://openalex.org/I27765905"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014427910","display_name":"Daniel T. Haydon","orcid":"https://orcid.org/0000-0002-1240-1886"},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]},{"id":"https://openalex.org/I4210155983","display_name":"Glasgow Centre for Population Health","ror":"https://ror.org/04j2yny21","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210155983"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Daniel T. Haydon","raw_affiliation_strings":["Boyd Orr Centre for Population and Ecosystem Health, University of Glasgow, Glasgow, United Kingdom","Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Boyd Orr Centre for Population and Ecosystem Health, University of Glasgow, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I4210155983","https://openalex.org/I7882870"]},{"raw_affiliation_string":"Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088198439","display_name":"Francois F. Maree","orcid":"https://orcid.org/0000-0002-8777-250X"},"institutions":[{"id":"https://openalex.org/I4210146252","display_name":"Onderstepoort Veterinary Institute","ror":"https://ror.org/05dqm7k77","country_code":"ZA","type":"facility","lineage":["https://openalex.org/I4210146252","https://openalex.org/I4210151505"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Francois F. Maree","raw_affiliation_strings":["Transboundary Animal Diseases Programme, Onderstepoort Veterinary Institute, Agricultural Research Council, Onderstepoort, South Africa"],"affiliations":[{"raw_affiliation_string":"Transboundary Animal Diseases Programme, Onderstepoort Veterinary Institute, Agricultural Research Council, Onderstepoort, South Africa","institution_ids":["https://openalex.org/I4210146252"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5027685288"],"corresponding_institution_ids":["https://openalex.org/I4210155983","https://openalex.org/I7882870"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":6.2425,"has_fulltext":true,"cited_by_count":75,"citation_normalized_percentile":{"value":0.9586395,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"6","issue":"12","first_page":"e1001027","last_page":"e1001027"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11560","display_name":"Animal Disease Management and Epidemiology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1102","display_name":"Agronomy and Crop Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11560","display_name":"Animal Disease Management and Epidemiology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1102","display_name":"Agronomy and Crop Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12733","display_name":"Vector-Borne Animal Diseases","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epitope","display_name":"Epitope","score":0.7639856934547424},{"id":"https://openalex.org/keywords/foot-and-mouth-disease-virus","display_name":"Foot-and-mouth disease virus","score":0.6935319304466248},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.6905698776245117},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6566950082778931},{"id":"https://openalex.org/keywords/serotype","display_name":"Serotype","score":0.6109583973884583},{"id":"https://openalex.org/keywords/outbreak","display_name":"Outbreak","score":0.5975496172904968},{"id":"https://openalex.org/keywords/antigenic-variation","display_name":"Antigenic variation","score":0.5041803121566772},{"id":"https://openalex.org/keywords/viral-evolution","display_name":"Viral evolution","score":0.48293206095695496},{"id":"https://openalex.org/keywords/capsid","display_name":"Capsid","score":0.47452226281166077},{"id":"https://openalex.org/keywords/foot-and-mouth-disease","display_name":"Foot-and-mouth disease","score":0.45293667912483215},{"id":"https://openalex.org/keywords/serology","display_name":"Serology","score":0.4490825831890106},{"id":"https://openalex.org/keywords/aphthovirus","display_name":"Aphthovirus","score":0.42420047521591187},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.4128493666648865},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.30961257219314575},{"id":"https://openalex.org/keywords/antigen","display_name":"Antigen","score":0.30546075105667114},{"id":"https://openalex.org/keywords/antibody","display_name":"Antibody","score":0.15441793203353882},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.08478036522865295},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.06345474720001221}],"concepts":[{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.7639856934547424},{"id":"https://openalex.org/C2776151397","wikidata":"https://www.wikidata.org/wiki/Q1911079","display_name":"Foot-and-mouth disease virus","level":3,"score":0.6935319304466248},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6905698776245117},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6566950082778931},{"id":"https://openalex.org/C10389963","wikidata":"https://www.wikidata.org/wiki/Q848328","display_name":"Serotype","level":2,"score":0.6109583973884583},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.5975496172904968},{"id":"https://openalex.org/C191942190","wikidata":"https://www.wikidata.org/wiki/Q4774739","display_name":"Antigenic variation","level":3,"score":0.5041803121566772},{"id":"https://openalex.org/C8769409","wikidata":"https://www.wikidata.org/wiki/Q2066554","display_name":"Viral evolution","level":4,"score":0.48293206095695496},{"id":"https://openalex.org/C202878990","wikidata":"https://www.wikidata.org/wiki/Q830465","display_name":"Capsid","level":3,"score":0.47452226281166077},{"id":"https://openalex.org/C2779070877","wikidata":"https://www.wikidata.org/wiki/Q152401","display_name":"Foot-and-mouth disease","level":3,"score":0.45293667912483215},{"id":"https://openalex.org/C45189115","wikidata":"https://www.wikidata.org/wiki/Q502159","display_name":"Serology","level":3,"score":0.4490825831890106},{"id":"https://openalex.org/C2779102375","wikidata":"https://www.wikidata.org/wiki/Q618549","display_name":"Aphthovirus","level":4,"score":0.42420047521591187},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4128493666648865},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30961257219314575},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.30546075105667114},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.15441793203353882},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.08478036522865295},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06345474720001221}],"mesh":[{"descriptor_ui":"D000353","descriptor_name":"Africa, Southern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000353","descriptor_name":"Africa, Southern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000353","descriptor_name":"Africa, Southern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000940","descriptor_name":"Antigenic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000940","descriptor_name":"Antigenic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000940","descriptor_name":"Antigenic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002020","descriptor_name":"Buffaloes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D002020","descriptor_name":"Buffaloes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D002020","descriptor_name":"Buffaloes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005536","descriptor_name":"Foot-and-Mouth Disease","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D005536","descriptor_name":"Foot-and-Mouth Disease","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D005536","descriptor_name":"Foot-and-Mouth Disease","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D029544","descriptor_name":"Foot-and-Mouth Disease Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029544","descriptor_name":"Foot-and-Mouth Disease Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029544","descriptor_name":"Foot-and-Mouth Disease Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D036022","descriptor_name":"Capsid Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D036022","descriptor_name":"Capsid Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D036022","descriptor_name":"Capsid Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pcbi.1001027","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1001027","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1001027&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:21151576","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21151576","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:eprints.gla.ac.uk:46099","is_oa":false,"landing_page_url":"https://eprints.gla.ac.uk/view/journal_volume/PLoS_Computational_Biology.html>,","pdf_url":null,"source":{"id":"https://openalex.org/S4210235606","display_name":"ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)","issn_l":"2622-8912","issn":["2622-8912","2622-8920"],"is_oa":false,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.807.1169","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.807.1169","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/e3/a8/pcbi.1001027.PMC3000348.pdf","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1001027","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1001027","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:7df684d164f5422b9d01823f9093a3f6","is_oa":true,"landing_page_url":"https://doaj.org/article/7df684d164f5422b9d01823f9093a3f6","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 6, Iss 12, p e1001027 (2010)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/140157","is_oa":true,"landing_page_url":"https://figshare.com/articles/Sequence_Based_Prediction_for_Vaccine_Strain_Selection_and_Identification_of_Antigenic_Variability_in_Foot_and_Mouth_Disease_Virus/140157","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:3000348","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3000348","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:repository.up.ac.za:2263/15883","is_oa":true,"landing_page_url":"http://hdl.handle.net/2263/15883","pdf_url":null,"source":{"id":"https://openalex.org/S4306401870","display_name":"UpSpace Institutional Repository (University of Pretoria)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I69552723","host_organization_name":"University of Pretoria","host_organization_lineage":["https://openalex.org/I69552723"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1001027","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1001027","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1001027&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G5689689047","display_name":null,"funder_award_id":"BB/E010326/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2044162698.pdf","grobid_xml":"https://content.openalex.org/works/W2044162698.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W87967796","https://openalex.org/W194238234","https://openalex.org/W1492927791","https://openalex.org/W1513186671","https://openalex.org/W1533179050","https://openalex.org/W1556185869","https://openalex.org/W1673726422","https://openalex.org/W1784469211","https://openalex.org/W1864465724","https://openalex.org/W1975779540","https://openalex.org/W1979158913","https://openalex.org/W1988724578","https://openalex.org/W1998954852","https://openalex.org/W2013410948","https://openalex.org/W2015986646","https://openalex.org/W2022291864","https://openalex.org/W2034296843","https://openalex.org/W2041646166","https://openalex.org/W2041740757","https://openalex.org/W2041753380","https://openalex.org/W2044307883","https://openalex.org/W2046561010","https://openalex.org/W2049376874","https://openalex.org/W2053848339","https://openalex.org/W2056265093","https://openalex.org/W2057839080","https://openalex.org/W2057904514","https://openalex.org/W2063589678","https://openalex.org/W2077440490","https://openalex.org/W2081201606","https://openalex.org/W2086027046","https://openalex.org/W2094206246","https://openalex.org/W2097347209","https://openalex.org/W2110835349","https://openalex.org/W2120286555","https://openalex.org/W2121044470","https://openalex.org/W2139026373","https://openalex.org/W2141844925","https://openalex.org/W2142656395","https://openalex.org/W2146602601","https://openalex.org/W2146714484","https://openalex.org/W2160216426","https://openalex.org/W2160383645","https://openalex.org/W2166229810","https://openalex.org/W2171288396","https://openalex.org/W2474823182","https://openalex.org/W2582743722"],"related_works":["https://openalex.org/W2089013062","https://openalex.org/W2795196031","https://openalex.org/W2038067235","https://openalex.org/W3036752761","https://openalex.org/W2736102065","https://openalex.org/W2034296843","https://openalex.org/W2077907491","https://openalex.org/W1558991446","https://openalex.org/W3125813642","https://openalex.org/W2087994121"],"abstract_inverted_index":{"Identifying":[0,223],"when":[1],"past":[2],"exposure":[3],"to":[4,16,101,262,294],"an":[5,32],"infectious":[6,264],"disease":[7,38],"will":[8],"protect":[9],"against":[10],"newly":[11],"emerging":[12],"strains":[13],"is":[14],"central":[15],"understanding":[17,287],"the":[18,21,26,54,83,136,145,167,182,201,213,226,247,274],"spread":[19],"and":[20,64,77,92,113,144,211,224,254,282,291],"severity":[22,55],"of":[23,28,56,85,127,129,134,147,149,203,209,216,228,249,288],"epidemics,":[24],"but":[25,240],"prediction":[27,133],"viral":[29,111,232],"cross-protection":[30,49],"remains":[31],"important":[33],"unsolved":[34],"problem.":[35],"For":[36],"foot-and-mouth":[37],"virus":[39,143],"(FMDV)":[40],"research":[41],"in":[42,105,120,220,246],"particular,":[43],"improved":[44],"methods":[45],"for":[46,52,71,103,140,181,185,198,237],"predicting":[47,53],"this":[48,279],"are":[50,125,174],"critical":[51],"outbreaks":[57],"within":[58],"endemic":[59],"settings":[60],"where":[61,266],"multiple":[62],"serotypes":[63,243],"subtypes":[65],"commonly":[66],"co-circulate,":[67],"as":[68,70,157,159],"well":[69],"deciding":[72],"whether":[73],"appropriate":[74],"vaccine(s)":[75],"exist":[76],"how":[78],"much":[79],"they":[80],"could":[81],"mitigate":[82],"effects":[84,99],"any":[86,141,263],"outbreak.":[87],"To":[88],"identify":[89],"antigenic":[90,289],"relationships":[91,290],"their":[93,154],"predictors,":[94],"we":[95,193],"used":[96],"linear":[97],"mixed":[98],"models":[100],"account":[102],"variation":[104],"pairwise":[106],"cross-neutralization":[107],"titres":[108],"using":[109],"only":[110],"sequences":[112,156],"structural":[114,122],"data.":[115],"We":[116],"identified":[117],"those":[118],"substitutions":[119],"surface-exposed":[121],"proteins":[123],"that":[124,173,230],"correlates":[126],"loss":[128],"cross-reactivity.":[130],"These":[131,257],"allowed":[132],"both":[135,285],"best":[137],"vaccine":[138,151],"match":[139],"single":[142,238],"breadth":[146],"coverage":[148],"new":[150],"candidates":[152],"from":[153],"capsid":[155],"effectively":[158],"or":[160],"better":[161,252],"than":[162],"serology.":[163],"Sub-sequences":[164],"chosen":[165],"by":[166],"model-building":[168],"process":[169],"all":[170],"contained":[171],"sites":[172,229],"known":[175],"epitopes":[176,187,205],"on":[177],"other":[178],"serotypes.":[179],"Furthermore,":[180],"SAT1":[183],"serotype,":[184],"which":[186],"have":[188,269],"never":[189],"previously":[190],"been":[191,270],"identified,":[192],"provide":[194],"strong":[195],"evidence--by":[196],"controlling":[197],"phylogenetic":[199],"structure--for":[200],"presence":[202],"three":[204],"across":[206,241],"a":[207],"panel":[208],"viruses":[210,239],"quantify":[212],"relative":[214],"significance":[215],"some":[217],"individual":[218],"residues":[219],"determining":[221],"cross-neutralization.":[222],"quantifying":[225],"importance":[227],"predict":[231],"strain":[233],"cross-reactivity":[234,267],"not":[235],"just":[236],"entire":[242],"can":[244,259],"help":[245],"design":[248],"vaccines":[250],"with":[251],"targeting":[253],"broader":[255],"coverage.":[256],"techniques":[258],"be":[260],"generalized":[261],"agents":[265],"assays":[268],"carried":[271],"out.":[272],"As":[273],"parameterization":[275],"uses":[276],"pre-existing":[277],"datasets,":[278],"approach":[280],"quickly":[281],"cheaply":[283],"increases":[284],"our":[286,292],"power":[293],"control":[295],"disease.":[296]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}