{"id":"https://openalex.org/W2154482842","doi":"https://doi.org/10.1371/journal.pcbi.1000896","title":"Modeling Chemotaxis Reveals the Role of Reversed Phosphotransfer and a Bi-Functional Kinase-Phosphatase","display_name":"Modeling Chemotaxis Reveals the Role of Reversed Phosphotransfer and a Bi-Functional Kinase-Phosphatase","publication_year":2010,"publication_date":"2010-08-19","ids":{"openalex":"https://openalex.org/W2154482842","doi":"https://doi.org/10.1371/journal.pcbi.1000896","mag":"2154482842","pmid":"https://pubmed.ncbi.nlm.nih.gov/20808885"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000896","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000896","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000896&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000896&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051202360","display_name":"Marcus J. Tindall","orcid":"https://orcid.org/0000-0001-6069-5260"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210120676","display_name":"Mathematical Institute of the Slovak Academy of Sciences","ror":"https://ror.org/02fhy7464","country_code":"SK","type":"facility","lineage":["https://openalex.org/I207624831","https://openalex.org/I4210120676"]},{"id":"https://openalex.org/I71052956","display_name":"University of Reading","ror":"https://ror.org/05v62cm79","country_code":"GB","type":"education","lineage":["https://openalex.org/I71052956"]}],"countries":["GB","SK"],"is_corresponding":true,"raw_author_name":"Marcus J. Tindall","raw_affiliation_strings":["Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, United Kingdom. m.tindall@reading.ac.uk","Department of Mathematics, University of Reading, Reading, United Kingdom","Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, United Kingdom","Institute of Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, Reading, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, United Kingdom. m.tindall@reading.ac.uk","institution_ids":["https://openalex.org/I4210120676"]},{"raw_affiliation_string":"Department of Mathematics, University of Reading, Reading, United Kingdom","institution_ids":["https://openalex.org/I71052956"]},{"raw_affiliation_string":"Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Institute of Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, Reading, United Kingdom","institution_ids":["https://openalex.org/I71052956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035823250","display_name":"Steven L. Porter","orcid":"https://orcid.org/0000-0002-7851-236X"},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Steven L. Porter","raw_affiliation_strings":["Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, Oxford, United Kingdom","School of Biosciences, University of Exeter, Exeter, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"School of Biosciences, University of Exeter, Exeter, United Kingdom","institution_ids":["https://openalex.org/I23923803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025791169","display_name":"Philip K. Maini","orcid":"https://orcid.org/0000-0002-0146-9164"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Philip K. Maini","raw_affiliation_strings":["Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, United Kingdom","Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032570390","display_name":"Judith P. Armitage","orcid":"https://orcid.org/0000-0003-4983-9731"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Judith P. Armitage","raw_affiliation_strings":["Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5035823250","https://openalex.org/A5051202360"],"corresponding_institution_ids":["https://openalex.org/I23923803","https://openalex.org/I40120149","https://openalex.org/I4210120676","https://openalex.org/I71052956"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.8099,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.91342323,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"6","issue":"8","first_page":"e1000896","last_page":"e1000896"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11879","display_name":"Protist diversity and phylogeny","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histidine-kinase","display_name":"Histidine kinase","score":0.8384613394737244},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"Chemotaxis","score":0.8274509906768799},{"id":"https://openalex.org/keywords/response-regulator","display_name":"Response regulator","score":0.7002846598625183},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6817070841789246},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.6281771063804626},{"id":"https://openalex.org/keywords/phosphatase","display_name":"Phosphatase","score":0.6273554563522339},{"id":"https://openalex.org/keywords/rhodobacter-sphaeroides","display_name":"Rhodobacter sphaeroides","score":0.6238223314285278},{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.6112971901893616},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.5489799976348877},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"Phosphorylation","score":0.4819200336933136},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.4761008024215698},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"Protein kinase A","score":0.415515273809433},{"id":"https://openalex.org/keywords/histidine","display_name":"Histidine","score":0.2462402880191803},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.16291946172714233},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.14873135089874268},{"id":"https://openalex.org/keywords/bacterial-protein","display_name":"Bacterial protein","score":0.06925740838050842},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.06392127275466919}],"concepts":[{"id":"https://openalex.org/C2778905257","wikidata":"https://www.wikidata.org/wiki/Q1620721","display_name":"Histidine kinase","level":4,"score":0.8384613394737244},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.8274509906768799},{"id":"https://openalex.org/C2781196521","wikidata":"https://www.wikidata.org/wiki/Q24965710","display_name":"Response regulator","level":4,"score":0.7002846598625183},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6817070841789246},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.6281771063804626},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.6273554563522339},{"id":"https://openalex.org/C2777897970","wikidata":"https://www.wikidata.org/wiki/Q4186823","display_name":"Rhodobacter sphaeroides","level":3,"score":0.6238223314285278},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6112971901893616},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5489799976348877},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4819200336933136},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4761008024215698},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.415515273809433},{"id":"https://openalex.org/C2778460671","wikidata":"https://www.wikidata.org/wiki/Q485277","display_name":"Histidine","level":3,"score":0.2462402880191803},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16291946172714233},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.14873135089874268},{"id":"https://openalex.org/C2993175405","wikidata":"https://www.wikidata.org/wiki/Q8054","display_name":"Bacterial protein","level":3,"score":0.06925740838050842},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06392127275466919},{"id":"https://openalex.org/C183688256","wikidata":"https://www.wikidata.org/wiki/Q11982","display_name":"Photosynthesis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071677","descriptor_name":"Histidine Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071677","descriptor_name":"Histidine Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071677","descriptor_name":"Histidine Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071677","descriptor_name":"Histidine Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005407","descriptor_name":"Flagella","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005407","descriptor_name":"Flagella","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005407","descriptor_name":"Flagella","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005407","descriptor_name":"Flagella","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005407","descriptor_name":"Flagella","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005407","descriptor_name":"Flagella","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005407","descriptor_name":"Flagella","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005407","descriptor_name":"Flagella","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012242","descriptor_name":"Rhodobacter sphaeroides","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D012242","descriptor_name":"Rhodobacter sphaeroides","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D012242","descriptor_name":"Rhodobacter sphaeroides","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D012242","descriptor_name":"Rhodobacter sphaeroides","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D012242","descriptor_name":"Rhodobacter sphaeroides","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012242","descriptor_name":"Rhodobacter sphaeroides","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012242","descriptor_name":"Rhodobacter sphaeroides","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012242","descriptor_name":"Rhodobacter sphaeroides","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":10,"locations":[{"id":"doi:10.1371/journal.pcbi.1000896","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000896","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000896&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:20808885","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20808885","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:centaur.reading.ac.uk:7905","is_oa":false,"landing_page_url":"https://centaur.reading.ac.uk/view/creators/90000996.html>,","pdf_url":null,"source":{"id":"https://openalex.org/S4306402273","display_name":"CentAUR (University of Reading)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I71052956","host_organization_name":"University of Reading","host_organization_lineage":["https://openalex.org/I71052956"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:5d5ebb4c44914ca8956fbdad176e81d9","is_oa":true,"landing_page_url":"https://doaj.org/article/5d5ebb4c44914ca8956fbdad176e81d9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 6, Iss 8, p e1000896 (2010)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/142050","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Modeling_Chemotaxis_Reveals_the_Role_of_Reversed_Phosphotransfer_and_a_Bi_Functional_Kinase_Phosphatase/142050","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:figshare.com:article/29698145","is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Modeling_chemotaxis_reveals_the_role_of_reversed_phosphotransfer_and_a_bi-functional_kinase-phosphatase/29698145","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:8bba78b2-5ee3-412a-9150-01db6071bbd2","is_oa":true,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:8bba78b2-5ee3-412a-9150-01db6071bbd2","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symplectic Elements at Oxford","raw_type":"Journal article"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:c4f6e3ab-dd90-4b19-80f7-8c28cdbfa53f","is_oa":false,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:c4f6e3ab-dd90-4b19-80f7-8c28cdbfa53f","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symplectic Elements at Oxford","raw_type":"Journal article"},{"id":"pmh:oai:ore.exeter.ac.uk:10871/9782","is_oa":true,"landing_page_url":"http://hdl.handle.net/10871/9782","pdf_url":null,"source":{"id":"https://openalex.org/S4306401998","display_name":"Open Research Exeter (University of Exeter)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I23923803","host_organization_name":"University of Exeter","host_organization_lineage":["https://openalex.org/I23923803"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2924250","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2924250","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000896","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000896","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000896&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land","score":0.4699999988079071}],"awards":[{"id":"https://openalex.org/G1187693377","display_name":null,"funder_award_id":"BB/C513350/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G6336648101","display_name":null,"funder_award_id":"EP/E500536/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2154482842.pdf","grobid_xml":"https://content.openalex.org/works/W2154482842.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W1510952273","https://openalex.org/W1549925010","https://openalex.org/W1556270322","https://openalex.org/W1568106481","https://openalex.org/W1577906027","https://openalex.org/W1637936532","https://openalex.org/W1878250067","https://openalex.org/W1968997545","https://openalex.org/W1972642574","https://openalex.org/W1979581724","https://openalex.org/W1980432432","https://openalex.org/W1981625822","https://openalex.org/W1982762561","https://openalex.org/W1992717202","https://openalex.org/W1993304408","https://openalex.org/W1994207290","https://openalex.org/W1994217704","https://openalex.org/W1997196594","https://openalex.org/W2002637675","https://openalex.org/W2004634942","https://openalex.org/W2008888978","https://openalex.org/W2017066482","https://openalex.org/W2017139960","https://openalex.org/W2024573387","https://openalex.org/W2026078372","https://openalex.org/W2034300542","https://openalex.org/W2037280748","https://openalex.org/W2037543821","https://openalex.org/W2049716406","https://openalex.org/W2050922096","https://openalex.org/W2056066940","https://openalex.org/W2056744111","https://openalex.org/W2062965385","https://openalex.org/W2064441783","https://openalex.org/W2069464490","https://openalex.org/W2071082661","https://openalex.org/W2087171142","https://openalex.org/W2091313602","https://openalex.org/W2091926965","https://openalex.org/W2094821778","https://openalex.org/W2099134954","https://openalex.org/W2101499441","https://openalex.org/W2105783449","https://openalex.org/W2108559568","https://openalex.org/W2108949591","https://openalex.org/W2114368118","https://openalex.org/W2116505389","https://openalex.org/W2119108218","https://openalex.org/W2122028698","https://openalex.org/W2125472575","https://openalex.org/W2127096639","https://openalex.org/W2128045301","https://openalex.org/W2132006133","https://openalex.org/W2137365831","https://openalex.org/W2138502657","https://openalex.org/W2139215912","https://openalex.org/W2142362330","https://openalex.org/W2150217382","https://openalex.org/W2150478471","https://openalex.org/W2150700723","https://openalex.org/W2154370940","https://openalex.org/W2156488367","https://openalex.org/W2156580043","https://openalex.org/W2157979510","https://openalex.org/W2159501862","https://openalex.org/W2164454149","https://openalex.org/W2164464789","https://openalex.org/W2902565061","https://openalex.org/W3023958910"],"related_works":["https://openalex.org/W2141612196","https://openalex.org/W1535625299","https://openalex.org/W2010394763","https://openalex.org/W2278025825","https://openalex.org/W2110343075","https://openalex.org/W2093358630","https://openalex.org/W2166247218","https://openalex.org/W2085792075","https://openalex.org/W1641812275","https://openalex.org/W1485394292"],"abstract_inverted_index":{"Understanding":[0],"how":[1,72],"multiple":[2,197],"signals":[3,204],"are":[4,38],"integrated":[5],"in":[6,18,46],"living":[7],"cells":[8],"to":[9,40,44,92,143,158,169,202],"produce":[10,170],"a":[11,15,52,62,69,114,123,171],"balanced":[12,172],"response":[13,34],"is":[14],"major":[16],"challenge":[17],"biology.":[19],"Two-component":[20],"signal":[21,175],"transduction":[22],"pathways,":[23],"such":[24],"as":[25,113],"bacterial":[26],"chemotaxis,":[27],"comprise":[28],"histidine":[29],"protein":[30],"kinases":[31],"(HPKs)":[32],"and":[33,42,121,140,160,200],"regulators":[35],"(RRs).":[36],"These":[37,148],"used":[39,183],"sense":[41],"respond":[43],"changes":[45],"the":[47,73,76,96,108,118,129,135,152,162],"environment.":[48],"Rhodobacter":[49],"sphaeroides":[50],"has":[51],"complex":[53],"chemosensory":[54],"network":[55],"with":[56,134],"two":[57,77,149],"signaling":[58,78,167],"clusters,":[59],"each":[60,166],"containing":[61],"HPK,":[63],"CheA.":[64],"Here":[65],"we":[66],"demonstrate,":[67],"using":[68],"mathematical":[70,86],"model,":[71],"outputs":[74],"of":[75,156,165,193],"clusters":[79],"may":[80,180],"be":[81,181],"integrated.":[82],"We":[83],"use":[84],"our":[85],"model":[87],"supported":[88],"by":[89,104,184],"experimental":[90],"data":[91],"predict":[93],"that:":[94],"(1)":[95],"main":[97],"RR":[98],"controlling":[99],"flagellar":[100],"rotation,":[101],"CheY(6),":[102],"aided":[103],"its":[105],"specific":[106],"phosphatase,":[107],"bifunctional":[109,153],"kinase":[110,132,138],"CheA(3),":[111],"acts":[112],"phosphate":[115],"sink":[116],"for":[117],"other":[119,185],"RRs;":[120],"(2)":[122],"phosphorelay":[124],"pathway":[125],"involving":[126],"CheB(2)":[127],"connects":[128],"cytoplasmic":[130],"cluster":[131,168],"CheA(3)":[133,157],"polar":[136],"localised":[137],"CheA(2),":[139],"allows":[141],"CheA(3)-P":[142],"phosphorylate":[144],"non-cognate":[145],"chemotaxis":[146],"RRs.":[147],"mechanisms":[150,177],"enable":[151],"kinase/phosphatase":[154],"activity":[155],"integrate":[159,203],"tune":[161],"sensory":[163],"output":[164],"response.":[173],"The":[174],"integration":[176],"identified":[178],"here":[179],"widely":[182],"bacteria,":[186],"since":[187],"like":[188],"R.":[189],"sphaeroides,":[190],"over":[191],"50%":[192],"chemotactic":[194],"bacteria":[195],"have":[196],"cheA":[198],"homologues":[199],"need":[201],"from":[205],"different":[206],"sources.":[207]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":6}],"updated_date":"2026-07-25T09:21:30.201066","created_date":"2025-10-10T00:00:00"}