{"id":"https://openalex.org/W1980436361","doi":"https://doi.org/10.1371/journal.pcbi.1000849","title":"Computational Analysis of Whole-Genome Differential Allelic Expression Data in Human","display_name":"Computational Analysis of Whole-Genome Differential Allelic Expression Data in Human","publication_year":2010,"publication_date":"2010-07-08","ids":{"openalex":"https://openalex.org/W1980436361","doi":"https://doi.org/10.1371/journal.pcbi.1000849","mag":"1980436361","pmid":"https://pubmed.ncbi.nlm.nih.gov/20628616"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000849","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000849","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000849&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000849&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041773585","display_name":"James Wagner","orcid":"https://orcid.org/0000-0002-8823-3110"},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"James R. Wagner","raw_affiliation_strings":["School of Computer Science, McGill University, Montreal, Quebec, Canada","School of Computer Science, McGill University Montreal Quebec Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"School of Computer Science, McGill University Montreal Quebec Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039291953","display_name":"Bing Ge","orcid":"https://orcid.org/0000-0003-2527-5580"},"institutions":[{"id":"https://openalex.org/I4210148969","display_name":"McGill University and G\u00e9nome Qu\u00e9bec Innovation Centre","ror":"https://ror.org/0589bxs97","country_code":"CA","type":"education","lineage":["https://openalex.org/I4210148969"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Bing Ge","raw_affiliation_strings":["McGill University and Genome Quebec Innovation Centre, Montreal, Quebec, Canada","McGill University and Genome Qu\u00e9bec Innovation Centre, Montr\u00e9al, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McGill University and Genome Quebec Innovation Centre, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I4210148969"]},{"raw_affiliation_string":"McGill University and Genome Qu\u00e9bec Innovation Centre, Montr\u00e9al, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I4210148969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109926086","display_name":"Dmitry Pokholok","orcid":null},"institutions":[{"id":"https://openalex.org/I178645029","display_name":"Illumina (United States)","ror":"https://ror.org/05k34t975","country_code":"US","type":"company","lineage":["https://openalex.org/I178645029"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dmitry Pokholok","raw_affiliation_strings":["Illumina, San Diego, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Illumina, San Diego, California, United States of America","institution_ids":["https://openalex.org/I178645029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112813229","display_name":"Kevin L. Gunderson","orcid":null},"institutions":[{"id":"https://openalex.org/I178645029","display_name":"Illumina (United States)","ror":"https://ror.org/05k34t975","country_code":"US","type":"company","lineage":["https://openalex.org/I178645029"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin L. Gunderson","raw_affiliation_strings":["Illumina, San Diego, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Illumina, San Diego, California, United States of America","institution_ids":["https://openalex.org/I178645029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028053766","display_name":"Tomi Pastinen","orcid":"https://orcid.org/0000-0003-4016-5021"},"institutions":[{"id":"https://openalex.org/I4210148969","display_name":"McGill University and G\u00e9nome Qu\u00e9bec Innovation Centre","ror":"https://ror.org/0589bxs97","country_code":"CA","type":"education","lineage":["https://openalex.org/I4210148969"]},{"id":"https://openalex.org/I2801766832","display_name":"McGill University Health Centre","ror":"https://ror.org/04cpxjv19","country_code":"CA","type":"funder","lineage":["https://openalex.org/I2801766832"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Tomi Pastinen","raw_affiliation_strings":["Department of Human and Medical Genetics, McGill University Health Centre, McGill University, Montreal, Quebec, Canada","McGill University and Genome Quebec Innovation Centre, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human and Medical Genetics, McGill University Health Centre, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2801766832"]},{"raw_affiliation_string":"McGill University and Genome Quebec Innovation Centre, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I4210148969"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065720651","display_name":"Mathieu Blanchette","orcid":"https://orcid.org/0000-0002-9555-860X"},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Mathieu Blanchette","raw_affiliation_strings":["School of Computer Science, McGill University, Montreal, Quebec, Canada","School of Computer Science, McGill University Montreal Quebec Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"School of Computer Science, McGill University Montreal Quebec Canada","institution_ids":["https://openalex.org/I5023651"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5065720651"],"corresponding_institution_ids":["https://openalex.org/I5023651"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.4746,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.89321493,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"6","issue":"7","first_page":"e1000849","last_page":"e1000849"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9934999942779541,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/international-hapmap-project","display_name":"International HapMap Project","score":0.7723987102508545},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6593965888023376},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5898852348327637},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.5806000828742981},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5090298652648926},{"id":"https://openalex.org/keywords/human-genome","display_name":"Human genome","score":0.4779900908470154},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.47253942489624023},{"id":"https://openalex.org/keywords/genotyping","display_name":"Genotyping","score":0.44950875639915466},{"id":"https://openalex.org/keywords/allele","display_name":"Allele","score":0.44928881525993347},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.37804776430130005},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.17952847480773926}],"concepts":[{"id":"https://openalex.org/C177580304","wikidata":"https://www.wikidata.org/wiki/Q1147298","display_name":"International HapMap Project","level":5,"score":0.7723987102508545},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6593965888023376},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5898852348327637},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5806000828742981},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5090298652648926},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.4779900908470154},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.47253942489624023},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.44950875639915466},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.44928881525993347},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37804776430130005},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.17952847480773926}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D022981","descriptor_name":"Allelic Imbalance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D022981","descriptor_name":"Allelic Imbalance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D022981","descriptor_name":"Allelic Imbalance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1000849","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000849","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000849&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:20628616","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20628616","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.355.4991","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.355.4991","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/63/bc/PLoS_Comput_Biol_2010_Jul_8_6(7)_e1000849.tar.gz","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1000849","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1000849","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:fc16ecc7bf85479592c0e95ffb4646ab","is_oa":true,"landing_page_url":"https://doaj.org/article/fc16ecc7bf85479592c0e95ffb4646ab","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 6, Iss 7, p e1000849 (2010)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/142716","is_oa":true,"landing_page_url":"https://figshare.com/articles/Computational_Analysis_of_Whole_Genome_Differential_Allelic_Expression_Data_in_Human/142716","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:2900287","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2900287","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000849","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000849","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000849&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310787","display_name":"Genome Canada","ror":"https://ror.org/029s29983"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1980436361.pdf","grobid_xml":"https://content.openalex.org/works/W1980436361.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1967042859","https://openalex.org/W1971115224","https://openalex.org/W1980516963","https://openalex.org/W1988785484","https://openalex.org/W1991133427","https://openalex.org/W2006583840","https://openalex.org/W2014143877","https://openalex.org/W2020958409","https://openalex.org/W2023369015","https://openalex.org/W2030051325","https://openalex.org/W2040912377","https://openalex.org/W2042802855","https://openalex.org/W2045615262","https://openalex.org/W2046674864","https://openalex.org/W2049633694","https://openalex.org/W2070015764","https://openalex.org/W2084063783","https://openalex.org/W2086699924","https://openalex.org/W2090974702","https://openalex.org/W2092343534","https://openalex.org/W2102304447","https://openalex.org/W2107903949","https://openalex.org/W2113574907","https://openalex.org/W2119279196","https://openalex.org/W2122598328","https://openalex.org/W2125838338","https://openalex.org/W2127028166","https://openalex.org/W2128016314","https://openalex.org/W2130365449","https://openalex.org/W2134672574","https://openalex.org/W2137518296","https://openalex.org/W2142260323","https://openalex.org/W2142299653","https://openalex.org/W2142452151","https://openalex.org/W2144137532","https://openalex.org/W2149152197","https://openalex.org/W2149681218","https://openalex.org/W2151595196","https://openalex.org/W2151831732","https://openalex.org/W2157012805","https://openalex.org/W2158893485","https://openalex.org/W2160331596","https://openalex.org/W2171005514","https://openalex.org/W6679079381","https://openalex.org/W6738852829"],"related_works":["https://openalex.org/W2784408333","https://openalex.org/W2474139959","https://openalex.org/W2018955152","https://openalex.org/W2353066939","https://openalex.org/W2098149062","https://openalex.org/W1977857377","https://openalex.org/W2227014354","https://openalex.org/W2051239254","https://openalex.org/W2152830733","https://openalex.org/W2441052099"],"abstract_inverted_index":{"Allelic":[0],"imbalance":[1,148],"(AI)":[2],"is":[3,119,149],"a":[4,11,20,57,97,106,172,181],"phenomenon":[5],"where":[6,270],"the":[7,31,48,64,191,248,261],"two":[8,32,92],"alleles":[9],"of":[10,25,28,30,36,50,94,108,156,162,229,252,264],"given":[12,21,173],"gene":[13],"are":[14,175],"expressed":[15,152],"at":[16,56,159,179],"different":[17],"levels":[18],"in":[19,39,83,158,171,178,190],"cell,":[22],"either":[23],"because":[24,35],"epigenetic":[26],"inactivation":[27],"one":[29,161],"alleles,":[33],"or":[34],"genetic":[37,262],"variation":[38,272],"regulatory":[40],"regions.":[41],"Recently,":[42],"Bing":[43],"et":[44],"al.":[45],"have":[46],"described":[47],"use":[49],"genotyping":[51],"arrays":[52],"to":[53,73,135,194,276],"assay":[54],"AI":[55,82,157,169,187,213],"high":[58],"resolution":[59],"(approximately":[60],"750,000":[61],"SNPs":[62],"across":[63],"autosomes).":[65],"In":[66],"this":[67,75,271],"paper,":[68],"we":[69],"investigate":[70],"computational":[71],"approaches":[72,111,144,241],"analyze":[74],"data":[76,125,138],"and":[77,86,104,166,236,250,267],"identify":[78,268],"genomic":[79,210],"regions":[80,170,188,211],"with":[81,130,200,212,219],"an":[84],"unbiased":[85],"robust":[87],"statistical":[88,98],"manner.":[89],"We":[90,206],"propose":[91],"families":[93],"approaches:":[95],"(i)":[96],"approach":[99],"based":[100,112],"on":[101,113,247],"z-score":[102],"computations,":[103],"(ii)":[105],"family":[107],"machine":[109],"learning":[110],"Hidden":[114],"Markov":[115],"Models.":[116],"Each":[117],"method":[118],"evaluated":[120],"using":[121],"previously":[122],"published":[123],"experimental":[124],"sets":[126],"as":[127,129,233],"well":[128],"permutation":[131],"testing.":[132],"When":[133],"applied":[134],"whole":[136],"genome":[137,192],"from":[139],"53":[140,164],"HapMap":[141],"samples,":[142],"our":[143,163],"reveal":[145],"that":[146,167,209],"allelic":[147,230,253,265],"widespread":[150],"(most":[151],"genes":[153],"show":[154],"evidence":[155],"least":[160,180],"samples)":[165],"most":[168],"individual":[174],"also":[176,207,225,257],"found":[177],"few":[182],"other":[183],"individuals.":[184],"While":[185],"many":[186],"identified":[189],"correspond":[193],"known":[195],"protein-coding":[196],"transcripts,":[197],"others":[198],"overlap":[199],"recently":[201],"discovered":[202],"long":[203],"non-coding":[204],"RNAs.":[205],"observe":[208],"not":[214,243],"only":[215,244],"include":[216],"complete":[217],"transcripts":[218],"consistent":[220],"differential":[221],"expression":[222,231,266],"levels,":[223],"but":[224,255],"more":[226],"complex":[227],"patterns":[228],"such":[232],"alternative":[234,237],"promoters":[235],"3'":[238],"end.":[239],"The":[240],"developed":[242],"shed":[245],"light":[246],"incidence":[249],"mechanisms":[251],"expression,":[254],"will":[256],"help":[258],"towards":[259],"mapping":[260],"causes":[263],"cases":[269],"may":[273],"be":[274],"linked":[275],"diseases.":[277]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":7}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}