{"id":"https://openalex.org/W2003441269","doi":"https://doi.org/10.1371/journal.pcbi.1000798","title":"Expansion of the Protein Repertoire in Newly Explored Environments: Human Gut Microbiome Specific Protein Families","display_name":"Expansion of the Protein Repertoire in Newly Explored Environments: Human Gut Microbiome Specific Protein Families","publication_year":2010,"publication_date":"2010-06-03","ids":{"openalex":"https://openalex.org/W2003441269","doi":"https://doi.org/10.1371/journal.pcbi.1000798","mag":"2003441269","pmid":"https://pubmed.ncbi.nlm.nih.gov/20532204"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000798","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000798","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000798&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000798&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055055227","display_name":"Kyle Ellrott","orcid":"https://orcid.org/0000-0002-6573-5900"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210091204","display_name":"Joint Center for Structural Genomics","ror":"https://ror.org/00exr1241","country_code":"US","type":"other","lineage":["https://openalex.org/I4210091204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle Ellrott","raw_affiliation_strings":["Joint Center for Structural Genomics, Bioinformatics Core, University of California San Diego, La Jolla, California, USA","Joint Center for Structural Genomics, Bioinformatics Core, University of California San Diego, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Center for Structural Genomics, Bioinformatics Core, University of California San Diego, La Jolla, California, USA","institution_ids":["https://openalex.org/I4210091204"]},{"raw_affiliation_string":"Joint Center for Structural Genomics, Bioinformatics Core, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210091204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066090493","display_name":"Lukasz Jaroszewski","orcid":null},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]},{"id":"https://openalex.org/I4210091204","display_name":"Joint Center for Structural Genomics","ror":"https://ror.org/00exr1241","country_code":"US","type":"other","lineage":["https://openalex.org/I4210091204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lukasz Jaroszewski","raw_affiliation_strings":["Joint Center for Structural Genomics, Bioinformatics Core, Burnham Institute for Medical Research, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Center for Structural Genomics, Bioinformatics Core, Burnham Institute for Medical Research, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I188891513","https://openalex.org/I4210091204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027145422","display_name":"Weizhong Li","orcid":"https://orcid.org/0000-0003-1804-9403"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weizhong Li","raw_affiliation_strings":["California Institute for Telecommunications and Information Technology, University of California San Diego, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"California Institute for Telecommunications and Information Technology, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113578406","display_name":"John Wooley","orcid":null},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210091204","display_name":"Joint Center for Structural Genomics","ror":"https://ror.org/00exr1241","country_code":"US","type":"other","lineage":["https://openalex.org/I4210091204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John C. Wooley","raw_affiliation_strings":["California Institute for Telecommunications and Information Technology, University of California San Diego, La Jolla, California, United States of America","Joint Center for Structural Genomics, Bioinformatics Core, Burnham Institute for Medical Research, La Jolla, California, United States of America","Joint Center for Structural Genomics, Bioinformatics Core, University of California San Diego, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"California Institute for Telecommunications and Information Technology, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Joint Center for Structural Genomics, Bioinformatics Core, Burnham Institute for Medical Research, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I188891513","https://openalex.org/I4210091204"]},{"raw_affiliation_string":"Joint Center for Structural Genomics, Bioinformatics Core, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210091204"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010671148","display_name":"Adam Godzik","orcid":"https://orcid.org/0000-0002-2425-852X"},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210091204","display_name":"Joint Center for Structural Genomics","ror":"https://ror.org/00exr1241","country_code":"US","type":"other","lineage":["https://openalex.org/I4210091204"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Adam Godzik","raw_affiliation_strings":["California Institute for Telecommunications and Information Technology, University of California San Diego, La Jolla, California, United States of America","Joint Center for Molecular Modeling, Burnham Institute for Medical Research, La Jolla, California, United States of America","Joint Center for Structural Genomics, Bioinformatics Core, Burnham Institute for Medical Research, La Jolla, California, United States of America","Joint Center for Structural Genomics, Bioinformatics Core, University of California San Diego, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"California Institute for Telecommunications and Information Technology, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Joint Center for Molecular Modeling, Burnham Institute for Medical Research, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I188891513"]},{"raw_affiliation_string":"Joint Center for Structural Genomics, Bioinformatics Core, Burnham Institute for Medical Research, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I188891513","https://openalex.org/I4210091204"]},{"raw_affiliation_string":"Joint Center for Structural Genomics, Bioinformatics Core, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210091204"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5010671148"],"corresponding_institution_ids":["https://openalex.org/I188891513","https://openalex.org/I36258959","https://openalex.org/I4210091204"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":3.2367,"has_fulltext":true,"cited_by_count":73,"citation_normalized_percentile":{"value":0.92443909,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"6","issue":"6","first_page":"e1000798","last_page":"e1000798"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.982200026512146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9812999963760376,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7391882538795471},{"id":"https://openalex.org/keywords/repertoire","display_name":"Repertoire","score":0.6710473299026489},{"id":"https://openalex.org/keywords/metagenomics","display_name":"Metagenomics","score":0.6692322492599487},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5648130774497986},{"id":"https://openalex.org/keywords/niche","display_name":"Niche","score":0.55599445104599},{"id":"https://openalex.org/keywords/protein-family","display_name":"Protein family","score":0.5515949726104736},{"id":"https://openalex.org/keywords/gut-microbiome","display_name":"Gut microbiome","score":0.5258936285972595},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.5116077065467834},{"id":"https://openalex.org/keywords/microbiome","display_name":"Microbiome","score":0.5072962641716003},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.47761270403862},{"id":"https://openalex.org/keywords/human-microbiome-project","display_name":"Human Microbiome Project","score":0.4169371426105499},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.393303781747818},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.24577131867408752},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.20112723112106323}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7391882538795471},{"id":"https://openalex.org/C2778473898","wikidata":"https://www.wikidata.org/wiki/Q2145110","display_name":"Repertoire","level":2,"score":0.6710473299026489},{"id":"https://openalex.org/C15151743","wikidata":"https://www.wikidata.org/wiki/Q903778","display_name":"Metagenomics","level":3,"score":0.6692322492599487},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5648130774497986},{"id":"https://openalex.org/C153991713","wikidata":"https://www.wikidata.org/wiki/Q17142856","display_name":"Niche","level":2,"score":0.55599445104599},{"id":"https://openalex.org/C171897839","wikidata":"https://www.wikidata.org/wiki/Q417841","display_name":"Protein family","level":3,"score":0.5515949726104736},{"id":"https://openalex.org/C3019978661","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut microbiome","level":3,"score":0.5258936285972595},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5116077065467834},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.5072962641716003},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.47761270403862},{"id":"https://openalex.org/C190944805","wikidata":"https://www.wikidata.org/wiki/Q3922751","display_name":"Human Microbiome Project","level":4,"score":0.4169371426105499},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.393303781747818},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.24577131867408752},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20112723112106323},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D054892","descriptor_name":"Metagenome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054892","descriptor_name":"Metagenome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054892","descriptor_name":"Metagenome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054892","descriptor_name":"Metagenome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1000798","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000798","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000798&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:20532204","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20532204","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:ark:/13030/qt2g11r3gf","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1000798","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1000798","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:cbfca5529d49463e89e2f7d28d18038d","is_oa":true,"landing_page_url":"https://doaj.org/article/cbfca5529d49463e89e2f7d28d18038d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 6, Iss 6, p e1000798 (2010)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt2g11r3gf","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/2g11r3gf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS computational biology, vol 6, iss 6","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/143174","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Expansion_of_the_Protein_Repertoire_in_Newly_Explored_Environments_Human_Gut_Microbiome_Specific_Protein_Families/143174","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:2880560","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2880560","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000798","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000798","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000798&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","score":0.6200000047683716,"id":"https://metadata.un.org/sdg/15"}],"awards":[{"id":"https://openalex.org/G1442054956","display_name":null,"funder_award_id":"U54 GM074898","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2391189260","display_name":null,"funder_award_id":"U54 GM 074898","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5874415062","display_name":null,"funder_award_id":"P20 GM 076221","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2003441269.pdf","grobid_xml":"https://content.openalex.org/works/W2003441269.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1791999417","https://openalex.org/W1977852030","https://openalex.org/W1985609109","https://openalex.org/W1988925586","https://openalex.org/W2042045767","https://openalex.org/W2051151530","https://openalex.org/W2056930789","https://openalex.org/W2089999388","https://openalex.org/W2097551408","https://openalex.org/W2116423958","https://openalex.org/W2124166542","https://openalex.org/W2127415562","https://openalex.org/W2131186249","https://openalex.org/W2141885858","https://openalex.org/W2145336165","https://openalex.org/W2149351690","https://openalex.org/W2155606054","https://openalex.org/W2156125289","https://openalex.org/W2156701707","https://openalex.org/W2158714788","https://openalex.org/W2169330513","https://openalex.org/W2169748335","https://openalex.org/W2175093233","https://openalex.org/W3147254695","https://openalex.org/W4210323379","https://openalex.org/W4210623056"],"related_works":["https://openalex.org/W3120300186","https://openalex.org/W3034541089","https://openalex.org/W3115809841","https://openalex.org/W4230736309","https://openalex.org/W3044286215","https://openalex.org/W2923081087","https://openalex.org/W4320918683","https://openalex.org/W2775633464","https://openalex.org/W4380448847","https://openalex.org/W4243895322"],"abstract_inverted_index":{"The":[0,176],"microbes":[1],"that":[2,13,42,54,59,63,105,166],"inhabit":[3],"particular":[4],"environments":[5],"must":[6],"be":[7],"able":[8],"to":[9,20,108,171,193],"perform":[10],"molecular":[11,27],"functions":[12,28,58],"provide":[14,184],"them":[15],"with":[16,186],"a":[17,46,134,156],"competitive":[18],"advantage":[19],"thrive":[21],"in":[22,45,62,72,97,118,141],"those":[23],"environments.":[24],"As":[25],"most":[26],"are":[29,34,55,60,106],"performed":[30],"by":[31,79,85],"proteins":[32],"and":[33,82,125,178,196],"conserved":[35],"between":[36],"related":[37],"proteins,":[38],"we":[39,111,132,167],"can":[40],"expect":[41],"organisms":[43],"successful":[44],"given":[47],"environmental":[48],"niche":[49],"would":[50],"contain":[51,89],"protein":[52,94,103,116,137,162],"families":[53,95,104,117,138,150,182],"specific":[56,107],"for":[57],"important":[61],"environment.":[64,175],"For":[65],"instance,":[66],"the":[67,75,80,113,119,142],"human":[68,122,143],"gut":[69,123],"is":[70,83],"rich":[71],"polysaccharides":[73],"from":[74],"diet":[76],"or":[77],"secreted":[78],"host,":[81],"dominated":[84],"Bacteroides,":[86],"whose":[87],"genomes":[88],"highly":[90],"expanded":[91],"repertoire":[92],"of":[93,115,136,159,180],"involved":[96],"carbohydrate":[98],"metabolism.":[99],"To":[100],"identify":[101],"other":[102],"this":[109,174],"environment,":[110],"investigated":[112],"distribution":[114],"currently":[120],"available":[121],"genomic":[124],"metagenomic":[126],"data.":[127],"Using":[128],"an":[129,190],"automated":[130],"procedure,":[131],"identified":[133],"group":[135,158],"strongly":[139],"overrepresented":[140],"gut.":[144],"These":[145],"not":[146],"only":[147],"include":[148],"many":[149],"described":[151],"previously":[152,160],"but":[153],"also,":[154],"interestingly,":[155],"large":[157],"unrecognized":[161],"families,":[163],"which":[164],"suggests":[165],"still":[168],"have":[169],"much":[170],"discover":[172],"about":[173,189],"identification":[177],"analysis":[179],"these":[181],"could":[183],"us":[185],"new":[187],"information":[188],"environment":[191],"critical":[192],"our":[194],"health":[195],"well":[197],"being.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":9}],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2025-10-10T00:00:00"}