{"id":"https://openalex.org/W2044719035","doi":"https://doi.org/10.1371/journal.pcbi.1000756","title":"Simulating Microdosimetry in a Virtual Hepatic Lobule","display_name":"Simulating Microdosimetry in a Virtual Hepatic Lobule","publication_year":2010,"publication_date":"2010-04-22","ids":{"openalex":"https://openalex.org/W2044719035","doi":"https://doi.org/10.1371/journal.pcbi.1000756","mag":"2044719035","pmid":"https://pubmed.ncbi.nlm.nih.gov/20421935"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000756","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000756","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000756&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000756&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047390888","display_name":"John F. Wambaugh","orcid":"https://orcid.org/0000-0002-4024-534X"},"institutions":[{"id":"https://openalex.org/I1302368450","display_name":"Environmental Protection Agency","ror":"https://ror.org/03tns0030","country_code":"US","type":"government","lineage":["https://openalex.org/I1302368450"]},{"id":"https://openalex.org/I1309191912","display_name":"Research Triangle Park Foundation","ror":"https://ror.org/03eqttr49","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1309191912"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John Wambaugh","raw_affiliation_strings":["National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America. wambaugh.john@epa.gov","National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America. wambaugh.john@epa.gov","institution_ids":["https://openalex.org/I1309191912"]},{"raw_affiliation_string":"National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America","institution_ids":["https://openalex.org/I1309191912","https://openalex.org/I1302368450"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101805304","display_name":"Imran Shah","orcid":"https://orcid.org/0000-0003-0808-0140"},"institutions":[{"id":"https://openalex.org/I1302368450","display_name":"Environmental Protection Agency","ror":"https://ror.org/03tns0030","country_code":"US","type":"government","lineage":["https://openalex.org/I1302368450"]},{"id":"https://openalex.org/I1309191912","display_name":"Research Triangle Park Foundation","ror":"https://ror.org/03eqttr49","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1309191912"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Imran Shah","raw_affiliation_strings":["National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America","institution_ids":["https://openalex.org/I1309191912","https://openalex.org/I1302368450"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5047390888"],"corresponding_institution_ids":["https://openalex.org/I1302368450","https://openalex.org/I1309191912"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":3.4721,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.91672975,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"6","issue":"4","first_page":"e1000756","last_page":"e1000756"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9914000034332275,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9914000034332275,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9714000225067139,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9151999950408936,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lobules-of-liver","display_name":"Lobules of liver","score":0.7597860097885132},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.48221099376678467},{"id":"https://openalex.org/keywords/modular-design","display_name":"Modular design","score":0.4703754782676697},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4137651324272156},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.35924452543258667},{"id":"https://openalex.org/keywords/physiology","display_name":"Physiology","score":0.3492905795574188},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.3382880389690399},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.33447927236557007},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.3299523591995239},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3077658414840698},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2039562463760376}],"concepts":[{"id":"https://openalex.org/C57322979","wikidata":"https://www.wikidata.org/wiki/Q11611496","display_name":"Lobules of liver","level":2,"score":0.7597860097885132},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48221099376678467},{"id":"https://openalex.org/C101468663","wikidata":"https://www.wikidata.org/wiki/Q1620158","display_name":"Modular design","level":2,"score":0.4703754782676697},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4137651324272156},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.35924452543258667},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3492905795574188},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3382880389690399},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33447927236557007},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3299523591995239},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3077658414840698},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2039562463760376},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004781","descriptor_name":"Environmental Exposure","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004781","descriptor_name":"Environmental Exposure","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004781","descriptor_name":"Environmental Exposure","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004785","descriptor_name":"Environmental Pollutants","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D004785","descriptor_name":"Environmental Pollutants","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D004785","descriptor_name":"Environmental Pollutants","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D006503","descriptor_name":"Hepatic Veins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006503","descriptor_name":"Hepatic Veins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006503","descriptor_name":"Hepatic Veins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018675","descriptor_name":"Toxicity Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018675","descriptor_name":"Toxicity Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018675","descriptor_name":"Toxicity Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1000756","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000756","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000756&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:20421935","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20421935","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1000756","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1000756","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:9533a02ee2f7487e95351188b9e05c9d","is_oa":true,"landing_page_url":"https://doaj.org/article/9533a02ee2f7487e95351188b9e05c9d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 6, Iss 4, p e1000756 (2010)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2858695","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2858695","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000756","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000756","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000756&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2044719035.pdf","grobid_xml":"https://content.openalex.org/works/W2044719035.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W152943885","https://openalex.org/W414133342","https://openalex.org/W605068603","https://openalex.org/W1579194856","https://openalex.org/W1876153904","https://openalex.org/W1920965755","https://openalex.org/W1967977080","https://openalex.org/W1969415106","https://openalex.org/W1989572172","https://openalex.org/W1997369444","https://openalex.org/W1997457016","https://openalex.org/W1998229567","https://openalex.org/W2004429971","https://openalex.org/W2004566760","https://openalex.org/W2006360372","https://openalex.org/W2020106098","https://openalex.org/W2020138408","https://openalex.org/W2028696793","https://openalex.org/W2029393511","https://openalex.org/W2031829321","https://openalex.org/W2039585333","https://openalex.org/W2042506106","https://openalex.org/W2043456783","https://openalex.org/W2044249462","https://openalex.org/W2044814462","https://openalex.org/W2056455169","https://openalex.org/W2076325336","https://openalex.org/W2080482503","https://openalex.org/W2088284942","https://openalex.org/W2090058128","https://openalex.org/W2096474952","https://openalex.org/W2107730987","https://openalex.org/W2114493453","https://openalex.org/W2122025333","https://openalex.org/W2125273308","https://openalex.org/W2132296608","https://openalex.org/W2155418451","https://openalex.org/W2156433146","https://openalex.org/W2165429151","https://openalex.org/W2166962164","https://openalex.org/W2432203972","https://openalex.org/W2480173306","https://openalex.org/W2582743722","https://openalex.org/W2608169504","https://openalex.org/W3145128584","https://openalex.org/W4388166335","https://openalex.org/W6635433165","https://openalex.org/W7029321148"],"related_works":["https://openalex.org/W2021521361","https://openalex.org/W2282440321","https://openalex.org/W1978097758","https://openalex.org/W2378076731","https://openalex.org/W4286888643","https://openalex.org/W3210795196","https://openalex.org/W1899793246","https://openalex.org/W2467957350","https://openalex.org/W338265355","https://openalex.org/W2088988140"],"abstract_inverted_index":{"The":[0,125,191],"liver":[1,72,184],"plays":[2],"a":[3,80,88,139,160,187],"key":[4],"role":[5],"in":[6,70,103,169,173,180,186],"removing":[7],"harmful":[8],"chemicals":[9,131,144],"from":[10],"the":[11,17,35,48,92,104,109,117,151,156,181,197],"body":[12],"and":[13,114,138,213],"is":[14,30,47,57,67,200],"therefore":[15],"often":[16],"first":[18],"tissue":[19],"to":[20,32,42,68,78,99,123,195],"suffer":[21],"potentially":[22],"adverse":[23],"consequences.":[24],"To":[25],"protect":[26],"public":[27],"health":[28],"it":[29,56],"necessary":[31],"quantitatively":[33],"estimate":[34],"risk":[36,54],"of":[37,91,111,128,150],"long-term":[38,205],"low":[39],"dose":[40],"exposure":[41,122],"environmental":[43],"pollutants.":[44],"Animal":[45],"testing":[46],"primary":[49],"tool":[50],"for":[51,203,208,215],"extrapolating":[52],"human":[53],"but":[55],"fraught":[58],"with":[59,74,217],"uncertainty,":[60],"necessitating":[61],"novel":[62],"alternative":[63],"approaches.":[64],"Our":[65],"goal":[66],"integrate":[69],"vitro":[71],"experiments":[73],"agent-based":[75],"cellular":[76,171,211],"models":[77],"simulate":[79],"spatially":[81,163],"extended":[82,164],"hepatic":[83,105,198],"lobule.":[84,106],"Here":[85],"we":[86],"describe":[87],"graphical":[89,193],"model":[90],"sinusoidal":[93],"network":[94],"that":[95],"efficiently":[96],"simulates":[97],"portal":[98],"centrilobular":[100],"mass":[101],"transfer":[102],"We":[107],"analyzed":[108],"effects":[110],"vascular":[112,136,157],"topology":[113],"metabolism":[115],"on":[116],"cell-level":[118],"distribution":[119,127],"following":[120],"oral":[121],"chemicals.":[124],"spatial":[126],"metabolically":[129],"inactive":[130],"was":[132],"similar":[133],"across":[134,155],"different":[135],"networks":[137],"baseline":[140],"well-mixed":[141,183],"compartment.":[142],"When":[143],"were":[145,178],"rapidly":[146],"metabolized,":[147],"concentration":[148],"heterogeneity":[149],"parent":[152],"compound":[153],"increased":[154],"network.":[158],"As":[159],"result,":[161],"our":[162],"lobule":[165,199],"generated":[166],"greater":[167],"variability":[168],"dose-dependent":[170],"responses,":[172],"this":[174],"case":[175],"apoptosis,":[176],"than":[177],"observed":[179],"classical":[182],"or":[185],"parallel":[188],"tubes":[189],"model.":[190],"mass-balanced":[192],"approach":[194],"modeling":[196],"computationally":[201],"efficient":[202],"simulating":[204],"exposure,":[206],"modular":[207],"incorporating":[209],"complex":[210],"interactions,":[212],"flexible":[214],"dealing":[216],"evolving":[218],"tissues.":[219]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":6}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}