{"id":"https://openalex.org/W2143736326","doi":"https://doi.org/10.1371/journal.pcbi.1000737","title":"New Insights into the Genetic Control of Gene Expression using a Bayesian Multi-tissue Approach","display_name":"New Insights into the Genetic Control of Gene Expression using a Bayesian Multi-tissue Approach","publication_year":2010,"publication_date":"2010-04-08","ids":{"openalex":"https://openalex.org/W2143736326","doi":"https://doi.org/10.1371/journal.pcbi.1000737","mag":"2143736326","pmid":"https://pubmed.ncbi.nlm.nih.gov/20386736"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000737","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000737","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000737&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000737&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070290329","display_name":"Enrico Petretto","orcid":"https://orcid.org/0000-0003-2163-5921"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"funder","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Enrico Petretto","raw_affiliation_strings":["Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, United Kingdom","Department of Epidemiology and Biostatistics, Faculty of Medicine, Imperial College, London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I90344618","https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, Faculty of Medicine, Imperial College, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016094222","display_name":"Leonardo Bottolo","orcid":"https://orcid.org/0000-0002-6381-2327"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"funder","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Leonardo Bottolo","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, Faculty of Medicine, Imperial College, London, United Kingdom","Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, Faculty of Medicine, Imperial College, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I90344618","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062596666","display_name":"Sarah R. Langley","orcid":"https://orcid.org/0000-0003-4419-476X"},"institutions":[{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"funder","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sarah R. Langley","raw_affiliation_strings":["Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I90344618","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012712519","display_name":"Matthias Heinig","orcid":"https://orcid.org/0000-0002-5612-1720"},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Heinig","raw_affiliation_strings":["Max-Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany"],"affiliations":[{"raw_affiliation_string":"Max-Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074671228","display_name":"Chris McDermott\u2010Roe","orcid":null},"institutions":[{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"funder","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Chris McDermott-Roe","raw_affiliation_strings":["Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I90344618","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047755260","display_name":"Rizwan Sarwar","orcid":"https://orcid.org/0000-0003-3297-2528"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"funder","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rizwan Sarwar","raw_affiliation_strings":["Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I90344618","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033492851","display_name":"Michal Pravenec","orcid":"https://orcid.org/0000-0001-9197-5871"},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"funder","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210166371","display_name":"Czech Academy of Sciences, Institute of Physiology","ror":"https://ror.org/05xw0ep96","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210166371"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Michal Pravenec","raw_affiliation_strings":["Charles University in Prague, Institute of Biology and Medical Genetics of the First Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic","Institute of Physiology, Czech Academy of Sciences and Centre for Applied Genomics, Prague, Czech Republic"],"affiliations":[{"raw_affiliation_string":"Charles University in Prague, Institute of Biology and Medical Genetics of the First Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic","institution_ids":["https://openalex.org/I21250087"]},{"raw_affiliation_string":"Institute of Physiology, Czech Academy of Sciences and Centre for Applied Genomics, Prague, Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210166371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058205173","display_name":"Norbert H\u00fcbner","orcid":"https://orcid.org/0000-0002-1218-6223"},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Norbert H\u00fcbner","raw_affiliation_strings":["Max-Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany"],"affiliations":[{"raw_affiliation_string":"Max-Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041822939","display_name":"Timothy J. Aitman","orcid":"https://orcid.org/0000-0002-7875-4502"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"funder","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Timothy J. Aitman","raw_affiliation_strings":["Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, United Kingdom","Section of Molecular Genetics and Rheumatology, Division and Faculty of Medicine, Imperial College, London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I90344618","https://openalex.org/I47508984"]},{"raw_affiliation_string":"Section of Molecular Genetics and Rheumatology, Division and Faculty of Medicine, Imperial College, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071216592","display_name":"Stuart A. Cook","orcid":"https://orcid.org/0000-0001-6628-194X"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"funder","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stuart A. Cook","raw_affiliation_strings":["Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, United Kingdom","National Heart and Lung Institute, Imperial College, London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I90344618","https://openalex.org/I47508984"]},{"raw_affiliation_string":"National Heart and Lung Institute, Imperial College, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086827100","display_name":"Sylvia Richardson","orcid":"https://orcid.org/0000-0003-1998-492X"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Sylvia Richardson","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, Faculty of Medicine, Imperial College, London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, Faculty of Medicine, Imperial College, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5086827100"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":7.0195,"has_fulltext":true,"cited_by_count":108,"citation_normalized_percentile":{"value":0.97458164,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"6","issue":"4","first_page":"e1000737","last_page":"e1000737"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/expression-quantitative-trait-loci","display_name":"Expression quantitative trait loci","score":0.9274359941482544},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6594066619873047},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6226771473884583},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.4833516776561737},{"id":"https://openalex.org/keywords/quantitative-trait-locus","display_name":"Quantitative trait locus","score":0.47564956545829773},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4612601697444916},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.4570472538471222},{"id":"https://openalex.org/keywords/generality","display_name":"Generality","score":0.42940717935562134},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.4129316806793213},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3616454303264618},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.333059698343277},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.241708904504776},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.12406110763549805}],"concepts":[{"id":"https://openalex.org/C168393362","wikidata":"https://www.wikidata.org/wiki/Q5421706","display_name":"Expression quantitative trait loci","level":5,"score":0.9274359941482544},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6594066619873047},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6226771473884583},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.4833516776561737},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.47564956545829773},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4612601697444916},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4570472538471222},{"id":"https://openalex.org/C2780767217","wikidata":"https://www.wikidata.org/wiki/Q5532421","display_name":"Generality","level":2,"score":0.42940717935562134},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4129316806793213},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3616454303264618},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.333059698343277},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.241708904504776},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.12406110763549805},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":16,"locations":[{"id":"doi:10.1371/journal.pcbi.1000737","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000737","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000737&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:20386736","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20386736","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pure.ed.ac.uk:openaire/4a9912d2-01c9-49e3-8e04-969e9eeaea3a","is_oa":true,"landing_page_url":"https://www.research.ed.ac.uk/en/publications/4a9912d2-01c9-49e3-8e04-969e9eeaea3a","pdf_url":null,"source":{"id":"https://openalex.org/S4306400321","display_name":"Edinburgh Research Explorer (University of Edinburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I98677209","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/I98677209"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Petretto, E, Bottolo, L, Langley, S R, Heinig, M, McDermott-Roe, C, Sarwar, R, Pravenec, M, H\u00fcbner, N, Aitman, T J, Cook, S A & Richardson, S 2010, 'New insights into the genetic control of gene expression using a Bayesian multi-tissue approach', PLoS Computational Biology, vol. 6, no. 4, pp. e1000737. https://doi.org/10.1371/journal.pcbi.1000737","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:edoc.mdc-berlin.de:10973","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306400224","display_name":"MDC Repository (Max-Delbrueck-Center for Molecular Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/141855","is_oa":false,"landing_page_url":"http://scholarbank.nus.edu.sg/handle/10635/141855","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus","raw_type":"Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.813.8175","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.813.8175","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/f6/5b/pcbi.1000737.PMC2851562.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.832.1472","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.832.1472","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://spiral.imperial.ac.uk/bitstream/10044/1/6169/1/journal.pcbi.1000737.pdf","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1000737","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1000737","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:asep.lib.cas.cz:CavUnEpca/0342527","is_oa":false,"landing_page_url":"http://hdl.handle.net/11104/0185241","pdf_url":null,"source":{"id":"https://openalex.org/S7407055266","display_name":"ASEP","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doaj.org/article:fa03e8369f94439c891b89f213b42112","is_oa":true,"landing_page_url":"https://doaj.org/article/fa03e8369f94439c891b89f213b42112","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 6, Iss 4, p e1000737 (2010)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/143953","is_oa":true,"landing_page_url":"https://figshare.com/articles/New_Insights_into_the_Genetic_Control_of_Gene_Expression_using_a_Bayesian_Multi_tissue_Approach/143953","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:https://orca.cardiff.ac.uk:162137","is_oa":false,"landing_page_url":"https://orca.cardiff.ac.uk/id/eprint/162137/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/aee0eaca-407b-466b-83aa-8b33bb65946a","is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/aee0eaca-407b-466b-83aa-8b33bb65946a","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Petretto, E, Bottolo, L, Langley, S R, Heinig, M, McDermott-Roe, C, Sarwar, R, Pravenec, M, H\u00fcbner, N, Aitman, T J, Cook, S A & Richardson, S 2010, 'New insights into the genetic control of gene expression using a Bayesian multi-tissue approach', PL o S Computational Biology, vol. 6, no. 4, pp. e1000737. https://doi.org/10.1371/journal.pcbi.1000737","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:pubmedcentral.nih.gov:2851562","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2851562","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:pure.ed.ac.uk:publications/4a9912d2-01c9-49e3-8e04-969e9eeaea3a","is_oa":true,"landing_page_url":"http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1000737","pdf_url":null,"source":{"id":"https://openalex.org/S4306400321","display_name":"Edinburgh Research Explorer (University of Edinburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I98677209","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/I98677209"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/6169","is_oa":true,"landing_page_url":"http://hdl.handle.net/10044/1/6169","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"e1000737","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000737","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000737","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000737&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/17","display_name":"Partnerships for the goals","score":0.44999998807907104}],"awards":[{"id":"https://openalex.org/G1773549302","display_name":null,"funder_award_id":"Leducq","funder_id":"https://openalex.org/F4320320890","funder_display_name":"Fondation Leducq"},{"id":"https://openalex.org/G5855488573","display_name":null,"funder_award_id":"G0600","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G8051717526","display_name":null,"funder_award_id":"Grant","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"},{"id":"https://openalex.org/F4320320240","display_name":"Research Councils UK","ror":"https://ror.org/00dq2kk65"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320890","display_name":"Fondation Leducq","ror":"https://ror.org/01czwga19"},{"id":"https://openalex.org/F4320321006","display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","ror":"https://ror.org/01pv73b02"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2143736326.pdf","grobid_xml":"https://content.openalex.org/works/W2143736326.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1486016120","https://openalex.org/W1985135683","https://openalex.org/W1996184324","https://openalex.org/W2007656267","https://openalex.org/W2010064539","https://openalex.org/W2013524758","https://openalex.org/W2020389170","https://openalex.org/W2031452361","https://openalex.org/W2033270597","https://openalex.org/W2039627167","https://openalex.org/W2043842514","https://openalex.org/W2048868021","https://openalex.org/W2049228615","https://openalex.org/W2063040034","https://openalex.org/W2067245109","https://openalex.org/W2068646716","https://openalex.org/W2074693857","https://openalex.org/W2078644085","https://openalex.org/W2090808827","https://openalex.org/W2091988898","https://openalex.org/W2094248448","https://openalex.org/W2105381419","https://openalex.org/W2106067432","https://openalex.org/W2108334325","https://openalex.org/W2109972881","https://openalex.org/W2110614590","https://openalex.org/W2112440119","https://openalex.org/W2116265489","https://openalex.org/W2119149290","https://openalex.org/W2122137553","https://openalex.org/W2122538288","https://openalex.org/W2123168196","https://openalex.org/W2127801899","https://openalex.org/W2131668296","https://openalex.org/W2134066661","https://openalex.org/W2135046866","https://openalex.org/W2145090915","https://openalex.org/W2152294923","https://openalex.org/W2152933101","https://openalex.org/W2154201415","https://openalex.org/W2154998360","https://openalex.org/W2159347337","https://openalex.org/W2161503382","https://openalex.org/W2164701731","https://openalex.org/W2166624680","https://openalex.org/W2169986196","https://openalex.org/W2171070506","https://openalex.org/W3214323364","https://openalex.org/W4211177544"],"related_works":["https://openalex.org/W2045049461","https://openalex.org/W4381094582","https://openalex.org/W1978893398","https://openalex.org/W1977906818","https://openalex.org/W2201908702","https://openalex.org/W2369625323","https://openalex.org/W2364579609","https://openalex.org/W1522139108","https://openalex.org/W2353528968","https://openalex.org/W2602141149"],"abstract_inverted_index":{"The":[0],"majority":[1],"of":[2,30,46,55,86,108,118,147,156,194,212],"expression":[3,32,48,149,190],"quantitative":[4],"trait":[5],"locus":[6],"(eQTL)":[7],"studies":[8],"have":[9,59],"been":[10,60],"carried":[11],"out":[12],"in":[13,33,89,103,162],"single":[14,168],"tissues":[15,35,50,76,152],"or":[16],"cell":[17],"types,":[18],"using":[19],"methods":[20,96],"that":[21,94,131],"ignore":[22],"information":[23],"shared":[24],"across":[25,49,79,150],"tissues.":[26,80],"Although":[27],"global":[28,188],"analysis":[29,45,54,211],"RNA":[31],"multiple":[34,56,213],"is":[36],"now":[37],"feasible,":[38],"few":[39],"integrated":[40],"statistical":[41],"frameworks":[42],"for":[43,71,127,153],"joint":[44],"gene":[47,130,148,189],"combined":[51],"with":[52,167,207],"simultaneous":[53],"genetic":[57,145,184],"variants":[58],"developed":[61],"to":[62,181,201,210],"date.":[63],"Here,":[64],"we":[65,92,121],"propose":[66],"Sparse":[67],"Bayesian":[68],"Regression":[69],"models":[70],"mapping":[72],"eQTLs":[73,163],"within":[74],"individual":[75],"and":[77,135,205,215],"simultaneously":[78],"Testing":[81],"these":[82],"on":[83],"a":[84,123,178],"set":[85],"2,000":[87],"genes":[88],"four":[90,151],"tissues,":[91],"demonstrate":[93],"our":[95,119,195],"are":[97],"more":[98],"powerful":[99],"than":[100],"traditional":[101],"approaches":[102],"revealing":[104],"the":[105,109,113,116,128,192],"true":[106],"complexity":[107],"eQTL":[110],"landscape":[111],"at":[112,171],"systems-level.":[114],"Highlighting":[115],"power":[117],"method,":[120],"identified":[122],"two-eQTL":[124],"model":[125,203],"(cis/trans)":[126],"Hopx":[129],"was":[132,136],"experimentally":[133],"validated":[134],"not":[137],"detected":[138],"by":[139],"conventional":[140],"approaches.":[141],"We":[142],"showed":[143],"common":[144],"regulation":[146],"approximately":[154],"27%":[155],"transcripts,":[157],"providing":[158],">5":[159],"fold":[160],"increase":[161],"detection":[164],"when":[165],"compared":[166],"tissue":[169],"analyses":[170],"5%":[172],"FDR":[173],"level.":[174],"These":[175],"findings":[176],"provide":[177],"new":[179],"opportunity":[180],"uncover":[182],"complex":[183],"regulatory":[185],"mechanisms":[186],"controlling":[187],"while":[191],"generality":[193],"modelling":[196],"approach":[197],"makes":[198],"it":[199],"adaptable":[200],"other":[202],"systems":[204],"humans,":[206],"broad":[208],"application":[209],"intermediate":[214],"whole-body":[216],"phenotypes.":[217]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":9}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}