{"id":"https://openalex.org/W1991949383","doi":"https://doi.org/10.1371/journal.pcbi.1000734","title":"A Human-Specific De Novo Protein-Coding Gene Associated with Human Brain Functions","display_name":"A Human-Specific De Novo Protein-Coding Gene Associated with Human Brain Functions","publication_year":2010,"publication_date":"2010-03-25","ids":{"openalex":"https://openalex.org/W1991949383","doi":"https://doi.org/10.1371/journal.pcbi.1000734","mag":"1991949383","pmid":"https://pubmed.ncbi.nlm.nih.gov/20376170"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000734","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000734","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000734&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000734&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103513536","display_name":"Chuan-Yun Li","orcid":null},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chuan-Yun Li","raw_affiliation_strings":["Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing, China","Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University. Beijing, China"],"affiliations":[{"raw_affiliation_string":"Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University. Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113427686","display_name":"Yong Zhang","orcid":"https://orcid.org/0000-0002-2281-4481"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Yong Zhang","raw_affiliation_strings":["Department of Ecology and Evolution, The University of Chicago, Chicago, Illinois, United States of America","Institute of Molecular Medicine, Peking University, Beijing, China","Department of Ecology & Evolution, The University of Chicago, Chicago, Illinois, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolution, The University of Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Institute of Molecular Medicine, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Department of Ecology & Evolution, The University of Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101878679","display_name":"Zhanbo Wang","orcid":"https://orcid.org/0000-0002-4316-887X"},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhanbo Wang","raw_affiliation_strings":["Department of Pathology, Chinese PLA General Hospital, Beijing, China","Department of pathology, Chinese PLA General Hospital, Beijing, China"],"affiliations":[{"raw_affiliation_string":"Department of Pathology, Chinese PLA General Hospital, Beijing, China","institution_ids":["https://openalex.org/I2802939634"]},{"raw_affiliation_string":"Department of pathology, Chinese PLA General Hospital, Beijing, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100456324","display_name":"Yan Zhang","orcid":"https://orcid.org/0000-0002-8322-467X"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Yan Zhang","raw_affiliation_strings":["Department of Ecology and Evolution, The University of Chicago, Chicago, Illinois, United States of America","Institute of Molecular Medicine, Peking University, Beijing, China","Institute of Molecular Medicine Peking University  Beijing China"],"affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolution, The University of Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Institute of Molecular Medicine, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Institute of Molecular Medicine Peking University  Beijing China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101265788","display_name":"Chunmei Cao","orcid":"https://orcid.org/0000-0002-7192-5348"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunmei Cao","raw_affiliation_strings":["Institute of Molecular Medicine, Peking University, Beijing, China","Institute of Molecular Medicine Peking University  Beijing China"],"affiliations":[{"raw_affiliation_string":"Institute of Molecular Medicine, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Institute of Molecular Medicine Peking University  Beijing China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112240077","display_name":"Ping-Wu Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I1327069482","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I1327069482"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ping-Wu Zhang","raw_affiliation_strings":["Molecular Neurobiology Branch, NIDA, Baltimore, Maryland, United States of America"],"affiliations":[{"raw_affiliation_string":"Molecular Neurobiology Branch, NIDA, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I1327069482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067397554","display_name":"Shu-Juan Lu","orcid":null},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shu-Juan Lu","raw_affiliation_strings":["Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing, China","Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University. Beijing, China"],"affiliations":[{"raw_affiliation_string":"Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University. Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111593965","display_name":"Xiao-Mo Li","orcid":null},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Mo Li","raw_affiliation_strings":["Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing, China","Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University. Beijing, China"],"affiliations":[{"raw_affiliation_string":"Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University. Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016815153","display_name":"Yu Quan","orcid":"https://orcid.org/0000-0002-3103-3118"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Quan Yu","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing, China"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068870075","display_name":"Xiaofeng Zheng","orcid":"https://orcid.org/0000-0001-6790-0669"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaofeng Zheng","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing, China"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101986061","display_name":"Quan Du","orcid":"https://orcid.org/0000-0002-9871-0718"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Quan Du","raw_affiliation_strings":["Institute of Molecular Medicine, Peking University, Beijing, China","Institute of Molecular Medicine Peking University  Beijing China"],"affiliations":[{"raw_affiliation_string":"Institute of Molecular Medicine, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Institute of Molecular Medicine Peking University  Beijing China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061872948","display_name":"George R. Uhl","orcid":"https://orcid.org/0000-0001-8758-7913"},"institutions":[{"id":"https://openalex.org/I1327069482","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I1327069482"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George R. Uhl","raw_affiliation_strings":["Molecular Neurobiology Branch, NIDA, Baltimore, Maryland, United States of America"],"affiliations":[{"raw_affiliation_string":"Molecular Neurobiology Branch, NIDA, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I1327069482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022384896","display_name":"Qing\u2010Rong Liu","orcid":"https://orcid.org/0000-0001-8477-6452"},"institutions":[{"id":"https://openalex.org/I1327069482","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I1327069482"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Qing-Rong Liu","raw_affiliation_strings":["Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, NIH/DHHS, Baltimore, Maryland, United States of America"],"affiliations":[{"raw_affiliation_string":"Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, NIH/DHHS, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I1327069482"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022243401","display_name":"Liping Wei","orcid":"https://orcid.org/0000-0002-1795-8755"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Liping Wei","raw_affiliation_strings":["Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing, China","Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University. Beijing, China"],"affiliations":[{"raw_affiliation_string":"Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University. Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5022243401","https://openalex.org/A5022384896"],"corresponding_institution_ids":["https://openalex.org/I1327069482","https://openalex.org/I20231570"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":4.4729,"has_fulltext":true,"cited_by_count":133,"citation_normalized_percentile":{"value":0.9520384,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"6","issue":"3","first_page":"e1000734","last_page":"e1000734"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7794705629348755},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6869546175003052},{"id":"https://openalex.org/keywords/human-brain","display_name":"Human brain","score":0.6217970252037048},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.6178738474845886},{"id":"https://openalex.org/keywords/coding-region","display_name":"Coding region","score":0.5286405682563782},{"id":"https://openalex.org/keywords/human-genome","display_name":"Human genome","score":0.49537956714630127},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"Alternative splicing","score":0.4651079773902893},{"id":"https://openalex.org/keywords/exon","display_name":"Exon","score":0.45517921447753906},{"id":"https://openalex.org/keywords/open-reading-frame","display_name":"Open reading frame","score":0.4150780439376831},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.2457941174507141},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.21825596690177917},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.1661573350429535}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7794705629348755},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6869546175003052},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.6217970252037048},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6178738474845886},{"id":"https://openalex.org/C91779695","wikidata":"https://www.wikidata.org/wiki/Q3780824","display_name":"Coding region","level":3,"score":0.5286405682563782},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.49537956714630127},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.4651079773902893},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.45517921447753906},{"id":"https://openalex.org/C47289529","wikidata":"https://www.wikidata.org/wiki/Q908550","display_name":"Open reading frame","level":4,"score":0.4150780439376831},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.2457941174507141},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.21825596690177917},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.1661573350429535}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1000734","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000734","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000734&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:20376170","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20376170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:uchicago.tind.io:10222","is_oa":true,"landing_page_url":"http://knowledge.uchicago.edu/record/10222","pdf_url":null,"source":{"id":"https://openalex.org/S4306402460","display_name":"Knowledge@UChicago (University of Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I40347166","host_organization_name":"University of Chicago","host_organization_lineage":["https://openalex.org/I40347166"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://knowledge.uchicago.edu/record/10222","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:017e06904f1e4a31bd3453becfc9d0ae","is_oa":true,"landing_page_url":"https://doaj.org/article/017e06904f1e4a31bd3453becfc9d0ae","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 6, Iss 3, p e1000734 (2010)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/144061","is_oa":true,"landing_page_url":"https://figshare.com/articles/A_Human_Specific_De_Novo_Protein_Coding_Gene_Associated_with_Human_Brain_Functions/144061","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:2845654","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2845654","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000734","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000734","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000734&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3497591915","display_name":null,"funder_award_id":"(NIH)","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1991949383.pdf","grobid_xml":"https://content.openalex.org/works/W1991949383.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1566107011","https://openalex.org/W1945375853","https://openalex.org/W1970314595","https://openalex.org/W1971074826","https://openalex.org/W1971307410","https://openalex.org/W1973614663","https://openalex.org/W1976457249","https://openalex.org/W1981618829","https://openalex.org/W2017856476","https://openalex.org/W2025153944","https://openalex.org/W2031269976","https://openalex.org/W2034464839","https://openalex.org/W2043556230","https://openalex.org/W2046308099","https://openalex.org/W2060088620","https://openalex.org/W2077723521","https://openalex.org/W2078964153","https://openalex.org/W2084988623","https://openalex.org/W2093113214","https://openalex.org/W2096525273","https://openalex.org/W2102234847","https://openalex.org/W2103807671","https://openalex.org/W2110043783","https://openalex.org/W2110599247","https://openalex.org/W2114175948","https://openalex.org/W2114439159","https://openalex.org/W2119923823","https://openalex.org/W2121016876","https://openalex.org/W2127441450","https://openalex.org/W2128643990","https://openalex.org/W2145633859","https://openalex.org/W2160697532","https://openalex.org/W2160919518","https://openalex.org/W2161978970","https://openalex.org/W2164075646","https://openalex.org/W2168546553","https://openalex.org/W2168909179","https://openalex.org/W2740984310","https://openalex.org/W2772934464","https://openalex.org/W3124412114","https://openalex.org/W4211208250","https://openalex.org/W4239678514"],"related_works":["https://openalex.org/W2126915562","https://openalex.org/W4287110707","https://openalex.org/W2059202803","https://openalex.org/W1994154030","https://openalex.org/W2393371103","https://openalex.org/W2052050039","https://openalex.org/W2002013777","https://openalex.org/W2005844856","https://openalex.org/W1974337044","https://openalex.org/W2372080170"],"abstract_inverted_index":{"To":[0],"understand":[1],"whether":[2],"any":[3],"human-specific":[4,35,195,208],"new":[5],"genes":[6,211],"may":[7],"be":[8,221],"associated":[9],"with":[10],"human":[11,95,157,166,224],"brain":[12,167,185,225],"functions,":[13],"we":[14],"computationally":[15],"screened":[16],"the":[17,69,72,82,94,120,170,188,202],"genetic":[18],"vulnerable":[19],"factors":[20],"identified":[21],"through":[22],"Genome-Wide":[23],"Association":[24],"Studies":[25],"and":[26,32,76,87,89,101,116,160,216,220],"linkage":[27],"analyses":[28],"of":[29,51,62,71,107,172,179,190,197],"nicotine":[30],"addiction":[31],"found":[33],"one":[34],"de":[36,209],"novo":[37,210],"protein-coding":[38,214],"gene,":[39],"FLJ33706":[40,129,141,173,180,200],"(alternative":[41],"gene":[42,54,193],"symbol":[43],"C20orf203).":[44],"Cross-species":[45],"analysis":[46],"revealed":[47,169],"interesting":[48],"evolutionary":[49],"paths":[50],"how":[52],"this":[53,191],"had":[55],"originated":[56],"from":[57],"noncoding":[58],"DNA":[59],"sequences:":[60],"insertion":[61],"repeat":[63],"elements":[64],"especially":[65],"Alu":[66],"contributed":[67],"to":[68,85],"formation":[70],"first":[73],"coding":[74],"exon":[75],"six":[77],"standard":[78],"splice":[79],"junctions":[80],"on":[81],"branch":[83],"leading":[84],"humans":[86],"chimpanzees,":[88],"two":[90,98],"subsequent":[91],"substitutions":[92],"in":[93,119,124,134,164,175,183,194,223],"lineage":[96],"escaped":[97],"stop":[99],"codons":[100],"created":[102],"an":[103],"open":[104],"reading":[105],"frame":[106],"194":[108],"amino":[109],"acids.":[110],"We":[111],"experimentally":[112],"verified":[113],"FLJ33706's":[114],"mRNA":[115],"protein":[117,144,154,174,218],"expression":[118,155],"brain.":[121,135],"Real-Time":[122],"PCR":[123],"multiple":[125],"tissues":[126],"demonstrated":[127],"that":[128,140,207],"was":[130],"most":[131],"abundantly":[132],"expressed":[133],"Human":[136],"polymorphism":[137],"data":[138],"suggested":[139],"encodes":[142],"a":[143],"under":[145],"purifying":[146],"selection.":[147],"A":[148],"specifically":[149],"designed":[150],"antibody":[151],"detected":[152,182],"its":[153],"across":[156],"cortex,":[158],"cerebellum":[159],"midbrain.":[161],"Immunohistochemistry":[162],"study":[163],"normal":[165],"cortex":[168],"localization":[171],"neurons.":[176],"Elevated":[177],"expressions":[178],"were":[181],"Alzheimer's":[184,198],"samples,":[186],"suggesting":[187],"role":[189],"novel":[192],"pathogenesis":[196],"disease.":[199],"provided":[201],"strongest":[203],"evidence":[204],"so":[205],"far":[206],"can":[212],"have":[213],"potential":[215],"differential":[217],"expression,":[219],"involved":[222],"functions.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":10}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}