{"id":"https://openalex.org/W1970390819","doi":"https://doi.org/10.1371/journal.pcbi.1000723","title":"Temperature Control of Fimbriation Circuit Switch in Uropathogenic Escherichia coli: Quantitative Analysis via Automated Model Abstraction","display_name":"Temperature Control of Fimbriation Circuit Switch in Uropathogenic Escherichia coli: Quantitative Analysis via Automated Model Abstraction","publication_year":2010,"publication_date":"2010-03-25","ids":{"openalex":"https://openalex.org/W1970390819","doi":"https://doi.org/10.1371/journal.pcbi.1000723","mag":"1970390819","pmid":"https://pubmed.ncbi.nlm.nih.gov/20361050"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000723","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000723","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000723&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000723&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005997934","display_name":"Hiroyuki Kuwahara","orcid":"https://orcid.org/0000-0001-5333-6729"},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiroyuki Kuwahara","raw_affiliation_strings":["Ray and Stephanie Lane Center for Computational Biology, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ray and Stephanie Lane Center for Computational Biology, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111386695","display_name":"Chris J. Myers","orcid":null},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chris J. Myers","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Utah, Salt Lake City, Utah, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Utah, Salt Lake City, Utah, United States of America","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035183595","display_name":"Michael S. Samoilov","orcid":"https://orcid.org/0000-0003-3559-5326"},"institutions":[{"id":"https://openalex.org/I103922791","display_name":"QB3","ror":"https://ror.org/04n1n3n22","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I103922791","https://openalex.org/I180670191","https://openalex.org/I185103710","https://openalex.org/I95457486"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael S. Samoilov","raw_affiliation_strings":["QB3: California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"QB3: California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, California, United States of America","institution_ids":["https://openalex.org/I103922791","https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5035183595"],"corresponding_institution_ids":["https://openalex.org/I103922791","https://openalex.org/I95457486"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.4346,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.86587436,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"6","issue":"3","first_page":"e1000723","last_page":"e1000723"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9926000237464905,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/virulence","display_name":"Virulence","score":0.7475525736808777},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.6539586782455444},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6136569380760193},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.5985956788063049},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5752389430999756},{"id":"https://openalex.org/keywords/fimbria","display_name":"Fimbria","score":0.5109831094741821},{"id":"https://openalex.org/keywords/recombinase","display_name":"Recombinase","score":0.44762536883354187},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4359838366508484},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.42774122953414917},{"id":"https://openalex.org/keywords/crispr","display_name":"CRISPR","score":0.41983097791671753},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.39111247658729553},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.35192161798477173},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.3416646718978882},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2880546450614929}],"concepts":[{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.7475525736808777},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6539586782455444},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6136569380760193},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.5985956788063049},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5752389430999756},{"id":"https://openalex.org/C39103817","wikidata":"https://www.wikidata.org/wiki/Q1810775","display_name":"Fimbria","level":4,"score":0.5109831094741821},{"id":"https://openalex.org/C102414288","wikidata":"https://www.wikidata.org/wiki/Q1172461","display_name":"Recombinase","level":4,"score":0.44762536883354187},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4359838366508484},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.42774122953414917},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.41983097791671753},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39111247658729553},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.35192161798477173},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3416646718978882},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2880546450614929},{"id":"https://openalex.org/C156695909","wikidata":"https://www.wikidata.org/wiki/Q3373825","display_name":"Recombination","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010861","descriptor_name":"Fimbriae, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010861","descriptor_name":"Fimbriae, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010861","descriptor_name":"Fimbriae, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014552","descriptor_name":"Urinary Tract Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014552","descriptor_name":"Urinary Tract Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014552","descriptor_name":"Urinary Tract Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014552","descriptor_name":"Urinary Tract Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D014552","descriptor_name":"Urinary Tract Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D014552","descriptor_name":"Urinary Tract Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036781","descriptor_name":"Fimbriae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D036781","descriptor_name":"Fimbriae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D036781","descriptor_name":"Fimbriae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1000723","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000723","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000723&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:20361050","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20361050","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1000723","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1000723","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:cd179e23a4424f60a4c0d624d69076d1","is_oa":true,"landing_page_url":"https://doaj.org/article/cd179e23a4424f60a4c0d624d69076d1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 6, Iss 3, p e1000723 (2010)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/144072","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Temperature_Control_of_Fimbriation_Circuit_Switch_in_Uropathogenic_Escherichia_coli_Quantitative_Analysis_via_Automated_Model_Abstraction/144072","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:2845655","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2845655","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000723","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000723","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000723&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1889864904","display_name":"QSB:  A Principled Mapping of Regulatory Networks to Asynchronous Circuit Models for Stochastic Analysis","funder_award_id":"0331270","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2412247231","display_name":"CIF:SMALL:COLLABORATIVE: Soft-Logic Modeling and Design for Synthetic Biology","funder_award_id":"0916042","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1970390819.pdf","grobid_xml":"https://content.openalex.org/works/W1970390819.grobid-xml"},"referenced_works_count":166,"referenced_works":["https://openalex.org/W104911623","https://openalex.org/W116024569","https://openalex.org/W567852514","https://openalex.org/W639420188","https://openalex.org/W1484033701","https://openalex.org/W1499426843","https://openalex.org/W1502075862","https://openalex.org/W1504533062","https://openalex.org/W1509581155","https://openalex.org/W1522226996","https://openalex.org/W1563526939","https://openalex.org/W1581500231","https://openalex.org/W1604287911","https://openalex.org/W1609903326","https://openalex.org/W1642251103","https://openalex.org/W1643509203","https://openalex.org/W1645427546","https://openalex.org/W1648143438","https://openalex.org/W1890385119","https://openalex.org/W1921860486","https://openalex.org/W1941244085","https://openalex.org/W1946177469","https://openalex.org/W1964168847","https://openalex.org/W1967668980","https://openalex.org/W1968750111","https://openalex.org/W1970389624","https://openalex.org/W1973734543","https://openalex.org/W1973890190","https://openalex.org/W1977711073","https://openalex.org/W1981960889","https://openalex.org/W1986705282","https://openalex.org/W1987003260","https://openalex.org/W1987315263","https://openalex.org/W1988269419","https://openalex.org/W1988704611","https://openalex.org/W1990904807","https://openalex.org/W1997399849","https://openalex.org/W1997630656","https://openalex.org/W1997982531","https://openalex.org/W1998589643","https://openalex.org/W1999823179","https://openalex.org/W2002915579","https://openalex.org/W2010778377","https://openalex.org/W2010894368","https://openalex.org/W2011372623","https://openalex.org/W2018670096","https://openalex.org/W2018740132","https://openalex.org/W2019012729","https://openalex.org/W2019875425","https://openalex.org/W2022607224","https://openalex.org/W2023145868","https://openalex.org/W2023543015","https://openalex.org/W2027328359","https://openalex.org/W2027733508","https://openalex.org/W2030551718","https://openalex.org/W2030650670","https://openalex.org/W2031718086","https://openalex.org/W2032092088","https://openalex.org/W2032231424","https://openalex.org/W2034130679","https://openalex.org/W2034763553","https://openalex.org/W2034800603","https://openalex.org/W2036083275","https://openalex.org/W2037298848","https://openalex.org/W2037394929","https://openalex.org/W2039747539","https://openalex.org/W2039887581","https://openalex.org/W2040889971","https://openalex.org/W2042321087","https://openalex.org/W2042631968","https://openalex.org/W2044859335","https://openalex.org/W2046721427","https://openalex.org/W2047515584","https://openalex.org/W2048177812","https://openalex.org/W2048230270","https://openalex.org/W2049415064","https://openalex.org/W2053138162","https://openalex.org/W2054523450","https://openalex.org/W2055643667","https://openalex.org/W2062762730","https://openalex.org/W2062856462","https://openalex.org/W2066152842","https://openalex.org/W2066594542","https://openalex.org/W2067184822","https://openalex.org/W2069251857","https://openalex.org/W2073144086","https://openalex.org/W2073877315","https://openalex.org/W2074386655","https://openalex.org/W2074681199","https://openalex.org/W2075718102","https://openalex.org/W2078037562","https://openalex.org/W2078119846","https://openalex.org/W2078128192","https://openalex.org/W2078734278","https://openalex.org/W2081281982","https://openalex.org/W2084924279","https://openalex.org/W2085061065","https://openalex.org/W2086950966","https://openalex.org/W2087234479","https://openalex.org/W2087763058","https://openalex.org/W2088024298","https://openalex.org/W2088051922","https://openalex.org/W2091502936","https://openalex.org/W2092026469","https://openalex.org/W2096705138","https://openalex.org/W2097254426","https://openalex.org/W2098648939","https://openalex.org/W2099111195","https://openalex.org/W2102471334","https://openalex.org/W2102787760","https://openalex.org/W2106283620","https://openalex.org/W2108210068","https://openalex.org/W2111931353","https://openalex.org/W2113106276","https://openalex.org/W2118051267","https://openalex.org/W2119836979","https://openalex.org/W2120051475","https://openalex.org/W2122436512","https://openalex.org/W2123022664","https://openalex.org/W2124236793","https://openalex.org/W2124772160","https://openalex.org/W2126180048","https://openalex.org/W2132756887","https://openalex.org/W2135151689","https://openalex.org/W2136698980","https://openalex.org/W2136834693","https://openalex.org/W2139374901","https://openalex.org/W2141166258","https://openalex.org/W2144440398","https://openalex.org/W2147257769","https://openalex.org/W2149202606","https://openalex.org/W2149588608","https://openalex.org/W2150519862","https://openalex.org/W2150990196","https://openalex.org/W2152223517","https://openalex.org/W2153423882","https://openalex.org/W2154075906","https://openalex.org/W2154488487","https://openalex.org/W2154900915","https://openalex.org/W2155418451","https://openalex.org/W2157121418","https://openalex.org/W2158469604","https://openalex.org/W2159875969","https://openalex.org/W2160069794","https://openalex.org/W2160961850","https://openalex.org/W2161251399","https://openalex.org/W2162619327","https://openalex.org/W2162749433","https://openalex.org/W2167154952","https://openalex.org/W2169576771","https://openalex.org/W2256672332","https://openalex.org/W2271940346","https://openalex.org/W2335428857","https://openalex.org/W2407947203","https://openalex.org/W2612743911","https://openalex.org/W3008437073","https://openalex.org/W3094920492","https://openalex.org/W3101205262","https://openalex.org/W3104104650","https://openalex.org/W4206332865","https://openalex.org/W4211264807","https://openalex.org/W4213388037","https://openalex.org/W4239685621","https://openalex.org/W4246495358","https://openalex.org/W4256582558","https://openalex.org/W6636476624"],"related_works":["https://openalex.org/W1517395386","https://openalex.org/W4293199045","https://openalex.org/W2405656580","https://openalex.org/W2102654548","https://openalex.org/W4235490606","https://openalex.org/W2073678782","https://openalex.org/W1986479733","https://openalex.org/W2642604616","https://openalex.org/W3162049976","https://openalex.org/W4299502264"],"abstract_inverted_index":{"Uropathogenic":[0],"Escherichia":[1],"coli":[2,201],"(UPEC)":[3],"represent":[4],"the":[5,28,111,139,143,193,199,237,254,283,292],"predominant":[6],"cause":[7],"of":[8,30,48,63,77,95,110,119,142,172,198,216,240,253,262,294],"urinary":[9],"tract":[10],"infections":[11],"(UTIs).":[12],"A":[13],"key":[14],"UPEC":[15,68,103,217],"molecular":[16,218],"virulence":[17,219],"mechanism":[18,277],"is":[19,25,53],"type":[20],"1":[21],"fimbriae,":[22],"whose":[23],"expression":[24],"controlled":[26,248],"by":[27,266],"orientation":[29],"an":[31,55,165],"invertible":[32],"chromosomal":[33],"DNA":[34],"element-the":[35],"fim":[36,49,124,256],"switch.":[37],"Temperature":[38],"has":[39,129,187],"been":[40],"shown":[41],"to":[42,86,102,137,190,229,245,298],"act":[43],"as":[44,58,60,123,148,150,181],"a":[45,132,182,247],"major":[46],"regulator":[47],"switching":[50,257],"behavior":[51,197],"and":[52,82,98,155,196],"overall":[54],"important":[56],"indicator":[57],"well":[59,149],"functional":[61],"feature":[62],"many":[64],"urologic":[65],"diseases,":[66],"including":[67],"host-pathogen":[69],"interaction":[70],"dynamics.":[71,157],"Given":[72],"this":[73,185,214,275],"panoptic":[74],"physiological":[75],"role":[76,231],"temperature":[78,126,207],"during":[79],"UTI":[80],"progression":[81],"notable":[83],"empirical":[84],"challenges":[85],"its":[87,230],"direct":[88],"in":[89,92,232],"vivo":[90],"studies,":[91],"silico":[93],"modeling":[94],"corresponding":[96],"biochemical":[97],"biophysical":[99],"mechanisms":[100],"essential":[101],"pathogenicity":[104],"may":[105,243],"significantly":[106],"aid":[107],"our":[108,223],"understanding":[109,290],"underlying":[112],"disease":[113],"processes.":[114],"However,":[115],"rigorous":[116],"computational":[117,183,270],"analysis":[118,271],"biological":[120,173],"systems,":[121],"such":[122],"switch":[125,203],"control":[127],"circuit,":[128],"hereto":[130],"presented":[131],"notoriously":[133],"demanding":[134],"problem":[135],"due":[136],"both":[138],"substantial":[140],"complexity":[141],"gene":[144],"regulatory":[145],"networks":[146],"involved":[147],"their":[151],"often":[152],"characteristically":[153],"discrete":[154],"stochastic":[156],"To":[158],"address":[159],"these":[160],"issues,":[161],"we":[162],"have":[163],"developed":[164],"approach":[166],"that":[167,274],"enables":[168],"automated":[169],"multiscale":[170],"abstraction":[171],"system":[174],"descriptions":[175],"based":[176],"on":[177],"reaction":[178],"kinetics.":[179],"Implemented":[180],"tool,":[184],"method":[186],"allowed":[188],"us":[189],"efficiently":[191],"analyze":[192],"modular":[194],"organization":[195],"E.":[200],"fimbriation":[202],"circuit":[204],"at":[205],"different":[206],"settings,":[208],"thus":[209,286],"facilitating":[210],"new":[211],"insights":[212],"into":[213],"mode":[215],"regulation.":[220],"In":[221],"particular,":[222],"results":[224],"suggest":[225],"that,":[226],"with":[227],"respect":[228],"shutting":[233],"down":[234],"fimbriae":[235],"expression,":[236],"primary":[238],"function":[239],"FimB":[241],"recombinase":[242,267],"be":[244,279],"effect":[246],"down-regulation":[249,276],"(rather":[250],"than":[251],"increase)":[252],"ON-to-OFF":[255],"rate":[258],"via":[259],"temperature-dependent":[260],"suppression":[261],"competing":[263],"dynamics":[264],"mediated":[265],"FimE.":[268],"Our":[269],"further":[272,289],"implies":[273],"could":[278],"particularly":[280],"significant":[281],"inside":[282],"host":[284],"environment,":[285],"potentially":[287],"contributing":[288],"toward":[291],"development":[293],"novel":[295],"therapeutic":[296],"approaches":[297],"UPEC-caused":[299],"UTIs.":[300]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-06-26T08:34:08.712188","created_date":"2025-10-10T00:00:00"}
