{"id":"https://openalex.org/W1985827516","doi":"https://doi.org/10.1371/journal.pcbi.1000720","title":"Drug-Class Specific Impact of Antivirals on the Reproductive Capacity of HIV","display_name":"Drug-Class Specific Impact of Antivirals on the Reproductive Capacity of HIV","publication_year":2010,"publication_date":"2010-03-25","ids":{"openalex":"https://openalex.org/W1985827516","doi":"https://doi.org/10.1371/journal.pcbi.1000720","mag":"1985827516","pmid":"https://pubmed.ncbi.nlm.nih.gov/20361047"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000720","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000720","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000720&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000720&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089767325","display_name":"Max von Kleist","orcid":"https://orcid.org/0000-0001-6587-6394"},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]},{"id":"https://openalex.org/I157286207","display_name":"National University of Ireland, Maynooth","ror":"https://ror.org/048nfjm95","country_code":"IE","type":"education","lineage":["https://openalex.org/I157286207"]}],"countries":["DE","IE"],"is_corresponding":true,"raw_author_name":"Max von Kleist","raw_affiliation_strings":["Hamilton Institute, Computational Physiology Group, National University of Ireland Maynooth, Kildare, Ireland. vkleist@zedat.fu-berlin.de","Department of Mathematics and Computer Science, Freie Universit\u00e4t Berlin, Berlin, Germany","Hamilton Institute, Computational Physiology Group, National University of Ireland Maynooth, Kildare, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hamilton Institute, Computational Physiology Group, National University of Ireland Maynooth, Kildare, Ireland. vkleist@zedat.fu-berlin.de","institution_ids":["https://openalex.org/I157286207"]},{"raw_affiliation_string":"Department of Mathematics and Computer Science, Freie Universit\u00e4t Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]},{"raw_affiliation_string":"Hamilton Institute, Computational Physiology Group, National University of Ireland Maynooth, Kildare, Ireland","institution_ids":["https://openalex.org/I157286207"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114046178","display_name":"Stephan Menz","orcid":null},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stephan Menz","raw_affiliation_strings":["Department of Mathematics and Computer Science, Freie Universit\u00e4t Berlin, Berlin, Germany","Department of Mathematics and Computer Science, Freie Universitat Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Computer Science, Freie Universit\u00e4t Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]},{"raw_affiliation_string":"Department of Mathematics and Computer Science, Freie Universitat Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009945042","display_name":"Wilhelm Huisinga","orcid":"https://orcid.org/0000-0002-5249-3914"},"institutions":[{"id":"https://openalex.org/I157286207","display_name":"National University of Ireland, Maynooth","ror":"https://ror.org/048nfjm95","country_code":"IE","type":"education","lineage":["https://openalex.org/I157286207"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Wilhelm Huisinga","raw_affiliation_strings":["Hamilton Institute, Computational Physiology Group, National University of Ireland Maynooth, Kildare, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hamilton Institute, Computational Physiology Group, National University of Ireland Maynooth, Kildare, Ireland","institution_ids":["https://openalex.org/I157286207"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5089767325"],"corresponding_institution_ids":["https://openalex.org/I157286207","https://openalex.org/I75951250"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.1752,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.74586614,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"6","issue":"3","first_page":"e1000720","last_page":"e1000720"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.7593052387237549},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.7193439602851868},{"id":"https://openalex.org/keywords/integrase-inhibitor","display_name":"Integrase inhibitor","score":0.604320228099823},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"Drug resistance","score":0.562117338180542},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.5523456335067749},{"id":"https://openalex.org/keywords/drug-development","display_name":"Drug development","score":0.5508990287780762},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.5091747641563416},{"id":"https://openalex.org/keywords/viral-replication","display_name":"Viral replication","score":0.5069553852081299},{"id":"https://openalex.org/keywords/antiviral-drug","display_name":"Antiviral drug","score":0.504025399684906},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.49995899200439453},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3743641972541809},{"id":"https://openalex.org/keywords/human-immunodeficiency-virus","display_name":"Human immunodeficiency virus (HIV)","score":0.36696627736091614},{"id":"https://openalex.org/keywords/viral-load","display_name":"Viral load","score":0.33853334188461304},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3093471825122833},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.2571200728416443},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"Antiretroviral therapy","score":0.22893956303596497},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.18112611770629883},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.11106988787651062}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7593052387237549},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.7193439602851868},{"id":"https://openalex.org/C2777302000","wikidata":"https://www.wikidata.org/wiki/Q412251","display_name":"Integrase inhibitor","level":5,"score":0.604320228099823},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.562117338180542},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5523456335067749},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.5508990287780762},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5091747641563416},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.5069553852081299},{"id":"https://openalex.org/C2779756493","wikidata":"https://www.wikidata.org/wiki/Q846227","display_name":"Antiviral drug","level":3,"score":0.504025399684906},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49995899200439453},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3743641972541809},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.36696627736091614},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.33853334188461304},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3093471825122833},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.2571200728416443},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.22893956303596497},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.18112611770629883},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11106988787651062}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1000720","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000720","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000720&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:20361047","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20361047","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.355.5861","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.355.5861","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/2b/82/PLoS_Comput_Biol_2010_Mar_26_6(3)_e1000720.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:1778cf95d339416d85fecc29de5b83bf","is_oa":true,"landing_page_url":"https://doaj.org/article/1778cf95d339416d85fecc29de5b83bf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 6, Iss 3, p e1000720 (2010)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/144053","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Drug_Class_Specific_Impact_of_Antivirals_on_the_Reproductive_Capacity_of_HIV/144053","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:2845651","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2845651","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000720","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000720","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000720&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8399999737739563}],"awards":[],"funders":[{"id":"https://openalex.org/F4320311521","display_name":"National University of Ireland","ror":"https://ror.org/00shsf120"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320324521","display_name":"Freie Universit\u00e4t Berlin","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1985827516.pdf","grobid_xml":"https://content.openalex.org/works/W1985827516.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W8503389","https://openalex.org/W10132703","https://openalex.org/W105326446","https://openalex.org/W1523939479","https://openalex.org/W1562103219","https://openalex.org/W1595806441","https://openalex.org/W1966343819","https://openalex.org/W1967940959","https://openalex.org/W1973398091","https://openalex.org/W1976632658","https://openalex.org/W1980587508","https://openalex.org/W1981965848","https://openalex.org/W1986986909","https://openalex.org/W1999749052","https://openalex.org/W2000258383","https://openalex.org/W2007831756","https://openalex.org/W2011630381","https://openalex.org/W2020022444","https://openalex.org/W2022098233","https://openalex.org/W2028179886","https://openalex.org/W2032471469","https://openalex.org/W2035649655","https://openalex.org/W2039138612","https://openalex.org/W2039244520","https://openalex.org/W2039357236","https://openalex.org/W2044403736","https://openalex.org/W2051269276","https://openalex.org/W2053125329","https://openalex.org/W2053485968","https://openalex.org/W2058079473","https://openalex.org/W2060735144","https://openalex.org/W2067419109","https://openalex.org/W2082291203","https://openalex.org/W2090646713","https://openalex.org/W2093062540","https://openalex.org/W2098267700","https://openalex.org/W2104117639","https://openalex.org/W2104820327","https://openalex.org/W2109194095","https://openalex.org/W2109360985","https://openalex.org/W2109718048","https://openalex.org/W2112727291","https://openalex.org/W2116583079","https://openalex.org/W2117013048","https://openalex.org/W2117453669","https://openalex.org/W2117959947","https://openalex.org/W2120915945","https://openalex.org/W2124177834","https://openalex.org/W2124721471","https://openalex.org/W2125593632","https://openalex.org/W2127484412","https://openalex.org/W2129690138","https://openalex.org/W2132152854","https://openalex.org/W2132762790","https://openalex.org/W2134817712","https://openalex.org/W2139250164","https://openalex.org/W2147413871","https://openalex.org/W2148291080","https://openalex.org/W2150504993","https://openalex.org/W2157887699","https://openalex.org/W2166914988","https://openalex.org/W2168736565","https://openalex.org/W2168811006","https://openalex.org/W2169367102","https://openalex.org/W2169408873","https://openalex.org/W2170765088","https://openalex.org/W2171711893","https://openalex.org/W2188350343","https://openalex.org/W2339219218","https://openalex.org/W2610167300","https://openalex.org/W3189833542","https://openalex.org/W3191472758","https://openalex.org/W4211151736","https://openalex.org/W4214816144","https://openalex.org/W4249631582","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2102326449","https://openalex.org/W2032099305","https://openalex.org/W2738322136","https://openalex.org/W2561775660","https://openalex.org/W58170104","https://openalex.org/W2008041994","https://openalex.org/W4297259300","https://openalex.org/W2059698078","https://openalex.org/W4366353501","https://openalex.org/W1984944991"],"abstract_inverted_index":{"Predictive":[0],"markers":[1],"linking":[2],"drug":[3,14,35,73,80,131,138],"efficacy":[4,36,58,74,139,217],"to":[5,33,230],"clinical":[6,116],"outcome":[7],"are":[8,31],"a":[9,50,62,92,100,121,147,164,170,198],"key":[10,199],"component":[11],"in":[12,37,40,85,114,124,127,140,153,157,212,219],"the":[13,43,66,104,156,161,177,187,204,211,235,242],"discovery":[15,81],"and":[16,28,39,82,112,126,133,226,241],"development":[17,83],"process.":[18],"In":[19,87],"HIV":[20,220],"infection,":[21],"two":[22,55,70],"different":[23],"measures,":[24],"viral":[25,94,181,239],"load":[26],"decay":[27],"phenotypic":[29,165],"assays,":[30],"used":[32],"assess":[34],"vivo":[38,125,158,214],"vitro.":[41],"For":[42],"newly":[44],"introduced":[45],"class":[46],"of":[47,57,65,72,103,106,108,130,137,160,163,174,180,206,216,238,244],"integrase":[48],"inhibitors,":[49,228],"huge":[51],"discrepancy":[52],"between":[53,68,123],"these":[54,69],"measures":[56,71,129,218],"was":[59],"observed.":[60],"Hence,":[61],"thorough":[63],"understanding":[64],"relation":[67],"is":[75,144,197],"imperative":[76],"for":[77,99],"guiding":[78],"future":[79],"activities":[84],"HIV.":[86],"this":[88],"article,":[89],"we":[90,119,184],"developed":[91],"novel":[93],"dynamics":[95],"model,":[96],"which":[97],"allows":[98],"mechanistic":[101],"integration":[102],"mode":[105],"action":[107],"all":[109],"approved":[110],"drugs":[111,113],"late":[115],"trials.":[117],"Subsequently,":[118],"established":[120],"link":[122],"vitro":[128],"efficacy,":[132],"extract":[134],"important":[135],"determinants":[136],"vivo.":[141],"The":[142],"analysis":[143],"based":[145],"on":[146,176],"new":[148],"quantity-the":[149],"reproductive":[150],"capacity-that":[151],"represents":[152],"mathematical":[154],"terms":[155],"analog":[159],"read-out":[162],"assay.":[166],"Our":[167],"results":[168],"suggest":[169],"drug-class":[171],"specific":[172],"impact":[173],"antivirals":[175],"total":[178,236],"amount":[179,237],"replication.":[182],"Moreover,":[183],"showed":[185],"that":[186,201,224],"(drug-)target":[188],"half":[189],"life,":[190],"dominated":[191],"by":[192],"immune-system":[193],"related":[194],"clearance":[195],"processes,":[196],"characteristic":[200],"affects":[202],"both":[203],"emergence":[205,243],"resistance":[207,245],"as":[208,210],"well":[209],"vitro-in":[213],"correlation":[215],"treatment.":[221],"We":[222],"found":[223],"protease-":[225],"maturation":[227],"due":[229],"their":[231],"target":[232],"half-life,":[233],"decrease":[234],"replication":[240],"most":[246],"efficiently.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}