{"id":"https://openalex.org/W2050077524","doi":"https://doi.org/10.1371/journal.pcbi.1000670","title":"A Kinetic Model of Dopamine- and Calcium-Dependent Striatal Synaptic Plasticity","display_name":"A Kinetic Model of Dopamine- and Calcium-Dependent Striatal Synaptic Plasticity","publication_year":2010,"publication_date":"2010-02-11","ids":{"openalex":"https://openalex.org/W2050077524","doi":"https://doi.org/10.1371/journal.pcbi.1000670","mag":"2050077524","pmid":"https://pubmed.ncbi.nlm.nih.gov/20169176"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000670","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000670","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000670&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000670&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046895944","display_name":"T. Nakano","orcid":"https://orcid.org/0000-0003-0707-4486"},"institutions":[{"id":"https://openalex.org/I75917431","display_name":"Nara Institute of Science and Technology","ror":"https://ror.org/05bhada84","country_code":"JP","type":"education","lineage":["https://openalex.org/I75917431"]},{"id":"https://openalex.org/I142637625","display_name":"Okinawa Institute of Science and Technology Graduate University","ror":"https://ror.org/02qg15b79","country_code":"JP","type":"education","lineage":["https://openalex.org/I142637625"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Nakano","raw_affiliation_strings":["Graduate School of Information Science, Nara Institute of Science and Technology, Ikoma, Japan","Okinawa Institute of Science and Technology, Uruma, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Information Science, Nara Institute of Science and Technology, Ikoma, Japan","institution_ids":["https://openalex.org/I75917431"]},{"raw_affiliation_string":"Okinawa Institute of Science and Technology, Uruma, Japan","institution_ids":["https://openalex.org/I142637625"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010377548","display_name":"Tomokazu Doi","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomokazu Doi","raw_affiliation_strings":["Osaka Bioscience Institute, Suita, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Osaka Bioscience Institute, Suita, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071281836","display_name":"Junichiro Yoshimoto","orcid":"https://orcid.org/0000-0001-7995-0321"},"institutions":[{"id":"https://openalex.org/I75917431","display_name":"Nara Institute of Science and Technology","ror":"https://ror.org/05bhada84","country_code":"JP","type":"education","lineage":["https://openalex.org/I75917431"]},{"id":"https://openalex.org/I142637625","display_name":"Okinawa Institute of Science and Technology Graduate University","ror":"https://ror.org/02qg15b79","country_code":"JP","type":"education","lineage":["https://openalex.org/I142637625"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junichiro Yoshimoto","raw_affiliation_strings":["Graduate School of Information Science, Nara Institute of Science and Technology, Ikoma, Japan","Okinawa Institute of Science and Technology, Uruma, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Information Science, Nara Institute of Science and Technology, Ikoma, Japan","institution_ids":["https://openalex.org/I75917431"]},{"raw_affiliation_string":"Okinawa Institute of Science and Technology, Uruma, Japan","institution_ids":["https://openalex.org/I142637625"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004840638","display_name":"Kenji Doya","orcid":"https://orcid.org/0000-0002-2446-6820"},"institutions":[{"id":"https://openalex.org/I142637625","display_name":"Okinawa Institute of Science and Technology Graduate University","ror":"https://ror.org/02qg15b79","country_code":"JP","type":"education","lineage":["https://openalex.org/I142637625"]},{"id":"https://openalex.org/I75917431","display_name":"Nara Institute of Science and Technology","ror":"https://ror.org/05bhada84","country_code":"JP","type":"education","lineage":["https://openalex.org/I75917431"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kenji Doya","raw_affiliation_strings":["Graduate School of Information Science, Nara Institute of Science and Technology, Ikoma, Japan","Okinawa Institute of Science and Technology, Uruma, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Information Science, Nara Institute of Science and Technology, Ikoma, Japan","institution_ids":["https://openalex.org/I75917431"]},{"raw_affiliation_string":"Okinawa Institute of Science and Technology, Uruma, Japan","institution_ids":["https://openalex.org/I142637625"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5004840638"],"corresponding_institution_ids":["https://openalex.org/I142637625","https://openalex.org/I75917431"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":4.2395,"has_fulltext":true,"cited_by_count":109,"citation_normalized_percentile":{"value":0.95291853,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"6","issue":"2","first_page":"e1000670","last_page":"e1000670"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10614","display_name":"Transcranial Magnetic Stimulation Studies","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"Synaptic plasticity","score":0.6318416595458984},{"id":"https://openalex.org/keywords/long-term-potentiation","display_name":"Long-term potentiation","score":0.6205196380615234},{"id":"https://openalex.org/keywords/dopamine","display_name":"Dopamine","score":0.6129707098007202},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.5410926938056946},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.48762837052345276},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.44156014919281006},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3758241534233093},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.15630802512168884},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.15056777000427246}],"concepts":[{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.6318416595458984},{"id":"https://openalex.org/C25274449","wikidata":"https://www.wikidata.org/wiki/Q1805481","display_name":"Long-term potentiation","level":3,"score":0.6205196380615234},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.6129707098007202},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5410926938056946},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48762837052345276},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44156014919281006},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3758241534233093},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15630802512168884},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15056777000427246}],"mesh":[{"descriptor_ui":"D001479","descriptor_name":"Basal Ganglia","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001479","descriptor_name":"Basal Ganglia","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001479","descriptor_name":"Basal Ganglia","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001479","descriptor_name":"Basal Ganglia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001479","descriptor_name":"Basal Ganglia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001479","descriptor_name":"Basal Ganglia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054648","descriptor_name":"Protein Phosphatase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054648","descriptor_name":"Protein Phosphatase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054648","descriptor_name":"Protein Phosphatase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1000670","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000670","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000670&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:20169176","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20169176","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.356.5156","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.356.5156","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/d3/f7/PLoS_Comput_Biol_2010_Feb_12_6(2)_e1000670.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:143f8479a16b4350a44c5c1441428c58","is_oa":true,"landing_page_url":"https://doaj.org/article/143f8479a16b4350a44c5c1441428c58","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 6, Iss 2, p e1000670 (2010)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/144633","is_oa":true,"landing_page_url":"https://figshare.com/articles/A_Kinetic_Model_of_Dopamine_and_Calcium_Dependent_Striatal_Synaptic_Plasticity/144633","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:2820521","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2820521","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000670","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000670","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000670&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322443","display_name":"Okinawa Institute of Science and Technology Graduate University","ror":"https://ror.org/02qg15b79"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2050077524.pdf","grobid_xml":"https://content.openalex.org/works/W2050077524.grobid-xml"},"referenced_works_count":111,"referenced_works":["https://openalex.org/W42796100","https://openalex.org/W162908266","https://openalex.org/W1481125086","https://openalex.org/W1486362699","https://openalex.org/W1502676046","https://openalex.org/W1511761223","https://openalex.org/W1519847602","https://openalex.org/W1556109943","https://openalex.org/W1573584522","https://openalex.org/W1583292806","https://openalex.org/W1609834322","https://openalex.org/W1655808594","https://openalex.org/W1681161665","https://openalex.org/W1823711977","https://openalex.org/W1896569873","https://openalex.org/W1936735623","https://openalex.org/W1945424073","https://openalex.org/W1958547196","https://openalex.org/W1963881156","https://openalex.org/W1966293264","https://openalex.org/W1971851666","https://openalex.org/W1972331693","https://openalex.org/W1980046851","https://openalex.org/W1982852470","https://openalex.org/W1983252720","https://openalex.org/W1983285634","https://openalex.org/W1983759112","https://openalex.org/W1986603094","https://openalex.org/W1986782732","https://openalex.org/W1987907382","https://openalex.org/W1988269419","https://openalex.org/W1991603311","https://openalex.org/W1993049854","https://openalex.org/W1993135690","https://openalex.org/W1993774494","https://openalex.org/W1997778815","https://openalex.org/W2003312856","https://openalex.org/W2007870025","https://openalex.org/W2019982479","https://openalex.org/W2020174502","https://openalex.org/W2021235911","https://openalex.org/W2022402243","https://openalex.org/W2022709265","https://openalex.org/W2023406302","https://openalex.org/W2024624930","https://openalex.org/W2027436298","https://openalex.org/W2033844584","https://openalex.org/W2038010833","https://openalex.org/W2038754384","https://openalex.org/W2039641335","https://openalex.org/W2043212816","https://openalex.org/W2043615389","https://openalex.org/W2045129849","https://openalex.org/W2045626150","https://openalex.org/W2046174336","https://openalex.org/W2049668076","https://openalex.org/W2049796382","https://openalex.org/W2049856923","https://openalex.org/W2050088352","https://openalex.org/W2052305668","https://openalex.org/W2055523610","https://openalex.org/W2057605801","https://openalex.org/W2065921058","https://openalex.org/W2066764075","https://openalex.org/W2067598670","https://openalex.org/W2069992321","https://openalex.org/W2072164713","https://openalex.org/W2073618643","https://openalex.org/W2073803393","https://openalex.org/W2075171107","https://openalex.org/W2077406048","https://openalex.org/W2079285060","https://openalex.org/W2079336138","https://openalex.org/W2081116653","https://openalex.org/W2085275630","https://openalex.org/W2088587322","https://openalex.org/W2089132727","https://openalex.org/W2089752327","https://openalex.org/W2091789872","https://openalex.org/W2096551329","https://openalex.org/W2097875012","https://openalex.org/W2102653059","https://openalex.org/W2106828113","https://openalex.org/W2114715627","https://openalex.org/W2115801563","https://openalex.org/W2117726420","https://openalex.org/W2118444707","https://openalex.org/W2118596861","https://openalex.org/W2119384581","https://openalex.org/W2128574573","https://openalex.org/W2130851537","https://openalex.org/W2133667940","https://openalex.org/W2135535700","https://openalex.org/W2143100380","https://openalex.org/W2144948613","https://openalex.org/W2145719108","https://openalex.org/W2147122909","https://openalex.org/W2154974608","https://openalex.org/W2155645083","https://openalex.org/W2157092518","https://openalex.org/W2158691076","https://openalex.org/W2162520530","https://openalex.org/W2162532681","https://openalex.org/W2163334673","https://openalex.org/W2165909414","https://openalex.org/W2170532212","https://openalex.org/W2271932438","https://openalex.org/W2342694763","https://openalex.org/W4235391064","https://openalex.org/W4293082841","https://openalex.org/W6600565570"],"related_works":["https://openalex.org/W1983138582","https://openalex.org/W4282924888","https://openalex.org/W2051484555","https://openalex.org/W1971367829","https://openalex.org/W2376191914","https://openalex.org/W1989034907","https://openalex.org/W2408412772","https://openalex.org/W2901051008","https://openalex.org/W2011356607","https://openalex.org/W3016435672"],"abstract_inverted_index":{"Corticostriatal":[0],"synapse":[1],"plasticity":[2,102],"of":[3,84,87,101,110,124,146,182,198,277],"medium":[4],"spiny":[5],"neurons":[6],"is":[7,42,48,67],"regulated":[8],"by":[9,51,241],"glutamate":[10],"input":[11,17,212,234],"from":[12,18],"the":[13,19,31,75,85,95,98,121,157,177,192,203,217,236,256,271],"cortex":[14],"and":[15,66,90,126,138,163,168,191,209,228,232,280,288],"dopamine":[16,34,115,162,233,261],"substantia":[20],"nigra.":[21],"While":[22],"cortical":[23,52],"stimulation":[24,53],"alone":[25],"results":[26],"in":[27,54,74,156,172,255,274],"long-term":[28,38],"depression":[29],"(LTD),":[30],"combination":[32],"with":[33,93,142,161],"switches":[35],"LTD":[36,208],"to":[37,59,119],"potentiation":[39],"(LTP),":[40],"which":[41,57],"known":[43],"as":[44,69,150,152,202,293],"dopamine-dependent":[45,265],"plasticity.":[46,71,128,170,266],"LTP":[47],"also":[49],"induced":[50],"magnesium-free":[55],"solution,":[56],"leads":[58],"massive":[60],"calcium":[61,164,231],"influx":[62],"through":[63,216],"NMDA-type":[64],"receptors":[65,116],"regarded":[68],"calcium-dependent":[70,127,169],"Signaling":[72],"cascades":[73],"corticostriatal":[76,278],"spines":[77,111],"are":[78],"currently":[79],"under":[80],"investigation.":[81],"However,":[82],"because":[83],"existence":[86],"multiple":[88],"excitatory":[89],"inhibitory":[91],"pathways":[92],"loops,":[94],"mechanisms":[96,123,272],"regulating":[97],"two":[99],"types":[100],"remain":[103],"poorly":[104],"understood.":[105],"A":[106,185],"signaling":[107,134],"pathway":[108,227],"model":[109,130,269],"that":[112,176],"express":[113],"D1-type":[114],"was":[117],"constructed":[118],"analyze":[120],"dynamic":[122],"dopamine-":[125,137,167],"The":[129,245,267],"incorporated":[131],"all":[132],"major":[133,204],"molecules,":[135],"including":[136],"cyclic":[139,242],"AMP-regulated":[140],"phosphoprotein":[141],"a":[143],"molecular":[144],"weight":[145],"32":[147],"kDa":[148],"(DARPP32),":[149],"well":[151],"AMPA":[153],"receptor":[154],"trafficking":[155],"post-synaptic":[158],"membrane.":[159],"Simulations":[160],"inputs":[165],"reproduced":[166],"Further":[171],"silico":[173],"experiments":[174],"revealed":[175],"positive":[178,246],"feedback":[179,247],"loop":[180,215,237,248],"consisted":[181],"protein":[183,187],"kinase":[184,222,225],"(PKA),":[186],"phosphatase":[188],"2A":[189],"(PP2A),":[190],"phosphorylation":[193],"site":[194],"at":[195],"threonine":[196],"75":[197],"DARPP-32":[199],"(Thr75)":[200],"served":[201],"switch":[205],"for":[206,283,290],"inducing":[207],"LTP.":[210],"Calcium":[211],"modulated":[213],"this":[214,264],"PP2B":[218],"(phosphatase":[219],"2B)-CK1":[220],"(casein":[221],"1)-Cdk5":[223],"(cyclin-dependent":[224],"5)-Thr75":[226],"PP2A,":[229],"whereas":[230],"activated":[235],"via":[238],"PKA":[239],"activation":[240],"AMP":[243],"(cAMP).":[244],"displayed":[249],"robust":[250],"bi-stable":[251],"responses":[252],"following":[253],"changes":[254],"reaction":[257],"parameters.":[258],"Increased":[259],"basal":[260],"levels":[262],"disrupted":[263],"present":[268],"elucidated":[270],"involved":[273],"bidirectional":[275],"regulation":[276],"synapses":[279],"will":[281],"allow":[282],"further":[284],"exploration":[285],"into":[286],"causes":[287],"therapies":[289],"dysfunctions":[291],"such":[292],"drug":[294],"addiction.":[295]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":9},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":6}],"updated_date":"2026-05-12T08:28:47.272897","created_date":"2025-10-10T00:00:00"}
