{"id":"https://openalex.org/W2044555648","doi":"https://doi.org/10.1371/journal.pcbi.1000616","title":"Meta-analysis of Inter-species Liver Co-expression Networks Elucidates Traits Associated with Common Human Diseases","display_name":"Meta-analysis of Inter-species Liver Co-expression Networks Elucidates Traits Associated with Common Human Diseases","publication_year":2009,"publication_date":"2009-12-18","ids":{"openalex":"https://openalex.org/W2044555648","doi":"https://doi.org/10.1371/journal.pcbi.1000616","mag":"2044555648","pmid":"https://pubmed.ncbi.nlm.nih.gov/20019805"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000616","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000616","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000616&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000616&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100774874","display_name":"Kai Wang","orcid":"https://orcid.org/0000-0003-0567-3004"},"institutions":[{"id":"https://openalex.org/I4210148890","display_name":"Rosetta Stone (United States)","ror":"https://ror.org/05a1nta88","country_code":"US","type":"company","lineage":["https://openalex.org/I4210148890"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kai Wang","raw_affiliation_strings":["Department of Genetics, Rosetta Inpharmatics, Seattle, Washington, USA","Department of Genetics, Rosetta Inpharmatics, Seattle, Washington, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Genetics, Rosetta Inpharmatics, Seattle, Washington, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Genetics, Rosetta Inpharmatics, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210148890"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077782872","display_name":"Manikandan Narayanan","orcid":"https://orcid.org/0000-0002-8490-4087"},"institutions":[{"id":"https://openalex.org/I4210148890","display_name":"Rosetta Stone (United States)","ror":"https://ror.org/05a1nta88","country_code":"US","type":"company","lineage":["https://openalex.org/I4210148890"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manikandan Narayanan","raw_affiliation_strings":["Department of Genetics, Rosetta Inpharmatics, Seattle, Washington, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Genetics, Rosetta Inpharmatics, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210148890"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101978852","display_name":"Hua Zhong","orcid":"https://orcid.org/0000-0002-9358-1582"},"institutions":[{"id":"https://openalex.org/I4210148890","display_name":"Rosetta Stone (United States)","ror":"https://ror.org/05a1nta88","country_code":"US","type":"company","lineage":["https://openalex.org/I4210148890"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hua Zhong","raw_affiliation_strings":["Department of Genetics, Rosetta Inpharmatics, Seattle, Washington, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Genetics, Rosetta Inpharmatics, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210148890"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008676408","display_name":"Martin Tompa","orcid":null},"institutions":[{"id":"https://openalex.org/I4210148890","display_name":"Rosetta Stone (United States)","ror":"https://ror.org/05a1nta88","country_code":"US","type":"company","lineage":["https://openalex.org/I4210148890"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Tompa","raw_affiliation_strings":["Department of Computer Sciences, University of Washington, Seattle, Washington, United States of America","Department of Genetics, Rosetta Inpharmatics, Seattle, Washington, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Computer Sciences, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Genetics, Rosetta Inpharmatics, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210148890"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071946434","display_name":"Eric E. Schadt","orcid":"https://orcid.org/0000-0002-7892-8808"},"institutions":[{"id":"https://openalex.org/I4210148890","display_name":"Rosetta Stone (United States)","ror":"https://ror.org/05a1nta88","country_code":"US","type":"company","lineage":["https://openalex.org/I4210148890"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eric E. Schadt","raw_affiliation_strings":["Department of Genetics, Rosetta Inpharmatics, Seattle, Washington, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Genetics, Rosetta Inpharmatics, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210148890"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058745924","display_name":"Jun Zhu","orcid":"https://orcid.org/0000-0003-0834-8178"},"institutions":[{"id":"https://openalex.org/I4210148890","display_name":"Rosetta Stone (United States)","ror":"https://ror.org/05a1nta88","country_code":"US","type":"company","lineage":["https://openalex.org/I4210148890"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jun Zhu","raw_affiliation_strings":["Department of Genetics, Rosetta Inpharmatics, Seattle, Washington, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Genetics, Rosetta Inpharmatics, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210148890"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5058745924","https://openalex.org/A5071946434"],"corresponding_institution_ids":["https://openalex.org/I4210148890"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.952,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.91267145,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"5","issue":"12","first_page":"e1000616","last_page":"e1000616"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9943000078201294,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9934999942779541,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7694225311279297},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6466336846351624},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5754633545875549},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.5637847185134888},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.5320988893508911},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.49375614523887634},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.49049681425094604},{"id":"https://openalex.org/keywords/biological-pathway","display_name":"Biological pathway","score":0.4569327235221863},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.44450002908706665},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.38729244470596313}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7694225311279297},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6466336846351624},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5754633545875549},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.5637847185134888},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5320988893508911},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.49375614523887634},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.49049681425094604},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.4569327235221863},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.44450002908706665},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.38729244470596313}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1000616","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000616","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000616&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:20019805","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20019805","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1000616","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1000616","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:03ea6bfe9dee45a8b2496ac2d9c743ee","is_oa":true,"landing_page_url":"https://doaj.org/article/03ea6bfe9dee45a8b2496ac2d9c743ee","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 5, Iss 12, p e1000616 (2009)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:1894985","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2787626","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/145368","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Meta_analysis_of_Inter_species_Liver_Co_expression_Networks_Elucidates_Traits_Associated_with_Common_Human_Diseases/145368","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000616","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000616","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000616&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2044555648.pdf","grobid_xml":"https://content.openalex.org/works/W2044555648.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1485346440","https://openalex.org/W1511920456","https://openalex.org/W1812598206","https://openalex.org/W1928933333","https://openalex.org/W1969411569","https://openalex.org/W1970871693","https://openalex.org/W1974992961","https://openalex.org/W1982070737","https://openalex.org/W1986868176","https://openalex.org/W1993384523","https://openalex.org/W1999649023","https://openalex.org/W2000495354","https://openalex.org/W2002065650","https://openalex.org/W2013196115","https://openalex.org/W2020749481","https://openalex.org/W2022261649","https://openalex.org/W2025398303","https://openalex.org/W2027996669","https://openalex.org/W2029158589","https://openalex.org/W2034968148","https://openalex.org/W2036800461","https://openalex.org/W2037917220","https://openalex.org/W2042984464","https://openalex.org/W2043842514","https://openalex.org/W2048755332","https://openalex.org/W2049436788","https://openalex.org/W2056124433","https://openalex.org/W2068229930","https://openalex.org/W2078279629","https://openalex.org/W2085458327","https://openalex.org/W2090808827","https://openalex.org/W2091601026","https://openalex.org/W2091901410","https://openalex.org/W2098023168","https://openalex.org/W2105281057","https://openalex.org/W2106202847","https://openalex.org/W2109726592","https://openalex.org/W2117007075","https://openalex.org/W2118303980","https://openalex.org/W2118623169","https://openalex.org/W2120176508","https://openalex.org/W2123828448","https://openalex.org/W2130891992","https://openalex.org/W2136078375","https://openalex.org/W2150930051","https://openalex.org/W2152873040","https://openalex.org/W2160138207","https://openalex.org/W2162142896","https://openalex.org/W2164242630","https://openalex.org/W2167222948","https://openalex.org/W2171081680","https://openalex.org/W2171481228","https://openalex.org/W2347998626","https://openalex.org/W4229570919","https://openalex.org/W4246369350","https://openalex.org/W4250415090","https://openalex.org/W6640221526","https://openalex.org/W7001933324","https://openalex.org/W7002050966","https://openalex.org/W7071764571"],"related_works":["https://openalex.org/W2163262592","https://openalex.org/W2130939068","https://openalex.org/W3163717165","https://openalex.org/W2114466827","https://openalex.org/W2791736663","https://openalex.org/W2129949791","https://openalex.org/W2806770614","https://openalex.org/W1710460698","https://openalex.org/W249159571","https://openalex.org/W4385510321"],"abstract_inverted_index":{"Co-expression":[0],"networks":[1,17,199],"are":[2,28,40,215],"routinely":[3],"used":[4],"to":[5,23,77,135,151,171,205],"study":[6,121],"human":[7,31,183],"diseases":[8],"like":[9],"obesity":[10],"and":[11,32,80,110,143,178,184],"diabetes.":[12],"Systematic":[13],"comparison":[14],"of":[15],"these":[16],"between":[18,30,182],"species":[19,104],"has":[20,168],"the":[21,68],"potential":[22],"elucidate":[24],"common":[25,209],"mechanisms":[26],"that":[27,39,67,105,145,214],"conserved":[29,102],"rodent":[33],"species,":[34],"as":[35,37,113],"well":[36],"those":[38],"species-specific":[41,148],"characterizing":[42],"evolutionary":[43],"plasticity.":[44],"We":[45,98,129],"developed":[46,131],"a":[47,100,132,161,173,191],"semi-parametric":[48,69],"meta-analysis":[49],"approach":[50,189],"for":[51,125,137],"combining":[52],"gene-gene":[53],"co-expression":[54,83,198],"relationships":[55],"across":[56,103],"expression":[57],"profile":[58],"datasets":[59,204],"from":[60,200],"multiple":[61,141,201],"species.":[62],"The":[63],"simulation":[64],"results":[65],"showed":[66],"method":[70,86],"is":[71],"robust":[72],"against":[73],"noise.":[74],"When":[75],"applied":[76],"human,":[78],"mouse,":[79],"rat":[81],"liver":[82],"networks,":[84],"our":[85,188],"out-performed":[87],"existing":[88],"methods":[89],"in":[90,118,176,195],"identifying":[91],"gene":[92,123,197],"pairs":[93],"with":[94,147],"coherent":[95],"biological":[96,115],"functions.":[97],"identified":[99,160],"network":[101,138],"highlighted":[106],"cell-cell":[107],"signaling,":[108],"cell-adhesion":[109],"sterol":[111],"biosynthesis":[112],"main":[114],"processes":[116],"represented":[117],"genome-wide":[119],"association":[120],"candidate":[122],"sets":[124],"blood":[126],"lipid":[127],"levels.":[128],"further":[130],"heterogeneity":[133],"statistic":[134],"test":[136],"differences":[139,213],"among":[140],"datasets,":[142],"demonstrated":[144],"genes":[146],"interactions":[149],"tend":[150],"be":[152],"under":[153],"positive":[154],"selection":[155],"throughout":[156],"evolution.":[157],"Finally,":[158],"we":[159],"human-specific":[162],"sub-network":[163],"regulated":[164],"by":[165],"RXRG,":[166],"which":[167],"been":[169],"validated":[170],"play":[172],"different":[174],"role":[175],"hyperlipidemia":[177],"Type":[179],"2":[180],"diabetes":[181],"mouse.":[185],"Taken":[186],"together,":[187],"represents":[190],"novel":[192],"step":[193],"forward":[194],"integrating":[196],"large":[202],"scale":[203],"leverage":[206],"not":[207],"only":[208],"information":[210],"but":[211],"also":[212],"dataset-specific.":[216]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-03-10T16:38:18.471706","created_date":"2025-10-10T00:00:00"}