{"id":"https://openalex.org/W2055334948","doi":"https://doi.org/10.1371/journal.pcbi.1000604","title":"Integrin Clustering Is Driven by Mechanical Resistance from the Glycocalyx and the Substrate","display_name":"Integrin Clustering Is Driven by Mechanical Resistance from the Glycocalyx and the Substrate","publication_year":2009,"publication_date":"2009-12-10","ids":{"openalex":"https://openalex.org/W2055334948","doi":"https://doi.org/10.1371/journal.pcbi.1000604","mag":"2055334948","pmid":"https://pubmed.ncbi.nlm.nih.gov/20011123"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000604","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000604","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000604&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000604&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011554115","display_name":"Matthew J. Paszek","orcid":"https://orcid.org/0000-0003-0064-9400"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew J. Paszek","raw_affiliation_strings":["Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America","Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America","Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, San Francisco, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038575547","display_name":"David Boettiger","orcid":null},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Boettiger","raw_affiliation_strings":["Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America","Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America","Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022114303","display_name":"Valerie M. Weaver","orcid":"https://orcid.org/0000-0003-4786-6752"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I194456095","display_name":"California Institute for Regenerative Medicine","ror":"https://ror.org/033m8b439","country_code":"US","type":"government","lineage":["https://openalex.org/I194456095"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valerie M. Weaver","raw_affiliation_strings":["Department of Bioengineering and Therapeutic Sciences, Institute for Regenerative Medicine and UCSF Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, United States of America","Department of Anatomy, University of California, San Francisco, San Francisco, California, United States of America","Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, San Francisco, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering and Therapeutic Sciences, Institute for Regenerative Medicine and UCSF Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I194456095","https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Anatomy, University of California, San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059067804","display_name":"Daniel A. Hammer","orcid":"https://orcid.org/0000-0002-3522-3154"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniel A. Hammer","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America","Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America","Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5059067804"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":5.0708,"has_fulltext":true,"cited_by_count":261,"citation_normalized_percentile":{"value":0.95806165,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"5","issue":"12","first_page":"e1000604","last_page":"e1000604"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9908000230789185,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/integrin","display_name":"Integrin","score":0.8385272026062012},{"id":"https://openalex.org/keywords/cooperativity","display_name":"Cooperativity","score":0.5615916848182678},{"id":"https://openalex.org/keywords/glycocalyx","display_name":"Glycocalyx","score":0.48283156752586365},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"Extracellular matrix","score":0.4768620431423187},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"Cell adhesion","score":0.4758586287498474},{"id":"https://openalex.org/keywords/collagen-receptor","display_name":"Collagen receptor","score":0.43921172618865967},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.43395406007766724},{"id":"https://openalex.org/keywords/cell-adhesion-molecule","display_name":"Cell adhesion molecule","score":0.4236750602722168},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4153457283973694},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.4081581234931946},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2737252712249756},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.19612202048301697},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.17947715520858765}],"concepts":[{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.8385272026062012},{"id":"https://openalex.org/C166014724","wikidata":"https://www.wikidata.org/wiki/Q337217","display_name":"Cooperativity","level":2,"score":0.5615916848182678},{"id":"https://openalex.org/C2780098789","wikidata":"https://www.wikidata.org/wiki/Q898356","display_name":"Glycocalyx","level":2,"score":0.48283156752586365},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.4768620431423187},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.4758586287498474},{"id":"https://openalex.org/C119524353","wikidata":"https://www.wikidata.org/wiki/Q5145908","display_name":"Collagen receptor","level":4,"score":0.43921172618865967},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.43395406007766724},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.4236750602722168},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4153457283973694},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4081581234931946},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2737252712249756},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.19612202048301697},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17947715520858765}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019276","descriptor_name":"Glycocalyx","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019276","descriptor_name":"Glycocalyx","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019276","descriptor_name":"Glycocalyx","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1000604","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000604","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000604&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:20011123","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20011123","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.355.8191","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.355.8191","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/97/65/PLoS_Comput_Biol_2009_Dec_11_5(12)_e1000604.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:9a82159c84a14717b2548af5bfd9831f","is_oa":true,"landing_page_url":"https://doaj.org/article/9a82159c84a14717b2548af5bfd9831f","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 5, Iss 12, p e1000604 (2009)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt28m3f9j6","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/28m3f9j6","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS computational biology, vol 5, iss 12","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/146104","is_oa":true,"landing_page_url":"https://figshare.com/articles/Integrin_Clustering_Is_Driven_by_Mechanical_Resistance_from_the_Glycocalyx_and_the_Substrate/146104","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:2782178","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2782178","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:qt28m3f9j6","is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/28m3f9j6","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Paszek, MJ; Boettiger, D; Weaver, VM; & Hammer, DA. (2009). Integrin clustering is driven by mechanical resistance from the glycocalyx and the substrate. PLoS Computational Biology, 5(12). doi: 10.1371/journal.pcbi.1000604. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/28m3f9j6","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000604","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000604","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000604&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2825644042","display_name":null,"funder_award_id":"GM53788","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3301467722","display_name":null,"funder_award_id":"HL085303","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4119534169","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G514671509","display_name":null,"funder_award_id":"W81XWH-05-1-330","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G5850682332","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2055334948.pdf","grobid_xml":"https://content.openalex.org/works/W2055334948.grobid-xml"},"referenced_works_count":105,"referenced_works":["https://openalex.org/W14299924","https://openalex.org/W28705092","https://openalex.org/W988785063","https://openalex.org/W1505634985","https://openalex.org/W1506821897","https://openalex.org/W1534372645","https://openalex.org/W1559994288","https://openalex.org/W1576773659","https://openalex.org/W1604356365","https://openalex.org/W1967087511","https://openalex.org/W1969959931","https://openalex.org/W1972902383","https://openalex.org/W1973089587","https://openalex.org/W1973757009","https://openalex.org/W1974872356","https://openalex.org/W1974938825","https://openalex.org/W1975132186","https://openalex.org/W1977764445","https://openalex.org/W1978679809","https://openalex.org/W1981572498","https://openalex.org/W1982691790","https://openalex.org/W1982903250","https://openalex.org/W1983426119","https://openalex.org/W1986225001","https://openalex.org/W1986411839","https://openalex.org/W1987654715","https://openalex.org/W1990208523","https://openalex.org/W1991815226","https://openalex.org/W1992382028","https://openalex.org/W1993622985","https://openalex.org/W1996880045","https://openalex.org/W1998287390","https://openalex.org/W1999765951","https://openalex.org/W2000558918","https://openalex.org/W2006657990","https://openalex.org/W2015211029","https://openalex.org/W2016464728","https://openalex.org/W2020254162","https://openalex.org/W2021027041","https://openalex.org/W2023864585","https://openalex.org/W2029364173","https://openalex.org/W2030181238","https://openalex.org/W2030214324","https://openalex.org/W2030914872","https://openalex.org/W2037178709","https://openalex.org/W2040360234","https://openalex.org/W2040369209","https://openalex.org/W2040379229","https://openalex.org/W2041387847","https://openalex.org/W2043915658","https://openalex.org/W2047153928","https://openalex.org/W2047500027","https://openalex.org/W2049718632","https://openalex.org/W2052192720","https://openalex.org/W2053123180","https://openalex.org/W2053907724","https://openalex.org/W2054635074","https://openalex.org/W2058624942","https://openalex.org/W2065734773","https://openalex.org/W2073375166","https://openalex.org/W2077534353","https://openalex.org/W2077601062","https://openalex.org/W2082695261","https://openalex.org/W2084654852","https://openalex.org/W2088992013","https://openalex.org/W2095122418","https://openalex.org/W2098438673","https://openalex.org/W2099052265","https://openalex.org/W2105181228","https://openalex.org/W2111811045","https://openalex.org/W2112550344","https://openalex.org/W2114989145","https://openalex.org/W2116772603","https://openalex.org/W2120832308","https://openalex.org/W2122784431","https://openalex.org/W2122840995","https://openalex.org/W2123029770","https://openalex.org/W2125644189","https://openalex.org/W2128493116","https://openalex.org/W2131296668","https://openalex.org/W2134156839","https://openalex.org/W2136279614","https://openalex.org/W2136443584","https://openalex.org/W2136949471","https://openalex.org/W2147023756","https://openalex.org/W2148328620","https://openalex.org/W2148329395","https://openalex.org/W2150214660","https://openalex.org/W2151274733","https://openalex.org/W2152002380","https://openalex.org/W2152682817","https://openalex.org/W2155418451","https://openalex.org/W2156293127","https://openalex.org/W2157329863","https://openalex.org/W2158931259","https://openalex.org/W2159165113","https://openalex.org/W2170034857","https://openalex.org/W2171649228","https://openalex.org/W2314880570","https://openalex.org/W2507370390","https://openalex.org/W2903919837","https://openalex.org/W3100148641","https://openalex.org/W4285719527","https://openalex.org/W6682113935","https://openalex.org/W6725125144"],"related_works":["https://openalex.org/W2031209124","https://openalex.org/W1971114436","https://openalex.org/W2562563778","https://openalex.org/W828898328","https://openalex.org/W1976336086","https://openalex.org/W2108283255","https://openalex.org/W2014090532","https://openalex.org/W1996199591","https://openalex.org/W2123694231","https://openalex.org/W2118764913"],"abstract_inverted_index":{"Integrins":[0,25],"have":[1,193],"emerged":[2],"as":[3,205],"key":[4,129],"sensory":[5,206],"molecules":[6,207],"that":[7,21,36,65,92,171,188,208],"translate":[8],"chemical":[9,78,145,159],"and":[10,73,83,98,124,146,157],"physical":[11,147],"cues":[12],"from":[13],"the":[14,33,45,54,67,70,109,138,144,150,158],"extracellular":[15],"matrix":[16,155,211],"(ECM)":[17],"into":[18,29],"biochemical":[19],"signals":[20],"regulate":[22],"cell":[23],"behavior.":[24],"function":[26,204],"by":[27],"clustering":[28,39,106,136,173],"adhesion":[30,217],"plaques,":[31],"but":[32,183],"molecular":[34],"mechanisms":[35],"drive":[37,104],"integrin":[38,58,81,105,132,135,172],"in":[40,53,108,137],"response":[41],"to":[42,87,103,143],"interaction":[43],"with":[44,75,166,179],"ECM":[46,74],"remain":[47],"unclear.":[48],"To":[49],"explore":[50],"how":[51,200],"deformations":[52],"cell-ECM":[55],"interface":[56],"influence":[57],"clustering,":[59],"we":[60,90,169],"developed":[61],"a":[62,76,128],"spatial-temporal":[63],"simulation":[64],"integrates":[66],"micro-mechanics":[68],"of":[69,80,111,131,149,161],"cell,":[71],"glycocalyx,":[72],"simple":[77],"model":[79,139],"activation":[82],"ligand":[84,153,162,181,195],"interaction.":[85],"Due":[86],"mechanical":[88],"coupling,":[89],"find":[91,170],"integrin-ligand":[93],"interactions":[94],"are":[95,189,219],"highly":[96,190],"cooperative,":[97],"this":[99,122],"cooperativity":[100,123],"is":[101,140,174,184],"sufficient":[102],"even":[107,213],"absence":[110],"cytoskeletal":[112],"crosslinking":[113],"or":[114,192],"homotypic":[115],"integrin-integrin":[116],"interactions.":[117],"The":[118],"glycocalyx":[119],"largely":[120],"mediates":[121],"hence":[125],"may":[126],"be":[127],"regulator":[130],"function.":[133],"Remarkably,":[134],"naturally":[141],"responsive":[142],"properties":[148,212],"ECM,":[151],"including":[152],"density,":[154,182],"rigidity,":[156],"affinity":[160],"for":[163],"receptor.":[164],"Consistent":[165],"experimental":[167],"observations,":[168],"robust":[175],"on":[176,186],"rigid":[177],"substrates":[178,187],"high":[180],"impaired":[185],"compliant":[191],"low":[194],"density.":[196],"We":[197],"thus":[198],"demonstrate":[199],"integrins":[201],"themselves":[202],"could":[203],"begin":[209],"sensing":[210],"before":[214],"large":[215],"multi-molecular":[216],"complexes":[218],"assembled.":[220]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":20},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":23},{"year":2012,"cited_by_count":18}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}