{"id":"https://openalex.org/W1995080247","doi":"https://doi.org/10.1371/journal.pcbi.1000564","title":"Identifying Changes in Selective Constraints: Host Shifts in Influenza","display_name":"Identifying Changes in Selective Constraints: Host Shifts in Influenza","publication_year":2009,"publication_date":"2009-11-12","ids":{"openalex":"https://openalex.org/W1995080247","doi":"https://doi.org/10.1371/journal.pcbi.1000564","mag":"1995080247","pmid":"https://pubmed.ncbi.nlm.nih.gov/19911053"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000564","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000564","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000564&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000564&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086246480","display_name":"Asif U. Tamuri","orcid":"https://orcid.org/0000-0001-6633-3789"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Asif U. Tamuri","raw_affiliation_strings":["National Institute for Medical Research, London, United Kingdom","\u2020National Institute for Medical Research, London, United Kingdom;"],"affiliations":[{"raw_affiliation_string":"National Institute for Medical Research, London, United Kingdom","institution_ids":[]},{"raw_affiliation_string":"\u2020National Institute for Medical Research, London, United Kingdom;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001078049","display_name":"Mario dos Reis","orcid":"https://orcid.org/0000-0001-9514-3976"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mario dos Reis","raw_affiliation_strings":["National Institute for Medical Research, London, United Kingdom","\u2020National Institute for Medical Research, London, United Kingdom;"],"affiliations":[{"raw_affiliation_string":"National Institute for Medical Research, London, United Kingdom","institution_ids":[]},{"raw_affiliation_string":"\u2020National Institute for Medical Research, London, United Kingdom;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088721487","display_name":"Alan Hay","orcid":"https://orcid.org/0000-0002-6064-6183"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alan J. Hay","raw_affiliation_strings":["National Institute for Medical Research, London, United Kingdom","\u2020National Institute for Medical Research, London, United Kingdom;"],"affiliations":[{"raw_affiliation_string":"National Institute for Medical Research, London, United Kingdom","institution_ids":[]},{"raw_affiliation_string":"\u2020National Institute for Medical Research, London, United Kingdom;","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040571548","display_name":"Richard A. Goldstein","orcid":"https://orcid.org/0000-0001-5148-4672"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Richard A. Goldstein","raw_affiliation_strings":["National Institute for Medical Research, London, United Kingdom","\u2020National Institute for Medical Research, London, United Kingdom;"],"affiliations":[{"raw_affiliation_string":"National Institute for Medical Research, London, United Kingdom","institution_ids":[]},{"raw_affiliation_string":"\u2020National Institute for Medical Research, London, United Kingdom;","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5040571548"],"corresponding_institution_ids":[],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":4.6367,"has_fulltext":true,"cited_by_count":141,"citation_normalized_percentile":{"value":0.95009723,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"5","issue":"11","first_page":"e1000564","last_page":"e1000564"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9837999939918518,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9817000031471252,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/waterfowl","display_name":"Waterfowl","score":0.8432630300521851},{"id":"https://openalex.org/keywords/reassortment","display_name":"Reassortment","score":0.7709292769432068},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7029458284378052},{"id":"https://openalex.org/keywords/influenza-a-virus-subtype-h5n1","display_name":"Influenza A virus subtype H5N1","score":0.6793083548545837},{"id":"https://openalex.org/keywords/host","display_name":"Host (biology)","score":0.637401819229126},{"id":"https://openalex.org/keywords/pandemic","display_name":"Pandemic","score":0.613693118095398},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.6092517375946045},{"id":"https://openalex.org/keywords/phylogenetic-tree","display_name":"Phylogenetic tree","score":0.5593445897102356},{"id":"https://openalex.org/keywords/influenza-a-virus","display_name":"Influenza A virus","score":0.5306859016418457},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.48449060320854187},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.4777856767177582},{"id":"https://openalex.org/keywords/viral-evolution","display_name":"Viral evolution","score":0.44257745146751404},{"id":"https://openalex.org/keywords/natural-selection","display_name":"Natural selection","score":0.43054455518722534},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.37286707758903503},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.35638803243637085},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.2849608063697815},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.22412508726119995},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.19901686906814575},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.1859871745109558},{"id":"https://openalex.org/keywords/coronavirus-disease-2019","display_name":"Coronavirus disease 2019 (COVID-19)","score":0.12980055809020996}],"concepts":[{"id":"https://openalex.org/C2776834261","wikidata":"https://www.wikidata.org/wiki/Q21651","display_name":"Waterfowl","level":3,"score":0.8432630300521851},{"id":"https://openalex.org/C16154277","wikidata":"https://www.wikidata.org/wiki/Q2004399","display_name":"Reassortment","level":5,"score":0.7709292769432068},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7029458284378052},{"id":"https://openalex.org/C519248777","wikidata":"https://www.wikidata.org/wiki/Q160122","display_name":"Influenza A virus subtype H5N1","level":3,"score":0.6793083548545837},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.637401819229126},{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.613693118095398},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6092517375946045},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.5593445897102356},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.5306859016418457},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.48449060320854187},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.4777856767177582},{"id":"https://openalex.org/C8769409","wikidata":"https://www.wikidata.org/wiki/Q2066554","display_name":"Viral evolution","level":4,"score":0.44257745146751404},{"id":"https://openalex.org/C75268714","wikidata":"https://www.wikidata.org/wiki/Q43478","display_name":"Natural selection","level":3,"score":0.43054455518722534},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.37286707758903503},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.35638803243637085},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.2849608063697815},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22412508726119995},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.19901686906814575},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.1859871745109558},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.12980055809020996},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C185933670","wikidata":"https://www.wikidata.org/wiki/Q52105","display_name":"Habitat","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040961","descriptor_name":"Genetic Drift","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040961","descriptor_name":"Genetic Drift","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040961","descriptor_name":"Genetic Drift","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040961","descriptor_name":"Genetic Drift","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046090","descriptor_name":"Anseriformes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046090","descriptor_name":"Anseriformes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046090","descriptor_name":"Anseriformes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046090","descriptor_name":"Anseriformes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1000564","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000564","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000564&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:19911053","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19911053","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.801.6403","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.801.6403","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/7f/42/pcbi.1000564.PMC2770840.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:f36c75a4f9d2405096c9b0daf7ee63e8","is_oa":true,"landing_page_url":"https://doaj.org/article/f36c75a4f9d2405096c9b0daf7ee63e8","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 5, Iss 11, p e1000564 (2009)","raw_type":"article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1396080","is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1396080/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"   PLOS COMPUTATIONAL BIOLOGY , 5  (11)     (2009)      ","raw_type":"Article"},{"id":"pmh:oai:figshare.com:article/145793","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Identifying_Changes_in_Selective_Constraints_Host_Shifts_in_Influenza/145793","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:2770840","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2770840","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:qmro.qmul.ac.uk:123456789/14070","is_oa":true,"landing_page_url":"http://qmro.qmul.ac.uk/xmlui/handle/123456789/14070","pdf_url":null,"source":{"id":"https://openalex.org/S4306400530","display_name":"Queen Mary Research Online (Queen Mary University of London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I166337079","host_organization_name":"Queen Mary University of London","host_organization_lineage":["https://openalex.org/I166337079"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000564","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000564","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000564&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6899999976158142}],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1995080247.pdf","grobid_xml":"https://content.openalex.org/works/W1995080247.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W88711257","https://openalex.org/W420957490","https://openalex.org/W1603867145","https://openalex.org/W1968307251","https://openalex.org/W1973122974","https://openalex.org/W1974077212","https://openalex.org/W1981737570","https://openalex.org/W1983941241","https://openalex.org/W1984306711","https://openalex.org/W1988533731","https://openalex.org/W1997497517","https://openalex.org/W2004139298","https://openalex.org/W2009596137","https://openalex.org/W2019907599","https://openalex.org/W2022439632","https://openalex.org/W2024430413","https://openalex.org/W2024970913","https://openalex.org/W2029549914","https://openalex.org/W2031206741","https://openalex.org/W2032378111","https://openalex.org/W2035088373","https://openalex.org/W2041246993","https://openalex.org/W2045934762","https://openalex.org/W2046183549","https://openalex.org/W2053741669","https://openalex.org/W2054604776","https://openalex.org/W2061095809","https://openalex.org/W2062018285","https://openalex.org/W2062594085","https://openalex.org/W2062869638","https://openalex.org/W2065193241","https://openalex.org/W2074034244","https://openalex.org/W2091436152","https://openalex.org/W2092414509","https://openalex.org/W2096251834","https://openalex.org/W2097977090","https://openalex.org/W2102424972","https://openalex.org/W2103546861","https://openalex.org/W2104568825","https://openalex.org/W2106007739","https://openalex.org/W2106084478","https://openalex.org/W2110065044","https://openalex.org/W2110335151","https://openalex.org/W2111359724","https://openalex.org/W2119632499","https://openalex.org/W2124574957","https://openalex.org/W2125739732","https://openalex.org/W2126226517","https://openalex.org/W2132926880","https://openalex.org/W2134489190","https://openalex.org/W2135745126","https://openalex.org/W2137137210","https://openalex.org/W2143262622","https://openalex.org/W2156316331","https://openalex.org/W2157001909","https://openalex.org/W2160881014","https://openalex.org/W2163123197","https://openalex.org/W2286962642","https://openalex.org/W2312463092","https://openalex.org/W2517585216","https://openalex.org/W2547292717","https://openalex.org/W4230357098","https://openalex.org/W4231338500","https://openalex.org/W4237236497","https://openalex.org/W6646331680","https://openalex.org/W6666358845"],"related_works":["https://openalex.org/W1977560840","https://openalex.org/W2808049856","https://openalex.org/W4387744460","https://openalex.org/W1783971409","https://openalex.org/W2952199890","https://openalex.org/W2060839575","https://openalex.org/W2131755589","https://openalex.org/W2901821037","https://openalex.org/W2138426702","https://openalex.org/W1981836991"],"abstract_inverted_index":{"The":[0,129,170],"natural":[1],"reservoir":[2],"of":[3,61,97,120,143,152,167,173,185],"Influenza":[4],"A":[5],"is":[6,36,60,172,188],"waterfowl.":[7],"Normally,":[8],"waterfowl":[9,34],"viruses":[10,35,49,146],"are":[11],"not":[12],"adapted":[13],"to":[14,53,76,138,147,176],"infect":[15],"and":[16,66,103,114,126],"spread":[17,54],"in":[18,56,64,93,100,124,179],"the":[19,39,57,94,148,153,164,183,186],"human":[20,40,58,125,149],"population.":[21],"Sometimes,":[22],"through":[23,26],"reassortment":[24],"or":[25],"whole":[27],"host":[28,158],"shift":[29],"events,":[30],"genetic":[31],"material":[32],"from":[33,50],"introduced":[37],"into":[38,90],"population":[41,59],"causing":[42],"worldwide":[43],"pandemics.":[44,69],"Identifying":[45],"which":[46],"mutations":[47],"allow":[48],"avian":[51,127,144],"origin":[52],"successfully":[55],"great":[62],"importance":[63],"predicting":[65],"controlling":[67],"influenza":[68],"Here":[70],"we":[71,132],"describe":[72],"a":[73,82],"novel":[74],"approach":[75],"identify":[77,106,133],"such":[78],"mutations.":[79],"We":[80,105],"use":[81],"sitewise":[83],"non-homogeneous":[84],"phylogenetic":[85],"model":[86],"that":[87,131],"explicitly":[88],"takes":[89],"account":[91],"differences":[92],"equilibrium":[95],"frequencies":[96],"amino":[98,108],"acids":[99],"different":[101,121],"hosts":[102],"locations.":[104],"172":[107],"acid":[109],"sites":[110,116,130],"with":[111,117],"strong":[112],"support":[113,119],"518":[115],"moderate":[118],"selection":[122],"constraints":[123,181],"viruses.":[128],"provide":[134],"an":[135],"invaluable":[136],"resource":[137],"experimental":[139],"virologists":[140],"studying":[141],"adaptation":[142],"flu":[145],"host.":[150],"Identification":[151],"sequence":[154],"changes":[155,178,187],"necessary":[156],"for":[157],"shifts":[159],"would":[160],"help":[161],"us":[162],"predict":[163],"pandemic":[165],"potential":[166],"various":[168],"strains.":[169],"method":[171],"broad":[174],"applicability":[175],"investigating":[177],"selective":[180],"when":[182],"timing":[184],"known.":[189]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":9}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}