{"id":"https://openalex.org/W2125923866","doi":"https://doi.org/10.1371/journal.pcbi.1000537","title":"Subbarrel Patterns in Somatosensory Cortical Barrels Can Emerge from Local Dynamic Instabilities","display_name":"Subbarrel Patterns in Somatosensory Cortical Barrels Can Emerge from Local Dynamic Instabilities","publication_year":2009,"publication_date":"2009-10-15","ids":{"openalex":"https://openalex.org/W2125923866","doi":"https://doi.org/10.1371/journal.pcbi.1000537","mag":"2125923866","pmid":"https://pubmed.ncbi.nlm.nih.gov/19834600"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000537","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000537","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000537&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000537&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041060587","display_name":"Bard Ermentrout","orcid":"https://orcid.org/0000-0002-5854-0654"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bard Ermentrout","raw_affiliation_strings":["Department of Mathematics, University of Pittsburgh, Pittsburgh, Pennsylvannia, United States of America. bard@pitt.edu","Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvannia, United States of America","Department of Mathematics, University of Pittsburgh, Pittsburgh, Pennsylvannia, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of Pittsburgh, Pittsburgh, Pennsylvannia, United States of America. bard@pitt.edu","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvannia, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Mathematics, University of Pittsburgh, Pittsburgh, Pennsylvannia, United States of America","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006468035","display_name":"Daniel J. Simons","orcid":"https://orcid.org/0000-0001-7545-1621"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J. Simons","raw_affiliation_strings":["Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvannia, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvannia, United States of America","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072050904","display_name":"Peter W. Land","orcid":null},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter W. Land","raw_affiliation_strings":["Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvannia, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvannia, United States of America","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5041060587"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.1407,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.52951222,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"5","issue":"10","first_page":"e1000537","last_page":"e1000537"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9939000010490417,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11187","display_name":"Nonlinear Dynamics and Pattern Formation","score":0.993399977684021,"subfield":{"id":"https://openalex.org/subfields/1705","display_name":"Computer Networks and Communications"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/somatosensory-system","display_name":"Somatosensory system","score":0.8229063153266907},{"id":"https://openalex.org/keywords/barrel","display_name":"Barrel (horology)","score":0.5934937596321106},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4925411641597748},{"id":"https://openalex.org/keywords/simple","display_name":"Simple (philosophy)","score":0.4645144045352936},{"id":"https://openalex.org/keywords/barrel-cortex","display_name":"Barrel cortex","score":0.4592565894126892},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.4472469091415405},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.43829983472824097},{"id":"https://openalex.org/keywords/pattern-formation","display_name":"Pattern formation","score":0.41566282510757446},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.3868675231933594},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.32901519536972046},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.27911144495010376},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.24536973237991333},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.10400956869125366}],"concepts":[{"id":"https://openalex.org/C172497186","wikidata":"https://www.wikidata.org/wiki/Q328835","display_name":"Somatosensory system","level":2,"score":0.8229063153266907},{"id":"https://openalex.org/C172227984","wikidata":"https://www.wikidata.org/wiki/Q1400397","display_name":"Barrel (horology)","level":2,"score":0.5934937596321106},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4925411641597748},{"id":"https://openalex.org/C2780586882","wikidata":"https://www.wikidata.org/wiki/Q7520643","display_name":"Simple (philosophy)","level":2,"score":0.4645144045352936},{"id":"https://openalex.org/C2781347215","wikidata":"https://www.wikidata.org/wiki/Q4863332","display_name":"Barrel cortex","level":3,"score":0.4592565894126892},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.4472469091415405},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.43829983472824097},{"id":"https://openalex.org/C207016750","wikidata":"https://www.wikidata.org/wiki/Q1955627","display_name":"Pattern formation","level":2,"score":0.41566282510757446},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3868675231933594},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.32901519536972046},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.27911144495010376},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24536973237991333},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.10400956869125366},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013003","descriptor_name":"Somatosensory Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013003","descriptor_name":"Somatosensory Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013003","descriptor_name":"Somatosensory Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1000537","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000537","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000537&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:19834600","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19834600","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:d-scholarship.pitt.edu:13279","is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/13279/8/licence.txt","pdf_url":null,"source":{"id":"https://openalex.org/S4306402375","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"pmh:oai:doaj.org/article:ac6ea14f332d4044bca1086fb07303c2","is_oa":true,"landing_page_url":"https://doaj.org/article/ac6ea14f332d4044bca1086fb07303c2","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 5, Iss 10, p e1000537 (2009)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/146000","is_oa":true,"landing_page_url":"https://figshare.com/articles/Subbarrel_Patterns_in_Somatosensory_Cortical_Barrels_Can_Emerge_from_Local_Dynamic_Instabilities/146000","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:2759004","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2759004","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000537","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000537","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000537&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15","score":0.550000011920929}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2125923866.pdf","grobid_xml":"https://content.openalex.org/works/W2125923866.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1561541164","https://openalex.org/W1580229328","https://openalex.org/W1949328498","https://openalex.org/W1964745881","https://openalex.org/W1967435385","https://openalex.org/W1971730120","https://openalex.org/W1978941072","https://openalex.org/W1985072454","https://openalex.org/W2002818439","https://openalex.org/W2021313062","https://openalex.org/W2037731838","https://openalex.org/W2059060894","https://openalex.org/W2063621508","https://openalex.org/W2067265108","https://openalex.org/W2073573906","https://openalex.org/W2077811595","https://openalex.org/W2087103619","https://openalex.org/W2089840306","https://openalex.org/W2113851985","https://openalex.org/W2114767939","https://openalex.org/W2149073178","https://openalex.org/W2169476756","https://openalex.org/W2207079540","https://openalex.org/W2475997554","https://openalex.org/W2487249630","https://openalex.org/W2991126964","https://openalex.org/W7024974029"],"related_works":["https://openalex.org/W2950587248","https://openalex.org/W2055857548","https://openalex.org/W4231720955","https://openalex.org/W2074888583","https://openalex.org/W2124503686","https://openalex.org/W2163492988","https://openalex.org/W2100212553","https://openalex.org/W2031077791","https://openalex.org/W1854866437","https://openalex.org/W2113197787"],"abstract_inverted_index":{"Complex":[0],"spatial":[1],"patterning,":[2],"common":[3],"in":[4,10,111,178],"the":[5,29,43,77,98,104,122,128,139,147,150],"brain":[6],"as":[7,9,16],"well":[8],"other":[11],"biological":[12],"systems,":[13],"can":[14,65,169],"emerge":[15],"a":[17,55,156],"result":[18],"of":[19,34,54,70,80,100,103,113,131,149],"dynamic":[20,117],"interactions":[21,75],"that":[22,62,87,97,138],"occur":[23],"locally":[24],"within":[25,76,106],"developing":[26],"structures.":[27],"In":[28],"rodent":[30],"somatosensory":[31],"cortex,":[32],"groups":[33],"neurons":[35],"called":[36],"\"barrels\"":[37],"correspond":[38],"to":[39,126,146],"individual":[40],"whiskers":[41],"on":[42,155],"contralateral":[44],"face.":[45],"Barrels":[46],"themselves":[47],"often":[48],"contain":[49,90],"subbarrels":[50],"organized":[51],"into":[52],"one":[53],"few":[56],"characteristic":[57],"patterns.":[58],"Here":[59],"we":[60,136],"demonstrate":[61,127],"similar":[63],"patterns":[64,105,154],"be":[66,109],"simulated":[67],"by":[68,152],"means":[69],"local":[71],"growth-promoting":[72],"and":[73,102,175,180],"growth-retarding":[74],"circular":[78],"domains":[79],"single":[81],"barrels.":[82],"The":[83],"model":[84],"correctly":[85],"predicts":[86],"larger":[88],"barrels":[89,101],"more":[91],"spatially":[92],"complex":[93,179],"subbarrel":[94],"patterns,":[95],"suggesting":[96],"development":[99],"them":[107],"may":[108],"understood":[110],"terms":[112],"some":[114],"relatively":[115],"simple":[116,165],"processes.":[118],"We":[119],"also":[120],"simulate":[121],"full":[123],"nonlinear":[124],"equations":[125],"predictive":[129],"value":[130],"our":[132],"linear":[133],"analysis.":[134],"Finally,":[135],"show":[137],"pattern":[140,166],"formation":[141],"is":[142],"robust":[143],"with":[144],"respect":[145],"geometry":[148],"barrel":[151,159],"simulating":[153],"realistically":[157],"shaped":[158],"domain.":[160],"This":[161],"work":[162],"shows":[163],"how":[164],"forming":[167],"mechanisms":[168],"explain":[170],"neural":[171],"wiring":[172],"both":[173],"qualitatively":[174],"quantitatively":[176],"even":[177],"irregular":[181],"domains.":[182]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2016-06-24T00:00:00"}