{"id":"https://openalex.org/W2067354644","doi":"https://doi.org/10.1371/journal.pcbi.1000527","title":"The Mechanism of Ubiquitination in the Cullin-RING E3 Ligase Machinery: Conformational Control of Substrate Orientation","display_name":"The Mechanism of Ubiquitination in the Cullin-RING E3 Ligase Machinery: Conformational Control of Substrate Orientation","publication_year":2009,"publication_date":"2009-10-01","ids":{"openalex":"https://openalex.org/W2067354644","doi":"https://doi.org/10.1371/journal.pcbi.1000527","mag":"2067354644","pmid":"https://pubmed.ncbi.nlm.nih.gov/19798438"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000527","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000527","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000527&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000527&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100327035","display_name":"Jin Liu","orcid":"https://orcid.org/0000-0002-1067-4063"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jin Liu","raw_affiliation_strings":["Basic Science Program, SAIC-Frederick, Inc., Center for Cancer Research Nanobiology Program, NCI-Frederick, Frederick, Maryland, USA"],"affiliations":[{"raw_affiliation_string":"Basic Science Program, SAIC-Frederick, Inc., Center for Cancer Research Nanobiology Program, NCI-Frederick, Frederick, Maryland, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025357844","display_name":"Ruth Nussinov","orcid":"https://orcid.org/0000-0002-8115-6415"},"institutions":[{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"id":"https://openalex.org/I880747138","display_name":"Science Applications International Corporation (United States)","ror":"https://ror.org/00zv91802","country_code":"US","type":"company","lineage":["https://openalex.org/I880747138"]},{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL","US"],"is_corresponding":true,"raw_author_name":"Ruth Nussinov","raw_affiliation_strings":["Basic Science Program, SAIC-Frederick, Inc., Center for Cancer Research Nanobiology Program, NCI-Frederick, Frederick, Maryland, United States of America","Sackler Institute of Molecular Medicine, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"],"affiliations":[{"raw_affiliation_string":"Basic Science Program, SAIC-Frederick, Inc., Center for Cancer Research Nanobiology Program, NCI-Frederick, Frederick, Maryland, United States of America","institution_ids":["https://openalex.org/I880747138","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"Sackler Institute of Molecular Medicine, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5025357844"],"corresponding_institution_ids":["https://openalex.org/I16391192","https://openalex.org/I4210149717","https://openalex.org/I880747138"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.6176,"has_fulltext":true,"cited_by_count":58,"citation_normalized_percentile":{"value":0.82729554,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"5","issue":"10","first_page":"e1000527","last_page":"e1000527"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ubiquitin-ligase","display_name":"Ubiquitin ligase","score":0.8216025829315186},{"id":"https://openalex.org/keywords/ubiquitin","display_name":"Ubiquitin","score":0.7159983515739441},{"id":"https://openalex.org/keywords/ubiquitin-protein-ligases","display_name":"Ubiquitin-Protein Ligases","score":0.7129189372062683},{"id":"https://openalex.org/keywords/cell-division-control-protein-4","display_name":"Cell division control protein 4","score":0.6937887072563171},{"id":"https://openalex.org/keywords/cullin","display_name":"Cullin","score":0.6086017489433289},{"id":"https://openalex.org/keywords/f-box-protein","display_name":"F-box protein","score":0.5869783759117126},{"id":"https://openalex.org/keywords/linker","display_name":"Linker","score":0.5744954943656921},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.5007257461547852},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.42617255449295044},{"id":"https://openalex.org/keywords/plasma-protein-binding","display_name":"Plasma protein binding","score":0.4193114638328552},{"id":"https://openalex.org/keywords/ubiquitin-conjugating-enzyme","display_name":"Ubiquitin-conjugating enzyme","score":0.4167150557041168},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.4032902717590332},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.4019647240638733},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3701786994934082},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.09561851620674133}],"concepts":[{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.8216025829315186},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.7159983515739441},{"id":"https://openalex.org/C2908868211","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin-Protein Ligases","level":5,"score":0.7129189372062683},{"id":"https://openalex.org/C162863750","wikidata":"https://www.wikidata.org/wiki/Q5058186","display_name":"Cell division control protein 4","level":5,"score":0.6937887072563171},{"id":"https://openalex.org/C2778567606","wikidata":"https://www.wikidata.org/wiki/Q41797435","display_name":"Cullin","level":5,"score":0.6086017489433289},{"id":"https://openalex.org/C131312102","wikidata":"https://www.wikidata.org/wiki/Q5423632","display_name":"F-box protein","level":5,"score":0.5869783759117126},{"id":"https://openalex.org/C2780557392","wikidata":"https://www.wikidata.org/wiki/Q523796","display_name":"Linker","level":2,"score":0.5744954943656921},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5007257461547852},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42617255449295044},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.4193114638328552},{"id":"https://openalex.org/C182561583","wikidata":"https://www.wikidata.org/wiki/Q7876535","display_name":"Ubiquitin-conjugating enzyme","level":5,"score":0.4167150557041168},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4032902717590332},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4019647240638733},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3701786994934082},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.09561851620674133},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014452","descriptor_name":"Ubiquitins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D014452","descriptor_name":"Ubiquitins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D014452","descriptor_name":"Ubiquitins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D014452","descriptor_name":"Ubiquitins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D014452","descriptor_name":"Ubiquitins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014452","descriptor_name":"Ubiquitins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014452","descriptor_name":"Ubiquitins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014452","descriptor_name":"Ubiquitins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D044842","descriptor_name":"Cullin Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D044842","descriptor_name":"Cullin Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D044842","descriptor_name":"Cullin Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D044842","descriptor_name":"Cullin Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D044842","descriptor_name":"Cullin Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D044842","descriptor_name":"Cullin Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D044842","descriptor_name":"Cullin Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D044842","descriptor_name":"Cullin Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1000527","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000527","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000527&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:19798438","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19798438","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1000527","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1000527","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:b96a557814f840eea14d66239c3190a5","is_oa":true,"landing_page_url":"https://doaj.org/article/b96a557814f840eea14d66239c3190a5","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 5, Iss 10, p e1000527 (2009)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/146152","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/The_Mechanism_of_Ubiquitination_in_the_Cullin_RING_E3_Ligase_Machinery_Conformational_Control_of_Substrate_Orientation/146152","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:2741574","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2741574","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000527","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000527","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000527&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3277247684","display_name":null,"funder_award_id":"N01-CO-12400","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4705127230","display_name":null,"funder_award_id":"1-CO-12400","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6977636623","display_name":null,"funder_award_id":"1-CO-12400","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7504989611","display_name":null,"funder_award_id":"N01-CO-12400","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2067354644.pdf","grobid_xml":"https://content.openalex.org/works/W2067354644.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W216496289","https://openalex.org/W1501553911","https://openalex.org/W1597762634","https://openalex.org/W1603251764","https://openalex.org/W1965076207","https://openalex.org/W1981849277","https://openalex.org/W1988876415","https://openalex.org/W1991634033","https://openalex.org/W1997477098","https://openalex.org/W2000428670","https://openalex.org/W2005474992","https://openalex.org/W2006061805","https://openalex.org/W2010004274","https://openalex.org/W2012618272","https://openalex.org/W2015291446","https://openalex.org/W2016386715","https://openalex.org/W2027408247","https://openalex.org/W2028968631","https://openalex.org/W2049682677","https://openalex.org/W2051776202","https://openalex.org/W2055043387","https://openalex.org/W2059692439","https://openalex.org/W2060619005","https://openalex.org/W2061090993","https://openalex.org/W2061156149","https://openalex.org/W2063070658","https://openalex.org/W2074316070","https://openalex.org/W2079347968","https://openalex.org/W2095420958","https://openalex.org/W2102830593","https://openalex.org/W2107238748","https://openalex.org/W2110847661","https://openalex.org/W2112053365","https://openalex.org/W2113030357","https://openalex.org/W2121077625","https://openalex.org/W2123529526","https://openalex.org/W2137885288","https://openalex.org/W2140219059","https://openalex.org/W2147291971","https://openalex.org/W2147466870","https://openalex.org/W2150981663","https://openalex.org/W2160648204","https://openalex.org/W2166987747","https://openalex.org/W2596045242","https://openalex.org/W6888794338"],"related_works":["https://openalex.org/W2998502719","https://openalex.org/W2156685011","https://openalex.org/W3216759499","https://openalex.org/W1995520312","https://openalex.org/W2079760361","https://openalex.org/W1581255397","https://openalex.org/W2034268892","https://openalex.org/W2392396993","https://openalex.org/W1964021682","https://openalex.org/W2066147619"],"abstract_inverted_index":{"In":[0,127],"cullin-RING":[1],"E3":[2,32,83],"ubiquitin":[3,27,113,180],"ligases,":[4],"substrate":[5,37,44,104,172,177],"binding":[6,45,105,158,173],"proteins,":[7,15],"such":[8],"as":[9,99],"VHL-box,":[10],"SOCS-box":[11],"or":[12,66],"the":[13,24,31,36,58,78,80,94,103,121,130,135,140,144,150,167,171,176,179],"F-box":[14],"recruit":[16],"substrates":[17,25],"for":[18,26,112,178,187],"ubiquitination,":[19],"accurately":[20,109],"positioning":[21,110],"and":[22,55,61,108,134,189],"orienting":[23],"transfer.":[28,114,181],"Yet,":[29],"how":[30],"machinery":[33],"precisely":[34],"positions":[35],"is":[38,137],"unknown.":[39],"Here,":[40],"we":[41],"simulated":[42],"nine":[43,70,125],"proteins:":[46],"Skp2,":[47],"Fbw7,":[48],"beta-TrCP1,":[49],"Cdc4,":[50],"Fbs1,":[51],"TIR1,":[52],"pVHL,":[53],"SOCS2,":[54],"SOCS4,":[56],"in":[57,91,120,170],"unbound":[59],"form":[60],"bound":[62],"to":[63,77,82],"Skp1,":[64],"ASK1":[65],"Elongin":[67],"C.":[68,87],"All":[69],"proteins":[71,174],"have":[72],"two":[73],"domains:":[74],"one":[75],"binds":[76],"substrate;":[79],"other":[81],"ligase":[84],"modules":[85],"Skp1/ASK1/Elongin":[86],"We":[88,115,146,164],"discovered":[89],"that":[90,149,166,192],"all":[92,124,128],"cases":[93],"flexible":[95,168],"inter-domain":[96],"linker":[97,122,151,169],"serves":[98],"a":[100,117,185],"hinge,":[101],"rotating":[102],"domain,":[106],"optimally":[107],"it":[111],"observed":[116,148],"conserved":[118],"proline":[119],"of":[123],"proteins.":[126],"cases,":[129],"prolines":[131],"pucker":[132,136],"substantially":[133],"associated":[138,160],"with":[139,161],"backbone":[141],"rotation":[142],"toward":[143],"E2/ubiquitin.":[145],"further":[147],"flexibility":[152],"could":[153],"be":[154],"regulated":[155],"allosterically":[156],"by":[157],"events":[159],"either":[162],"domain.":[163],"conclude":[165],"orients":[175],"Our":[182],"findings":[183],"provide":[184],"mechanism":[186],"ubiquitination":[188],"polyubiquitination,":[190],"illustrating":[191],"these":[193],"processes":[194],"are":[195],"under":[196],"conformational":[197],"control.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":2}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
