{"id":"https://openalex.org/W2092026469","doi":"https://doi.org/10.1371/journal.pcbi.1000518","title":"Integrating Extrinsic and Intrinsic Cues into a Minimal Model of Lineage Commitment for Hematopoietic Progenitors","display_name":"Integrating Extrinsic and Intrinsic Cues into a Minimal Model of Lineage Commitment for Hematopoietic Progenitors","publication_year":2009,"publication_date":"2009-09-25","ids":{"openalex":"https://openalex.org/W2092026469","doi":"https://doi.org/10.1371/journal.pcbi.1000518","mag":"2092026469","pmid":"https://pubmed.ncbi.nlm.nih.gov/19911036"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000518","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000518","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000518&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000518&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104753793","display_name":"Santhosh Palani","orcid":null},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Santhosh Palani","raw_affiliation_strings":["Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA","Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033706843","display_name":"Casim A. Sarkar","orcid":"https://orcid.org/0000-0002-0276-8203"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Casim A. Sarkar","raw_affiliation_strings":["Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America","Department of Chemical & Biomolecular Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Chemical & Biomolecular Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5033706843"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.0784,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.76495031,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"5","issue":"9","first_page":"e1000518","last_page":"e1000518"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.6921992301940918},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6803961992263794},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.5580659508705139},{"id":"https://openalex.org/keywords/progenitor-cell","display_name":"Progenitor cell","score":0.5454897880554199},{"id":"https://openalex.org/keywords/cellular-differentiation","display_name":"Cellular differentiation","score":0.501673698425293},{"id":"https://openalex.org/keywords/haematopoiesis","display_name":"Haematopoiesis","score":0.4972069561481476},{"id":"https://openalex.org/keywords/lineage","display_name":"Lineage (genetic)","score":0.48638108372688293},{"id":"https://openalex.org/keywords/cell-fate-determination","display_name":"Cell fate determination","score":0.43935996294021606},{"id":"https://openalex.org/keywords/cytokine-receptor","display_name":"Cytokine receptor","score":0.4137829542160034},{"id":"https://openalex.org/keywords/stem-cell","display_name":"Stem cell","score":0.30172842741012573},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.29058676958084106},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.24178439378738403},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.16852939128875732}],"concepts":[{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6921992301940918},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6803961992263794},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5580659508705139},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5454897880554199},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.501673698425293},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.4972069561481476},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.48638108372688293},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.43935996294021606},{"id":"https://openalex.org/C2775855021","wikidata":"https://www.wikidata.org/wiki/Q968436","display_name":"Cytokine receptor","level":3,"score":0.4137829542160034},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.30172842741012573},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29058676958084106},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.24178439378738403},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16852939128875732}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1000518","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000518","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000518&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:19911036","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19911036","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:109505e8a4aa4747ab26acea6e9c2358","is_oa":true,"landing_page_url":"https://doaj.org/article/109505e8a4aa4747ab26acea6e9c2358","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 5, Iss 9, p e1000518 (2009)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/146385","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Integrating_Extrinsic_and_Intrinsic_Cues_into_a_Minimal_Model_of_Lineage_Commitment_for_Hematopoietic_Progenitors/146385","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:2736398","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2736398","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000518","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000518","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000518&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G873107756","display_name":null,"funder_award_id":"0835132N","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320320290","display_name":"University of Oxford","ror":"https://ror.org/052gg0110"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2092026469.pdf","grobid_xml":"https://content.openalex.org/works/W2092026469.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W43784428","https://openalex.org/W1502074492","https://openalex.org/W1557148833","https://openalex.org/W1809670150","https://openalex.org/W1972589365","https://openalex.org/W1978529593","https://openalex.org/W1980860344","https://openalex.org/W1981560281","https://openalex.org/W1982130774","https://openalex.org/W1985543426","https://openalex.org/W1987373734","https://openalex.org/W1993517451","https://openalex.org/W1995838447","https://openalex.org/W2024520070","https://openalex.org/W2025847301","https://openalex.org/W2026816019","https://openalex.org/W2029991507","https://openalex.org/W2033687970","https://openalex.org/W2049336663","https://openalex.org/W2054345991","https://openalex.org/W2061866900","https://openalex.org/W2071797615","https://openalex.org/W2090786449","https://openalex.org/W2103054294","https://openalex.org/W2106407590","https://openalex.org/W2107696800","https://openalex.org/W2108170942","https://openalex.org/W2122968144","https://openalex.org/W2123880844","https://openalex.org/W2132980978","https://openalex.org/W2135535700","https://openalex.org/W2139374901","https://openalex.org/W2152414109","https://openalex.org/W2155418451","https://openalex.org/W2159559130","https://openalex.org/W2161743101","https://openalex.org/W2165625463","https://openalex.org/W2168221215","https://openalex.org/W2333297026","https://openalex.org/W2399252479","https://openalex.org/W4236153851","https://openalex.org/W4249341641","https://openalex.org/W6601757200"],"related_works":["https://openalex.org/W2506149209","https://openalex.org/W2352153050","https://openalex.org/W2140071436","https://openalex.org/W4210395781","https://openalex.org/W2114792939","https://openalex.org/W2412711773","https://openalex.org/W1995507342","https://openalex.org/W2888867414","https://openalex.org/W2508191807","https://openalex.org/W2048939079"],"abstract_inverted_index":{"Autoregulation":[0],"of":[1,32,52,118,162,182],"transcription":[2,8,38,127],"factors":[3,9],"and":[4,49,61,96,115,152,201,211],"cross-antagonism":[5],"between":[6],"lineage-specific":[7,33,37,126,194],"are":[10,122],"a":[11,43,81,165,203],"recurrent":[12],"theme":[13],"in":[14,25,54,69,215],"cell":[15,66,120,167],"differentiation.":[16],"An":[17],"equally":[18],"prevalent":[19],"event":[20],"that":[21,46,74,159,184,206,217],"is":[22,29,185],"frequently":[23],"overlooked":[24],"lineage":[26,135],"commitment":[27,67,136,183,213],"models":[28],"the":[30,113,160,172,180],"upregulation":[31],"receptors,":[34],"often":[35],"through":[36],"factors.":[39],"Here,":[40],"we":[41],"use":[42],"minimal":[44],"model":[45,108,189],"combines":[47],"cell-extrinsic":[48],"cell-intrinsic":[50],"elements":[51],"regulation":[53],"order":[55],"to":[56,84,93,111,164],"understand":[57],"how":[58],"both":[59,94,112,209],"instructive":[60,114],"stochastic":[62,116],"events":[63],"can":[64,79,132,169,207],"inform":[65],"decisions":[68,143],"hematopoiesis.":[70],"Our":[71,107],"results":[72],"suggest":[73,158],"cytokine-mediated":[75],"positive":[76],"receptor":[77,195],"feedback":[78],"induce":[80],"\"switch-like\"":[82],"response":[83],"external":[85],"stimuli":[86],"during":[87],"multilineage":[88],"differentiation":[89,104,163],"by":[90,125,137],"providing":[91],"robustness":[92],"bipotent":[95],"committed":[97],"states":[98],"while":[99],"protecting":[100],"progenitors":[101],"from":[102,198],"noise-induced":[103],"or":[105],"decommitment.":[106],"provides":[109,202],"support":[110],"theories":[117],"commitment:":[119],"fates":[121],"ultimately":[123],"driven":[124],"factors,":[128],"but":[129],"cytokine":[130],"signaling":[131],"strongly":[133],"bias":[134],"regulating":[138],"these":[139],"inherently":[140],"noisy":[141],"cell-fate":[142],"with":[144,193],"complex,":[145],"pertinent":[146],"behaviors":[147],"such":[148],"as":[149,176,178],"ligand-mediated":[150],"ultrasensitivity":[151],"robust":[153],"multistability.":[154],"The":[155],"simulations":[156],"further":[157],"kinetics":[161,197],"mature":[166],"state":[168,175],"depend":[170],"on":[171,179],"starting":[173],"progenitor":[174],"well":[177],"route":[181],"chosen.":[186],"Lastly,":[187],"our":[188],"shows":[190],"good":[191],"agreement":[192],"expression":[196],"microarray":[199],"experiments":[200],"computational":[204],"framework":[205],"integrate":[208],"classical":[210],"alternative":[212],"paths":[214],"hematopoiesis":[216],"have":[218],"been":[219],"observed":[220],"experimentally.":[221]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}