{"id":"https://openalex.org/W1985048498","doi":"https://doi.org/10.1371/journal.pcbi.1000492","title":"Thermodynamic Selection of Steric Zipper Patterns in the Amyloid Cross-\u03b2 Spine","display_name":"Thermodynamic Selection of Steric Zipper Patterns in the Amyloid Cross-\u03b2 Spine","publication_year":2009,"publication_date":"2009-09-03","ids":{"openalex":"https://openalex.org/W1985048498","doi":"https://doi.org/10.1371/journal.pcbi.1000492","mag":"1985048498","pmid":"https://pubmed.ncbi.nlm.nih.gov/19730673"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000492","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000492","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000492&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000492&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100625761","display_name":"Jiyong Park","orcid":"https://orcid.org/0000-0002-3225-4510"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jiyong Park","raw_affiliation_strings":["Department of Physics and Astronomy, Seoul National University, Seoul, Korea","Department of Physics and Astronomy, Seoul National University , Seoul, Korea"],"affiliations":[{"raw_affiliation_string":"Department of Physics and Astronomy, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Physics and Astronomy, Seoul National University , Seoul, Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015642017","display_name":"B. Kahng","orcid":"https://orcid.org/0000-0002-9099-6395"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Byungnam Kahng","raw_affiliation_strings":["Department of Physics and Astronomy, Seoul National University, Seoul, Korea,","Department of Physics and Astronomy, Seoul National University , Seoul, Korea"],"affiliations":[{"raw_affiliation_string":"Department of Physics and Astronomy, Seoul National University, Seoul, Korea,","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Physics and Astronomy, Seoul National University , Seoul, Korea","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061603084","display_name":"Wonmuk Hwang","orcid":"https://orcid.org/0000-0001-7514-3186"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wonmuk Hwang","raw_affiliation_strings":["Department of Biomedical Engineering, Texas A&M University, College Station, Texas, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Texas A&M University, College Station, Texas, United States of America","institution_ids":["https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100625761"],"corresponding_institution_ids":["https://openalex.org/I139264467"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":4.2166,"has_fulltext":true,"cited_by_count":71,"citation_normalized_percentile":{"value":0.93929259,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"5","issue":"9","first_page":"e1000492","last_page":"e1000492"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11419","display_name":"Supramolecular Self-Assembly in Materials","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11419","display_name":"Supramolecular Self-Assembly in Materials","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zipper","display_name":"Zipper","score":0.9004685878753662},{"id":"https://openalex.org/keywords/steric-effects","display_name":"Steric effects","score":0.7604948878288269},{"id":"https://openalex.org/keywords/bilayer","display_name":"Bilayer","score":0.7535398006439209},{"id":"https://openalex.org/keywords/crystallography","display_name":"Crystallography","score":0.5878363251686096},{"id":"https://openalex.org/keywords/van-der-waals-force","display_name":"van der Waals force","score":0.5796088576316833},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5626754760742188},{"id":"https://openalex.org/keywords/lipid-bilayer","display_name":"Lipid bilayer","score":0.5268815159797668},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.5226863622665405},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.44422122836112976},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.42105263471603394},{"id":"https://openalex.org/keywords/chemical-physics","display_name":"Chemical physics","score":0.3818681240081787},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.312061607837677},{"id":"https://openalex.org/keywords/molecule","display_name":"Molecule","score":0.28444942831993103},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.21285584568977356},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.15150469541549683},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.11621317267417908},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.0857103168964386}],"concepts":[{"id":"https://openalex.org/C105782903","wikidata":"https://www.wikidata.org/wiki/Q6577686","display_name":"Zipper","level":2,"score":0.9004685878753662},{"id":"https://openalex.org/C201194858","wikidata":"https://www.wikidata.org/wiki/Q898238","display_name":"Steric effects","level":2,"score":0.7604948878288269},{"id":"https://openalex.org/C192157962","wikidata":"https://www.wikidata.org/wiki/Q4087243","display_name":"Bilayer","level":3,"score":0.7535398006439209},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.5878363251686096},{"id":"https://openalex.org/C126061179","wikidata":"https://www.wikidata.org/wiki/Q189627","display_name":"van der Waals force","level":3,"score":0.5796088576316833},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5626754760742188},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.5268815159797668},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.5226863622665405},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.44422122836112976},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.42105263471603394},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.3818681240081787},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.312061607837677},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.28444942831993103},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.21285584568977356},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15150469541549683},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11621317267417908},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0857103168964386},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1000492","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000492","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000492&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:19730673","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19730673","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1000492","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1000492","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:61eaeef89eba4e699ab6122914e6e4b4","is_oa":true,"landing_page_url":"https://doaj.org/article/61eaeef89eba4e699ab6122914e6e4b4","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 5, Iss 9, p e1000492 (2009)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/146549","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Thermodynamic_Selection_of_Steric_Zipper_Patterns_in_the_Amyloid_Cross_Spine/146549","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:oaktrust.library.tamu.edu:1969.1/180569","is_oa":false,"landing_page_url":"https://hdl.handle.net/1969.1/180569","pdf_url":null,"source":{"id":"https://openalex.org/S4306400291","display_name":"OakTrust (Texas A&M University Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I91045830","host_organization_name":"Texas A&M University","host_organization_lineage":["https://openalex.org/I91045830"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""},{"id":"pmh:oai:pubmedcentral.nih.gov:2723932","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2723932","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000492","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000492","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000492&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8700000047683716,"id":"https://metadata.un.org/sdg/7","display_name":"Affordable and clean energy"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1985048498.pdf","grobid_xml":"https://content.openalex.org/works/W1985048498.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W1491063910","https://openalex.org/W1572030366","https://openalex.org/W1648265574","https://openalex.org/W1667165204","https://openalex.org/W1964741226","https://openalex.org/W1964807023","https://openalex.org/W1965650805","https://openalex.org/W1969699475","https://openalex.org/W1971280976","https://openalex.org/W1972881060","https://openalex.org/W1973897761","https://openalex.org/W1976494357","https://openalex.org/W1978548150","https://openalex.org/W1980699575","https://openalex.org/W1980706539","https://openalex.org/W1980947093","https://openalex.org/W1984569087","https://openalex.org/W1990427131","https://openalex.org/W1991470077","https://openalex.org/W1992453786","https://openalex.org/W1995309381","https://openalex.org/W1996333777","https://openalex.org/W1997758497","https://openalex.org/W2000036069","https://openalex.org/W2000588442","https://openalex.org/W2004098528","https://openalex.org/W2006225923","https://openalex.org/W2008708467","https://openalex.org/W2010511290","https://openalex.org/W2012467000","https://openalex.org/W2014451295","https://openalex.org/W2022879191","https://openalex.org/W2030837263","https://openalex.org/W2035001102","https://openalex.org/W2036947036","https://openalex.org/W2037346440","https://openalex.org/W2039667582","https://openalex.org/W2040809566","https://openalex.org/W2043642345","https://openalex.org/W2044846740","https://openalex.org/W2046331206","https://openalex.org/W2052737579","https://openalex.org/W2054788798","https://openalex.org/W2064959295","https://openalex.org/W2067214887","https://openalex.org/W2072327749","https://openalex.org/W2076468390","https://openalex.org/W2078645571","https://openalex.org/W2082351355","https://openalex.org/W2085899859","https://openalex.org/W2087357689","https://openalex.org/W2087389265","https://openalex.org/W2088865014","https://openalex.org/W2095782512","https://openalex.org/W2107317356","https://openalex.org/W2117537971","https://openalex.org/W2118280241","https://openalex.org/W2120717592","https://openalex.org/W2122294662","https://openalex.org/W2127396193","https://openalex.org/W2128547681","https://openalex.org/W2143678630","https://openalex.org/W2144481414","https://openalex.org/W2144775933","https://openalex.org/W2149478284","https://openalex.org/W2161337867","https://openalex.org/W2162166182","https://openalex.org/W2162741488","https://openalex.org/W2163210644","https://openalex.org/W2166745505","https://openalex.org/W2168025729","https://openalex.org/W2168527507","https://openalex.org/W4296154147","https://openalex.org/W4301253858","https://openalex.org/W6629520463","https://openalex.org/W7024001005"],"related_works":["https://openalex.org/W2389992822","https://openalex.org/W2061481432","https://openalex.org/W2100090167","https://openalex.org/W2031051143","https://openalex.org/W4367601614","https://openalex.org/W2718515487","https://openalex.org/W2072230736","https://openalex.org/W1963901611","https://openalex.org/W2320621004","https://openalex.org/W2059795428"],"abstract_inverted_index":{"At":[0],"the":[1,7,17,26,40,86,97,128,131,169,209,227,260,281],"core":[2],"of":[3,13,28,100,116,174,201,220,262,277],"amyloid":[4,238],"fibrils":[5,239],"is":[6,32,67,150,205,284],"cross-beta":[8],"spine,":[9],"a":[10,33,43,51,102,106,196,202,217],"long":[11],"tape":[12],"beta-sheets":[14,253,271],"formed":[15,112],"by":[16,90,113,148,166,208,287],"constituent":[18],"proteins.":[19],"Recent":[20],"high-resolution":[21],"x-ray":[22],"studies":[23],"show":[24],"that":[25,127,179,237],"unit":[27],"this":[29],"filamentous":[30],"structure":[31],"beta-sheet":[34,107,197],"bilayer":[35,41,55,203,282],"with":[36,130,141],"side":[37,224,264],"chains":[38,225,265],"within":[39],"forming":[42],"tightly":[44],"interdigitating":[45],"\"steric":[46],"zipper\"":[47],"interface.":[48],"However,":[49],"for":[50,231],"given":[52],"peptide,":[53],"different":[54],"patterns":[56,129],"are":[57,154,183],"possible,":[58],"and":[59,123,125,213,248],"no":[60],"quantitative":[61,218],"explanation":[62],"exists":[63],"regarding":[64],"which":[65,280],"pattern":[66,79,204],"selected":[68],"or":[69,245],"under":[70],"what":[71],"condition":[72],"there":[73,153],"can":[74],"be":[75],"more":[76,155,241],"than":[77,156,168],"one":[78,157],"observed,":[80],"exhibiting":[81],"molecular":[82,92],"polymorphism.":[83],"We":[84,109],"address":[85],"structural":[87],"selection":[88,200],"mechanism":[89],"performing":[91],"dynamics":[93],"simulations":[94],"to":[95,137,267,272],"calculate":[96],"free":[98,134,163],"energy":[99,135,176],"incorporating":[101,194],"peptide":[103],"monomer":[104],"into":[105,195],"bilayer.":[108,198],"test":[110],"filaments":[111],"several":[114],"types":[115],"peptides":[117,182],"including":[118],"GNNQQNY,":[119],"NNQQ,":[120,149],"VEALYL,":[121],"KLVFFAE":[122],"STVIIE,":[124],"find":[126],"lowest":[132],"binding":[133,162],"correspond":[136],"available":[138],"atomistic":[139],"structures":[140,160],"high":[142],"accuracy.":[143],"Molecular":[144],"polymorphism,":[145],"as":[146,216],"exhibited":[147],"likely":[151,285],"because":[152],"most":[158],"stable":[159],"whose":[161],"energies":[164],"differ":[165],"less":[167],"thermal":[170],"energy.":[171],"Detailed":[172],"analysis":[173],"individual":[175],"terms":[177],"reveals":[178],"these":[180],"short":[181],"not":[184],"strained":[185],"nor":[186],"do":[187],"they":[188],"lose":[189],"much":[190],"conformational":[191],"entropy":[192],"upon":[193],"The":[199,229],"determined":[206],"mainly":[207],"van":[210],"der":[211],"Waals":[212],"hydrophobic":[214],"forces":[215],"measure":[219],"shape":[221],"complementarity":[222],"among":[223,243],"between":[226],"beta-sheets.":[228],"requirement":[230],"self-complementary":[232],"steric":[233],"zipper":[234],"formation":[235,283],"supports":[236],"form":[240,273],"easily":[242],"similar":[244],"same":[246],"sequences,":[247],"it":[249],"also":[250],"makes":[251],"parallel":[252],"generally":[254],"preferred":[255],"over":[256],"anti-parallel":[257,270],"ones.":[258],"But":[259],"presence":[261],"charged":[263],"appears":[266],"kinetically":[268],"drive":[269],"at":[274],"early":[275],"stages":[276],"assembly,":[278],"after":[279],"driven":[286],"energetics.":[288]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":9}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2016-06-24T00:00:00"}