{"id":"https://openalex.org/W2013487313","doi":"https://doi.org/10.1371/journal.pcbi.1000472","title":"On the Accessibility of Adaptive Phenotypes of a Bacterial Metabolic Network","display_name":"On the Accessibility of Adaptive Phenotypes of a Bacterial Metabolic Network","publication_year":2009,"publication_date":"2009-08-20","ids":{"openalex":"https://openalex.org/W2013487313","doi":"https://doi.org/10.1371/journal.pcbi.1000472","mag":"2013487313","pmid":"https://pubmed.ncbi.nlm.nih.gov/19696877"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000472","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000472","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000472&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["arxiv","crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000472&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041306570","display_name":"Wilfred Ndifon","orcid":"https://orcid.org/0000-0001-6022-432X"},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wilfred Ndifon","raw_affiliation_strings":["Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, USA. ndifon@gmail.com","Department of Ecology & Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, USA. ndifon@gmail.com","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Department of Ecology & Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073702596","display_name":"Joshua B. Plotkin","orcid":"https://orcid.org/0000-0003-2349-6304"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua B. Plotkin","raw_affiliation_strings":["Department of Biology and Program in Applied Mathematics and Computational Science, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biology and Program in Applied Mathematics and Computational Science, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071611289","display_name":"Jonathan Dushoff","orcid":"https://orcid.org/0000-0003-0506-4794"},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jonathan Dushoff","raw_affiliation_strings":["Department of Biology, McMaster University, Hamilton, Ontario, Canada","Department, of Biology, McMaster University Hamilton, Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Biology, McMaster University, Hamilton, Ontario, Canada","institution_ids":["https://openalex.org/I98251732"]},{"raw_affiliation_string":"Department, of Biology, McMaster University Hamilton, Ontario, Canada","institution_ids":["https://openalex.org/I98251732"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5041306570"],"corresponding_institution_ids":["https://openalex.org/I20089843"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.674,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.68637943,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"5","issue":"8","first_page":"e1000472","last_page":"e1000472"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.8255650997161865},{"id":"https://openalex.org/keywords/adaptation","display_name":"Adaptation (eye)","score":0.6680145263671875},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6061578989028931},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5728355050086975},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.4969184696674347},{"id":"https://openalex.org/keywords/phenotypic-plasticity","display_name":"Phenotypic plasticity","score":0.4715060293674469},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.4701540470123291},{"id":"https://openalex.org/keywords/adaptive-evolution","display_name":"Adaptive evolution","score":0.4538097381591797},{"id":"https://openalex.org/keywords/flux","display_name":"Flux (metallurgy)","score":0.4206969738006592},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3943783938884735},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.33677780628204346},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.3240325450897217},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.27547961473464966},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.16971233487129211},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.09409084916114807}],"concepts":[{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.8255650997161865},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.6680145263671875},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6061578989028931},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5728355050086975},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4969184696674347},{"id":"https://openalex.org/C62277055","wikidata":"https://www.wikidata.org/wiki/Q295130","display_name":"Phenotypic plasticity","level":2,"score":0.4715060293674469},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4701540470123291},{"id":"https://openalex.org/C2992278830","wikidata":"https://www.wikidata.org/wiki/Q483921","display_name":"Adaptive evolution","level":3,"score":0.4538097381591797},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.4206969738006592},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3943783938884735},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33677780628204346},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.3240325450897217},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27547961473464966},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.16971233487129211},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.09409084916114807},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000220","descriptor_name":"Adaptation, Biological","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000220","descriptor_name":"Adaptation, Biological","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000220","descriptor_name":"Adaptation, Biological","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1000472","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000472","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000472&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:19696877","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19696877","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:arXiv.org:0908.2024","is_oa":true,"landing_page_url":"http://arxiv.org/abs/0908.2024","pdf_url":"https://arxiv.org/pdf/0908.2024","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.329.2878","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.329.2878","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://mathbio.sas.upenn.edu/Papers/Ndifon2009.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:b974ec9f99cc40e280508bf3886d4839","is_oa":true,"landing_page_url":"https://doaj.org/article/b974ec9f99cc40e280508bf3886d4839","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 5, Iss 8, p e1000472 (2009)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/146654","is_oa":true,"landing_page_url":"https://figshare.com/articles/On_the_Accessibility_of_Adaptive_Phenotypes_of_a_Bacterial_Metabolic_Network/146654","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:2716542","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2716542","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000472","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000472","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000472&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5,"display_name":"No poverty","id":"https://metadata.un.org/sdg/1"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306151","display_name":"Alfred P. Sloan Foundation","ror":"https://ror.org/052csg198"},{"id":"https://openalex.org/F4320306183","display_name":"James S. McDonnell Foundation","ror":"https://ror.org/03dy4aq19"},{"id":"https://openalex.org/F4320332180","display_name":"Defense Advanced Research Projects Agency","ror":"https://ror.org/02caytj08"},{"id":"https://openalex.org/F4320332603","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48"},{"id":"https://openalex.org/F4320332815","display_name":"Advanced Research Projects Agency","ror":"https://ror.org/02caytj08"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"},{"id":"https://openalex.org/F4320337427","display_name":"Kavli Institute for Theoretical Physics, University of California, Santa Barbara","ror":"https://ror.org/02t274463"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2013487313.pdf","grobid_xml":"https://content.openalex.org/works/W2013487313.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W139884376","https://openalex.org/W285471286","https://openalex.org/W1529898704","https://openalex.org/W1570124823","https://openalex.org/W1572104345","https://openalex.org/W1758395617","https://openalex.org/W1969857637","https://openalex.org/W1971399377","https://openalex.org/W1971541535","https://openalex.org/W1977940795","https://openalex.org/W1993296569","https://openalex.org/W2003489966","https://openalex.org/W2005869314","https://openalex.org/W2018041072","https://openalex.org/W2025663053","https://openalex.org/W2040644461","https://openalex.org/W2046585679","https://openalex.org/W2048513931","https://openalex.org/W2076963640","https://openalex.org/W2083011190","https://openalex.org/W2092500478","https://openalex.org/W2094399313","https://openalex.org/W2099111195","https://openalex.org/W2099465311","https://openalex.org/W2102164505","https://openalex.org/W2105557836","https://openalex.org/W2111421616","https://openalex.org/W2119559861","https://openalex.org/W2120549641","https://openalex.org/W2126176298","https://openalex.org/W2126487485","https://openalex.org/W2127366503","https://openalex.org/W2131900713","https://openalex.org/W2153373497","https://openalex.org/W2153453282","https://openalex.org/W2153685804","https://openalex.org/W2170427655","https://openalex.org/W3125669346","https://openalex.org/W4212903495","https://openalex.org/W4256259619"],"related_works":["https://openalex.org/W1840542775","https://openalex.org/W2294133139","https://openalex.org/W2108714279","https://openalex.org/W3128849054","https://openalex.org/W4249696493","https://openalex.org/W4287735120","https://openalex.org/W3214243847","https://openalex.org/W2941355599","https://openalex.org/W1977884439","https://openalex.org/W2506965389"],"abstract_inverted_index":{"The":[0,225],"mechanisms":[1],"by":[2,137],"which":[3,174],"adaptive":[4,53,116,195,268],"phenotypes":[5,54,117,196],"spread":[6],"within":[7],"an":[8,63,228],"evolving":[9,152],"population":[10],"after":[11],"their":[12,36],"emergence":[13,37],"are":[14,202],"understood":[15],"fairly":[16],"well.":[17],"Much":[18],"less":[19,121],"is":[20,146,185],"known":[21],"about":[22,182,251],"the":[23,27,44,50,70,79,95,103,132,141,144,162,176,192,205,215,218,221,242,265,277],"factors":[24],"that":[25,102,115,161,212],"influence":[26,45],"evolutionary":[28,233,283],"accessibility":[29,51,193,266],"of":[30,46,52,55,67,81,97,131,167,191,194,207,223,267],"such":[31,124,156],"phenotypes,":[32,269],"a":[33,39,73,106,208,245],"pre-requisite":[34],"for":[35,72,232,274],"in":[38,110,123,140,197,239,264],"population.":[40],"Here,":[41],"we":[42,159],"investigate":[43],"environmental":[47],"quality":[48],"on":[49,94,127],"Escherichia":[56],"coli's":[57],"central":[58],"metabolic":[59,92],"network.":[60],"We":[61,77,100],"used":[62],"established":[64],"flux-balance":[65],"model":[66],"metabolism":[68],"as":[69],"basis":[71],"genotype-phenotype":[74],"map":[75],"(GPM).":[76],"quantified":[78],"effects":[80],"seven":[82],"qualitatively":[83,111],"different":[84,198],"environments":[85,240],"(corresponding":[86],"to":[87,154,171,179,248],"both":[88],"carbohydrate":[89],"and":[90,220,270,282],"gluconeogenic":[91],"substrates)":[93],"structure":[96,109],"this":[98,149],"GPM.":[99],"found":[101,160],"GPM":[104,145,243],"has":[105,244],"more":[107],"rugged":[108],"poorer":[112],"environments,":[113],"suggesting":[114],"could":[118,150,236],"be":[119,135,237],"intrinsically":[120],"accessible":[122],"environments.":[125,199],"Nevertheless,":[126],"average":[128],"approximately":[129],"74%":[130],"genotype":[133,168],"can":[134],"altered":[136],"neutral":[138],"drift,":[139],"environment":[142],"where":[143,241],"most":[147],"rugged;":[148],"allow":[151],"populations":[153],"circumvent":[155],"ruggedness.":[157],"Furthermore,":[158],"normalized":[163],"mutual":[164],"information":[165,181,250,280],"(NMI)":[166],"differences":[169,263],"relative":[170],"phenotype":[172,183,252],"differences,":[173,184],"measures":[175],"GPM's":[177],"capacity":[178,247],"transmit":[180,249],"positively":[186],"correlated":[187],"with":[188,204],"(simulation-based)":[189],"estimates":[190],"These":[200],"results":[201,226,257],"consistent":[203],"predictions":[206],"simple":[209],"analytic":[210],"theory":[211,281],"makes":[213],"explicit":[214],"relationship":[216],"between":[217,279],"NMI":[219],"speed":[222],"adaptation.":[224],"suggest":[227,272],"intuitive":[229],"information-theoretic":[230],"principle":[231],"adaptation;":[234],"adaptation":[235],"faster":[238],"greater":[246],"differences.":[253],"More":[254],"generally,":[255],"our":[256],"provide":[258],"insight":[259],"into":[260],"fundamental":[261],"environment-specific":[262],"they":[271],"opportunities":[273],"research":[275],"at":[276],"interface":[278],"biology.":[284]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}