{"id":"https://openalex.org/W2152689442","doi":"https://doi.org/10.1371/journal.pcbi.1000394","title":"Structural Adaptation and Heterogeneity of Normal and Tumor Microvascular Networks","display_name":"Structural Adaptation and Heterogeneity of Normal and Tumor Microvascular Networks","publication_year":2009,"publication_date":"2009-05-28","ids":{"openalex":"https://openalex.org/W2152689442","doi":"https://doi.org/10.1371/journal.pcbi.1000394","mag":"2152689442","pmid":"https://pubmed.ncbi.nlm.nih.gov/19478883"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000394","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000394","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000394&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000394&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062462095","display_name":"Axel R. Pries","orcid":"https://orcid.org/0000-0002-8742-3369"},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"funder","lineage":["https://openalex.org/I7877124"]},{"id":"https://openalex.org/I4210105663","display_name":"Deutsches Herzzentrum der Charit\u00e9","ror":"https://ror.org/01mmady97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210105663","https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Axel R. Pries","raw_affiliation_strings":["Department of Physiology, Charit\u00e9, Berlin, Germany","Deutsches Herzzentrum Berlin, Berlin, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Physiology, Charit\u00e9, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Deutsches Herzzentrum Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I4210105663"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036568356","display_name":"Annemiek J. M. Cornelissen","orcid":"https://orcid.org/0000-0002-0882-3277"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"funder","lineage":["https://openalex.org/I7877124"]},{"id":"https://openalex.org/I4210127056","display_name":"Laboratoire Mati\u00e8re et Syst\u00e8mes Complexes","ror":"https://ror.org/032w6q449","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4210095849","https://openalex.org/I4210127056"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]}],"countries":["DE","FR"],"is_corresponding":false,"raw_author_name":"Annemiek J. M. Cornelissen","raw_affiliation_strings":["Department of Physiology, Charit\u00e9, Berlin, Germany","Laboratoire Mati\u00e8re et Syst\u00e8mes Complexes (MSC), UMR 7057 CNRS & Universit\u00e9 Paris-Diderot, Paris, France"],"affiliations":[{"raw_affiliation_string":"Department of Physiology, Charit\u00e9, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Laboratoire Mati\u00e8re et Syst\u00e8mes Complexes (MSC), UMR 7057 CNRS & Universit\u00e9 Paris-Diderot, Paris, France","institution_ids":["https://openalex.org/I4210127056","https://openalex.org/I204730241","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045926110","display_name":"Anoek A. Sloot","orcid":null},"institutions":[{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Anoek A. Sloot","raw_affiliation_strings":["Department of Man Machine Systems, Faculty of Mechanical Engineering and Marine Technology, Delft University of Technology, Delft, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Department of Man Machine Systems, Faculty of Mechanical Engineering and Marine Technology, Delft University of Technology, Delft, The Netherlands","institution_ids":["https://openalex.org/I98358874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000559848","display_name":"Marlene Hinkeldey","orcid":null},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"funder","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marlene Hinkeldey","raw_affiliation_strings":["Department of Physiology, Charit\u00e9, Berlin, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Physiology, Charit\u00e9, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021288206","display_name":"Matthew R. Dreher","orcid":null},"institutions":[{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew R. Dreher","raw_affiliation_strings":["National Institutes of Health, Clinical Center, Radiology and Imaging Sciences, Bethesda, Maryland, United States of America"],"affiliations":[{"raw_affiliation_string":"National Institutes of Health, Clinical Center, Radiology and Imaging Sciences, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I4210155647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101430383","display_name":"Michael H\u00f6pfner","orcid":"https://orcid.org/0000-0003-0785-9451"},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"funder","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael H\u00f6pfner","raw_affiliation_strings":["Department of Physiology, Charit\u00e9, Berlin, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Physiology, Charit\u00e9, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071519548","display_name":"Mark W. Dewhirst","orcid":"https://orcid.org/0000-0003-3459-6546"},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark W. Dewhirst","raw_affiliation_strings":["Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082795338","display_name":"Timothy W. Secomb","orcid":"https://orcid.org/0000-0002-0176-5502"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Timothy W. Secomb","raw_affiliation_strings":["Department of Physiology, University of Arizona, Tucson, Arizona, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Arizona, Tucson, Arizona, United States of America","institution_ids":["https://openalex.org/I138006243"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5082795338"],"corresponding_institution_ids":["https://openalex.org/I138006243"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":4.8529,"has_fulltext":true,"cited_by_count":189,"citation_normalized_percentile":{"value":0.9600161,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"5","issue":"5","first_page":"e1000394","last_page":"e1000394"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microcirculation","display_name":"Microcirculation","score":0.8458875417709351},{"id":"https://openalex.org/keywords/hemodynamics","display_name":"Hemodynamics","score":0.7926920652389526},{"id":"https://openalex.org/keywords/adaptation","display_name":"Adaptation (eye)","score":0.5464096069335938},{"id":"https://openalex.org/keywords/intravital-microscopy","display_name":"Intravital microscopy","score":0.539850652217865},{"id":"https://openalex.org/keywords/metabolic-adaptation","display_name":"Metabolic adaptation","score":0.42412546277046204},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.37160933017730713},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.3247586488723755},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.29581940174102783},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.27728527784347534},{"id":"https://openalex.org/keywords/metabolism","display_name":"Metabolism","score":0.0842788815498352}],"concepts":[{"id":"https://openalex.org/C12722491","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microcirculation","level":2,"score":0.8458875417709351},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.7926920652389526},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.5464096069335938},{"id":"https://openalex.org/C2859252","wikidata":"https://www.wikidata.org/wiki/Q1543928","display_name":"Intravital microscopy","level":3,"score":0.539850652217865},{"id":"https://openalex.org/C3018542373","wikidata":"https://www.wikidata.org/wiki/Q14901436","display_name":"Metabolic adaptation","level":3,"score":0.42412546277046204},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37160933017730713},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3247586488723755},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29581940174102783},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27728527784347534},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.0842788815498352}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013152","descriptor_name":"Splanchnic Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013152","descriptor_name":"Splanchnic Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013152","descriptor_name":"Splanchnic Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1000394","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000394","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000394&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:19478883","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19478883","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:e71a5c0b47f64a75b4068d7534e95a09","is_oa":true,"landing_page_url":"https://doaj.org/article/e71a5c0b47f64a75b4068d7534e95a09","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 5, Iss 5, p e1000394 (2009)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:1458959","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC2682204","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2682204","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2682204","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:tudelft.nl:uuid:a9520692-2d93-4e9d-81c4-d884960495a6","is_oa":true,"landing_page_url":"http://resolver.tudelft.nl/uuid:a9520692-2d93-4e9d-81c4-d884960495a6","pdf_url":null,"source":{"id":"https://openalex.org/S4306400906","display_name":"Research Repository (Delft University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I98358874","host_organization_name":"Delft University of Technology","host_organization_lineage":["https://openalex.org/I98358874"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal article"},{"id":"pmh:oai:tudelft.nl:uuid:f1ea8dea-0adb-4f09-8dd3-203024342819","is_oa":true,"landing_page_url":"http://resolver.tudelft.nl/uuid:f1ea8dea-0adb-4f09-8dd3-203024342819","pdf_url":null,"source":{"id":"https://openalex.org/S4306400906","display_name":"Research Repository (Delft University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I98358874","host_organization_name":"Delft University of Technology","host_organization_lineage":["https://openalex.org/I98358874"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000394","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000394","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000394&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5299999713897705}],"awards":[{"id":"https://openalex.org/G8807577368","display_name":null,"funder_award_id":"HL034555","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320322777","display_name":"KWF Kankerbestrijding","ror":"https://ror.org/0368jnd28"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2152689442.pdf","grobid_xml":"https://content.openalex.org/works/W2152689442.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W60558353","https://openalex.org/W72344367","https://openalex.org/W1492429334","https://openalex.org/W1496914563","https://openalex.org/W1531126820","https://openalex.org/W1573363574","https://openalex.org/W1603230122","https://openalex.org/W1610210274","https://openalex.org/W1934351474","https://openalex.org/W1971076526","https://openalex.org/W1971126975","https://openalex.org/W1978139448","https://openalex.org/W1978708429","https://openalex.org/W1981731521","https://openalex.org/W1983906025","https://openalex.org/W1988257057","https://openalex.org/W1988957088","https://openalex.org/W1994614767","https://openalex.org/W2000315161","https://openalex.org/W2006202974","https://openalex.org/W2021724833","https://openalex.org/W2028999918","https://openalex.org/W2046322851","https://openalex.org/W2055009621","https://openalex.org/W2063656915","https://openalex.org/W2064075744","https://openalex.org/W2067724480","https://openalex.org/W2072537043","https://openalex.org/W2083245381","https://openalex.org/W2086619383","https://openalex.org/W2097025096","https://openalex.org/W2102916742","https://openalex.org/W2115218292","https://openalex.org/W2116531861","https://openalex.org/W2121421529","https://openalex.org/W2122241249","https://openalex.org/W2126410943","https://openalex.org/W2130175726","https://openalex.org/W2132416992","https://openalex.org/W2132907499","https://openalex.org/W2138717469","https://openalex.org/W2143385760","https://openalex.org/W2144108543","https://openalex.org/W2146255347","https://openalex.org/W2153040252","https://openalex.org/W2153135349","https://openalex.org/W2156264000","https://openalex.org/W2159780487","https://openalex.org/W2163715194","https://openalex.org/W2164878073","https://openalex.org/W2169030683","https://openalex.org/W2169758472","https://openalex.org/W2171074980","https://openalex.org/W2171265745","https://openalex.org/W2332974012","https://openalex.org/W2394571791","https://openalex.org/W2405574261","https://openalex.org/W2414891330","https://openalex.org/W2428815793","https://openalex.org/W2475161560","https://openalex.org/W4250428608","https://openalex.org/W4251787912","https://openalex.org/W6717767676"],"related_works":["https://openalex.org/W2415863142","https://openalex.org/W2007723183","https://openalex.org/W1972729343","https://openalex.org/W2401010498","https://openalex.org/W2052123576","https://openalex.org/W1975227126","https://openalex.org/W2076615410","https://openalex.org/W2021675383","https://openalex.org/W4286855522","https://openalex.org/W2061237997"],"abstract_inverted_index":{"Relative":[0],"to":[1,13,30,38,45,79,86,93,102,120,150,234],"normal":[2,64,167,188],"tissues,":[3],"tumor":[4,52,67,176,221],"microcirculation":[5,222],"exhibits":[6],"high":[7],"structural":[8,26,228],"and":[9,16,41,48,58,66,82,85,96,104,111,123,144,158,163,170,185,194,208],"functional":[10],"heterogeneity":[11],"leading":[12],"hypoxic":[14],"regions":[15],"impairing":[17],"treatment":[18],"efficacy.":[19],"Here,":[20],"computational":[21],"simulations":[22],"of":[23,51,63,115,130,146,174,220],"blood":[24,60],"vessel":[25],"adaptation":[27,90,125,197],"are":[28],"used":[29,78],"explore":[31],"the":[32,107,112,154,175,217],"hypothesis":[33],"that":[34,216],"abnormal":[35],"adaptive":[36],"responses":[37,117,233],"local":[39],"hemodynamic":[40,49,103],"metabolic":[42,95],"stimuli":[43],"contribute":[44],"aberrant":[46],"morphological":[47],"characteristics":[50,192],"microcirculation.":[53],"Topology,":[54],"vascular":[55,68,88,108,116,131,139],"diameter,":[56],"length,":[57],"red":[59],"cell":[61],"velocity":[62],"mesenteric":[65],"networks":[69,132,168,189],"were":[70,77,118,133,160],"recorded":[71],"by":[72,135],"intravital":[73],"microscopy.":[74],"Computational":[75],"models":[76],"estimate":[80],"hemodynamics":[81],"oxygen":[83,147],"distribution":[84],"simulate":[87,121],"diameter":[89,136],"in":[91,166],"response":[92],"hemodynamic,":[94],"conducted":[97,105,203,235],"stimuli.":[98,236],"The":[99,127],"assumed":[100],"sensitivity":[101],"signals,":[106],"growth":[109,206],"tendency,":[110,207],"random":[113,210],"variability":[114],"altered":[119],"'normal'":[122,179],"'tumor'":[124,199],"modes.":[126],"heterogeneous":[128],"properties":[129,219],"characterized":[134],"mismatch":[137],"at":[138],"branch":[140],"points":[141],"(d(3)":[142],"(var))":[143],"deficit":[145],"delivery":[148],"relative":[149],"demand":[151],"(O(2def)).":[152],"In":[153],"tumor,":[155],"d(3)":[156],"(var)":[157],"O(2def)":[159],"higher":[161],"(0.404":[162],"0.182)":[164],"than":[165],"(0.278":[169],"0.099).":[171,186],"Simulated":[172],"remodeling":[173],"network":[177],"with":[178,198],"parameters":[180],"gave":[181],"low":[182,202],"values":[183],"(0.288":[184],"Conversely,":[187],"attained":[190],"tumor-like":[191],"(0.41":[193],"0.179)":[195],"upon":[196],"parameters,":[200],"including":[201,230],"sensitivity,":[204],"increased":[205],"elevated":[209],"biological":[211],"variability.":[212],"It":[213],"is":[214],"concluded":[215],"deviant":[218],"may":[223],"result":[224],"largely":[225],"from":[226],"defective":[227],"adaptation,":[229],"strongly":[231],"reduced":[232]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":15}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
