{"id":"https://openalex.org/W1991917050","doi":"https://doi.org/10.1371/journal.pcbi.1000393","title":"A Correspondence Between Solution-State Dynamics of an Individual Protein and the Sequence and Conformational Diversity of its Family","display_name":"A Correspondence Between Solution-State Dynamics of an Individual Protein and the Sequence and Conformational Diversity of its Family","publication_year":2009,"publication_date":"2009-05-28","ids":{"openalex":"https://openalex.org/W1991917050","doi":"https://doi.org/10.1371/journal.pcbi.1000393","mag":"1991917050","pmid":"https://pubmed.ncbi.nlm.nih.gov/19478996"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000393","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000393","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000393&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000393&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058884796","display_name":"Gregory D. Friedland","orcid":null},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I103922791","display_name":"QB3","ror":"https://ror.org/04n1n3n22","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I103922791","https://openalex.org/I180670191","https://openalex.org/I185103710","https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory D. Friedland","raw_affiliation_strings":["Graduate Group in Biophysics, University of California San Francisco, San Francisco, California, United States of America","Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America","California Institute for Quantitative Biosciences, University of California San Francisco, San Francisco, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Graduate Group in Biophysics, University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"California Institute for Quantitative Biosciences, University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I103922791","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028663856","display_name":"Nils\u2010Alexander Lakomek","orcid":"https://orcid.org/0000-0002-4285-6339"},"institutions":[{"id":"https://openalex.org/I4210131661","display_name":"Max Planck Institute for Biophysical Chemistry","ror":"https://ror.org/03e76ya46","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210131661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nils-Alexander Lakomek","raw_affiliation_strings":["Department for NMR-based Structural Biology, Max-Planck Institute for Biophysical Chemistry, Goettingen, Germany"],"affiliations":[{"raw_affiliation_string":"Department for NMR-based Structural Biology, Max-Planck Institute for Biophysical Chemistry, Goettingen, Germany","institution_ids":["https://openalex.org/I4210131661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037375841","display_name":"Christian Griesinger","orcid":"https://orcid.org/0000-0002-1266-4344"},"institutions":[{"id":"https://openalex.org/I4210131661","display_name":"Max Planck Institute for Biophysical Chemistry","ror":"https://ror.org/03e76ya46","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210131661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Griesinger","raw_affiliation_strings":["Department for NMR-based Structural Biology, Max-Planck Institute for Biophysical Chemistry, Goettingen, Germany"],"affiliations":[{"raw_affiliation_string":"Department for NMR-based Structural Biology, Max-Planck Institute for Biophysical Chemistry, Goettingen, Germany","institution_ids":["https://openalex.org/I4210131661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025842562","display_name":"Jens Meiler","orcid":"https://orcid.org/0000-0001-8945-193X"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jens Meiler","raw_affiliation_strings":["Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America"],"affiliations":[{"raw_affiliation_string":"Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000906927","display_name":"Tanja Kortemme","orcid":"https://orcid.org/0000-0002-8494-680X"},"institutions":[{"id":"https://openalex.org/I103922791","display_name":"QB3","ror":"https://ror.org/04n1n3n22","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I103922791","https://openalex.org/I180670191","https://openalex.org/I185103710","https://openalex.org/I95457486"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tanja Kortemme","raw_affiliation_strings":["California Institute for Quantitative Biosciences, University of California San Francisco, San Francisco, California, United States of America","Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America","Graduate Group in Biophysics, University of California San Francisco, San Francisco, California, United States of America"],"affiliations":[{"raw_affiliation_string":"California Institute for Quantitative Biosciences, University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I103922791","https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Graduate Group in Biophysics, University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5000906927","https://openalex.org/A5025842562"],"corresponding_institution_ids":["https://openalex.org/I103922791","https://openalex.org/I180670191","https://openalex.org/I200719446"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":4.3137,"has_fulltext":true,"cited_by_count":76,"citation_normalized_percentile":{"value":0.9497878,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"5","issue":"5","first_page":"e1000393","last_page":"e1000393"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-dynamics","display_name":"Protein dynamics","score":0.6829752922058105},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.624248743057251},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.5701286792755127},{"id":"https://openalex.org/keywords/conformational-ensembles","display_name":"Conformational ensembles","score":0.5240459442138672},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.47511324286460876},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4475114643573761},{"id":"https://openalex.org/keywords/conformational-isomerism","display_name":"Conformational isomerism","score":0.4226991832256317},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3848631680011749},{"id":"https://openalex.org/keywords/chemical-physics","display_name":"Chemical physics","score":0.3640415668487549},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.2712326943874359},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15957900881767273},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.10429611802101135},{"id":"https://openalex.org/keywords/molecule","display_name":"Molecule","score":0.10002222657203674}],"concepts":[{"id":"https://openalex.org/C2775981520","wikidata":"https://www.wikidata.org/wiki/Q17156992","display_name":"Protein dynamics","level":3,"score":0.6829752922058105},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.624248743057251},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.5701286792755127},{"id":"https://openalex.org/C2777936996","wikidata":"https://www.wikidata.org/wiki/Q17148461","display_name":"Conformational ensembles","level":3,"score":0.5240459442138672},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.47511324286460876},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4475114643573761},{"id":"https://openalex.org/C18705241","wikidata":"https://www.wikidata.org/wiki/Q1128023","display_name":"Conformational isomerism","level":3,"score":0.4226991832256317},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3848631680011749},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.3640415668487549},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.2712326943874359},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15957900881767273},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10429611802101135},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.10002222657203674},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pcbi.1000393","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000393","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000393&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:19478996","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19478996","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:ark:/13030/qt9hj2c440","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1000393","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1000393","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:225de4e516b44beab328ea8bd289c3a4","is_oa":true,"landing_page_url":"https://doaj.org/article/225de4e516b44beab328ea8bd289c3a4","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 5, Iss 5, p e1000393 (2009)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt9hj2c440","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/9hj2c440","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS computational biology, vol 5, iss 5","raw_type":"article"},{"id":"pmh:oai:europepmc.org:1455334","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC2682763","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/147471","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/A_Correspondence_Between_Solution_State_Dynamics_of_an_Individual_Protein_and_the_Sequence_and_Conformational_Diversity_of_its_Family/147471","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:2682763","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2682763","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000393","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000393","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000393&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5699999928474426,"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15"}],"awards":[{"id":"https://openalex.org/G5206884482","display_name":"CAREER: A Computational Design Approach for Predicting and Reengineering Plasticity and Selectivity in Protein-protein Interfaces","funder_award_id":"0744541","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6671297155","display_name":null,"funder_award_id":"CAREER","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306151","display_name":"Alfred P. Sloan Foundation","ror":"https://ror.org/052csg198"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1991917050.pdf","grobid_xml":"https://content.openalex.org/works/W1991917050.grobid-xml"},"referenced_works_count":84,"referenced_works":["https://openalex.org/W1514682783","https://openalex.org/W1597762634","https://openalex.org/W1964163459","https://openalex.org/W1964209812","https://openalex.org/W1969644422","https://openalex.org/W1972662122","https://openalex.org/W1974225312","https://openalex.org/W1974454607","https://openalex.org/W1976553215","https://openalex.org/W1977157176","https://openalex.org/W1977630495","https://openalex.org/W1980139576","https://openalex.org/W1980211602","https://openalex.org/W1985490516","https://openalex.org/W1988396923","https://openalex.org/W1990338952","https://openalex.org/W1994906426","https://openalex.org/W1997477098","https://openalex.org/W2001430943","https://openalex.org/W2001842251","https://openalex.org/W2003744720","https://openalex.org/W2004607866","https://openalex.org/W2008708467","https://openalex.org/W2012057091","https://openalex.org/W2018262140","https://openalex.org/W2020383882","https://openalex.org/W2024980748","https://openalex.org/W2025221718","https://openalex.org/W2025717854","https://openalex.org/W2026513163","https://openalex.org/W2027238103","https://openalex.org/W2028664561","https://openalex.org/W2030764004","https://openalex.org/W2035056536","https://openalex.org/W2039248602","https://openalex.org/W2039821956","https://openalex.org/W2042033233","https://openalex.org/W2042287552","https://openalex.org/W2045297521","https://openalex.org/W2046002103","https://openalex.org/W2049934777","https://openalex.org/W2055497972","https://openalex.org/W2066961392","https://openalex.org/W2071739012","https://openalex.org/W2072434492","https://openalex.org/W2073486807","https://openalex.org/W2081325432","https://openalex.org/W2083144176","https://openalex.org/W2083262282","https://openalex.org/W2083824385","https://openalex.org/W2086429541","https://openalex.org/W2086862822","https://openalex.org/W2089710023","https://openalex.org/W2091594405","https://openalex.org/W2092591319","https://openalex.org/W2096506888","https://openalex.org/W2097767833","https://openalex.org/W2098511780","https://openalex.org/W2103838926","https://openalex.org/W2107238748","https://openalex.org/W2107743509","https://openalex.org/W2110692235","https://openalex.org/W2123529526","https://openalex.org/W2126296369","https://openalex.org/W2127362915","https://openalex.org/W2131529311","https://openalex.org/W2134059200","https://openalex.org/W2134731229","https://openalex.org/W2135815512","https://openalex.org/W2137475884","https://openalex.org/W2137604324","https://openalex.org/W2143210482","https://openalex.org/W2144482528","https://openalex.org/W2144731691","https://openalex.org/W2152193893","https://openalex.org/W2153153865","https://openalex.org/W2155648172","https://openalex.org/W2155812479","https://openalex.org/W2158266834","https://openalex.org/W2159985140","https://openalex.org/W2164958220","https://openalex.org/W2470665661","https://openalex.org/W2582743722","https://openalex.org/W2908736965"],"related_works":["https://openalex.org/W2772226369","https://openalex.org/W2610329791","https://openalex.org/W2027077329","https://openalex.org/W2378801510","https://openalex.org/W2290574198","https://openalex.org/W2010414728","https://openalex.org/W2321182289","https://openalex.org/W2946078915","https://openalex.org/W2059608951","https://openalex.org/W1991917050"],"abstract_inverted_index":{"Conformational":[0],"ensembles":[1],"are":[2,53],"increasingly":[3],"recognized":[4],"as":[5],"a":[6,86,101],"useful":[7],"representation":[8],"to":[9,56,185],"describe":[10],"fundamental":[11],"relationships":[12,79],"between":[13,80,88,103,166],"protein":[14,83,108,128,157,167,187],"structure,":[15],"dynamics":[16,90,104,130,168],"and":[17,91,99,109,143,148,169],"function.":[18],"Here":[19],"we":[20,75],"present":[21,138],"an":[22,58,106,163],"ensemble":[23,59],"of":[24,82,105,146],"ubiquitin":[25,140,156],"in":[26,46,96,139,154,175],"solution":[27],"that":[28,60,120],"is":[29],"created":[30],"by":[31,42,114,132,190],"sampling":[32,145],"conformational":[33,93,111,136,147,170],"space":[34],"without":[35],"experimental":[36],"information":[37],"using":[38],"\"Backrub\"":[39],"motions":[40],"inspired":[41],"alternative":[43],"conformations":[44],"observed":[45,95],"sub-Angstrom":[47],"resolution":[48],"crystal":[49,97],"structures.":[50],"Backrub-generated":[51],"structures":[52,142],"then":[54],"selected":[55],"produce":[57],"optimizes":[61],"agreement":[62],"with":[63],"nuclear":[64],"magnetic":[65],"resonance":[66],"(NMR)":[67],"Residual":[68],"Dipolar":[69],"Couplings":[70],"(RDCs).":[71],"Using":[72],"this":[73],"ensemble,":[74],"probe":[76],"two":[77],"proposed":[78],"properties":[81],"ensembles:":[84],"(i)":[85],"link":[87],"native-state":[89,129,194],"the":[92,110,121,135,155,179],"heterogeneity":[94],"structures,":[98],"(ii)":[100],"relation":[102,165],"individual":[107],"variability":[112,137,150],"explored":[113],"its":[115],"natural":[116],"family.":[117,158],"We":[118],"show":[119],"Backrub":[122],"motional":[123],"mechanism":[124],"can":[125,182],"simultaneously":[126],"explore":[127],"measured":[131],"RDCs,":[133],"encompass":[134],"complex":[141],"facilitate":[144],"sequence":[149,173],"matching":[151],"those":[152],"occurring":[153],"Our":[159],"results":[160],"thus":[161],"support":[162],"overall":[164],"changes":[171,174],"enabling":[172],"evolution.":[176],"More":[177],"practically,":[178],"presented":[180],"method":[181],"be":[183],"applied":[184],"improve":[186],"design":[188],"predictions":[189],"accounting":[191],"for":[192],"intrinsic":[193],"dynamics.":[195]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":9}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}