{"id":"https://openalex.org/W2118279186","doi":"https://doi.org/10.1371/journal.pcbi.1000384","title":"Minimum Criteria for DNA Damage-Induced Phase Advances in Circadian Rhythms","display_name":"Minimum Criteria for DNA Damage-Induced Phase Advances in Circadian Rhythms","publication_year":2009,"publication_date":"2009-05-07","ids":{"openalex":"https://openalex.org/W2118279186","doi":"https://doi.org/10.1371/journal.pcbi.1000384","mag":"2118279186","pmid":"https://pubmed.ncbi.nlm.nih.gov/19424508"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000384","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000384","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000384&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000384&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066645117","display_name":"Christian I. Hong","orcid":"https://orcid.org/0000-0001-8618-8128"},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian I. Hong","raw_affiliation_strings":["Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire, USA"],"affiliations":[{"raw_affiliation_string":"Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire, USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060660652","display_name":"Judit Z\u00e1mborszky","orcid":"https://orcid.org/0000-0002-7661-3554"},"institutions":[{"id":"https://openalex.org/I193223587","display_name":"University of Trento","ror":"https://ror.org/05trd4x28","country_code":"IT","type":"education","lineage":["https://openalex.org/I193223587"]},{"id":"https://openalex.org/I2802934434","display_name":"The Microsoft Research - University of Trento Centre for Computational and Systems Biology","ror":"https://ror.org/04kcgyj43","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I1290206253","https://openalex.org/I193223587","https://openalex.org/I2802934434","https://openalex.org/I4210164937"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Judit Z\u00e1mborszky","raw_affiliation_strings":["The Microsoft Research\u2013University of Trento Centre for Computational and Systems Biology, Povo (Trento), Italy","The Microsoft Research - University of Trento, Centre for Computational and Systems Biology, Povo/Trento, Italy"],"affiliations":[{"raw_affiliation_string":"The Microsoft Research\u2013University of Trento Centre for Computational and Systems Biology, Povo (Trento), Italy","institution_ids":["https://openalex.org/I2802934434","https://openalex.org/I193223587"]},{"raw_affiliation_string":"The Microsoft Research - University of Trento, Centre for Computational and Systems Biology, Povo/Trento, Italy","institution_ids":["https://openalex.org/I2802934434","https://openalex.org/I193223587"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017814227","display_name":"Attila Csik\u00e1sz\u2010Nagy","orcid":"https://orcid.org/0000-0002-2919-5601"},"institutions":[{"id":"https://openalex.org/I2802934434","display_name":"The Microsoft Research - University of Trento Centre for Computational and Systems Biology","ror":"https://ror.org/04kcgyj43","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I1290206253","https://openalex.org/I193223587","https://openalex.org/I2802934434","https://openalex.org/I4210164937"]},{"id":"https://openalex.org/I193223587","display_name":"University of Trento","ror":"https://ror.org/05trd4x28","country_code":"IT","type":"education","lineage":["https://openalex.org/I193223587"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Attila Csik\u00e1sz-Nagy","raw_affiliation_strings":["The Microsoft Research\u2013University of Trento Centre for Computational and Systems Biology, Povo (Trento), Italy","The Microsoft Research - University of Trento, Centre for Computational and Systems Biology, Povo/Trento, Italy"],"affiliations":[{"raw_affiliation_string":"The Microsoft Research\u2013University of Trento Centre for Computational and Systems Biology, Povo (Trento), Italy","institution_ids":["https://openalex.org/I2802934434","https://openalex.org/I193223587"]},{"raw_affiliation_string":"The Microsoft Research - University of Trento, Centre for Computational and Systems Biology, Povo/Trento, Italy","institution_ids":["https://openalex.org/I2802934434","https://openalex.org/I193223587"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5017814227"],"corresponding_institution_ids":["https://openalex.org/I193223587","https://openalex.org/I2802934434"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.3466,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.53370998,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"5","issue":"5","first_page":"e1000384","last_page":"e1000384"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11268","display_name":"Light effects on plants","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circadian-clock","display_name":"Circadian clock","score":0.8670830726623535},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"Circadian rhythm","score":0.8503127098083496},{"id":"https://openalex.org/keywords/bacterial-circadian-rhythms","display_name":"Bacterial circadian rhythms","score":0.7208749055862427},{"id":"https://openalex.org/keywords/oscillating-gene","display_name":"Oscillating gene","score":0.6849418878555298},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6656920313835144},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.6557191014289856},{"id":"https://openalex.org/keywords/per1","display_name":"PER1","score":0.6264710426330566},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.4979369640350342},{"id":"https://openalex.org/keywords/per2","display_name":"PER2","score":0.4881821274757385},{"id":"https://openalex.org/keywords/light-effects-on-circadian-rhythm","display_name":"Light effects on circadian rhythm","score":0.4427393078804016},{"id":"https://openalex.org/keywords/wee1","display_name":"Wee1","score":0.44266921281814575},{"id":"https://openalex.org/keywords/phase-response-curve","display_name":"Phase response curve","score":0.4400365948677063},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"Cell cycle","score":0.43685054779052734},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.35995936393737793},{"id":"https://openalex.org/keywords/clock","display_name":"CLOCK","score":0.22971779108047485},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.20286601781845093},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.1803608536720276},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.14555412530899048},{"id":"https://openalex.org/keywords/cyclin-dependent-kinase-1","display_name":"Cyclin-dependent kinase 1","score":0.0787229835987091}],"concepts":[{"id":"https://openalex.org/C38606739","wikidata":"https://www.wikidata.org/wiki/Q5121352","display_name":"Circadian clock","level":3,"score":0.8670830726623535},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.8503127098083496},{"id":"https://openalex.org/C130679736","wikidata":"https://www.wikidata.org/wiki/Q3454009","display_name":"Bacterial circadian rhythms","level":4,"score":0.7208749055862427},{"id":"https://openalex.org/C125168821","wikidata":"https://www.wikidata.org/wiki/Q7106408","display_name":"Oscillating gene","level":5,"score":0.6849418878555298},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6656920313835144},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6557191014289856},{"id":"https://openalex.org/C2780360009","wikidata":"https://www.wikidata.org/wiki/Q15326762","display_name":"PER1","level":5,"score":0.6264710426330566},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4979369640350342},{"id":"https://openalex.org/C2779064383","wikidata":"https://www.wikidata.org/wiki/Q15323251","display_name":"PER2","level":5,"score":0.4881821274757385},{"id":"https://openalex.org/C201176492","wikidata":"https://www.wikidata.org/wiki/Q6546168","display_name":"Light effects on circadian rhythm","level":4,"score":0.4427393078804016},{"id":"https://openalex.org/C2781252693","wikidata":"https://www.wikidata.org/wiki/Q7979264","display_name":"Wee1","level":5,"score":0.44266921281814575},{"id":"https://openalex.org/C63531555","wikidata":"https://www.wikidata.org/wiki/Q7180960","display_name":"Phase response curve","level":4,"score":0.4400365948677063},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.43685054779052734},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35995936393737793},{"id":"https://openalex.org/C184738001","wikidata":"https://www.wikidata.org/wiki/Q14908739","display_name":"CLOCK","level":4,"score":0.22971779108047485},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.20286601781845093},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.1803608536720276},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.14555412530899048},{"id":"https://openalex.org/C120504264","wikidata":"https://www.wikidata.org/wiki/Q1147372","display_name":"Cyclin-dependent kinase 1","level":4,"score":0.0787229835987091}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011839","descriptor_name":"Radiation, Ionizing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011839","descriptor_name":"Radiation, Ionizing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011839","descriptor_name":"Radiation, Ionizing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064447","descriptor_name":"Checkpoint Kinase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064447","descriptor_name":"Checkpoint Kinase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064447","descriptor_name":"Checkpoint Kinase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1000384","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000384","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000384&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:19424508","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19424508","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/f41bc2f3-8a48-4e5b-af44-2b9fa371134f","is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/f41bc2f3-8a48-4e5b-af44-2b9fa371134f","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hong, C I, Zamborszky, J & Csikasz-Nagy, A 2009, 'Minimum Criteria for DNA Damage-Induced Phase Advances in Circadian Rhythms', PL o S Computational Biology, vol. 5, no. 5, e1000384, pp. -. https://doi.org/10.1371/journal.pcbi.1000384","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doaj.org/article:cb97e53224c9446996d4e6e50111d36e","is_oa":true,"landing_page_url":"https://doaj.org/article/cb97e53224c9446996d4e6e50111d36e","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 5, Iss 5, p e1000384 (2009)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/147658","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Minimum_Criteria_for_DNA_Damage_Induced_Phase_Advances_in_Circadian_Rhythms/147658","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:2677641","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2677641","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000384","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000384","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000384&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321994","display_name":"Hungarian Scientific Research Fund","ror":"https://ror.org/00v349e63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2118279186.pdf","grobid_xml":"https://content.openalex.org/works/W2118279186.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1973099196","https://openalex.org/W1988876917","https://openalex.org/W1993885023","https://openalex.org/W2005174604","https://openalex.org/W2007207845","https://openalex.org/W2023325911","https://openalex.org/W2025397614","https://openalex.org/W2028214516","https://openalex.org/W2040617029","https://openalex.org/W2040650438","https://openalex.org/W2047279254","https://openalex.org/W2051497876","https://openalex.org/W2066440682","https://openalex.org/W2070672002","https://openalex.org/W2073036589","https://openalex.org/W2075873641","https://openalex.org/W2076650991","https://openalex.org/W2078978479","https://openalex.org/W2081882184","https://openalex.org/W2088848161","https://openalex.org/W2101122984","https://openalex.org/W2102492814","https://openalex.org/W2103505699","https://openalex.org/W2107062718","https://openalex.org/W2110817748","https://openalex.org/W2115980405","https://openalex.org/W2129569342","https://openalex.org/W2135694744","https://openalex.org/W2137252071","https://openalex.org/W2142478420","https://openalex.org/W2152503338","https://openalex.org/W2153846347","https://openalex.org/W2161548459","https://openalex.org/W2163183531","https://openalex.org/W2165580893","https://openalex.org/W2169497835","https://openalex.org/W2172136432","https://openalex.org/W4235527302","https://openalex.org/W6681373357"],"related_works":["https://openalex.org/W2044665170","https://openalex.org/W2135658843","https://openalex.org/W2188028020","https://openalex.org/W2271811454","https://openalex.org/W2035006113","https://openalex.org/W103616653","https://openalex.org/W3175062821","https://openalex.org/W2150892098","https://openalex.org/W2127447141","https://openalex.org/W1965201873"],"abstract_inverted_index":{"Robust":[0],"oscillatory":[1],"behaviors":[2],"are":[3,124,251,282],"common":[4],"features":[5],"of":[6,20,89,147,158,241,255,279],"circadian":[7,52,85,109,131,160,186,220,243],"and":[8,23,114,135,156,225,231,273,277],"cell":[9,91,98,120,149,223],"cycle":[10,92,99,121,150],"rhythms.":[11,86],"These":[12],"cyclic":[13],"processes,":[14],"however,":[15],"behave":[16],"distinctively":[17],"in":[18,25,84,116,165,169,184,222,261,269],"terms":[19],"their":[21],"periods":[22],"phases":[24],"response":[26,204],"to":[27,71,79,96,126,154,192,200,218,263,285],"external":[28],"influences":[29],"such":[30],"as":[31],"light,":[32],"temperature,":[33],"nutrients,":[34],"etc.":[35],"Nevertheless,":[36],"several":[37],"links":[38],"have":[39,54],"been":[40,55,141],"found":[41],"between":[42],"these":[43],"two":[44,249],"oscillators.":[45],"Cell":[46],"division":[47],"cycles":[48],"gated":[49],"by":[50,106,129],"the":[51,58,62,90,97,107,130,148,173,185,242,264,270],"clock":[53,110,132,161,187,244,271],"observed":[56],"since":[57],"late":[59],"1950s.":[60],"On":[61],"other":[63,119],"hand,":[64],"ionizing":[65],"radiation":[66],"(IR)":[67],"treatments":[68],"cause":[69],"cells":[70],"undergo":[72],"a":[73,159],"DNA":[74,144,178,246],"damage":[75,179,247],"response,":[76],"which":[77],"leads":[78,153],"phase":[80,182,203,229,236],"shifts":[81],"(mostly":[82],"advances)":[83],"Circadian":[87],"gating":[88],"can":[93],"be":[94,127],"attributed":[95],"inhibitor":[100],"kinase":[101],"Wee1":[102],"(which":[103],"is":[104,216],"regulated":[105,128],"heterodimeric":[108],"transcription":[111],"factor,":[112],"BMAL1/CLK),":[113],"possibly":[115],"conjunction":[117],"with":[118,238],"components":[122],"that":[123,143,281],"known":[125,217],"(i.e.,":[133,163],"c-Myc":[134],"cyclin":[136],"D1).":[137],"It":[138],"has":[139],"also":[140],"shown":[142],"damage-induced":[145],"activation":[146],"regulator,":[151],"Chk2,":[152],"phosphorylation":[155,276],"destruction":[157],"component":[162],"PER1":[164],"Mus":[166],"or":[167,211],"FRQ":[168],"Neurospora":[170],"crassa).":[171],"However,":[172],"molecular":[174],"mechanism":[175,260],"underlying":[176],"how":[177],"causes":[180],"predominantly":[181],"advances":[183,230],"remains":[188],"unknown.":[189],"In":[190],"order":[191],"address":[193],"this":[194],"question,":[195],"we":[196],"employ":[197],"mathematical":[198],"modeling":[199],"simulate":[201],"different":[202],"curves":[205],"(PRCs)":[206],"from":[207],"either":[208],"dexamethasone":[209],"(Dex)":[210],"IR":[212],"treatment":[213],"experiments.":[214],"Dex":[215],"synchronize":[219],"rhythms":[221],"culture":[224],"may":[226],"generate":[227],"both":[228],"delays.":[232],"We":[233],"observe":[234],"unique":[235],"responses":[237],"minimum":[239],"delays":[240],"upon":[245],"when":[248],"criteria":[250],"met:":[252],"(1)":[253],"existence":[254],"an":[256],"autocatalytic":[257],"positive":[258],"feedback":[259,267],"addition":[262],"time-delayed":[265],"negative":[266],"loop":[268],"system":[272],"(2)":[274],"Chk2-dependent":[275],"degradation":[278],"PERs":[280],"not":[283],"bound":[284],"BMAL1/CLK.":[286]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}