{"id":"https://openalex.org/W2139329624","doi":"https://doi.org/10.1371/journal.pcbi.1000382","title":"A Differential Wiring Analysis of Expression Data Correctly Identifies the Gene Containing the Causal Mutation","display_name":"A Differential Wiring Analysis of Expression Data Correctly Identifies the Gene Containing the Causal Mutation","publication_year":2009,"publication_date":"2009-04-30","ids":{"openalex":"https://openalex.org/W2139329624","doi":"https://doi.org/10.1371/journal.pcbi.1000382","mag":"2139329624","pmid":"https://pubmed.ncbi.nlm.nih.gov/19412532"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000382","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000382","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000382&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000382&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035281923","display_name":"Nicholas J. Hudson","orcid":"https://orcid.org/0000-0002-3549-9396"},"institutions":[{"id":"https://openalex.org/I4210166208","display_name":"Animal, Food and Health Sciences","ror":"https://ror.org/05rke7t32","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1292875679","https://openalex.org/I2801453606","https://openalex.org/I4210166208","https://openalex.org/I4387156119"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Nicholas J. Hudson","raw_affiliation_strings":["Food Futures Flagship and Livestock Industries, Commonwealth Scientific and Industrial Research Organisation, Queensland Bioscience Precinct, St Lucia Brisbane, Queensland, Australia","Industrial Research Organisation, Queensland Bioscience Precinct, St. Lucia","Brisbane, Queensland, Australia","Food Futures Flagship and Livestock Industries, Commonwealth Scientific"],"affiliations":[{"raw_affiliation_string":"Food Futures Flagship and Livestock Industries, Commonwealth Scientific and Industrial Research Organisation, Queensland Bioscience Precinct, St Lucia Brisbane, Queensland, Australia","institution_ids":[]},{"raw_affiliation_string":"Industrial Research Organisation, Queensland Bioscience Precinct, St. Lucia","institution_ids":[]},{"raw_affiliation_string":"Brisbane, Queensland, Australia","institution_ids":[]},{"raw_affiliation_string":"Food Futures Flagship and Livestock Industries, Commonwealth Scientific","institution_ids":["https://openalex.org/I4210166208"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074319488","display_name":"Ant\u00f4nio Reverter","orcid":"https://orcid.org/0000-0002-4681-9404"},"institutions":[{"id":"https://openalex.org/I4210166208","display_name":"Animal, Food and Health Sciences","ror":"https://ror.org/05rke7t32","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1292875679","https://openalex.org/I2801453606","https://openalex.org/I4210166208","https://openalex.org/I4387156119"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Antonio Reverter","raw_affiliation_strings":["Brisbane, Queensland, Australia","Food Futures Flagship and Livestock Industries, Commonwealth Scientific","and Industrial Research Organisation, Queensland Bioscience Precinct, St. Lucia","Industrial Research Organisation, Queensland Bioscience Precinct, St. Lucia"],"affiliations":[{"raw_affiliation_string":"Brisbane, Queensland, Australia","institution_ids":[]},{"raw_affiliation_string":"Food Futures Flagship and Livestock Industries, Commonwealth Scientific","institution_ids":["https://openalex.org/I4210166208"]},{"raw_affiliation_string":"and Industrial Research Organisation, Queensland Bioscience Precinct, St. Lucia","institution_ids":["https://openalex.org/I4210166208"]},{"raw_affiliation_string":"Industrial Research Organisation, Queensland Bioscience Precinct, St. Lucia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030549341","display_name":"Brian P. Dalrymple","orcid":"https://orcid.org/0000-0003-3891-5233"},"institutions":[{"id":"https://openalex.org/I4210166208","display_name":"Animal, Food and Health Sciences","ror":"https://ror.org/05rke7t32","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1292875679","https://openalex.org/I2801453606","https://openalex.org/I4210166208","https://openalex.org/I4387156119"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Brian P. Dalrymple","raw_affiliation_strings":["Brisbane, Queensland, Australia","Food Futures Flagship and Livestock Industries, Commonwealth Scientific","and Industrial Research Organisation, Queensland Bioscience Precinct, St. Lucia","Industrial Research Organisation, Queensland Bioscience Precinct, St. Lucia"],"affiliations":[{"raw_affiliation_string":"Brisbane, Queensland, Australia","institution_ids":[]},{"raw_affiliation_string":"Food Futures Flagship and Livestock Industries, Commonwealth Scientific","institution_ids":["https://openalex.org/I4210166208"]},{"raw_affiliation_string":"and Industrial Research Organisation, Queensland Bioscience Precinct, St. Lucia","institution_ids":["https://openalex.org/I4210166208"]},{"raw_affiliation_string":"Industrial Research Organisation, Queensland Bioscience Precinct, St. Lucia","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5074319488"],"corresponding_institution_ids":["https://openalex.org/I4210166208"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":4.8529,"has_fulltext":true,"cited_by_count":232,"citation_normalized_percentile":{"value":0.95986812,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"5","issue":"5","first_page":"e1000382","last_page":"e1000382"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9930999875068665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myostatin","display_name":"Myostatin","score":0.7593104839324951},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7050707936286926},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.631380558013916},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5325474143028259},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.518485963344574},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.5081286430358887},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.4861311614513397},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.48506560921669006},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.47509920597076416},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.4577345848083496},{"id":"https://openalex.org/keywords/regulator","display_name":"Regulator","score":0.45345187187194824},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.4522913992404938},{"id":"https://openalex.org/keywords/missense-mutation","display_name":"Missense mutation","score":0.4288161098957062},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.4180728793144226}],"concepts":[{"id":"https://openalex.org/C2777488582","wikidata":"https://www.wikidata.org/wiki/Q29630","display_name":"Myostatin","level":3,"score":0.7593104839324951},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7050707936286926},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.631380558013916},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5325474143028259},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.518485963344574},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5081286430358887},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.4861311614513397},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.48506560921669006},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47509920597076416},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4577345848083496},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.45345187187194824},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4522913992404938},{"id":"https://openalex.org/C75563809","wikidata":"https://www.wikidata.org/wiki/Q2656896","display_name":"Missense mutation","level":4,"score":0.4288161098957062},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4180728793144226}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012323","descriptor_name":"RNA Processing, Post-Transcriptional","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012323","descriptor_name":"RNA Processing, Post-Transcriptional","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012323","descriptor_name":"RNA Processing, Post-Transcriptional","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055435","descriptor_name":"Myostatin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055435","descriptor_name":"Myostatin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055435","descriptor_name":"Myostatin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1000382","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000382","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000382&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:19412532","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19412532","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.795.6461","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.795.6461","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/48/64/pcbi.1000382.PMC2671163.pdf","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1000382","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1000382","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:e1cc8001612048df96b3827d02b672ef","is_oa":true,"landing_page_url":"https://doaj.org/article/e1cc8001612048df96b3827d02b672ef","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 5, Iss 5, p e1000382 (2009)","raw_type":"article"},{"id":"pmh:oai:espace.library.uq.edu.au:UQ:386897","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306402388","display_name":"Queensland's institutional digital repository (The University of Queensland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I165143802","host_organization_name":"The University of Queensland","host_organization_lineage":["https://openalex.org/I165143802"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:figshare.com:article/147740","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/A_Differential_Wiring_Analysis_of_Expression_Data_Correctly___Identifies_the_Gene_Containing_the_Causal_Mutation/147740","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:2671163","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2671163","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000382","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000382","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000382&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8399999737739563,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139329624.pdf","grobid_xml":"https://content.openalex.org/works/W2139329624.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1573241294","https://openalex.org/W1734583295","https://openalex.org/W1966485417","https://openalex.org/W1973022314","https://openalex.org/W1976529648","https://openalex.org/W1979430177","https://openalex.org/W1988603298","https://openalex.org/W1988640690","https://openalex.org/W1996351707","https://openalex.org/W2000339262","https://openalex.org/W2014347464","https://openalex.org/W2017408113","https://openalex.org/W2019448053","https://openalex.org/W2029485495","https://openalex.org/W2037187863","https://openalex.org/W2037580712","https://openalex.org/W2038963685","https://openalex.org/W2060705109","https://openalex.org/W2069733150","https://openalex.org/W2078039848","https://openalex.org/W2079574756","https://openalex.org/W2086072815","https://openalex.org/W2090827859","https://openalex.org/W2096207972","https://openalex.org/W2097171062","https://openalex.org/W2102043440","https://openalex.org/W2109742936","https://openalex.org/W2110153755","https://openalex.org/W2112044524","https://openalex.org/W2113286112","https://openalex.org/W2123845663","https://openalex.org/W2125537604","https://openalex.org/W2132040456","https://openalex.org/W2134586291","https://openalex.org/W2134648549","https://openalex.org/W2141445133","https://openalex.org/W2141660903","https://openalex.org/W2148636094","https://openalex.org/W2150182123","https://openalex.org/W2151820055","https://openalex.org/W2152227081","https://openalex.org/W2159675211","https://openalex.org/W2159993062","https://openalex.org/W2160513989","https://openalex.org/W2165868509","https://openalex.org/W2166606182","https://openalex.org/W2168264491","https://openalex.org/W2170052308","https://openalex.org/W2312522445","https://openalex.org/W4206653471"],"related_works":["https://openalex.org/W2183420549","https://openalex.org/W1982897783","https://openalex.org/W2081507994","https://openalex.org/W2077582941","https://openalex.org/W2012175027","https://openalex.org/W2593123794","https://openalex.org/W308751227","https://openalex.org/W1972696957","https://openalex.org/W2039699813","https://openalex.org/W2132193638"],"abstract_inverted_index":{"Transcription":[0],"factor":[1],"(TF)":[2],"regulation":[3],"is":[4,81,128,188],"often":[5],"post-translational.":[6],"TF":[7,21],"modifications":[8],"such":[9],"as":[10,35],"reversible":[11],"phosphorylation":[12],"and":[13,118],"missense":[14],"mutations,":[15],"which":[16],"can":[17],"act":[18],"independent":[19],"of":[20,87,108,111,173],"expression":[22,28],"level,":[23],"are":[24],"overlooked":[25],"by":[26,65,153],"differential":[27,116,119],"analysis.":[29],"Using":[30],"bovine":[31],"Piedmontese":[32,62],"myostatin":[33,56,80,99],"mutants":[34],"proof-of-concept,":[36],"we":[37,77],"propose":[38],"a":[39,67,72,103],"new":[40,147],"algorithm":[41,96],"that":[42,79,182],"correctly":[43],"identifies":[44,97,149],"the":[45,48,59,95,98,123,134,142,169,174],"gene":[46],"containing":[47],"causal":[49,150],"mutation":[50,57],"from":[51],"microarray":[52,112],"data":[53],"alone.":[54],"The":[55,159],"releases":[58],"brakes":[60],"on":[61],"muscle":[63],"growth":[64],"translating":[66],"dysfunctional":[68],"protein.":[69],"Compared":[70],"to":[71,133,168,178,191],"less":[73],"muscular":[74],"non-mutant":[75],"breed":[76],"find":[78],"not":[82,189],"differentially":[83,131,137],"expressed":[84,138],"at":[85],"any":[86],"ten":[88],"developmental":[89],"time":[90],"points.":[91],"Despite":[92],"this":[93],"challenge,":[94],"'smoking":[100],"gun'":[101],"through":[102],"coordinated,":[104],"simultaneous,":[105],"weighted":[106],"integration":[107],"three":[109],"sources":[110],"information:":[113],"transcript":[114],"abundance,":[115],"expression,":[117],"wiring.":[120],"By":[121],"asking":[122],"novel":[124],"question":[125],"\"which":[126],"regulator":[127],"cumulatively":[129],"most":[130,136],"wired":[132],"abundant":[135],"genes?\"":[139],"it":[140],"yields":[141],"correct":[143],"answer,":[144],"\"myostatin\".":[145],"Our":[146],"approach":[148],"regulatory":[151,165],"changes":[152],"globally":[154],"contrasting":[155],"co-expression":[156,184],"network":[157],"dynamics.":[158],"entirely":[160],"data-driven":[161],"'weighting'":[162],"procedure":[163],"emphasises":[164],"movement":[166],"relative":[167],"phenotypically":[170],"relevant":[171],"part":[172],"network.":[175],"In":[176],"contrast":[177],"other":[179],"published":[180],"methods":[181],"compare":[183],"networks,":[185],"significance":[186],"testing":[187],"used":[190],"eliminate":[192],"connections.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":21},{"year":2015,"cited_by_count":26},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":13}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
