{"id":"https://openalex.org/W1984214499","doi":"https://doi.org/10.1371/journal.pcbi.1000332","title":"Systems Analysis of Bioenergetics and Growth of the Extreme Halophile Halobacterium salinarum","display_name":"Systems Analysis of Bioenergetics and Growth of the Extreme Halophile Halobacterium salinarum","publication_year":2009,"publication_date":"2009-04-02","ids":{"openalex":"https://openalex.org/W1984214499","doi":"https://doi.org/10.1371/journal.pcbi.1000332","mag":"1984214499","pmid":"https://pubmed.ncbi.nlm.nih.gov/19401785"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000332","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000332","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000332&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000332&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102159650","display_name":"Orland Gonzalez","orcid":null},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"funder","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210150093","display_name":"Max Planck Institute of Biochemistry","ror":"https://ror.org/04py35477","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Orland Gonzalez","raw_affiliation_strings":["Department of Membrane Biochemistry, Max-Planck Institute for Biochemistry, Martinsried, Germany. gonzalez@biochem.mpg.de","Oesterhelt, Dieter / Membrane Biochemistry, Max Planck Institute of Biochemistry, Max Planck Society"],"affiliations":[{"raw_affiliation_string":"Department of Membrane Biochemistry, Max-Planck Institute for Biochemistry, Martinsried, Germany. gonzalez@biochem.mpg.de","institution_ids":["https://openalex.org/I4210150093"]},{"raw_affiliation_string":"Oesterhelt, Dieter / Membrane Biochemistry, Max Planck Institute of Biochemistry, Max Planck Society","institution_ids":["https://openalex.org/I4210150093","https://openalex.org/I149899117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035481746","display_name":"Susanne von Gronau","orcid":null},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"funder","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210150093","display_name":"Max Planck Institute of Biochemistry","ror":"https://ror.org/04py35477","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Susanne Gronau","raw_affiliation_strings":["Biochemistry, Martinsried, Germany","Department of Membrane Biochemistry, Max-Planck Institute for","Department of Membrane Biochemistry, Max-Planck-Institute for Biochemistry, Martinsried, Germany"],"affiliations":[{"raw_affiliation_string":"Biochemistry, Martinsried, Germany","institution_ids":["https://openalex.org/I4210150093"]},{"raw_affiliation_string":"Department of Membrane Biochemistry, Max-Planck Institute for","institution_ids":[]},{"raw_affiliation_string":"Department of Membrane Biochemistry, Max-Planck-Institute for Biochemistry, Martinsried, Germany","institution_ids":["https://openalex.org/I149899117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013221314","display_name":"Friedhelm Pfeiffer","orcid":"https://orcid.org/0000-0003-4691-3246"},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"funder","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210150093","display_name":"Max Planck Institute of Biochemistry","ror":"https://ror.org/04py35477","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Friedhelm Pfeiffer","raw_affiliation_strings":["Biochemistry, Martinsried, Germany","Department of Membrane Biochemistry, Max-Planck Institute for","Oesterhelt, Dieter / Membrane Biochemistry, Max Planck Institute of Biochemistry, Max Planck Society"],"affiliations":[{"raw_affiliation_string":"Biochemistry, Martinsried, Germany","institution_ids":["https://openalex.org/I4210150093"]},{"raw_affiliation_string":"Department of Membrane Biochemistry, Max-Planck Institute for","institution_ids":[]},{"raw_affiliation_string":"Oesterhelt, Dieter / Membrane Biochemistry, Max Planck Institute of Biochemistry, Max Planck Society","institution_ids":["https://openalex.org/I4210150093","https://openalex.org/I149899117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102763919","display_name":"Eduardo Mendoza","orcid":"https://orcid.org/0000-0002-8984-5549"},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]},{"id":"https://openalex.org/I87074743","display_name":"University of the Philippines Diliman","ror":"https://ror.org/03tbh6y23","country_code":"PH","type":"education","lineage":["https://openalex.org/I103911934","https://openalex.org/I87074743"]},{"id":"https://openalex.org/I2801304276","display_name":"Center for NanoScience","ror":"https://ror.org/002epp671","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2801304276","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I4210102090","display_name":"Maxim Integrated (Germany)","ror":"https://ror.org/017z4ep79","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210102090","https://openalex.org/I4210152613"]}],"countries":["DE","PH"],"is_corresponding":false,"raw_author_name":"Eduardo Mendoza","raw_affiliation_strings":["Computer Science Department, University of the Philippines, Diliman","Ludwig-Maximillians-University Munich, Munich, Germany","Philippines","Physics Department and Center for Nanoscience","Physics Department and Center for Nanoscience,#N#                    Ludwig-Maximillians-University Munich, Munich, Germany","Computer Science Department, University of the Philippines, Diliman,#N#                    Philippines"],"affiliations":[{"raw_affiliation_string":"Computer Science Department, University of the Philippines, Diliman","institution_ids":["https://openalex.org/I87074743"]},{"raw_affiliation_string":"Ludwig-Maximillians-University Munich, Munich, Germany","institution_ids":["https://openalex.org/I4210102090"]},{"raw_affiliation_string":"Philippines","institution_ids":[]},{"raw_affiliation_string":"Physics Department and Center for Nanoscience","institution_ids":["https://openalex.org/I2801304276"]},{"raw_affiliation_string":"Physics Department and Center for Nanoscience,#N#                    Ludwig-Maximillians-University Munich, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"Computer Science Department, University of the Philippines, Diliman,#N#                    Philippines","institution_ids":["https://openalex.org/I87074743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068859428","display_name":"Ralf Zimmer","orcid":"https://orcid.org/0000-0003-1439-2327"},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ralf Zimmer","raw_affiliation_strings":["Germany","Institute for Informatics, Ludwig-Maximillians-University Munich, Munich","Institute for Informatics, Ludwig-Maximillians-University Munich, Munich, Germany"],"affiliations":[{"raw_affiliation_string":"Germany","institution_ids":[]},{"raw_affiliation_string":"Institute for Informatics, Ludwig-Maximillians-University Munich, Munich","institution_ids":[]},{"raw_affiliation_string":"Institute for Informatics, Ludwig-Maximillians-University Munich, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077404586","display_name":"Dieter Oesterhelt","orcid":null},"institutions":[{"id":"https://openalex.org/I4210150093","display_name":"Max Planck Institute of Biochemistry","ror":"https://ror.org/04py35477","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]},{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"funder","lineage":["https://openalex.org/I149899117"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dieter Oesterhelt","raw_affiliation_strings":["Biochemistry, Martinsried, Germany","Department of Membrane Biochemistry, Max-Planck Institute for","Oesterhelt, Dieter / Membrane Biochemistry, Max Planck Institute of Biochemistry, Max Planck Society"],"affiliations":[{"raw_affiliation_string":"Biochemistry, Martinsried, Germany","institution_ids":["https://openalex.org/I4210150093"]},{"raw_affiliation_string":"Department of Membrane Biochemistry, Max-Planck Institute for","institution_ids":[]},{"raw_affiliation_string":"Oesterhelt, Dieter / Membrane Biochemistry, Max Planck Institute of Biochemistry, Max Planck Society","institution_ids":["https://openalex.org/I4210150093","https://openalex.org/I149899117"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5102159650"],"corresponding_institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210150093"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":1931,"currency":"EUR","value_usd":2082},"fwci":1.0438,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.79378712,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"5","issue":"4","first_page":"e1000332","last_page":"e1000332"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10476","display_name":"Algal biology and biofuel production","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/2105","display_name":"Renewable Energy, Sustainability and the Environment"},"field":{"id":"https://openalex.org/fields/21","display_name":"Energy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10476","display_name":"Algal biology and biofuel production","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/2105","display_name":"Renewable Energy, Sustainability and the Environment"},"field":{"id":"https://openalex.org/fields/21","display_name":"Energy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10303","display_name":"Photosynthetic Processes and Mechanisms","score":0.9578999876976013,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/halobacterium-salinarum","display_name":"Halobacterium salinarum","score":0.9779027700424194},{"id":"https://openalex.org/keywords/halophile","display_name":"Halophile","score":0.9095916748046875},{"id":"https://openalex.org/keywords/bioenergetics","display_name":"Bioenergetics","score":0.843540608882904},{"id":"https://openalex.org/keywords/haloarchaea","display_name":"Haloarchaea","score":0.706645131111145},{"id":"https://openalex.org/keywords/halobacterium","display_name":"Halobacterium","score":0.6787958145141602},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5001025199890137},{"id":"https://openalex.org/keywords/extreme-environment","display_name":"Extreme environment","score":0.46239838004112244},{"id":"https://openalex.org/keywords/halobacteriaceae","display_name":"Halobacteriaceae","score":0.44796988368034363},{"id":"https://openalex.org/keywords/extremophile","display_name":"Extremophile","score":0.4423221945762634},{"id":"https://openalex.org/keywords/archaea","display_name":"Archaea","score":0.27385005354881287},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.20178493857383728},{"id":"https://openalex.org/keywords/thermophile","display_name":"Thermophile","score":0.14181867241859436},{"id":"https://openalex.org/keywords/bacteria","display_name":"Bacteria","score":0.1091691255569458},{"id":"https://openalex.org/keywords/mitochondrion","display_name":"Mitochondrion","score":0.07686313986778259}],"concepts":[{"id":"https://openalex.org/C2778113554","wikidata":"https://www.wikidata.org/wiki/Q3782756","display_name":"Halobacterium salinarum","level":4,"score":0.9779027700424194},{"id":"https://openalex.org/C80642116","wikidata":"https://www.wikidata.org/wiki/Q946633","display_name":"Halophile","level":3,"score":0.9095916748046875},{"id":"https://openalex.org/C100206155","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Bioenergetics","level":3,"score":0.843540608882904},{"id":"https://openalex.org/C2779926853","wikidata":"https://www.wikidata.org/wiki/Q1054206","display_name":"Haloarchaea","level":4,"score":0.706645131111145},{"id":"https://openalex.org/C2776733701","wikidata":"https://www.wikidata.org/wiki/Q139014","display_name":"Halobacterium","level":4,"score":0.6787958145141602},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5001025199890137},{"id":"https://openalex.org/C93642007","wikidata":"https://www.wikidata.org/wiki/Q5422399","display_name":"Extreme environment","level":3,"score":0.46239838004112244},{"id":"https://openalex.org/C2776509742","wikidata":"https://www.wikidata.org/wiki/Q764133","display_name":"Halobacteriaceae","level":5,"score":0.44796988368034363},{"id":"https://openalex.org/C205458427","wikidata":"https://www.wikidata.org/wiki/Q206912","display_name":"Extremophile","level":4,"score":0.4423221945762634},{"id":"https://openalex.org/C550995028","wikidata":"https://www.wikidata.org/wiki/Q10872","display_name":"Archaea","level":3,"score":0.27385005354881287},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20178493857383728},{"id":"https://openalex.org/C27911776","wikidata":"https://www.wikidata.org/wiki/Q834023","display_name":"Thermophile","level":3,"score":0.14181867241859436},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.1091691255569458},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.07686313986778259}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019617","descriptor_name":"Halobacterium salinarum","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D019617","descriptor_name":"Halobacterium salinarum","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D019617","descriptor_name":"Halobacterium salinarum","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D019617","descriptor_name":"Halobacterium salinarum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019617","descriptor_name":"Halobacterium salinarum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019617","descriptor_name":"Halobacterium salinarum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019843","descriptor_name":"Archaeal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019843","descriptor_name":"Archaeal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019843","descriptor_name":"Archaeal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1000332","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000332","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000332&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:19401785","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19401785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:4d97b3b49b42427cbe575b9eeac54e3e","is_oa":true,"landing_page_url":"https://doaj.org/article/4d97b3b49b42427cbe575b9eeac54e3e","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 5, Iss 4, p e1000332 (2009)","raw_type":"article"},{"id":"pmh:oai:edoc.mpg.de:431909","is_oa":true,"landing_page_url":"http://edoc.mpg.de/431909","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, v.5, [1]-[12] (2009)","raw_type":"Article"},{"id":"pmh:oai:epub.ub.uni-muenchen.de:15111","is_oa":false,"landing_page_url":"http://nbn-resolving.de/urn:nbn:de:bvb:19-epub-15111-7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401845","display_name":"Open access LMU (Ludwid Maxmilian's Universitat Munchen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I8204097","host_organization_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","host_organization_lineage":["https://openalex.org/I8204097"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS Computational Biology","raw_type":"doc-type:article"},{"id":"pmh:oai:figshare.com:article/147970","is_oa":true,"landing_page_url":"https://figshare.com/articles/Systems_Analysis_of_Bioenergetics_and_Growth_of_the_Extreme_Halophile____Halobacterium_salinarum_/147970","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:2674319","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2674319","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:pure.mpg.de:item_1579331","is_oa":true,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-0010-5A10-1","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000332","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000332","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000332&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Affordable and clean energy","score":0.800000011920929,"id":"https://metadata.un.org/sdg/7"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1984214499.pdf","grobid_xml":"https://content.openalex.org/works/W1984214499.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W285851164","https://openalex.org/W1540426782","https://openalex.org/W1543388089","https://openalex.org/W1597762351","https://openalex.org/W1966823474","https://openalex.org/W1968211042","https://openalex.org/W1978289664","https://openalex.org/W1981564460","https://openalex.org/W1988198398","https://openalex.org/W1989245457","https://openalex.org/W1994472360","https://openalex.org/W1996791690","https://openalex.org/W1998607430","https://openalex.org/W2008669517","https://openalex.org/W2009020603","https://openalex.org/W2015794762","https://openalex.org/W2016308696","https://openalex.org/W2026089579","https://openalex.org/W2037977504","https://openalex.org/W2047228180","https://openalex.org/W2076262841","https://openalex.org/W2078556735","https://openalex.org/W2084112242","https://openalex.org/W2090112913","https://openalex.org/W2091687284","https://openalex.org/W2101155309","https://openalex.org/W2110017370","https://openalex.org/W2110612352","https://openalex.org/W2111421616","https://openalex.org/W2117971049","https://openalex.org/W2119828149","https://openalex.org/W2120653528","https://openalex.org/W2120661262","https://openalex.org/W2135940126","https://openalex.org/W2143517204","https://openalex.org/W2143861551","https://openalex.org/W2144856591","https://openalex.org/W2159059233","https://openalex.org/W2160079005","https://openalex.org/W2169997543","https://openalex.org/W2170056871","https://openalex.org/W2996145477"],"related_works":["https://openalex.org/W2954685260","https://openalex.org/W2107813129","https://openalex.org/W2594980939","https://openalex.org/W3030134104","https://openalex.org/W2022789748","https://openalex.org/W1609069107","https://openalex.org/W4246297206","https://openalex.org/W2115498420","https://openalex.org/W2166200707","https://openalex.org/W2032842739"],"abstract_inverted_index":{"Halobacterium":[0],"salinarum":[1],"is":[2,190],"a":[3,21,25,43,219,282],"bioenergetically":[4],"flexible,":[5],"halophilic":[6],"microorganism":[7],"that":[8,32,45,72,81,112,131,139,184,205,221,229,244,276],"can":[9,46,200],"generate":[10],"energy":[11,61,123,202],"by":[12,254],"respiration,":[13],"photosynthesis,":[14],"and":[15,65,158,197,199,233],"the":[16,33,49,86,92,103,147,155,164,171,209,222,231,237,245,255,286,295],"fermentation":[17],"of":[18,51,94,137,160,167,173,175,239,252],"arginine.":[19],"In":[20,178],"previous":[22],"study,":[23],"using":[24,68],"genome-scale":[26],"metabolic":[27],"model,":[28],"we":[29,57,90,110],"have":[30],"shown":[31],"archaeon":[34],"unexpectedly":[35],"degrades":[36],"essential":[37,116],"amino":[38,117],"acids":[39,118],"under":[40,132],"aerobic":[41],"conditions,":[42],"behavior":[44,248],"lead":[47],"to":[48,97,101,188,208,257,288],"termination":[50],"growth":[52,228],"earlier":[53],"than":[54],"necessary.":[55],"Here,":[56],"further":[58],"integratively":[59],"investigate":[60],"generation,":[62],"nutrient":[63],"utilization,":[64],"biomass":[66,148],"production":[67,157],"an":[69,225],"extended":[70,274],"methodology":[71],"accounts":[73],"for":[74,273],"dynamically":[75],"changing":[76],"transport":[77],"patterns,":[78],"including":[79],"those":[80],"arise":[82],"from":[83],"interactions":[84],"among":[85],"supplied":[87],"metabolites.":[88],"Moreover,":[89],"widen":[91],"scope":[93],"our":[95,180],"analysis":[96],"include":[98],"phototrophic":[99],"conditions":[100,134,296],"explore":[102],"interplay":[104],"between":[105],"different":[106],"bioenergetic":[107,211],"modes.":[108],"Surprisingly,":[109],"found":[111,130],"cells":[113,287],"also":[114,129,182],"degrade":[115],"even":[119,235],"during":[120],"phototropy,":[121],"when":[122,294],"should":[124],"already":[125],"be":[126,271],"abundant.":[127],"We":[128,242],"both":[133],"considerable":[135,156],"amounts":[136],"nutrients":[138,262],"were":[140,143],"taken":[141],"up":[142],"neither":[144],"incorporated":[145],"into":[146],"nor":[149],"used":[150],"as":[151,290,292],"respiratory":[152],"substrates,":[153],"implying":[154],"accumulation":[159],"several":[161,279],"metabolites":[162],"in":[163,203],"medium.":[165],"Some":[166],"these":[168],"are":[169,206,263],"likely":[170],"products":[172],"forms":[174],"overflow":[176],"metabolism.":[177],"addition,":[179],"results":[181],"show":[183],"arginine":[185],"fermentation,":[186],"contrary":[187],"what":[189],"typically":[191],"assumed,":[192],"occurs":[193],"simultaneously":[194],"with":[195],"respiration":[196],"photosynthesis":[198],"contribute":[201],"levels":[204],"comparable":[207],"primary":[210],"modes,":[212],"if":[213],"not":[214,264],"more.":[215],"These":[216],"findings":[217],"portray":[218],"picture":[220],"organism":[223,256],"takes":[224],"approach":[226],"toward":[227],"favors":[230],"here":[232],"now,":[234],"at":[236],"cost":[238],"longer-term":[240],"concerns.":[241],"believe":[243],"seemingly":[246],"\"greedy\"":[247],"exhibited":[249],"actually":[250],"consists":[251],"adaptations":[253],"its":[258],"natural":[259],"environments,":[260],"where":[261],"only":[265],"irregularly":[266],"available":[267],"but":[268],"may":[269,277],"altogether":[270],"absent":[272],"periods":[275],"span":[278],"years.":[280],"Such":[281],"setting":[283],"probably":[284],"predisposed":[285],"grow":[289],"much":[291],"possible":[293],"become":[297],"favorable.":[298]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
