{"id":"https://openalex.org/W2093617915","doi":"https://doi.org/10.1371/journal.pcbi.1000330","title":"Positional Information Generated by Spatially Distributed Signaling Cascades","display_name":"Positional Information Generated by Spatially Distributed Signaling Cascades","publication_year":2009,"publication_date":"2009-03-19","ids":{"openalex":"https://openalex.org/W2093617915","doi":"https://doi.org/10.1371/journal.pcbi.1000330","mag":"2093617915","pmid":"https://pubmed.ncbi.nlm.nih.gov/19300504"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000330","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000330","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000330&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000330&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052336528","display_name":"Javier Mu\u00f1oz-Garc\u00eda","orcid":"https://orcid.org/0000-0002-7594-9507"},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Javier Mu\u00f1oz-Garc\u00eda","raw_affiliation_strings":["School of Mathematical Sciences and Complex Adaptive Systems Laboratory, University College Dublin, Dublin, Ireland","Grupo Interdisciplinar de Sistemas Complejos (GISC), Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"School of Mathematical Sciences and Complex Adaptive Systems Laboratory, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"Grupo Interdisciplinar de Sistemas Complejos (GISC), Madrid, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055338740","display_name":"Zolt\u00e1n Neufeld","orcid":"https://orcid.org/0000-0003-3236-9278"},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Zoltan Neufeld","raw_affiliation_strings":["School of Mathematical Sciences and Complex Adaptive Systems Laboratory, University College Dublin, Dublin, Ireland"],"affiliations":[{"raw_affiliation_string":"School of Mathematical Sciences and Complex Adaptive Systems Laboratory, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003776093","display_name":"Boris \u039d. Kholodenko","orcid":"https://orcid.org/0000-0002-9483-4975"},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]},{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE","US"],"is_corresponding":true,"raw_author_name":"Boris N. Kholodenko","raw_affiliation_strings":["Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America","UCD Conway Institute, University College Dublin, Dublin, Ireland"],"affiliations":[{"raw_affiliation_string":"Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"UCD Conway Institute, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5003776093"],"corresponding_institution_ids":["https://openalex.org/I100930933","https://openalex.org/I149251103"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.022,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.86362856,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"5","issue":"3","first_page":"e1000330","last_page":"e1000330"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cascade","display_name":"Cascade","score":0.7006676197052002},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.618220329284668},{"id":"https://openalex.org/keywords/radio-propagation","display_name":"Radio propagation","score":0.5165959596633911},{"id":"https://openalex.org/keywords/signal","display_name":"SIGNAL (programming language)","score":0.5032240748405457},{"id":"https://openalex.org/keywords/mass-diffusivity","display_name":"Mass diffusivity","score":0.48695477843284607},{"id":"https://openalex.org/keywords/spatial-ecology","display_name":"Spatial ecology","score":0.41362473368644714},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.400025874376297},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.3865121901035309},{"id":"https://openalex.org/keywords/thermal-diffusivity","display_name":"Thermal diffusivity","score":0.3546033203601837},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3195189833641052},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2581637501716614},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.24241328239440918}],"concepts":[{"id":"https://openalex.org/C34146451","wikidata":"https://www.wikidata.org/wiki/Q5048094","display_name":"Cascade","level":2,"score":0.7006676197052002},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.618220329284668},{"id":"https://openalex.org/C202311505","wikidata":"https://www.wikidata.org/wiki/Q1474701","display_name":"Radio propagation","level":2,"score":0.5165959596633911},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.5032240748405457},{"id":"https://openalex.org/C203496682","wikidata":"https://www.wikidata.org/wiki/Q604008","display_name":"Mass diffusivity","level":3,"score":0.48695477843284607},{"id":"https://openalex.org/C158709400","wikidata":"https://www.wikidata.org/wiki/Q3578586","display_name":"Spatial ecology","level":2,"score":0.41362473368644714},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.400025874376297},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3865121901035309},{"id":"https://openalex.org/C37668627","wikidata":"https://www.wikidata.org/wiki/Q3381809","display_name":"Thermal diffusivity","level":2,"score":0.3546033203601837},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3195189833641052},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2581637501716614},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.24241328239440918},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1000330","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000330","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000330&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:19300504","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19300504","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:researchrepository.ucd.ie:10197/5040","is_oa":true,"landing_page_url":"http://hdl.handle.net/10197/5040","pdf_url":"http://hdl.handle.net/10197/5040","source":{"id":"https://openalex.org/S4306402280","display_name":"Research Repository UCD (University College Dublin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I100930933","host_organization_name":"University College Dublin","host_organization_lineage":["https://openalex.org/I100930933"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:jdc.jefferson.edu:pacbfp-1067","is_oa":false,"landing_page_url":"https://jdc.jefferson.edu/pacbfp/68","pdf_url":null,"source":{"id":"https://openalex.org/S4210178181","display_name":"The Medicine Forum","issn_l":"2325-2863","issn":["2325-2863"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Pathology, Anatomy, and Cell Biology Faculty Papers","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:2937a54b2a274d49bb997268b086e221","is_oa":true,"landing_page_url":"https://doaj.org/article/2937a54b2a274d49bb997268b086e221","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 5, Iss 3, p e1000330 (2009)","raw_type":"article"},{"id":"pmh:oai:espace.library.uq.edu.au:UQ:266446","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306402388","display_name":"Queensland's institutional digital repository (The University of Queensland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I165143802","host_organization_name":"The University of Queensland","host_organization_lineage":["https://openalex.org/I165143802"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:figshare.com:article/148303","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Positional_Information_Generated_by_Spatially_Distributed_Signaling_Cascades/148303","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:2654021","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2654021","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000330","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000330","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000330&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2462225066","display_name":null,"funder_award_id":"R33HL088283","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2976307097","display_name":null,"funder_award_id":"GM059570","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3048109742","display_name":null,"funder_award_id":"GM0595","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3530239307","display_name":null,"funder_award_id":"NHLBI","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320320847","display_name":"Science Foundation Ireland","ror":"https://ror.org/0271asj38"},{"id":"https://openalex.org/F4320330055","display_name":"Irish Centre for High-End Computing","ror":"https://ror.org/04te6a418"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2093617915.pdf","grobid_xml":"https://content.openalex.org/works/W2093617915.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1492555729","https://openalex.org/W1576664335","https://openalex.org/W1782369362","https://openalex.org/W1975038187","https://openalex.org/W1978911766","https://openalex.org/W1980396134","https://openalex.org/W1980661496","https://openalex.org/W1988805210","https://openalex.org/W1989438081","https://openalex.org/W1989712725","https://openalex.org/W1990736894","https://openalex.org/W1992963104","https://openalex.org/W1996405087","https://openalex.org/W1998597603","https://openalex.org/W2006098171","https://openalex.org/W2007378173","https://openalex.org/W2008390024","https://openalex.org/W2017747564","https://openalex.org/W2018160075","https://openalex.org/W2018896819","https://openalex.org/W2027964838","https://openalex.org/W2029225125","https://openalex.org/W2041603328","https://openalex.org/W2041718910","https://openalex.org/W2042735215","https://openalex.org/W2047365291","https://openalex.org/W2068728923","https://openalex.org/W2082566454","https://openalex.org/W2091643574","https://openalex.org/W2094374269","https://openalex.org/W2096018880","https://openalex.org/W2099530148","https://openalex.org/W2101744311","https://openalex.org/W2109936556","https://openalex.org/W2111778006","https://openalex.org/W2115873388","https://openalex.org/W2127006805","https://openalex.org/W2130240258","https://openalex.org/W2137490447","https://openalex.org/W2145225614","https://openalex.org/W2152940466","https://openalex.org/W2157989234","https://openalex.org/W2161112329","https://openalex.org/W2162689493","https://openalex.org/W2164925597","https://openalex.org/W2308740962","https://openalex.org/W4251607962"],"related_works":["https://openalex.org/W1991376628","https://openalex.org/W1503842481","https://openalex.org/W2023596821","https://openalex.org/W2015733608","https://openalex.org/W2080685063","https://openalex.org/W1970208896","https://openalex.org/W2365710061","https://openalex.org/W2091383165","https://openalex.org/W2981734143","https://openalex.org/W2313757453"],"abstract_inverted_index":{"The":[0,114,167],"temporal":[1,131],"and":[2,39,93,106,143,189],"stationary":[3],"behavior":[4],"of":[5,21,32,96,109,116,129,152],"protein":[6,104],"modification":[7],"cascades":[8,140],"has":[9],"been":[10],"extensively":[11],"studied,":[12],"yet":[13],"little":[14],"is":[15,157],"known":[16],"about":[17,192],"the":[18,29,55,90,101,107,110,117,127,150,153,193,197],"spatial":[19,30,80,118,183],"aspects":[20],"signal":[22,66,119,165,173],"propagation.":[23,166],"We":[24,82],"have":[25],"previously":[26],"shown":[27,158],"that":[28,88,180],"separation":[31],"opposing":[33,111,154],"enzymes,":[34],"such":[35],"as":[36],"a":[37,40,161,176],"kinase":[38],"phosphatase,":[41],"creates":[42],"signaling":[43,63,168],"activity":[44,70],"gradients.":[45],"Here":[46],"we":[47],"show":[48],"under":[49],"what":[50],"conditions":[51],"signals":[52],"stall":[53],"in":[54,69],"space":[56],"or":[57],"robustly":[58],"propagate":[59],"through":[60],"spatially":[61,134,138],"distributed":[62,139],"cascades.":[64,136],"Robust":[65],"propagation":[67,94,120,174],"results":[68],"gradients":[71,169],"with":[72,100],"long":[73],"plateaus,":[74],"which":[75],"abruptly":[76],"decay":[77],"at":[78],"successive":[79],"locations.":[81],"derive":[83],"an":[84],"approximate":[85],"analytical":[86],"solution":[87],"relates":[89],"maximal":[91],"amplitude":[92],"length":[95],"each":[97],"activation":[98],"profile":[99],"cascade":[102],"level,":[103],"diffusivity,":[105],"ratio":[108,151],"enzyme":[112,155],"activities.":[113],"control":[115,128],"appears":[121],"to":[122,159,196],"be":[123,160],"very":[124],"different":[125],"from":[126,148],"transient":[130],"responses":[132],"for":[133,171,185],"homogenous":[135],"For":[137],"where":[141],"activating":[142],"deactivating":[144],"enzymes":[145],"operate":[146],"far":[147],"saturation,":[149],"activities":[156],"key":[162],"parameter":[163],"controlling":[164],"characteristic":[170],"robust":[172],"exemplify":[175],"pattern":[177],"formation":[178],"mechanism":[179],"generates":[181],"precise":[182],"guidance":[184],"multiple":[186],"cellular":[187],"processes":[188],"conveys":[190],"information":[191],"cell":[194],"size":[195],"nucleus.":[198]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
