{"id":"https://openalex.org/W1988059443","doi":"https://doi.org/10.1371/journal.pcbi.1000294","title":"Agent-Based Model of Therapeutic Adipose-Derived Stromal Cell Trafficking during Ischemia Predicts Ability To Roll on P-Selectin","display_name":"Agent-Based Model of Therapeutic Adipose-Derived Stromal Cell Trafficking during Ischemia Predicts Ability To Roll on P-Selectin","publication_year":2009,"publication_date":"2009-02-26","ids":{"openalex":"https://openalex.org/W1988059443","doi":"https://doi.org/10.1371/journal.pcbi.1000294","mag":"1988059443","pmid":"https://pubmed.ncbi.nlm.nih.gov/19247427"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000294","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000294","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000294&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000294&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103579164","display_name":"Alexander M. Bailey","orcid":null},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander M. Bailey","raw_affiliation_strings":["Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA","Department of Biomedical Engineering, University of Virginia Charlottesville Virginia USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Department of Biomedical Engineering, University of Virginia Charlottesville Virginia USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102977836","display_name":"Michael B. Lawrence","orcid":"https://orcid.org/0000-0001-9028-0162"},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael B. Lawrence","raw_affiliation_strings":["Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America","Dept of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Dept of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108657530","display_name":"Hulan Shang","orcid":null},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hulan Shang","raw_affiliation_strings":["Department of Plastic Surgery, University of Virginia, Charlottesville, Virginia, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Plastic Surgery, University of Virginia, Charlottesville, Virginia, United States of America","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014280920","display_name":"Adam J. Katz","orcid":"https://orcid.org/0000-0001-6679-514X"},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam J. Katz","raw_affiliation_strings":["Department of Plastic Surgery, University of Virginia, Charlottesville, Virginia, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Plastic Surgery, University of Virginia, Charlottesville, Virginia, United States of America","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017480661","display_name":"Shayn M. Peirce","orcid":"https://orcid.org/0000-0001-5857-5606"},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shayn M. Peirce","raw_affiliation_strings":["Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America","Dept of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Dept of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5017480661"],"corresponding_institution_ids":["https://openalex.org/I51556381"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":4.3531,"has_fulltext":true,"cited_by_count":79,"citation_normalized_percentile":{"value":0.93932812,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"5","issue":"2","first_page":"e1000294","last_page":"e1000294"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/homing","display_name":"Homing (biology)","score":0.5684574842453003},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.5096704959869385},{"id":"https://openalex.org/keywords/extravasation","display_name":"Extravasation","score":0.4953540861606598},{"id":"https://openalex.org/keywords/chemokine","display_name":"Chemokine","score":0.4943225383758545},{"id":"https://openalex.org/keywords/leukocyte-trafficking","display_name":"Leukocyte Trafficking","score":0.4902990162372589},{"id":"https://openalex.org/keywords/cell-adhesion-molecule","display_name":"Cell adhesion molecule","score":0.45101645588874817},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"Adipose tissue","score":0.4333884119987488},{"id":"https://openalex.org/keywords/leukocyte-extravasation","display_name":"Leukocyte extravasation","score":0.4320065379142761},{"id":"https://openalex.org/keywords/ischemia","display_name":"Ischemia","score":0.4200904965400696},{"id":"https://openalex.org/keywords/inflammation","display_name":"Inflammation","score":0.3948536515235901},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.39049333333969116},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3366299867630005},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3146616816520691},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.10969451069831848}],"concepts":[{"id":"https://openalex.org/C151872237","wikidata":"https://www.wikidata.org/wiki/Q1410759","display_name":"Homing (biology)","level":2,"score":0.5684574842453003},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5096704959869385},{"id":"https://openalex.org/C2779540182","wikidata":"https://www.wikidata.org/wiki/Q1076345","display_name":"Extravasation","level":2,"score":0.4953540861606598},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.4943225383758545},{"id":"https://openalex.org/C2910341952","wikidata":"https://www.wikidata.org/wiki/Q570425","display_name":"Leukocyte Trafficking","level":4,"score":0.4902990162372589},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.45101645588874817},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.4333884119987488},{"id":"https://openalex.org/C2779974255","wikidata":"https://www.wikidata.org/wiki/Q1479893","display_name":"Leukocyte extravasation","level":3,"score":0.4320065379142761},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.4200904965400696},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3948536515235901},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39049333333969116},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3366299867630005},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3146616816520691},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10969451069831848},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017690","descriptor_name":"Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017690","descriptor_name":"Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017690","descriptor_name":"Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019007","descriptor_name":"P-Selectin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019007","descriptor_name":"P-Selectin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019007","descriptor_name":"P-Selectin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1000294","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000294","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000294&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:19247427","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19247427","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:c9ef016b7aa64ec4b625912d9bc0228b","is_oa":true,"landing_page_url":"https://doaj.org/article/c9ef016b7aa64ec4b625912d9bc0228b","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 5, Iss 2, p e1000294 (2009)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/148366","is_oa":true,"landing_page_url":"https://figshare.com/articles/Agent_Based_Model_of_Therapeutic_Adipose_Derived_Stromal_Cell_Trafficking_during_Ischemia_Predicts_Ability_To_Roll_on_P_Selectin/148366","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:2636895","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2636895","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000294","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000294","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000294&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310536","display_name":"University of Virginia","ror":"https://ror.org/0153tk833"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1988059443.pdf"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1510331108","https://openalex.org/W1522536354","https://openalex.org/W1525971636","https://openalex.org/W1605333504","https://openalex.org/W1661430296","https://openalex.org/W1841920206","https://openalex.org/W1970552364","https://openalex.org/W1974012373","https://openalex.org/W1982861439","https://openalex.org/W1983460607","https://openalex.org/W1989986582","https://openalex.org/W1997405293","https://openalex.org/W2006012747","https://openalex.org/W2009534120","https://openalex.org/W2012275753","https://openalex.org/W2021634519","https://openalex.org/W2024771744","https://openalex.org/W2026705594","https://openalex.org/W2029816148","https://openalex.org/W2031644578","https://openalex.org/W2033387117","https://openalex.org/W2035809865","https://openalex.org/W2039809334","https://openalex.org/W2042337023","https://openalex.org/W2050196094","https://openalex.org/W2065937657","https://openalex.org/W2071166532","https://openalex.org/W2073420114","https://openalex.org/W2074639523","https://openalex.org/W2077820055","https://openalex.org/W2079812171","https://openalex.org/W2085259589","https://openalex.org/W2085371331","https://openalex.org/W2086269546","https://openalex.org/W2088829655","https://openalex.org/W2098743872","https://openalex.org/W2099675490","https://openalex.org/W2100221605","https://openalex.org/W2107375511","https://openalex.org/W2110059498","https://openalex.org/W2114952275","https://openalex.org/W2119533880","https://openalex.org/W2126278579","https://openalex.org/W2126410943","https://openalex.org/W2140305087","https://openalex.org/W2148408276","https://openalex.org/W2155189258","https://openalex.org/W2157999920","https://openalex.org/W2163904859","https://openalex.org/W2167602295","https://openalex.org/W2173497140","https://openalex.org/W2238628308","https://openalex.org/W2266998221","https://openalex.org/W2401770061","https://openalex.org/W2440099833","https://openalex.org/W2547372360","https://openalex.org/W4230891511","https://openalex.org/W6737919741"],"related_works":["https://openalex.org/W2284352892","https://openalex.org/W1970802765","https://openalex.org/W2122081106","https://openalex.org/W1906414470","https://openalex.org/W2114433225","https://openalex.org/W2619544969","https://openalex.org/W2065664874","https://openalex.org/W4245130961","https://openalex.org/W2025784612","https://openalex.org/W2132654030"],"abstract_inverted_index":{"Intravenous":[0],"delivery":[1],"of":[2,15,35,43,51,60,63,104,111,120,152,178,190,201,208,228,247,267,282,305],"human":[3],"adipose-derived":[4],"stromal":[5],"cells":[6],"(hASCs)":[7],"is":[8,69,97],"a":[9,57,115,150,226,280,301],"promising":[10],"option":[11],"for":[12],"the":[13,25,47,61,67,91,102,109,153,172,236,245],"treatment":[14],"ischemia.":[16],"After":[17],"delivery,":[18],"hASCs":[19,65,283],"that":[20,56,75],"reside":[21],"and":[22,38,49,74,82,137,166,180,204,214],"persist":[23],"in":[24,90,135,185,211,231,256],"injured":[26,197],"extravascular":[27],"space":[28],"have":[29,310],"been":[30],"shown":[31],"to":[32,71,107,224,252,258,300],"aid":[33],"recovery":[34],"tissue":[36],"perfusion":[37],"function,":[39],"although":[40],"low":[41,292],"rates":[42],"incorporation":[44],"currently":[45],"limit":[46],"safety":[48],"efficacy":[50],"these":[52],"therapies.":[53],"We":[54,113],"submit":[55],"better":[58],"understanding":[59,304],"trafficking":[62,122,143,181],"therapeutic":[64,312],"through":[66],"microcirculation":[68],"needed":[70],"address":[72],"this":[73,278],"selective":[76],"control":[77],"over":[78,130],"their":[79],"homing":[80,92],"(organ-":[81],"injury-specific)":[83],"may":[84,309],"be":[85],"possible":[86],"by":[87,263],"targeting":[88],"bottlenecks":[89],"process.":[93],"This":[94],"process,":[95],"however,":[96],"incredibly":[98],"complex,":[99],"which":[100,308],"merited":[101],"use":[103],"computational":[105],"techniques":[106],"speed":[108],"rate":[110],"discovery.":[112],"developed":[114],"multicell":[116],"agent-based":[117],"model":[118,173],"(ABM)":[119],"hASC":[121,241,254,264,306],"during":[123],"acute":[124],"skeletal":[125],"muscle":[126],"ischemia,":[127],"based":[128],"on":[129,196,286],"150":[131],"literature-based":[132],"rules":[133],"instituted":[134],"Netlogo":[136],"MatLab":[138],"software":[139],"programs.":[140],"In":[141,274],"silico,":[142],"phenomena":[144],"within":[145],"cell":[146],"populations":[147],"emerged":[148],"as":[149,291,293],"result":[151],"dynamic":[154],"interactions":[155],"between":[156],"adhesion":[157,193],"molecule":[158,251],"expression,":[159],"chemokine":[160],"secretion,":[161],"integrin":[162],"affinity":[163],"states,":[164],"hemodynamics":[165],"microvascular":[167],"network":[168],"architectures.":[169],"As":[170],"verification,":[171],"reasonably":[174],"reproduced":[175],"key":[176,191],"aspects":[177],"ischemia":[179],"behavior":[182,261],"including":[183],"increases":[184],"wall":[186],"shear":[187],"stress,":[188],"upregulation":[189],"cellular":[192],"molecules":[194],"expressed":[195],"endothelium,":[198],"increased":[199],"secretion":[200],"inflammatory":[202],"chemokines":[203],"cytokines,":[205],"quantified":[206],"levels":[207],"monocyte":[209,216],"extravasation":[210],"selectin":[212],"knockouts,":[213],"circulating":[215],"rolling":[217,260],"distances.":[218],"Successful":[219],"ABM":[220],"verification":[221],"prompted":[222],"us":[223],"conduct":[225],"series":[227],"systematic":[229],"knockouts":[230],"silico":[232],"aimed":[233],"at":[234,289],"identifying":[235],"most":[237],"critical":[238],"parameters":[239],"mediating":[240],"trafficking.":[242],"Simulations":[243],"predicted":[244],"necessity":[246],"an":[248],"unknown":[249],"selectin-binding":[250],"achieve":[253],"extravasation,":[255],"addition":[257],"any":[259],"mediated":[262],"surface":[265],"expression":[266],"CD15s,":[268],"CD34,":[269],"CD62e,":[270],"CD62p,":[271],"or":[272],"CD65.":[273],"vitro":[275],"experiments":[276],"confirmed":[277],"prediction;":[279],"subpopulation":[281],"slowly":[284],"rolled":[285],"immobilized":[287],"P-selectin":[288],"speeds":[290],"2":[294],"microm/s.":[295],"Thus,":[296],"our":[297],"work":[298],"led":[299],"fundamentally":[302],"new":[303],"biology,":[307],"important":[311],"implications.":[313]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":7}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
