{"id":"https://openalex.org/W2002405581","doi":"https://doi.org/10.1371/journal.pcbi.1000292","title":"Identification of Potential Pathway Mediation Targets in Toll-like Receptor Signaling","display_name":"Identification of Potential Pathway Mediation Targets in Toll-like Receptor Signaling","publication_year":2009,"publication_date":"2009-02-19","ids":{"openalex":"https://openalex.org/W2002405581","doi":"https://doi.org/10.1371/journal.pcbi.1000292","mag":"2002405581","pmid":"https://pubmed.ncbi.nlm.nih.gov/19229310"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000292","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000292","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000292&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000292&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100373562","display_name":"Fan Li","orcid":"https://orcid.org/0000-0002-2400-9021"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fan Li","raw_affiliation_strings":["Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074725115","display_name":"Ines Thiele","orcid":"https://orcid.org/0000-0002-8071-7110"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ines Thiele","raw_affiliation_strings":["Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America","Ph.D. Program in Bioinformatics, University of California San Diego, La Jolla, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Ph.D. Program in Bioinformatics, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031218218","display_name":"Neema Jamshidi","orcid":"https://orcid.org/0000-0003-3857-9735"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neema Jamshidi","raw_affiliation_strings":["Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051097609","display_name":"Bernhard \u00d8. Palsson","orcid":"https://orcid.org/0000-0003-2357-6785"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bernhard \u00d8. Palsson","raw_affiliation_strings":["Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5051097609"],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":10.6051,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.98740012,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"5","issue":"2","first_page":"e1000292","last_page":"e1000292"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.994700014591217,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9901000261306763,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/toll-like-receptor","display_name":"Toll-like receptor","score":0.6139024496078491},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.6039286255836487},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.583369791507721},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5568740367889404},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.43079501390457153},{"id":"https://openalex.org/keywords/mediation","display_name":"Mediation","score":0.4223915636539459},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.42021408677101135},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.4015046954154968},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.32079949975013733},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.23313182592391968},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.1124330461025238},{"id":"https://openalex.org/keywords/innate-immune-system","display_name":"Innate immune system","score":0.09827220439910889}],"concepts":[{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.6139024496078491},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6039286255836487},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.583369791507721},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5568740367889404},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43079501390457153},{"id":"https://openalex.org/C179420905","wikidata":"https://www.wikidata.org/wiki/Q223871","display_name":"Mediation","level":2,"score":0.4223915636539459},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42021408677101135},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4015046954154968},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32079949975013733},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23313182592391968},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.1124330461025238},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.09827220439910889},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002451","descriptor_name":"Cell Compartmentation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002451","descriptor_name":"Cell Compartmentation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002451","descriptor_name":"Cell Compartmentation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pcbi.1000292","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000292","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000292&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:19229310","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19229310","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:ark:/13030/qt9368j36z","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.785.8008","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.785.8008","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/ef/6c/pcbi.1000292.PMC2634968.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:7c7a56edbd534ff2b4ad606be741a5c8","is_oa":true,"landing_page_url":"https://doaj.org/article/7c7a56edbd534ff2b4ad606be741a5c8","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 5, Iss 2, p e1000292 (2009)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt9368j36z","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/9368j36z","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS computational biology, vol 5, iss 2","raw_type":"article"},{"id":"pmh:oai:europepmc.org:1940742","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2634968","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/148459","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Identification_of_Potential_Pathway_Mediation_Targets_in_Toll_like_Receptor_Signaling/148459","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:orbilu.uni.lu:10993/13047","is_oa":false,"landing_page_url":"https://orbilu.uni.lu/handle/10993/13047","pdf_url":null,"source":{"id":"https://openalex.org/S4306401815","display_name":"Open Repository and Bibliography (University of Luxembourg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I186903577","host_organization_name":"University of Luxembourg","host_organization_lineage":["https://openalex.org/I186903577"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 5 (2), e1000292 (2009)","raw_type":"peer reviewed"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000292","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000292","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000292&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Partnerships for the goals","id":"https://metadata.un.org/sdg/17","score":0.4300000071525574}],"awards":[],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2002405581.pdf","grobid_xml":"https://content.openalex.org/works/W2002405581.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W980071643","https://openalex.org/W1515994079","https://openalex.org/W1529898704","https://openalex.org/W1534551308","https://openalex.org/W1767727568","https://openalex.org/W1969430178","https://openalex.org/W1973376761","https://openalex.org/W1978877435","https://openalex.org/W1979955019","https://openalex.org/W1984026160","https://openalex.org/W1989518843","https://openalex.org/W1994134392","https://openalex.org/W1996529795","https://openalex.org/W2006943154","https://openalex.org/W2009940763","https://openalex.org/W2010453472","https://openalex.org/W2011678998","https://openalex.org/W2013732386","https://openalex.org/W2020389804","https://openalex.org/W2025140782","https://openalex.org/W2025960625","https://openalex.org/W2026089579","https://openalex.org/W2033431458","https://openalex.org/W2033897405","https://openalex.org/W2035413309","https://openalex.org/W2036767516","https://openalex.org/W2056281205","https://openalex.org/W2056423038","https://openalex.org/W2057498577","https://openalex.org/W2062245653","https://openalex.org/W2082948758","https://openalex.org/W2084880831","https://openalex.org/W2085701175","https://openalex.org/W2086503221","https://openalex.org/W2089476104","https://openalex.org/W2090640877","https://openalex.org/W2097588479","https://openalex.org/W2098257571","https://openalex.org/W2098672681","https://openalex.org/W2099551325","https://openalex.org/W2101363646","https://openalex.org/W2104108767","https://openalex.org/W2105746559","https://openalex.org/W2108399976","https://openalex.org/W2116324021","https://openalex.org/W2117047223","https://openalex.org/W2121933593","https://openalex.org/W2126175129","https://openalex.org/W2126176298","https://openalex.org/W2126676163","https://openalex.org/W2129110097","https://openalex.org/W2141040025","https://openalex.org/W2141977920","https://openalex.org/W2144568050","https://openalex.org/W2147472054","https://openalex.org/W2149071811","https://openalex.org/W2149913704","https://openalex.org/W2152164604","https://openalex.org/W2152186211","https://openalex.org/W2152452001","https://openalex.org/W2153258203","https://openalex.org/W2155916024","https://openalex.org/W2166280494","https://openalex.org/W2528271650","https://openalex.org/W4238101851","https://openalex.org/W4246077736","https://openalex.org/W4256259619"],"related_works":["https://openalex.org/W2261545136","https://openalex.org/W2374348893","https://openalex.org/W1650842635","https://openalex.org/W4382203901","https://openalex.org/W3086657857","https://openalex.org/W4387116737","https://openalex.org/W4210560169","https://openalex.org/W3202911088","https://openalex.org/W2390176872","https://openalex.org/W2368345297"],"abstract_inverted_index":{"Recent":[0],"advances":[1],"in":[2,145],"reconstruction":[3,27,39],"and":[4,21,47,78,115,155],"analytical":[5],"methods":[6,71],"for":[7,104,142],"signaling":[8,33,54,109,153],"networks":[9],"have":[10],"spurred":[11],"the":[12,29,53,70,94,146,150],"development":[13],"of":[14,28,44,60,72,93,107,133,148],"large-scale":[15,73],"models":[16],"that":[17,51],"incorporate":[18],"fully":[19],"functional":[20],"biologically":[22],"relevant":[23],"features.":[24],"An":[25],"extended":[26],"human":[30],"Toll-like":[31,151],"receptor":[32,152],"network":[34,82,95,154],"is":[35],"presented":[36],"herein.":[37],"This":[38],"contains":[40],"an":[41],"extensive":[42],"complement":[43],"kinases,":[45],"phosphatases,":[46],"other":[48],"associated":[49,62],"proteins":[50],"mediate":[52],"cascade":[55],"along":[56],"with":[57,110],"a":[58],"delineation":[59],"their":[61,113],"chemical":[63],"reactions.":[64],"A":[65],"computational":[66],"framework":[67],"based":[68],"on":[69],"convex":[74],"analysis":[75,100],"was":[76],"developed":[77],"applied":[79],"to":[80,83,112,121,138],"this":[81,134],"characterize":[84],"input-output":[85,88],"relationships.":[86],"The":[87,99,131],"relationships":[89],"enabled":[90],"significant":[91],"modularization":[92],"into":[96],"ten":[97],"pathways.":[98],"identified":[101],"potential":[102],"candidates":[103],"inhibitory":[105],"mediation":[106],"TLR":[108],"respect":[111],"specificity":[114],"potency.":[116],"Subsequently,":[117],"we":[118],"were":[119],"able":[120],"identify":[122],"eight":[123],"novel":[124],"inhibition":[125],"targets":[126],"through":[127],"constraint-based":[128],"modeling":[129],"methods.":[130],"results":[132],"study":[135],"are":[136],"expected":[137],"yield":[139],"meaningful":[140],"avenues":[141],"further":[143],"research":[144],"task":[147],"mediating":[149],"its":[156],"effects.":[157]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":10}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}
