{"id":"https://openalex.org/W2117261424","doi":"https://doi.org/10.1371/journal.pcbi.1000250","title":"Identification of Mechanosensitive Genes during Embryonic Bone Formation","display_name":"Identification of Mechanosensitive Genes during Embryonic Bone Formation","publication_year":2008,"publication_date":"2008-12-26","ids":{"openalex":"https://openalex.org/W2117261424","doi":"https://doi.org/10.1371/journal.pcbi.1000250","mag":"2117261424","pmid":"https://pubmed.ncbi.nlm.nih.gov/19112485"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000250","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000250","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000250&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000250&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059933736","display_name":"Niamh C. Nowlan","orcid":"https://orcid.org/0000-0002-9083-6279"},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Niamh C. Nowlan","raw_affiliation_strings":["Department of Zoology, School of Natural Sciences, Trinity College Dublin, Dublin, Ireland. nowlann@tcd.ie","Department of Zoology, School of Natural Sciences, Trinity College\n                    Dublin, Dublin, Ireland","Trinity Centre for Bioengineering, School of Engineering, Trinity College\n                    Dublin, Dublin, Ireland"],"affiliations":[{"raw_affiliation_string":"Department of Zoology, School of Natural Sciences, Trinity College Dublin, Dublin, Ireland. nowlann@tcd.ie","institution_ids":["https://openalex.org/I205274468"]},{"raw_affiliation_string":"Department of Zoology, School of Natural Sciences, Trinity College\n                    Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]},{"raw_affiliation_string":"Trinity Centre for Bioengineering, School of Engineering, Trinity College\n                    Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113554693","display_name":"Patrick J. Prendergast","orcid":null},"institutions":[{"id":"https://openalex.org/I204442077","display_name":"Trinity College","ror":"https://ror.org/019dhar59","country_code":"CA","type":"education","lineage":["https://openalex.org/I204442077"]},{"id":"https://openalex.org/I4210118750","display_name":"22q11 Ireland","ror":"https://ror.org/03fbzmy04","country_code":"IE","type":"nonprofit","lineage":["https://openalex.org/I4210118750"]},{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["CA","IE"],"is_corresponding":false,"raw_author_name":"Patrick J. Prendergast","raw_affiliation_strings":["Dublin, Dublin, Ireland","Trinity Centre for Bioengineering, School of Engineering, Trinity College","Trinity Centre for Bioengineering, School of Engineering, Trinity College\n                    Dublin, Dublin, Ireland"],"affiliations":[{"raw_affiliation_string":"Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I4210118750"]},{"raw_affiliation_string":"Trinity Centre for Bioengineering, School of Engineering, Trinity College","institution_ids":["https://openalex.org/I204442077"]},{"raw_affiliation_string":"Trinity Centre for Bioengineering, School of Engineering, Trinity College\n                    Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015673217","display_name":"Paula Murphy","orcid":"https://orcid.org/0000-0002-8048-6850"},"institutions":[{"id":"https://openalex.org/I204442077","display_name":"Trinity College","ror":"https://ror.org/019dhar59","country_code":"CA","type":"education","lineage":["https://openalex.org/I204442077"]},{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]},{"id":"https://openalex.org/I4210118750","display_name":"22q11 Ireland","ror":"https://ror.org/03fbzmy04","country_code":"IE","type":"nonprofit","lineage":["https://openalex.org/I4210118750"]}],"countries":["CA","IE"],"is_corresponding":false,"raw_author_name":"Paula Murphy","raw_affiliation_strings":["Department of Zoology, School of Natural Sciences, Trinity College","Dublin, Dublin, Ireland","Department of Zoology, School of Natural Sciences, Trinity College\n                    Dublin, Dublin, Ireland"],"affiliations":[{"raw_affiliation_string":"Department of Zoology, School of Natural Sciences, Trinity College","institution_ids":["https://openalex.org/I204442077"]},{"raw_affiliation_string":"Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I4210118750"]},{"raw_affiliation_string":"Department of Zoology, School of Natural Sciences, Trinity College\n                    Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5059933736"],"corresponding_institution_ids":["https://openalex.org/I205274468"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.5945,"has_fulltext":true,"cited_by_count":77,"citation_normalized_percentile":{"value":0.81439049,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"4","issue":"12","first_page":"e1000250","last_page":"e1000250"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10658","display_name":"Bone fractures and treatments","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11068","display_name":"Tendon Structure and Treatment","score":0.991100013256073,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mechanosensitive-channels","display_name":"Mechanosensitive channels","score":0.973746120929718},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6694954633712769},{"id":"https://openalex.org/keywords/in-ovo","display_name":"In ovo","score":0.6356704235076904},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.6130928993225098},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4423450231552124},{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"Mechanotransduction","score":0.43371957540512085},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.43040287494659424},{"id":"https://openalex.org/keywords/embryonic-stem-cell","display_name":"Embryonic stem cell","score":0.4235243797302246},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.3919371962547302},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3682091236114502},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.3260224461555481},{"id":"https://openalex.org/keywords/embryo","display_name":"Embryo","score":0.23876750469207764}],"concepts":[{"id":"https://openalex.org/C4001165","wikidata":"https://www.wikidata.org/wiki/Q6804689","display_name":"Mechanosensitive channels","level":4,"score":0.973746120929718},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6694954633712769},{"id":"https://openalex.org/C2778765379","wikidata":"https://www.wikidata.org/wiki/Q17055931","display_name":"In ovo","level":3,"score":0.6356704235076904},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6130928993225098},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4423450231552124},{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.43371957540512085},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.43040287494659424},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.4235243797302246},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3919371962547302},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3682091236114502},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3260224461555481},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.23876750469207764},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001846","descriptor_name":"Bone Development","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001846","descriptor_name":"Bone Development","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001846","descriptor_name":"Bone Development","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D024121","descriptor_name":"Collagen Type X","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024121","descriptor_name":"Collagen Type X","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024121","descriptor_name":"Collagen Type X","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1000250","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000250","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000250&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:19112485","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19112485","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1000250","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1000250","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:70b062d7becf4e31b38b024bf482015b","is_oa":true,"landing_page_url":"https://doaj.org/article/70b062d7becf4e31b38b024bf482015b","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 4, Iss 12, p e1000250 (2008)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2592698","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2592698","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:tara.tcd.ie:2262/39557","is_oa":false,"landing_page_url":"http://hdl.handle.net/2262/39557","pdf_url":null,"source":{"id":"https://openalex.org/S4306400387","display_name":"Trinity's Access to Research Output (TARA) (Trinity College Dublin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205274468","host_organization_name":"Trinity College Dublin","host_organization_lineage":["https://openalex.org/I205274468"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000250","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000250","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000250&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3404898063","display_name":null,"funder_award_id":"083539/Z/07/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320310838","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320842","display_name":"Irish Research Council for Science, Engineering and Technology","ror":"https://ror.org/051xex213"},{"id":"https://openalex.org/F4320320864","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19"},{"id":"https://openalex.org/F4320321056","display_name":"Irish Research Council","ror":"https://ror.org/051xex213"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2117261424.pdf","grobid_xml":"https://content.openalex.org/works/W2117261424.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W38084633","https://openalex.org/W139486898","https://openalex.org/W1484163259","https://openalex.org/W1487688765","https://openalex.org/W1526154605","https://openalex.org/W1709599847","https://openalex.org/W1931051077","https://openalex.org/W1936633632","https://openalex.org/W1964473537","https://openalex.org/W1982096373","https://openalex.org/W1984325351","https://openalex.org/W1988418842","https://openalex.org/W1992751656","https://openalex.org/W1993000387","https://openalex.org/W2009244370","https://openalex.org/W2010751506","https://openalex.org/W2013572062","https://openalex.org/W2040785797","https://openalex.org/W2044630254","https://openalex.org/W2045683512","https://openalex.org/W2065005994","https://openalex.org/W2070040120","https://openalex.org/W2076419655","https://openalex.org/W2084590381","https://openalex.org/W2085530184","https://openalex.org/W2086145297","https://openalex.org/W2087457097","https://openalex.org/W2090103863","https://openalex.org/W2108704056","https://openalex.org/W2110341920","https://openalex.org/W2111312751","https://openalex.org/W2117757706","https://openalex.org/W2120761640","https://openalex.org/W2121681341","https://openalex.org/W2126545660","https://openalex.org/W2128641290","https://openalex.org/W2132905373","https://openalex.org/W2140343451","https://openalex.org/W2143633999","https://openalex.org/W2144246516","https://openalex.org/W2154453865","https://openalex.org/W2158714788","https://openalex.org/W6628996979"],"related_works":["https://openalex.org/W2286255985","https://openalex.org/W3008358504","https://openalex.org/W945838631","https://openalex.org/W4223497726","https://openalex.org/W2057185402","https://openalex.org/W2027880075","https://openalex.org/W2927703930","https://openalex.org/W2117513500","https://openalex.org/W3082536056","https://openalex.org/W4240365997"],"abstract_inverted_index":{"Although":[0],"it":[1,44],"is":[2,29,45,58],"known":[3],"that":[4,50,224,241,259],"mechanical":[5,62,172,278],"forces":[6,32,63],"are":[7,20,33,263],"needed":[8],"for":[9,239],"normal":[10],"bone":[11,131,168,285],"development,":[12],"the":[13,51,55,100,121,165,177,255,277,281,288],"current":[14],"understanding":[15],"of":[16,54,71,85,99,115,124,136,167,204,210,228,284],"how":[17],"biophysical":[18,86,116,151,205,229],"stimuli":[19,117,152,230],"interpreted":[21],"by":[22,40,76,154],"and":[23,110,113,142,202,207,217,261,268],"integrated":[24],"with":[25,83,120,150],"genetic":[26,52],"regulatory":[27],"mechanisms":[28],"limited.":[30],"Mechanical":[31],"thought":[34],"to":[35,48,130,148,189,234,280],"be":[36,232,270],"mediated":[37],"in":[38,64,78,164,176,187,200,215,247,249,265,273,287],"cells":[39],"\"mechanosensitive\"":[41],"genes,":[42,138],"but":[43],"a":[46,68,181,208,236,244],"challenge":[47],"demonstrate":[49,258],"regulation":[53,283],"biological":[56],"system":[57],"dependant":[59],"on":[60],"particular":[61,248],"vivo.":[65],"We":[66],"propose":[67],"new":[69],"means":[70],"selecting":[72],"candidate":[73,126],"mechanosensitive":[74,127],"genes":[75,128,240],"comparing":[77],"vivo":[79,250],"gene":[80],"expression":[81,122,134],"patterns":[82,84,114,123,135,203,227],"stimuli,":[87,206],"computed":[88],"using":[89,106],"finite":[90,96],"element":[91,97,195],"analysis.":[92],"In":[93],"this":[94],"study,":[95],"analyses":[98,196],"avian":[101],"embryonic":[102,155,178],"limb":[103],"were":[104,118,146],"performed":[105],"anatomically":[107],"realistic":[108],"rudiment":[109],"muscle":[111,156,192],"morphologies,":[112],"compared":[119],"four":[125],"integral":[129],"development.":[132],"The":[133,220],"two":[137],"Collagen":[139],"X":[140],"(ColX)":[141],"Indian":[143],"hedgehog":[144],"(Ihh),":[145],"shown":[147],"colocalise":[149],"induced":[153,175],"contractions,":[157],"identifying":[158],"them":[159],"as":[160],"potentially":[161],"being":[162],"involved":[163,264],"mechanoregulation":[166],"formation.":[169],"An":[170],"altered":[171],"environment":[173,279],"was":[174,185],"chick,":[179],"where":[180],"neuromuscular":[182],"blocking":[183],"agent":[184],"administered":[186],"ovo":[188],"modify":[190],"skeletal":[191],"contractions.":[193],"Finite":[194],"predicted":[197],"dramatic":[198],"changes":[199],"levels":[201],"number":[209],"immobilised":[211],"specimens":[212],"exhibited":[213],"differences":[214],"ColX":[216,260],"Ihh":[218,262],"expression.":[219],"results":[221],"obtained":[222],"indicate":[223],"computationally":[225],"derived":[226],"can":[231],"used":[233],"inform":[235],"directed":[237],"search":[238],"may":[242,269],"play":[243],"mechanoregulatory":[245,266],"role":[246],"events":[251],"or":[252],"processes.":[253],"Furthermore,":[254],"experimental":[256],"data":[257],"pathways":[267],"key":[271],"mediators":[272],"translating":[274],"information":[275],"from":[276],"molecular":[282],"formation":[286],"embryo.":[289]},"counts_by_year":[{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
