{"id":"https://openalex.org/W1999503228","doi":"https://doi.org/10.1371/journal.pcbi.1000245","title":"Association Rate Constants of Ras-Effector Interactions Are Evolutionarily Conserved","display_name":"Association Rate Constants of Ras-Effector Interactions Are Evolutionarily Conserved","publication_year":2008,"publication_date":"2008-12-18","ids":{"openalex":"https://openalex.org/W1999503228","doi":"https://doi.org/10.1371/journal.pcbi.1000245","mag":"1999503228","pmid":"https://pubmed.ncbi.nlm.nih.gov/19096503"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000245","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000245","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000245&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000245&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013287255","display_name":"Christina Kiel","orcid":"https://orcid.org/0000-0001-8454-6008"},"institutions":[{"id":"https://openalex.org/I4210137962","display_name":"Centre for Genomic Regulation","ror":"https://ror.org/03wyzt892","country_code":"ES","type":"funder","lineage":["https://openalex.org/I4210132884","https://openalex.org/I4210137962","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Christina Kiel","raw_affiliation_strings":["EMBL-CRG Systems Biology Unit, Centre de Regulacio Genomica, Barcelona, Spain. christina.kiel@crg.es","EMBL-CRG Systems Biology Unit, Centre de Regulacio Genomica, Barcelona, Spain"],"affiliations":[{"raw_affiliation_string":"EMBL-CRG Systems Biology Unit, Centre de Regulacio Genomica, Barcelona, Spain. christina.kiel@crg.es","institution_ids":["https://openalex.org/I4210137962"]},{"raw_affiliation_string":"EMBL-CRG Systems Biology Unit, Centre de Regulacio Genomica, Barcelona, Spain","institution_ids":["https://openalex.org/I4210137962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081764970","display_name":"Dorothee Aydin","orcid":null},"institutions":[{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dorothee Aydin","raw_affiliation_strings":["EMBL-European Molecular Biology Laboratory, Heidelberg, Germany","EMBL (European Molecular Biology Laboratory) Heidelberg Germany"],"affiliations":[{"raw_affiliation_string":"EMBL-European Molecular Biology Laboratory, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210138560"]},{"raw_affiliation_string":"EMBL (European Molecular Biology Laboratory) Heidelberg Germany","institution_ids":["https://openalex.org/I4210138560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080707475","display_name":"Lu\u00eds Serrano","orcid":"https://orcid.org/0000-0002-5276-1392"},"institutions":[{"id":"https://openalex.org/I4210137962","display_name":"Centre for Genomic Regulation","ror":"https://ror.org/03wyzt892","country_code":"ES","type":"funder","lineage":["https://openalex.org/I4210132884","https://openalex.org/I4210137962","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Luis Serrano","raw_affiliation_strings":["ICREA Professor, EMBL-CRG Systems Biology Unit, Centre de Regulacio Genomica, Barcelona, Spain"],"affiliations":[{"raw_affiliation_string":"ICREA Professor, EMBL-CRG Systems Biology Unit, Centre de Regulacio Genomica, Barcelona, Spain","institution_ids":["https://openalex.org/I4210137962"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5013287255"],"corresponding_institution_ids":["https://openalex.org/I4210137962"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.6916,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.68951448,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"4","issue":"12","first_page":"e1000245","last_page":"e1000245"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/effector","display_name":"Effector","score":0.8358207941055298},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6367059350013733},{"id":"https://openalex.org/keywords/conserved-sequence","display_name":"Conserved sequence","score":0.5925164818763733},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5776979923248291},{"id":"https://openalex.org/keywords/affinities","display_name":"Affinities","score":0.5524972677230835},{"id":"https://openalex.org/keywords/divergence","display_name":"Divergence (linguistics)","score":0.5161324739456177},{"id":"https://openalex.org/keywords/protein\u2013protein-interaction","display_name":"Protein\u2013protein interaction","score":0.4444630444049835},{"id":"https://openalex.org/keywords/kinetics","display_name":"Kinetics","score":0.4307868182659149},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4134790301322937},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.36106836795806885},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.25834810733795166},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.2163146436214447},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.16323143243789673},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.15759018063545227},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.14256766438484192}],"concepts":[{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.8358207941055298},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6367059350013733},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.5925164818763733},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5776979923248291},{"id":"https://openalex.org/C2780283098","wikidata":"https://www.wikidata.org/wiki/Q4688960","display_name":"Affinities","level":2,"score":0.5524972677230835},{"id":"https://openalex.org/C207390915","wikidata":"https://www.wikidata.org/wiki/Q1230525","display_name":"Divergence (linguistics)","level":2,"score":0.5161324739456177},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.4444630444049835},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.4307868182659149},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4134790301322937},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.36106836795806885},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.25834810733795166},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2163146436214447},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16323143243789673},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.15759018063545227},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14256766438484192},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1000245","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000245","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000245&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:19096503","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19096503","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.774.2220","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.774.2220","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/62/d5/pcbi.1000245.PMC2588540.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:c93086ea3995403faa83559cebfe13c5","is_oa":true,"landing_page_url":"https://doaj.org/article/c93086ea3995403faa83559cebfe13c5","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 4, Iss 12, p e1000245 (2008)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/148947","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Association_Rate_Constants_of_Ras_Effector_Interactions_Are_Evolutionarily_Conserved/148947","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:2588540","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2588540","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000245","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000245","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000245&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7400000095367432,"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1999503228.pdf","grobid_xml":"https://content.openalex.org/works/W1999503228.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1534963014","https://openalex.org/W1585517331","https://openalex.org/W1869861415","https://openalex.org/W1929729893","https://openalex.org/W1946879166","https://openalex.org/W1971541597","https://openalex.org/W1974868825","https://openalex.org/W1975060999","https://openalex.org/W1977598234","https://openalex.org/W1977922844","https://openalex.org/W1989764957","https://openalex.org/W1989964184","https://openalex.org/W1993202007","https://openalex.org/W1993385052","https://openalex.org/W1996372785","https://openalex.org/W1999332777","https://openalex.org/W2001620484","https://openalex.org/W2002127029","https://openalex.org/W2005189737","https://openalex.org/W2010537388","https://openalex.org/W2012189464","https://openalex.org/W2016344506","https://openalex.org/W2017260253","https://openalex.org/W2018019810","https://openalex.org/W2023490488","https://openalex.org/W2024755629","https://openalex.org/W2024980748","https://openalex.org/W2028170357","https://openalex.org/W2034665579","https://openalex.org/W2041085998","https://openalex.org/W2052051648","https://openalex.org/W2060908449","https://openalex.org/W2066696278","https://openalex.org/W2069491754","https://openalex.org/W2070505228","https://openalex.org/W2071337276","https://openalex.org/W2075161553","https://openalex.org/W2078993960","https://openalex.org/W2080099116","https://openalex.org/W2085543450","https://openalex.org/W2086936470","https://openalex.org/W2092387745","https://openalex.org/W2094280270","https://openalex.org/W2106072678","https://openalex.org/W2109099165","https://openalex.org/W2110057983","https://openalex.org/W2110803021","https://openalex.org/W2113307443","https://openalex.org/W2115150990","https://openalex.org/W2118025286","https://openalex.org/W2120772039","https://openalex.org/W2126841263","https://openalex.org/W2132439221","https://openalex.org/W2133757455","https://openalex.org/W2137464714","https://openalex.org/W2150317682","https://openalex.org/W2156571424","https://openalex.org/W2163181687","https://openalex.org/W2167188257","https://openalex.org/W2168770561","https://openalex.org/W4210241463","https://openalex.org/W4239530205"],"related_works":["https://openalex.org/W2419656700","https://openalex.org/W4247531298","https://openalex.org/W4252569736","https://openalex.org/W4233148870","https://openalex.org/W2081033912","https://openalex.org/W1966529741","https://openalex.org/W2085543450","https://openalex.org/W2021226373","https://openalex.org/W3087473412","https://openalex.org/W1999503228"],"abstract_inverted_index":{"Evolutionary":[0],"conservation":[1],"of":[2,23,98,157],"protein":[3,71],"interaction":[4],"properties":[5],"has":[6],"been":[7],"shown":[8],"to":[9,54,147],"be":[10],"a":[11,83],"valuable":[12],"indication":[13],"for":[14,129,135],"functional":[15],"importance.":[16],"Here":[17],"we":[18,77],"use":[19],"homology":[20],"interface":[21],"modeling":[22],"10":[24],"Ras-effector":[25,88,141],"complexes":[26],"by":[27,69],"selecting":[28],"ortholog":[29],"proteins":[30],"from":[31],"12":[32],"organisms":[33],"representing":[34],"the":[35,48,55,59,70,96,119],"major":[36],"eukaryotic":[37],"branches,":[38],"except":[39],"plants.":[40],"We":[41],"find":[42],"that":[43,94,104],"with":[44,52,118],"increasing":[45],"divergence":[46],"time":[47],"sequence":[49],"similarity":[50],"decreases":[51],"respect":[53],"human":[56],"protein,":[57],"but":[58,133],"affinities":[60],"and":[61,90,155],"association":[62],"rate":[63],"constants":[64,109,132],"are":[65,145],"conserved":[66],"as":[67],"predicted":[68],"design":[72],"algorithm,":[73],"FoldX.":[74],"In":[75],"parallel":[76],"have":[78,110],"done":[79],"computer":[80],"simulations":[81,156],"on":[82,87,113],"minimal":[84],"network":[85,114],"based":[86],"interactions,":[89],"our":[91],"results":[92],"indicate":[93],"in":[95,102,106,137,151],"absence":[97],"negative":[99],"feedback,":[100],"changes":[101],"kinetics":[103,136],"result":[105],"similar":[107],"binding":[108,131],"strong":[111],"consequences":[112],"behavior.":[115],"This,":[116],"together":[117],"previous":[120],"results,":[121],"suggests":[122],"an":[123],"important":[124,146],"biological":[125,158],"role,":[126],"not":[127],"only":[128],"equilibrium":[130],"also":[134],"signaling":[138],"processes":[139],"involving":[140],"interactions.":[142],"Our":[143],"findings":[144],"take":[148],"into":[149],"consideration":[150],"system":[152],"biology":[153],"approaches":[154],"networks.":[159]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}