{"id":"https://openalex.org/W2018751529","doi":"https://doi.org/10.1371/journal.pcbi.1000242","title":"Dependence of Bacterial Chemotaxis on Gradient Shape and Adaptation Rate","display_name":"Dependence of Bacterial Chemotaxis on Gradient Shape and Adaptation Rate","publication_year":2008,"publication_date":"2008-12-18","ids":{"openalex":"https://openalex.org/W2018751529","doi":"https://doi.org/10.1371/journal.pcbi.1000242","mag":"2018751529","pmid":"https://pubmed.ncbi.nlm.nih.gov/19096502"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000242","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000242","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000242&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000242&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078478374","display_name":"Nikita Vladimirov","orcid":"https://orcid.org/0000-0002-1159-0689"},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210124050","display_name":"Forschungsst\u00e4tte der Evangelischen Studiengemeinschaft","ror":"https://ror.org/02yh57h22","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210124050"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Nikita Vladimirov","raw_affiliation_strings":["Interdisziplin\u00e4res Zentrum f\u00fcr Wissenschaftliches Rechnen, University of Heidelberg, Heidelberg, Germany. nikita.vladimirov@gmail.com","Interdisziplin\u00e4res Zentrum f\u00fcr Wissenschaftliches Rechnen (IWR), University of Heidelberg, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Interdisziplin\u00e4res Zentrum f\u00fcr Wissenschaftliches Rechnen, University of Heidelberg, Heidelberg, Germany. nikita.vladimirov@gmail.com","institution_ids":["https://openalex.org/I4210124050","https://openalex.org/I223822909"]},{"raw_affiliation_string":"Interdisziplin\u00e4res Zentrum f\u00fcr Wissenschaftliches Rechnen (IWR), University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210124050","https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044069909","display_name":"Linda L\u00f8vdok","orcid":null},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Linda L\u00f8vdok","raw_affiliation_strings":["Zentrum f\u00fcr Molekulare Biologie (ZMBH), University of Heidelberg, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Zentrum f\u00fcr Molekulare Biologie (ZMBH), University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005776108","display_name":"Dirk Lebiedz","orcid":"https://orcid.org/0000-0002-2605-589X"},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dirk Lebiedz","raw_affiliation_strings":["Zentrum f\u00fcr Biosystemanalyse (ZBSA), University of Freiburg, Freiburg, Germany","Zentrum f\u00fcr Biosystemanalyse ZBSA, University of Freiburg Freiburg Germany"],"affiliations":[{"raw_affiliation_string":"Zentrum f\u00fcr Biosystemanalyse (ZBSA), University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Zentrum f\u00fcr Biosystemanalyse ZBSA, University of Freiburg Freiburg Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039785599","display_name":"Victor Sourjik","orcid":"https://orcid.org/0000-0003-1053-9192"},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Victor Sourjik","raw_affiliation_strings":["Zentrum f\u00fcr Molekulare Biologie (ZMBH), University of Heidelberg, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Zentrum f\u00fcr Molekulare Biologie (ZMBH), University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5078478374"],"corresponding_institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4210124050"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":4.745,"has_fulltext":true,"cited_by_count":118,"citation_normalized_percentile":{"value":0.94713078,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"4","issue":"12","first_page":"e1000242","last_page":"e1000242"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13052","display_name":"Molecular Communication and Nanonetworks","score":0.9958999752998352,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13052","display_name":"Molecular Communication and Nanonetworks","score":0.9958999752998352,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13362","display_name":"Slime Mold and Myxomycetes Research","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemotaxis","display_name":"Chemotaxis","score":0.9658728837966919},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.6265931129455566},{"id":"https://openalex.org/keywords/adaptation","display_name":"Adaptation (eye)","score":0.6075090169906616},{"id":"https://openalex.org/keywords/range","display_name":"Range (aeronautics)","score":0.541351318359375},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.44595223665237427},{"id":"https://openalex.org/keywords/electrochemical-gradient","display_name":"Electrochemical gradient","score":0.4386579096317291},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.38635796308517456},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.3481060862541199},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.33610352873802185},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.1763632893562317},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.13420629501342773},{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.13402840495109558},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1285019814968109},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.12310940027236938}],"concepts":[{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.9658728837966919},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.6265931129455566},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.6075090169906616},{"id":"https://openalex.org/C204323151","wikidata":"https://www.wikidata.org/wiki/Q905424","display_name":"Range (aeronautics)","level":2,"score":0.541351318359375},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.44595223665237427},{"id":"https://openalex.org/C90424259","wikidata":"https://www.wikidata.org/wiki/Q211026","display_name":"Electrochemical gradient","level":3,"score":0.4386579096317291},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38635796308517456},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3481060862541199},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33610352873802185},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.1763632893562317},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.13420629501342773},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.13402840495109558},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1285019814968109},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12310940027236938},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1000242","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000242","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000242&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:19096502","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19096502","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1000242","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1000242","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:152a31d2199648e1bf38e4254dbb9e08","is_oa":true,"landing_page_url":"https://doaj.org/article/152a31d2199648e1bf38e4254dbb9e08","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 4, Iss 12, p e1000242 (2008)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/148994","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Dependence_of_Bacterial_Chemotaxis_on_Gradient_Shape_and_Adaptation_Rate/148994","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:2588534","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2588534","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000242","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000242","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000242&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2018751529.pdf","grobid_xml":"https://content.openalex.org/works/W2018751529.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W84845582","https://openalex.org/W1596062696","https://openalex.org/W1637936532","https://openalex.org/W1889950964","https://openalex.org/W1963772282","https://openalex.org/W1964513612","https://openalex.org/W1972851868","https://openalex.org/W1976368335","https://openalex.org/W1979493558","https://openalex.org/W1983248089","https://openalex.org/W1987129107","https://openalex.org/W1992717202","https://openalex.org/W1993762267","https://openalex.org/W1994106464","https://openalex.org/W1998312155","https://openalex.org/W2000329555","https://openalex.org/W2007500238","https://openalex.org/W2026078372","https://openalex.org/W2029511738","https://openalex.org/W2033572662","https://openalex.org/W2034008520","https://openalex.org/W2038503726","https://openalex.org/W2040244503","https://openalex.org/W2047614519","https://openalex.org/W2048000994","https://openalex.org/W2054398867","https://openalex.org/W2058681208","https://openalex.org/W2060605538","https://openalex.org/W2071526531","https://openalex.org/W2074759798","https://openalex.org/W2077919298","https://openalex.org/W2079445816","https://openalex.org/W2079936039","https://openalex.org/W2084559690","https://openalex.org/W2091926965","https://openalex.org/W2092738963","https://openalex.org/W2095595785","https://openalex.org/W2096515244","https://openalex.org/W2104966407","https://openalex.org/W2108445040","https://openalex.org/W2111361043","https://openalex.org/W2111489775","https://openalex.org/W2111682035","https://openalex.org/W2112682311","https://openalex.org/W2114368118","https://openalex.org/W2114668427","https://openalex.org/W2117056464","https://openalex.org/W2117594322","https://openalex.org/W2118753015","https://openalex.org/W2131704513","https://openalex.org/W2134452786","https://openalex.org/W2135249385","https://openalex.org/W2137567526","https://openalex.org/W2140838007","https://openalex.org/W2144736357","https://openalex.org/W2146851826","https://openalex.org/W2155465948","https://openalex.org/W2165395014","https://openalex.org/W3022347268","https://openalex.org/W6671503652"],"related_works":["https://openalex.org/W1596865785","https://openalex.org/W2085357479","https://openalex.org/W2417007386","https://openalex.org/W1993973863","https://openalex.org/W2388783242","https://openalex.org/W1135436615","https://openalex.org/W2975251372","https://openalex.org/W2313472050","https://openalex.org/W2015038634","https://openalex.org/W2147110523"],"abstract_inverted_index":{"Simulation":[0],"of":[1,26,44,70,85,105,112,119,133,139,149,197,232],"cellular":[2],"behavior":[3,111],"on":[4],"multiple":[5],"scales":[6],"requires":[7],"models":[8],"that":[9,48,124,156,179,199],"are":[10],"sufficiently":[11],"detailed":[12,68],"to":[13,93,107,170,194,216],"capture":[14],"central":[15],"intracellular":[16],"processes":[17],"but":[18],"at":[19],"the":[20,24,50,58,81,91,116,140,146,157,166,172,183,239],"same":[21],"time":[22],"enable":[23],"simulation":[25,84],"entire":[27],"cell":[28,71],"populations":[29],"in":[30,96,129,180,185,204,208],"a":[31,41,67,101,130,209],"computationally":[32],"cheap":[33],"way.":[34],"In":[35],"this":[36,120],"paper":[37],"we":[38,122],"present":[39],"RapidCell,":[40],"hybrid":[42],"model":[43,69,74,92],"chemotactic":[45,110,162],"Escherichia":[46],"coli":[47,87],"combines":[49],"Monod-Wyman-Changeux":[51],"signal":[52],"processing":[53],"by":[54,62,164],"mixed":[55],"chemoreceptor":[56],"clusters,":[57],"adaptation":[59,186,233],"dynamics":[60],"described":[61],"ordinary":[63],"differential":[64],"equations,":[65],"and":[66,79,99],"tumbling.":[72],"Our":[73,152,176],"dramatically":[75],"reduces":[76],"computational":[77],"costs":[78],"allows":[80],"highly":[82],"efficient":[83],"E.":[86],"chemotaxis.":[88],"We":[89],"use":[90],"investigate":[94],"chemotaxis":[95,126],"different":[97,205],"gradients,":[98],"suggest":[100,178],"new,":[102],"constant-activity":[103],"type":[104],"gradient":[106],"systematically":[108],"study":[109],"virtual":[113],"bacteria.":[114],"Using":[115],"unique":[117],"properties":[118],"gradient,":[121],"show":[123],"optimal":[125],"is":[127,236],"observed":[128],"narrow":[131],"range":[132,148],"CheA":[134],"kinase":[135],"activity,":[136],"where":[137],"concentration":[138,169],"response":[141],"regulator":[142],"CheY-P":[143,168],"falls":[144],"into":[145],"operating":[147,174],"flagellar":[150],"motors.":[151],"simulations":[153],"also":[154],"confirm":[155],"CheB":[158],"phosphorylation":[159],"feedback":[160],"improves":[161],"efficiency":[163],"shifting":[165],"average":[167],"fit":[171],"motor":[173],"range.":[175],"results":[177],"liquid":[181],"media":[182],"variability":[184,214],"times":[187],"among":[188],"cells":[189],"may":[190],"be":[191,201,217],"evolutionary":[192],"favorable":[193],"ensure":[195],"coexistence":[196],"subpopulations":[198,228],"will":[200],"optimally":[202],"tactic":[203],"gradients.":[206],"However,":[207],"porous":[210],"medium":[211],"(agar)":[212],"such":[213],"appears":[215],"less":[218],"important,":[219],"because":[220],"agar":[221],"structure":[222],"poses":[223],"mainly":[224],"negative":[225],"selection":[226],"against":[227],"with":[229],"low":[230],"levels":[231],"enzymes.":[234],"RapidCell":[235],"available":[237],"from":[238],"authors":[240],"upon":[241],"request.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}