{"id":"https://openalex.org/W2132188964","doi":"https://doi.org/10.1371/journal.pcbi.1000238","title":"Formation and Growth of Oligomers: A Monte Carlo Study of an Amyloid Tau Fragment","display_name":"Formation and Growth of Oligomers: A Monte Carlo Study of an Amyloid Tau Fragment","publication_year":2008,"publication_date":"2008-12-04","ids":{"openalex":"https://openalex.org/W2132188964","doi":"https://doi.org/10.1371/journal.pcbi.1000238","mag":"2132188964","pmid":"https://pubmed.ncbi.nlm.nih.gov/19057640"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000238","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000238","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000238&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000238&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100324949","display_name":"Dawei Li","orcid":"https://orcid.org/0000-0002-3266-5272"},"institutions":[{"id":"https://openalex.org/I130785548","display_name":"Clark University","ror":"https://ror.org/04123ky43","country_code":"US","type":"education","lineage":["https://openalex.org/I130785548"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Da-Wei Li","raw_affiliation_strings":["Gustaf H Carlson School of Chemistry and Biochemistry, Clark University, Worcester, Massachusetts, United States of America","Gustaf H. Carlson School of Chemistry and Biochemistry, Clark University, Worcester, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Gustaf H Carlson School of Chemistry and Biochemistry, Clark University, Worcester, Massachusetts, United States of America","institution_ids":[]},{"raw_affiliation_string":"Gustaf H. Carlson School of Chemistry and Biochemistry, Clark University, Worcester, Massachusetts, United States of America","institution_ids":["https://openalex.org/I130785548"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089826765","display_name":"Sandipan Mohanty","orcid":"https://orcid.org/0000-0001-9822-427X"},"institutions":[{"id":"https://openalex.org/I4210113364","display_name":"John von Neumann Institute for Computing","ror":"https://ror.org/02zmk8084","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I1305996414","https://openalex.org/I1305996414","https://openalex.org/I169556180","https://openalex.org/I171892758","https://openalex.org/I2801876189","https://openalex.org/I4210113364"]},{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sandipan Mohanty","raw_affiliation_strings":["John von Neumann Institut f\u00fcr Computing, Forschungszentrum J\u00fclich, J\u00fclich, Germany"],"affiliations":[{"raw_affiliation_string":"John von Neumann Institut f\u00fcr Computing, Forschungszentrum J\u00fclich, J\u00fclich, Germany","institution_ids":["https://openalex.org/I4210113364","https://openalex.org/I171892758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060442147","display_name":"Anders Irb\u00e4ck","orcid":"https://orcid.org/0000-0003-1384-0626"},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Anders Irb\u00e4ck","raw_affiliation_strings":["Computational Biology and Biological Physics Division, Department of Theoretical Physics, Lund University, Lund, Sweden"],"affiliations":[{"raw_affiliation_string":"Computational Biology and Biological Physics Division, Department of Theoretical Physics, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032769652","display_name":"Shuanghong Huo","orcid":"https://orcid.org/0000-0002-2196-0858"},"institutions":[{"id":"https://openalex.org/I130785548","display_name":"Clark University","ror":"https://ror.org/04123ky43","country_code":"US","type":"education","lineage":["https://openalex.org/I130785548"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shuanghong Huo","raw_affiliation_strings":["Gustaf H. Carlson School of Chemistry and Biochemistry, Clark University, Worcester, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Gustaf H. Carlson School of Chemistry and Biochemistry, Clark University, Worcester, Massachusetts, United States of America","institution_ids":["https://openalex.org/I130785548"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5032769652","https://openalex.org/A5060442147"],"corresponding_institution_ids":["https://openalex.org/I130785548","https://openalex.org/I187531555"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":5.0097,"has_fulltext":true,"cited_by_count":115,"citation_normalized_percentile":{"value":0.95726125,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"4","issue":"12","first_page":"e1000238","last_page":"e1000238"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11152","display_name":"Stochastic processes and statistical mechanics","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2610","display_name":"Mathematical Physics"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antiparallel","display_name":"Antiparallel (mathematics)","score":0.6872082948684692},{"id":"https://openalex.org/keywords/zipper","display_name":"Zipper","score":0.6465151309967041},{"id":"https://openalex.org/keywords/beta-sheet","display_name":"Beta sheet","score":0.5614911913871765},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5441017150878906},{"id":"https://openalex.org/keywords/amyloid-fibril","display_name":"Amyloid fibril","score":0.5291391015052795},{"id":"https://openalex.org/keywords/steric-effects","display_name":"Steric effects","score":0.5194570422172546},{"id":"https://openalex.org/keywords/crystallography","display_name":"Crystallography","score":0.5109359622001648},{"id":"https://openalex.org/keywords/monte-carlo-method","display_name":"Monte Carlo method","score":0.4808812439441681},{"id":"https://openalex.org/keywords/fibril","display_name":"Fibril","score":0.4782744348049164},{"id":"https://openalex.org/keywords/nucleation","display_name":"Nucleation","score":0.433610200881958},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.3686993420124054},{"id":"https://openalex.org/keywords/chemical-physics","display_name":"Chemical physics","score":0.35984930396080017},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.34351205825805664},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.30943769216537476},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.2512213885784149},{"id":"https://openalex.org/keywords/amyloid-\u03b2","display_name":"Amyloid \u03b2","score":0.12140470743179321},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.11708280444145203},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.10405877232551575}],"concepts":[{"id":"https://openalex.org/C142089489","wikidata":"https://www.wikidata.org/wiki/Q1053976","display_name":"Antiparallel (mathematics)","level":3,"score":0.6872082948684692},{"id":"https://openalex.org/C105782903","wikidata":"https://www.wikidata.org/wiki/Q6577686","display_name":"Zipper","level":2,"score":0.6465151309967041},{"id":"https://openalex.org/C159547669","wikidata":"https://www.wikidata.org/wiki/Q283449","display_name":"Beta sheet","level":3,"score":0.5614911913871765},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5441017150878906},{"id":"https://openalex.org/C2994168385","wikidata":"https://www.wikidata.org/wiki/Q6740853","display_name":"Amyloid fibril","level":4,"score":0.5291391015052795},{"id":"https://openalex.org/C201194858","wikidata":"https://www.wikidata.org/wiki/Q898238","display_name":"Steric effects","level":2,"score":0.5194570422172546},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.5109359622001648},{"id":"https://openalex.org/C19499675","wikidata":"https://www.wikidata.org/wiki/Q232207","display_name":"Monte Carlo method","level":2,"score":0.4808812439441681},{"id":"https://openalex.org/C27523624","wikidata":"https://www.wikidata.org/wiki/Q14860849","display_name":"Fibril","level":2,"score":0.4782744348049164},{"id":"https://openalex.org/C61048295","wikidata":"https://www.wikidata.org/wiki/Q909022","display_name":"Nucleation","level":2,"score":0.433610200881958},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3686993420124054},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.35984930396080017},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.34351205825805664},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.30943769216537476},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.2512213885784149},{"id":"https://openalex.org/C3019447875","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid \u03b2","level":3,"score":0.12140470743179321},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.11708280444145203},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10405877232551575},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C115260700","wikidata":"https://www.wikidata.org/wiki/Q11408","display_name":"Magnetic field","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1000238","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000238","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000238&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:19057640","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19057640","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1000238","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1000238","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:commons.clarku.edu:chemistry-1101","is_oa":false,"landing_page_url":"https://commons.clarku.edu/chemistry/102","pdf_url":null,"source":{"id":"https://openalex.org/S4377196688","display_name":"Clark Digital Commons (Clark University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I130785548","host_organization_name":"Clark University","host_organization_lineage":["https://openalex.org/I130785548"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Chemistry","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:a99974b7d147484ab29b68aa168ad2fb","is_oa":true,"landing_page_url":"https://doaj.org/article/a99974b7d147484ab29b68aa168ad2fb","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 4, Iss 12, p e1000238 (2008)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/148954","is_oa":true,"landing_page_url":"https://figshare.com/articles/figure/Formation_and_Growth_of_Oligomers_A_Monte_Carlo_Study_of_an_Amyloid_Tau_Fragment/148954","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Image"},{"id":"pmh:oai:lup.lub.lu.se:ba7949df-31b7-4eb8-bcf0-f072a82ec63e","is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/1375169","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1553-7358","raw_type":"text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2583953","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2583953","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000238","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000238","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000238&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","score":0.6000000238418579,"id":"https://metadata.un.org/sdg/15"}],"awards":[{"id":"https://openalex.org/G5164035260","display_name":"Acquisition of a High Performance Parallel Computing Cluster for the Departments of Biology, Chemistry, Physics, and Mathematics and Computer Science at Clark University","funder_award_id":"0320875","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G848032724","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320332622","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2132188964.pdf","grobid_xml":"https://content.openalex.org/works/W2132188964.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W6777002","https://openalex.org/W653885821","https://openalex.org/W1964807023","https://openalex.org/W1965153954","https://openalex.org/W1965650805","https://openalex.org/W1965906560","https://openalex.org/W1971280976","https://openalex.org/W1972095648","https://openalex.org/W1978548150","https://openalex.org/W1978959047","https://openalex.org/W1981492171","https://openalex.org/W1992556206","https://openalex.org/W2002930710","https://openalex.org/W2010925911","https://openalex.org/W2018358224","https://openalex.org/W2020353121","https://openalex.org/W2022323132","https://openalex.org/W2022417585","https://openalex.org/W2028869988","https://openalex.org/W2030837263","https://openalex.org/W2035001102","https://openalex.org/W2035808421","https://openalex.org/W2035891349","https://openalex.org/W2037324314","https://openalex.org/W2037346440","https://openalex.org/W2039018328","https://openalex.org/W2043580674","https://openalex.org/W2046331206","https://openalex.org/W2048221161","https://openalex.org/W2049535318","https://openalex.org/W2051896853","https://openalex.org/W2057839591","https://openalex.org/W2062593465","https://openalex.org/W2063479157","https://openalex.org/W2063826033","https://openalex.org/W2064959295","https://openalex.org/W2067214887","https://openalex.org/W2068334126","https://openalex.org/W2071036069","https://openalex.org/W2074255526","https://openalex.org/W2080182899","https://openalex.org/W2082680257","https://openalex.org/W2088865014","https://openalex.org/W2089836617","https://openalex.org/W2101614182","https://openalex.org/W2104034347","https://openalex.org/W2105277973","https://openalex.org/W2108880064","https://openalex.org/W2109313436","https://openalex.org/W2113403117","https://openalex.org/W2117537971","https://openalex.org/W2117595572","https://openalex.org/W2123733934","https://openalex.org/W2126739134","https://openalex.org/W2128121742","https://openalex.org/W2128932095","https://openalex.org/W2131288855","https://openalex.org/W2132629607","https://openalex.org/W2135154912","https://openalex.org/W2135309154","https://openalex.org/W2137373119","https://openalex.org/W2140315476","https://openalex.org/W2140631432","https://openalex.org/W2142366168","https://openalex.org/W2143264455","https://openalex.org/W2150109193","https://openalex.org/W2153323361","https://openalex.org/W2154133125","https://openalex.org/W2155073864","https://openalex.org/W2161668221","https://openalex.org/W2164689497","https://openalex.org/W2171268876","https://openalex.org/W2291395437","https://openalex.org/W3098405609","https://openalex.org/W6645719494","https://openalex.org/W6828658795"],"related_works":["https://openalex.org/W2951937371","https://openalex.org/W2313505153","https://openalex.org/W2011433843","https://openalex.org/W2770601688","https://openalex.org/W1970329518","https://openalex.org/W1930638136","https://openalex.org/W2224361171","https://openalex.org/W4296459802","https://openalex.org/W1986183791","https://openalex.org/W1997916178"],"abstract_inverted_index":{"Small":[0],"oligomers":[1,93,119],"formed":[2],"early":[3,23],"in":[4,17,98,100,127,134,183,217],"the":[5,13,22,29,71,112,117,122,125,128,153,161,179,191,204,207,218],"process":[6],"of":[7,25,45,53,63,109,116,124,140,193,206,220],"amyloid":[8,26],"fibril":[9],"formation":[10,219],"may":[11],"be":[12],"major":[14],"toxic":[15],"species":[16],"Alzheimer's":[18],"disease.":[19],"We":[20,201],"investigate":[21],"stages":[24],"aggregation":[27],"for":[28,166],"tau":[30],"fragment":[31],"AcPHF6":[32],"(Ac-VQIVYK-NH2)":[33],"using":[34],"an":[35,61,213],"implicit":[36],"solvent":[37],"all-atom":[38],"model":[39],"and":[40,48,58,67,77],"extensive":[41],"Monte":[42],"Carlo":[43],"simulations":[44,87,136],"12,":[46],"24,":[47],"36":[49],"chains.":[50],"A":[51],"variety":[52],"small":[54],"metastable":[55],"aggregates":[56,132],"form":[57],"dissolve":[59],"until":[60],"aggregate":[62,199],"a":[64,95,171],"critical":[65],"size":[66],"conformation":[68],"arises.":[69],"However,":[70],"stable":[72,118],"oligomers,":[73],"which":[74,101],"are":[75,82,137],"beta-sheet-rich":[76],"feature":[78],"many":[79],"hydrophobic":[80,149],"contacts,":[81],"not":[83],"always":[84],"growth-ready.":[85],"The":[86,130],"indicate":[88],"instead":[89],"that":[90,190,203],"these":[91],"supercritical":[92],"spend":[94],"lengthy":[96],"period":[97],"equilibrium":[99],"considerable":[102],"reorganization":[103,205],"takes":[104],"place":[105],"accompanied":[106],"by":[107],"exchange":[108],"chains":[110,151],"with":[111,121,148,160,198],"solution.":[113],"Growth":[114],"competence":[115],"correlates":[120],"alignment":[123],"strands":[126],"beta-sheets.":[129],"larger":[131],"seen":[133],"our":[135],"all":[138],"composed":[139],"two":[141],"twisted":[142],"beta-sheets,":[143],"packed":[144],"against":[145],"each":[146],"other":[147],"side":[150],"at":[152],"sheet-sheet":[154],"interface.":[155],"These":[156],"beta-sandwiches":[157],"show":[158],"similarities":[159],"proposed":[162],"steric":[163],"zipper":[164],"structure":[165,196],"PHF6":[167,221],"fibrils":[168],"but":[169],"have":[170],"mixed":[172],"parallel/antiparallel":[173],"beta-strand":[174],"organization":[175,181],"as":[176],"opposed":[177],"to":[178],"parallel":[180,194,210],"found":[182],"experiments":[184],"on":[185],"fibrils.":[186,222],"Interestingly,":[187],"we":[188],"find":[189],"fraction":[192],"beta-sheet":[195],"increases":[197],"size.":[200],"speculate":[202],"beta-sheets":[208],"into":[209],"ones":[211],"is":[212],"important":[214],"rate-limiting":[215],"step":[216]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":6}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}
