{"id":"https://openalex.org/W1977896825","doi":"https://doi.org/10.1371/journal.pcbi.1000229","title":"Behavioral Sequence Analysis Reveals a Novel Role for \u00df2* Nicotinic Receptors in Exploration","display_name":"Behavioral Sequence Analysis Reveals a Novel Role for \u00df2* Nicotinic Receptors in Exploration","publication_year":2008,"publication_date":"2008-11-20","ids":{"openalex":"https://openalex.org/W1977896825","doi":"https://doi.org/10.1371/journal.pcbi.1000229","mag":"1977896825","pmid":"https://pubmed.ncbi.nlm.nih.gov/19023420"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000229","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000229","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000229&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000229&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048348286","display_name":"Nicolas Maubourguet","orcid":null},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"funder","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nicolas Maubourguet","raw_affiliation_strings":["Unit\u00e9 Neurobiologie Int\u00e9grative des Syst\u00e8mes Cholinergiques, Institut Pasteur, Paris, France","Syst\u00e8mes Cholinergiques, Institut Pasteur, Paris, France","Unit\u00e9 Neurobiologie Int\u00e9grative des","CNRS, URA 2182, Paris, France"],"affiliations":[{"raw_affiliation_string":"Unit\u00e9 Neurobiologie Int\u00e9grative des Syst\u00e8mes Cholinergiques, Institut Pasteur, Paris, France","institution_ids":[]},{"raw_affiliation_string":"Syst\u00e8mes Cholinergiques, Institut Pasteur, Paris, France","institution_ids":["https://openalex.org/I157536573"]},{"raw_affiliation_string":"Unit\u00e9 Neurobiologie Int\u00e9grative des","institution_ids":[]},{"raw_affiliation_string":"CNRS, URA 2182, Paris, France","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068924391","display_name":"Annick Lesne","orcid":"https://orcid.org/0000-0002-6647-612X"},"institutions":[{"id":"https://openalex.org/I84909340","display_name":"Institut des Hautes \u00c9tudes Scientifiques","ror":"https://ror.org/05d5m2r55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I84909340"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Annick Lesne","raw_affiliation_strings":["France","Institut des Hautes Etudes Scientifiques, Bures-sur-Yvette"],"affiliations":[{"raw_affiliation_string":"France","institution_ids":[]},{"raw_affiliation_string":"Institut des Hautes Etudes Scientifiques, Bures-sur-Yvette","institution_ids":["https://openalex.org/I84909340"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056074308","display_name":"Jean\u2010Pierre Changeux","orcid":"https://orcid.org/0000-0003-0297-1583"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"funder","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Pierre Changeux","raw_affiliation_strings":["CNRS, URA 2182, Paris, France","Syst\u00e8mes Cholinergiques, Institut Pasteur, Paris, France","Unit\u00e9 Neurobiologie Int\u00e9grative des"],"affiliations":[{"raw_affiliation_string":"CNRS, URA 2182, Paris, France","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Syst\u00e8mes Cholinergiques, Institut Pasteur, Paris, France","institution_ids":["https://openalex.org/I157536573"]},{"raw_affiliation_string":"Unit\u00e9 Neurobiologie Int\u00e9grative des","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004984882","display_name":"Uwe Maskos","orcid":"https://orcid.org/0000-0002-2029-1437"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"funder","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Uwe Maskos","raw_affiliation_strings":["CNRS, URA 2182, Paris, France","Syst\u00e8mes Cholinergiques, Institut Pasteur, Paris, France","Unit\u00e9 Neurobiologie Int\u00e9grative des"],"affiliations":[{"raw_affiliation_string":"CNRS, URA 2182, Paris, France","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Syst\u00e8mes Cholinergiques, Institut Pasteur, Paris, France","institution_ids":["https://openalex.org/I157536573"]},{"raw_affiliation_string":"Unit\u00e9 Neurobiologie Int\u00e9grative des","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083411884","display_name":"Philippe Faur\u00e9","orcid":"https://orcid.org/0000-0003-3573-4971"},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"funder","lineage":["https://openalex.org/I157536573"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Philippe Faure","raw_affiliation_strings":["CNRS, URA 2182, Paris, France","Syst\u00e8mes Cholinergiques, Institut Pasteur, Paris, France","Unit\u00e9 Neurobiologie Int\u00e9grative des"],"affiliations":[{"raw_affiliation_string":"CNRS, URA 2182, Paris, France","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Syst\u00e8mes Cholinergiques, Institut Pasteur, Paris, France","institution_ids":["https://openalex.org/I157536573"]},{"raw_affiliation_string":"Unit\u00e9 Neurobiologie Int\u00e9grative des","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5083411884"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I157536573"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.5214,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.81067734,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"4","issue":"11","first_page":"e1000229","last_page":"e1000229"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.9934999942779541,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nicotinic-agonist","display_name":"Nicotinic agonist","score":0.6986271142959595},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.6728214025497437},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5482597351074219},{"id":"https://openalex.org/keywords/acetylcholine-receptor","display_name":"Acetylcholine receptor","score":0.5430670380592346},{"id":"https://openalex.org/keywords/open-field","display_name":"Open field","score":0.5011961460113525},{"id":"https://openalex.org/keywords/markov-chain","display_name":"Markov chain","score":0.4403524398803711},{"id":"https://openalex.org/keywords/animal-behavior","display_name":"Animal behavior","score":0.43178680539131165},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.4279170334339142},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.3916672170162201},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2481364905834198},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.23506107926368713},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.15114960074424744},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.08050903677940369}],"concepts":[{"id":"https://openalex.org/C188987157","wikidata":"https://www.wikidata.org/wiki/Q7030581","display_name":"Nicotinic agonist","level":3,"score":0.6986271142959595},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6728214025497437},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5482597351074219},{"id":"https://openalex.org/C80161118","wikidata":"https://www.wikidata.org/wiki/Q408520","display_name":"Acetylcholine receptor","level":3,"score":0.5430670380592346},{"id":"https://openalex.org/C2779085643","wikidata":"https://www.wikidata.org/wiki/Q7096029","display_name":"Open field","level":2,"score":0.5011961460113525},{"id":"https://openalex.org/C98763669","wikidata":"https://www.wikidata.org/wiki/Q176645","display_name":"Markov chain","level":2,"score":0.4403524398803711},{"id":"https://openalex.org/C2988419192","wikidata":"https://www.wikidata.org/wiki/Q7155","display_name":"Animal behavior","level":2,"score":0.43178680539131165},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.4279170334339142},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3916672170162201},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2481364905834198},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23506107926368713},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.15114960074424744},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.08050903677940369},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005106","descriptor_name":"Exploratory Behavior","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005106","descriptor_name":"Exploratory Behavior","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005106","descriptor_name":"Exploratory Behavior","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006948","descriptor_name":"Hyperkinesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006948","descriptor_name":"Hyperkinesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006948","descriptor_name":"Hyperkinesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006948","descriptor_name":"Hyperkinesis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006948","descriptor_name":"Hyperkinesis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006948","descriptor_name":"Hyperkinesis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011978","descriptor_name":"Receptors, Nicotinic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011978","descriptor_name":"Receptors, Nicotinic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011978","descriptor_name":"Receptors, Nicotinic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011978","descriptor_name":"Receptors, Nicotinic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011978","descriptor_name":"Receptors, Nicotinic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011978","descriptor_name":"Receptors, Nicotinic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1000229","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000229","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000229&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:19023420","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19023420","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.278.1884","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.278.1884","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/62/5e/PLoS_Comput_Biol_2008_Nov_21_4(11)_e1000229.tar.gz","raw_type":"text"},{"id":"pmh:oai:HAL:pasteur-02935825v1","is_oa":true,"landing_page_url":"https://pasteur.hal.science/pasteur-02935825","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 2008, 4 (11), pp.e1000229. ⟨10.1371/journal.pcbi.1000229⟩","raw_type":"Journal articles"},{"id":"pmh:oai:RePEc:plo:pcbi00:1000229","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1000229","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:f6609c2a1d1f4a59be12b5597be7567e","is_oa":true,"landing_page_url":"https://doaj.org/article/f6609c2a1d1f4a59be12b5597be7567e","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 4, Iss 11, p e1000229 (2008)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/149144","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Behavioral_Sequence_Analysis_Reveals_a_Novel_Role_for___2_Nicotinic_Receptors_in_Exploration/149144","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:2581917","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2581917","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000229","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000229","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000229&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","score":0.5099999904632568,"id":"https://metadata.un.org/sdg/15"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320314128","display_name":"Les Laboratories Pierre Fabre","ror":"https://ror.org/04hdhz511"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"},{"id":"https://openalex.org/F4320325146","display_name":"Fondation Gilbert Lagrue","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1977896825.pdf","grobid_xml":"https://content.openalex.org/works/W1977896825.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W28922975","https://openalex.org/W647835105","https://openalex.org/W921310561","https://openalex.org/W1544301323","https://openalex.org/W1601427241","https://openalex.org/W1980310405","https://openalex.org/W1987769158","https://openalex.org/W1998599409","https://openalex.org/W2001823787","https://openalex.org/W2007963312","https://openalex.org/W2008382653","https://openalex.org/W2011485152","https://openalex.org/W2018613404","https://openalex.org/W2034708714","https://openalex.org/W2037160791","https://openalex.org/W2038848082","https://openalex.org/W2049717607","https://openalex.org/W2052576760","https://openalex.org/W2052676925","https://openalex.org/W2059058839","https://openalex.org/W2066842569","https://openalex.org/W2073924899","https://openalex.org/W2076465923","https://openalex.org/W2078251463","https://openalex.org/W2083806108","https://openalex.org/W2095513262","https://openalex.org/W2096669041","https://openalex.org/W2112175160","https://openalex.org/W2127905906","https://openalex.org/W2141456252","https://openalex.org/W2141514928","https://openalex.org/W2141839856","https://openalex.org/W2146672066","https://openalex.org/W2148705571","https://openalex.org/W2170194206","https://openalex.org/W2174658526","https://openalex.org/W4234650687","https://openalex.org/W6601191805","https://openalex.org/W6680836837","https://openalex.org/W6685629913"],"related_works":["https://openalex.org/W2077339822","https://openalex.org/W2356169571","https://openalex.org/W1981881599","https://openalex.org/W4317639052","https://openalex.org/W3023630691","https://openalex.org/W1983993763","https://openalex.org/W1570361834","https://openalex.org/W3126718520","https://openalex.org/W2035238491","https://openalex.org/W3104583766"],"abstract_inverted_index":{"Nicotinic":[0],"acetylcholine":[1],"receptors":[2],"(nAChRs)":[3],"are":[4,90,113],"widely":[5],"expressed":[6],"throughout":[7],"the":[8,54,69,85,100,103,119,128,163,185,199,211],"central":[9],"nervous":[10],"system":[11],"and":[12,77,125,172,207],"modulate":[13],"neuronal":[14],"function":[15],"in":[16,48,68,121,152,162,175,190,218],"most":[17],"mammalian":[18],"brain":[19,205],"structures.":[20],"The":[21],"contribution":[22,200],"of":[23,56,65,102,105,118,135,160,184,187,201,216],"defined":[24],"nAChR":[25],"subunits":[26],"to":[27,34,45,168,177,203],"a":[28,62,116,145,191],"specific":[29,106,146],"behavior":[30,67],"is":[31,99,150],"thus":[32],"difficult":[33],"assess.":[35],"Mice":[36],"deleted":[37],"for":[38],"beta2-containing":[39],"nAChRs":[40,202],"(beta2-/-)":[41],"have":[42],"been":[43],"shown":[44],"be":[46],"hyperactive":[47],"an":[49,157,170,188],"open-field":[50],"paradigm,":[51],"without":[52,141],"determining":[53],"origin":[55],"this":[57,97],"hyperactivity.":[58],"We":[59],"here":[60],"develop":[61],"quantitative":[63],"description":[64,94],"mouse":[66],"open":[70],"field":[71],"based":[72],"upon":[73],"first":[74],"order":[75,176],"Markov":[76,80],"variable":[78],"length":[79],"chain":[81],"analysis":[82,183],"focusing":[83],"on":[84],"time-organized":[86],"sequence":[87,134],"that":[88,96,130,149,213],"behaviors":[89,136,217],"composed":[91],"of.":[92],"This":[93,181],"reveals":[95],"hyperactivity":[98],"consequence":[101],"absence":[104],"inactive":[107],"states":[108],"or":[109],"\"stops\".":[110],"These":[111],"stops":[112,140],"associated":[114],"with":[115,139],"scanning":[117],"environment":[120,171,193],"wild-type":[122],"mice":[123],"(WT),":[124],"they":[126],"affect":[127],"way":[129],"animals":[131,167],"organize":[132,178,214],"their":[133,179],"when":[137],"compared":[138],"scanning.":[142],"They":[143],"characterize":[144],"\"decision":[147],"moment\"":[148],"reduced":[151],"beta2-/-":[153],"mutant":[154],"mice,":[155],"suggesting":[156],"important":[158],"role":[159],"beta2-nAChRs":[161],"strategy":[164],"used":[165],"by":[166],"explore":[169],"collect":[173],"information":[174],"behavior.":[180],"integrated":[182],"displacement":[186],"animal":[189],"simple":[192],"offers":[194],"new":[195],"insights,":[196],"specifically":[197],"into":[198,210],"higher":[204],"functions":[206],"more":[208],"generally":[209],"principles":[212],"sequences":[215],"animals.":[219]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}