{"id":"https://openalex.org/W2080948989","doi":"https://doi.org/10.1371/journal.pcbi.1000215","title":"Biomedical Discovery Acceleration, with Applications to Craniofacial Development","display_name":"Biomedical Discovery Acceleration, with Applications to Craniofacial Development","publication_year":2009,"publication_date":"2009-03-26","ids":{"openalex":"https://openalex.org/W2080948989","doi":"https://doi.org/10.1371/journal.pcbi.1000215","mag":"2080948989","pmid":"https://pubmed.ncbi.nlm.nih.gov/19325874"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000215","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000215","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000215&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000215&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041931115","display_name":"Sonia M. Leach","orcid":"https://orcid.org/0000-0003-2910-069X"},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sonia M. Leach","raw_affiliation_strings":["Center for Computational Pharmacology, University of Colorado at Denver, Denver, Colorado, USA","Center for Computational Pharmacology, University of Colorado at Denver,#N#                    Denver, Colorado, United States of America"],"affiliations":[{"raw_affiliation_string":"Center for Computational Pharmacology, University of Colorado at Denver, Denver, Colorado, USA","institution_ids":[]},{"raw_affiliation_string":"Center for Computational Pharmacology, University of Colorado at Denver,#N#                    Denver, Colorado, United States of America","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035290539","display_name":"Hannah Tipney","orcid":null},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]},{"id":"https://openalex.org/I4210147635","display_name":"Denver School of Nursing","ror":"https://ror.org/043j8fa20","country_code":"US","type":"education","lineage":["https://openalex.org/I4210147635"]},{"id":"https://openalex.org/I131651094","display_name":"University of Denver","ror":"https://ror.org/04w7skc03","country_code":"US","type":"education","lineage":["https://openalex.org/I131651094"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hannah Tipney","raw_affiliation_strings":["Center for Computational Pharmacology, University of Colorado at Denver","Denver, Colorado, United States of America","Center for Computational Pharmacology, University of Colorado at Denver,#N#                    Denver, Colorado, United States of America"],"affiliations":[{"raw_affiliation_string":"Center for Computational Pharmacology, University of Colorado at Denver","institution_ids":["https://openalex.org/I921990950","https://openalex.org/I131651094"]},{"raw_affiliation_string":"Denver, Colorado, United States of America","institution_ids":["https://openalex.org/I4210147635"]},{"raw_affiliation_string":"Center for Computational Pharmacology, University of Colorado at Denver,#N#                    Denver, Colorado, United States of America","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011099905","display_name":"Weiguo Feng","orcid":"https://orcid.org/0000-0003-1366-9208"},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]},{"id":"https://openalex.org/I4210147635","display_name":"Denver School of Nursing","ror":"https://ror.org/043j8fa20","country_code":"US","type":"education","lineage":["https://openalex.org/I4210147635"]},{"id":"https://openalex.org/I131651094","display_name":"University of Denver","ror":"https://ror.org/04w7skc03","country_code":"US","type":"education","lineage":["https://openalex.org/I131651094"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weiguo Feng","raw_affiliation_strings":["Denver, Colorado, United States of America","Department of Craniofacial Biology, University of Colorado at Denver","Department of Craniofacial Biology, University of Colorado at Denver, Denver, Colorado, United States of America"],"affiliations":[{"raw_affiliation_string":"Denver, Colorado, United States of America","institution_ids":["https://openalex.org/I4210147635"]},{"raw_affiliation_string":"Department of Craniofacial Biology, University of Colorado at Denver","institution_ids":["https://openalex.org/I131651094","https://openalex.org/I921990950"]},{"raw_affiliation_string":"Department of Craniofacial Biology, University of Colorado at Denver, Denver, Colorado, United States of America","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111881812","display_name":"William A. Baumgartner","orcid":null},"institutions":[{"id":"https://openalex.org/I131651094","display_name":"University of Denver","ror":"https://ror.org/04w7skc03","country_code":"US","type":"education","lineage":["https://openalex.org/I131651094"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]},{"id":"https://openalex.org/I4210147635","display_name":"Denver School of Nursing","ror":"https://ror.org/043j8fa20","country_code":"US","type":"education","lineage":["https://openalex.org/I4210147635"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William A. Baumgartner","raw_affiliation_strings":["Center for Computational Pharmacology, University of Colorado at Denver","Denver, Colorado, United States of America","Center for Computational Pharmacology, University of Colorado at Denver,#N#                    Denver, Colorado, United States of America"],"affiliations":[{"raw_affiliation_string":"Center for Computational Pharmacology, University of Colorado at Denver","institution_ids":["https://openalex.org/I921990950","https://openalex.org/I131651094"]},{"raw_affiliation_string":"Denver, Colorado, United States of America","institution_ids":["https://openalex.org/I4210147635"]},{"raw_affiliation_string":"Center for Computational Pharmacology, University of Colorado at Denver,#N#                    Denver, Colorado, United States of America","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028996976","display_name":"Priyanka Kasliwal","orcid":null},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]},{"id":"https://openalex.org/I131651094","display_name":"University of Denver","ror":"https://ror.org/04w7skc03","country_code":"US","type":"education","lineage":["https://openalex.org/I131651094"]},{"id":"https://openalex.org/I4210147635","display_name":"Denver School of Nursing","ror":"https://ror.org/043j8fa20","country_code":"US","type":"education","lineage":["https://openalex.org/I4210147635"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priyanka Kasliwal","raw_affiliation_strings":["Center for Computational Pharmacology, University of Colorado at Denver","Denver, Colorado, United States of America","Center for Computational Pharmacology, University of Colorado at Denver,#N#                    Denver, Colorado, United States of America"],"affiliations":[{"raw_affiliation_string":"Center for Computational Pharmacology, University of Colorado at Denver","institution_ids":["https://openalex.org/I921990950","https://openalex.org/I131651094"]},{"raw_affiliation_string":"Denver, Colorado, United States of America","institution_ids":["https://openalex.org/I4210147635"]},{"raw_affiliation_string":"Center for Computational Pharmacology, University of Colorado at Denver,#N#                    Denver, Colorado, United States of America","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065227462","display_name":"Ronald P. Schuyler","orcid":null},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]},{"id":"https://openalex.org/I131651094","display_name":"University of Denver","ror":"https://ror.org/04w7skc03","country_code":"US","type":"education","lineage":["https://openalex.org/I131651094"]},{"id":"https://openalex.org/I4210147635","display_name":"Denver School of Nursing","ror":"https://ror.org/043j8fa20","country_code":"US","type":"education","lineage":["https://openalex.org/I4210147635"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald P. Schuyler","raw_affiliation_strings":["Center for Computational Pharmacology, University of Colorado at Denver","Denver, Colorado, United States of America","Center for Computational Pharmacology, University of Colorado at Denver,#N#                    Denver, Colorado, United States of America"],"affiliations":[{"raw_affiliation_string":"Center for Computational Pharmacology, University of Colorado at Denver","institution_ids":["https://openalex.org/I921990950","https://openalex.org/I131651094"]},{"raw_affiliation_string":"Denver, Colorado, United States of America","institution_ids":["https://openalex.org/I4210147635"]},{"raw_affiliation_string":"Center for Computational Pharmacology, University of Colorado at Denver,#N#                    Denver, Colorado, United States of America","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046719540","display_name":"Trevor Williams","orcid":"https://orcid.org/0000-0002-2416-4603"},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]},{"id":"https://openalex.org/I4210147635","display_name":"Denver School of Nursing","ror":"https://ror.org/043j8fa20","country_code":"US","type":"education","lineage":["https://openalex.org/I4210147635"]},{"id":"https://openalex.org/I131651094","display_name":"University of Denver","ror":"https://ror.org/04w7skc03","country_code":"US","type":"education","lineage":["https://openalex.org/I131651094"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trevor Williams","raw_affiliation_strings":["Denver, Colorado, United States of America","Department of Craniofacial Biology, University of Colorado at Denver","Department of Craniofacial Biology, University of Colorado at Denver, Denver, Colorado, United States of America"],"affiliations":[{"raw_affiliation_string":"Denver, Colorado, United States of America","institution_ids":["https://openalex.org/I4210147635"]},{"raw_affiliation_string":"Department of Craniofacial Biology, University of Colorado at Denver","institution_ids":["https://openalex.org/I131651094","https://openalex.org/I921990950"]},{"raw_affiliation_string":"Department of Craniofacial Biology, University of Colorado at Denver, Denver, Colorado, United States of America","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079793510","display_name":"Richard A. Spritz","orcid":"https://orcid.org/0000-0002-8325-0026"},"institutions":[{"id":"https://openalex.org/I2801983979","display_name":"Denver Health Medical Center","ror":"https://ror.org/01fbz6h17","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801983979"]},{"id":"https://openalex.org/I2800421839","display_name":"Government of the United States of America","ror":"https://ror.org/02rcrvv70","country_code":"US","type":"government","lineage":["https://openalex.org/I2800421839"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard A. Spritz","raw_affiliation_strings":["Colorado, United States of America","Human Medical Genetics Program, University of Colorado at Denver, Denver","Human Medical Genetics Program, University of Colorado at Denver, Denver,#N#                    Colorado, United States of America"],"affiliations":[{"raw_affiliation_string":"Colorado, United States of America","institution_ids":["https://openalex.org/I2800421839"]},{"raw_affiliation_string":"Human Medical Genetics Program, University of Colorado at Denver, Denver","institution_ids":["https://openalex.org/I921990950","https://openalex.org/I2801983979"]},{"raw_affiliation_string":"Human Medical Genetics Program, University of Colorado at Denver, Denver,#N#                    Colorado, United States of America","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041860080","display_name":"Lawrence Hunter","orcid":"https://orcid.org/0000-0003-1455-3370"},"institutions":[{"id":"https://openalex.org/I4210147635","display_name":"Denver School of Nursing","ror":"https://ror.org/043j8fa20","country_code":"US","type":"education","lineage":["https://openalex.org/I4210147635"]},{"id":"https://openalex.org/I131651094","display_name":"University of Denver","ror":"https://ror.org/04w7skc03","country_code":"US","type":"education","lineage":["https://openalex.org/I131651094"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lawrence Hunter","raw_affiliation_strings":["Center for Computational Pharmacology, University of Colorado at Denver","Denver, Colorado, United States of America","Center for Computational Pharmacology, University of Colorado at Denver,#N#                    Denver, Colorado, United States of America"],"affiliations":[{"raw_affiliation_string":"Center for Computational Pharmacology, University of Colorado at Denver","institution_ids":["https://openalex.org/I921990950","https://openalex.org/I131651094"]},{"raw_affiliation_string":"Denver, Colorado, United States of America","institution_ids":["https://openalex.org/I4210147635"]},{"raw_affiliation_string":"Center for Computational Pharmacology, University of Colorado at Denver,#N#                    Denver, Colorado, United States of America","institution_ids":["https://openalex.org/I921990950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5041860080"],"corresponding_institution_ids":["https://openalex.org/I131651094","https://openalex.org/I4210147635","https://openalex.org/I921990950"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":4.1789,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.94825474,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"5","issue":"3","first_page":"e1000215","last_page":"e1000215"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10215","display_name":"Semantic Web and Ontologies","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9922999739646912,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7584741115570068},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.597225546836853},{"id":"https://openalex.org/keywords/biomedicine","display_name":"Biomedicine","score":0.5835373401641846},{"id":"https://openalex.org/keywords/parsing","display_name":"Parsing","score":0.4953252375125885},{"id":"https://openalex.org/keywords/reading","display_name":"Reading (process)","score":0.47519123554229736},{"id":"https://openalex.org/keywords/ontology","display_name":"Ontology","score":0.4593003988265991},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.438950777053833},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.1740967333316803}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7584741115570068},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.597225546836853},{"id":"https://openalex.org/C66782513","wikidata":"https://www.wikidata.org/wiki/Q864601","display_name":"Biomedicine","level":2,"score":0.5835373401641846},{"id":"https://openalex.org/C186644900","wikidata":"https://www.wikidata.org/wiki/Q194152","display_name":"Parsing","level":2,"score":0.4953252375125885},{"id":"https://openalex.org/C554936623","wikidata":"https://www.wikidata.org/wiki/Q199657","display_name":"Reading (process)","level":2,"score":0.47519123554229736},{"id":"https://openalex.org/C25810664","wikidata":"https://www.wikidata.org/wiki/Q44325","display_name":"Ontology","level":2,"score":0.4593003988265991},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.438950777053833},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.1740967333316803},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003628","descriptor_name":"Database Management Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003628","descriptor_name":"Database Management Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003628","descriptor_name":"Database Management Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005147","descriptor_name":"Facial Bones","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005147","descriptor_name":"Facial Bones","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005147","descriptor_name":"Facial Bones","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009323","descriptor_name":"Natural Language Processing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009323","descriptor_name":"Natural Language Processing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009323","descriptor_name":"Natural Language Processing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010506","descriptor_name":"Periodicals as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010506","descriptor_name":"Periodicals as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010506","descriptor_name":"Periodicals as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1000215","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000215","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000215&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:19325874","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19325874","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.792.4590","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.792.4590","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/46/6e/pcbi.1000215.PMC2653649.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:ec376e5f2e2045d18f42ca99e9b6c126","is_oa":true,"landing_page_url":"https://doaj.org/article/ec376e5f2e2045d18f42ca99e9b6c126","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 5, Iss 3, p e1000215 (2009)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/148074","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Biomedical_Discovery_Acceleration_with_Applications_to_Craniofacial___Development/148074","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:2653649","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2653649","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000215","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000215","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000215&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/4","display_name":"Quality Education","score":0.8700000047683716}],"awards":[{"id":"https://openalex.org/G178714339","display_name":null,"funder_award_id":"R01LM008111","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2553168204","display_name":null,"funder_award_id":"LM008111","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3611247453","display_name":null,"funder_award_id":"R01GM","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3945006501","display_name":null,"funder_award_id":"R01LM009254","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5976505316","display_name":null,"funder_award_id":"LM009254","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7695772115","display_name":null,"funder_award_id":"T15LM009451","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2080948989.pdf","grobid_xml":"https://content.openalex.org/works/W2080948989.grobid-xml"},"referenced_works_count":134,"referenced_works":["https://openalex.org/W40043925","https://openalex.org/W194648445","https://openalex.org/W1503791187","https://openalex.org/W1533936090","https://openalex.org/W1699455313","https://openalex.org/W1713855780","https://openalex.org/W1717807258","https://openalex.org/W1964831428","https://openalex.org/W1972129511","https://openalex.org/W1976316416","https://openalex.org/W1981849389","https://openalex.org/W1982428412","https://openalex.org/W1985026339","https://openalex.org/W1985901090","https://openalex.org/W1987135115","https://openalex.org/W1988393300","https://openalex.org/W1994801829","https://openalex.org/W1997223407","https://openalex.org/W1999649023","https://openalex.org/W2000844908","https://openalex.org/W2003218308","https://openalex.org/W2004275727","https://openalex.org/W2007116888","https://openalex.org/W2009423481","https://openalex.org/W2012771329","https://openalex.org/W2015705446","https://openalex.org/W2016686483","https://openalex.org/W2017994420","https://openalex.org/W2020492692","https://openalex.org/W2023582775","https://openalex.org/W2024938717","https://openalex.org/W2027087614","https://openalex.org/W2028745546","https://openalex.org/W2029230311","https://openalex.org/W2030281188","https://openalex.org/W2035498588","https://openalex.org/W2035596890","https://openalex.org/W2038558459","https://openalex.org/W2043102950","https://openalex.org/W2044514479","https://openalex.org/W2046618236","https://openalex.org/W2047205327","https://openalex.org/W2049208901","https://openalex.org/W2049470741","https://openalex.org/W2052006582","https://openalex.org/W2053697317","https://openalex.org/W2053906518","https://openalex.org/W2054486613","https://openalex.org/W2058766645","https://openalex.org/W2062163602","https://openalex.org/W2070480084","https://openalex.org/W2071804523","https://openalex.org/W2079007492","https://openalex.org/W2079665010","https://openalex.org/W2080182143","https://openalex.org/W2080499750","https://openalex.org/W2083756787","https://openalex.org/W2087956002","https://openalex.org/W2090766471","https://openalex.org/W2096358531","https://openalex.org/W2097698606","https://openalex.org/W2097928951","https://openalex.org/W2099607215","https://openalex.org/W2101114811","https://openalex.org/W2101674614","https://openalex.org/W2101727078","https://openalex.org/W2101791034","https://openalex.org/W2102281458","https://openalex.org/W2102957091","https://openalex.org/W2103017472","https://openalex.org/W2108659514","https://openalex.org/W2109899437","https://openalex.org/W2111193511","https://openalex.org/W2111755036","https://openalex.org/W2112811019","https://openalex.org/W2119043225","https://openalex.org/W2121048111","https://openalex.org/W2121507105","https://openalex.org/W2123280311","https://openalex.org/W2123500593","https://openalex.org/W2126991359","https://openalex.org/W2128817214","https://openalex.org/W2129485525","https://openalex.org/W2129619539","https://openalex.org/W2130410032","https://openalex.org/W2130687290","https://openalex.org/W2132582966","https://openalex.org/W2134873429","https://openalex.org/W2134962976","https://openalex.org/W2135601080","https://openalex.org/W2136549265","https://openalex.org/W2136638809","https://openalex.org/W2136739004","https://openalex.org/W2136850043","https://openalex.org/W2137075959","https://openalex.org/W2137883630","https://openalex.org/W2142237411","https://openalex.org/W2144317357","https://openalex.org/W2144344817","https://openalex.org/W2145650689","https://openalex.org/W2148130205","https://openalex.org/W2149310258","https://openalex.org/W2152641758","https://openalex.org/W2152723471","https://openalex.org/W2153161570","https://openalex.org/W2153577994","https://openalex.org/W2154947819","https://openalex.org/W2154972152","https://openalex.org/W2155484811","https://openalex.org/W2158564991","https://openalex.org/W2158887534","https://openalex.org/W2159675211","https://openalex.org/W2160238006","https://openalex.org/W2161444669","https://openalex.org/W2163736554","https://openalex.org/W2164881856","https://openalex.org/W2166699593","https://openalex.org/W2166754203","https://openalex.org/W2170190415","https://openalex.org/W2171403830","https://openalex.org/W2172049947","https://openalex.org/W2183023031","https://openalex.org/W2183969585","https://openalex.org/W2184942504","https://openalex.org/W2188280059","https://openalex.org/W2257214125","https://openalex.org/W2291745164","https://openalex.org/W2530183663","https://openalex.org/W2797884775","https://openalex.org/W2918103525","https://openalex.org/W4285719527","https://openalex.org/W4299527343","https://openalex.org/W6675438942","https://openalex.org/W7071764571"],"related_works":["https://openalex.org/W2017899917","https://openalex.org/W2080571363","https://openalex.org/W2481322495","https://openalex.org/W2898682754","https://openalex.org/W2889841093","https://openalex.org/W4246603716","https://openalex.org/W2365236913","https://openalex.org/W3194374240","https://openalex.org/W2151082141","https://openalex.org/W2993861175"],"abstract_inverted_index":{"The":[0,214],"profusion":[1],"of":[2,8,74,146,149,154,190,195,216,224,229,241],"high-throughput":[3],"instruments":[4],"and":[5,23,32,45,68,100,156,177],"the":[6,12,27,107,123,144,166,179,187,199,217,222,227],"explosion":[7],"new":[9],"results":[10,110],"in":[11,16,182,221,237],"scientific":[13],"literature,":[14],"particularly":[15],"molecular":[17],"biomedicine,":[18],"is":[19,131,201],"both":[20],"a":[21,24,54,61,139,152,159,170,183,204],"blessing":[22],"curse":[25],"to":[26,58,71,94,122,134,157,211],"bench":[28],"researcher.":[29],"Even":[30],"knowledgeable":[31],"experienced":[33],"scientists":[34],"can":[35],"benefit":[36],"from":[37,81,97,111,174],"computational":[38,56],"tools":[39],"that":[40,64,109,119,142,185,191],"help":[41],"navigate":[42],"this":[43,50,59,196],"vast":[44],"rapidly":[46],"evolving":[47],"terrain.":[48],"In":[49],"paper,":[51],"we":[52],"describe":[53],"novel":[55],"approach":[57],"challenge,":[60],"knowledge-based":[62,188],"system":[63],"combines":[65],"reading,":[66],"reasoning,":[67],"reporting":[69],"methods":[70,78,105,164],"facilitate":[72],"analysis":[73,189],"experimental":[75,175,248],"data.":[76,192],"Reading":[77],"extract":[79,95],"information":[80,96],"external":[82],"resources,":[83],"either":[84],"by":[85,246],"parsing":[86],"structured":[87],"data":[88,176],"or":[89,127],"using":[90],"biomedical":[91],"language":[92],"processing":[93],"unstructured":[98],"data,":[99],"track":[101],"knowledge":[102,108,140,167],"provenance.":[103],"Reasoning":[104,130],"enrich":[106],"reading":[112],"by,":[113],"for":[114],"example,":[115],"noting":[116],"two":[117],"genes":[118,231],"are":[120],"annotated":[121],"same":[124],"ontology":[125],"term":[126],"database":[128],"entry.":[129],"also":[132],"used":[133],"combine":[135,165],"all":[136,147],"sources":[137],"into":[138],"network":[141,168,172,181],"represents":[143],"integration":[145],"sorts":[148],"relationships":[150],"between":[151],"pair":[153],"genes,":[155],"calculate":[158],"combined":[160,180],"reliability":[161],"score.":[162],"Reporting":[163],"with":[169],"congruent":[171],"constructed":[173],"visualize":[178],"tool":[184,218],"facilitates":[186],"An":[193],"implementation":[194],"approach,":[197],"called":[198],"Hanalyzer,":[200],"demonstrated":[202],"on":[203],"large-scale":[205],"gene":[206],"expression":[207],"array":[208],"dataset":[209],"relevant":[210],"craniofacial":[212,238],"development.":[213],"use":[215],"was":[219,244],"critical":[220],"creation":[223],"hypotheses":[225,243],"regarding":[226],"roles":[228],"four":[230],"never":[232],"previously":[233],"characterized":[234],"as":[235],"involved":[236],"development;":[239],"each":[240],"these":[242],"validated":[245],"further":[247],"work.":[249]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":9}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}