{"id":"https://openalex.org/W2149152815","doi":"https://doi.org/10.1371/journal.pcbi.1000212","title":"A Model of Brain Circulation and Metabolism: NIRS Signal Changes during Physiological Challenges","display_name":"A Model of Brain Circulation and Metabolism: NIRS Signal Changes during Physiological Challenges","publication_year":2008,"publication_date":"2008-11-06","ids":{"openalex":"https://openalex.org/W2149152815","doi":"https://doi.org/10.1371/journal.pcbi.1000212","mag":"2149152815","pmid":"https://pubmed.ncbi.nlm.nih.gov/18989392"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000212","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000212","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000212&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000212&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034799827","display_name":"Murad Banaji","orcid":"https://orcid.org/0000-0002-4983-0377"},"institutions":[{"id":"https://openalex.org/I110002522","display_name":"University of Essex","ror":"https://ror.org/02nkf1q06","country_code":"GB","type":"education","lineage":["https://openalex.org/I110002522"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Murad Banaji","raw_affiliation_strings":["Department of Biological Sciences, University of Essex, Colchester, United Kingdom. m.banaji@ucl.ac.uk","United Kingdom","Department of Biological Sciences, University of Essex, Colchester"],"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Essex, Colchester, United Kingdom. m.banaji@ucl.ac.uk","institution_ids":["https://openalex.org/I110002522"]},{"raw_affiliation_string":"United Kingdom","institution_ids":[]},{"raw_affiliation_string":"Department of Biological Sciences, University of Essex, Colchester","institution_ids":["https://openalex.org/I110002522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016415460","display_name":"Alfred Mallet","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alfred Mallet","raw_affiliation_strings":["Department of Medical Physics and Bioengineering, University College","London, London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Department of Medical Physics and Bioengineering, University College","institution_ids":[]},{"raw_affiliation_string":"London, London, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033983882","display_name":"Clare E. Elwell","orcid":"https://orcid.org/0000-0002-7281-7234"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Clare E. Elwell","raw_affiliation_strings":["Department of Medical Physics and Bioengineering, University College","London, London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Department of Medical Physics and Bioengineering, University College","institution_ids":[]},{"raw_affiliation_string":"London, London, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080715929","display_name":"Peter Nicholls","orcid":"https://orcid.org/0000-0002-0648-577X"},"institutions":[{"id":"https://openalex.org/I110002522","display_name":"University of Essex","ror":"https://ror.org/02nkf1q06","country_code":"GB","type":"education","lineage":["https://openalex.org/I110002522"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peter Nicholls","raw_affiliation_strings":["Department of Biological Sciences, University of Essex, Colchester","United Kingdom"],"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Essex, Colchester","institution_ids":["https://openalex.org/I110002522"]},{"raw_affiliation_string":"United Kingdom","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078795442","display_name":"Chris E. Cooper","orcid":"https://orcid.org/0000-0003-0381-3990"},"institutions":[{"id":"https://openalex.org/I110002522","display_name":"University of Essex","ror":"https://ror.org/02nkf1q06","country_code":"GB","type":"education","lineage":["https://openalex.org/I110002522"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Chris E. Cooper","raw_affiliation_strings":["Department of Biological Sciences, University of Essex, Colchester","United Kingdom"],"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Essex, Colchester","institution_ids":["https://openalex.org/I110002522"]},{"raw_affiliation_string":"United Kingdom","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5034799827"],"corresponding_institution_ids":["https://openalex.org/I110002522"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":4.7279,"has_fulltext":true,"cited_by_count":91,"citation_normalized_percentile":{"value":0.94641653,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"4","issue":"11","first_page":"e1000212","last_page":"e1000212"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11196","display_name":"Non-Invasive Vital Sign Monitoring","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebral-circulation","display_name":"Cerebral circulation","score":0.4776914417743683},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"Energy metabolism","score":0.4741104245185852},{"id":"https://openalex.org/keywords/cerebral-blood-flow","display_name":"Cerebral blood flow","score":0.4597269892692566},{"id":"https://openalex.org/keywords/cytochrome-c-oxidase","display_name":"Cytochrome c oxidase","score":0.45713010430336},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.4346391558647156},{"id":"https://openalex.org/keywords/cellular-respiration","display_name":"Cellular respiration","score":0.4208710789680481},{"id":"https://openalex.org/keywords/blood-volume","display_name":"Blood volume","score":0.410356342792511},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.385028213262558},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3679032325744629},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.32705575227737427},{"id":"https://openalex.org/keywords/respiration","display_name":"Respiration","score":0.26031655073165894},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2570136785507202},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.2518983483314514},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.25177741050720215},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.18431559205055237},{"id":"https://openalex.org/keywords/mitochondrion","display_name":"Mitochondrion","score":0.10472169518470764},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.10202965140342712}],"concepts":[{"id":"https://openalex.org/C119671327","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral circulation","level":2,"score":0.4776914417743683},{"id":"https://openalex.org/C2986317502","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Energy metabolism","level":2,"score":0.4741104245185852},{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.4597269892692566},{"id":"https://openalex.org/C123249941","wikidata":"https://www.wikidata.org/wiki/Q306116","display_name":"Cytochrome c oxidase","level":3,"score":0.45713010430336},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4346391558647156},{"id":"https://openalex.org/C66517615","wikidata":"https://www.wikidata.org/wiki/Q912751","display_name":"Cellular respiration","level":3,"score":0.4208710789680481},{"id":"https://openalex.org/C37557685","wikidata":"https://www.wikidata.org/wiki/Q1896673","display_name":"Blood volume","level":2,"score":0.410356342792511},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.385028213262558},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3679032325744629},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32705575227737427},{"id":"https://openalex.org/C182215343","wikidata":"https://www.wikidata.org/wiki/Q472287","display_name":"Respiration","level":2,"score":0.26031655073165894},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2570136785507202},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.2518983483314514},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25177741050720215},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18431559205055237},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.10472169518470764},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.10202965140342712}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003576","descriptor_name":"Electron Transport Complex IV","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003576","descriptor_name":"Electron Transport Complex IV","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003576","descriptor_name":"Electron Transport Complex IV","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019265","descriptor_name":"Spectroscopy, Near-Infrared","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019265","descriptor_name":"Spectroscopy, Near-Infrared","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019265","descriptor_name":"Spectroscopy, Near-Infrared","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":12,"locations":[{"id":"doi:10.1371/journal.pcbi.1000212","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000212","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000212&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:18989392","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18989392","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:eprints.lancs.ac.uk:231033","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306401916","display_name":"Lancaster EPrints (Lancaster University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I67415387","host_organization_name":"Lancaster University","host_organization_lineage":["https://openalex.org/I67415387"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.277.8323","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.277.8323","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/1d/e6/PLoS_Comput_Biol_2008_Nov_7_4(11)_e1000212.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:6aa96c4331c544abaa534ec7664edfd1","is_oa":true,"landing_page_url":"https://doaj.org/article/6aa96c4331c544abaa534ec7664edfd1","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 4, Iss 11, p e1000212 (2008)","raw_type":"article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1298320","is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/1298320/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"   PLOS Computational Biology , 4  (11)    , Article e1000212. (2008)      ","raw_type":"Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:146803","is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/146803/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"   PLoS Computational Biology , 4  (11)    , Article e1000212. (2008)      ","raw_type":"Article"},{"id":"pmh:oai:figshare.com:article/149307","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/A_Model_of_Brain_Circulation_and_Metabolism_NIRS_Signal_Changes___during_Physiological_Challenges/149307","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:12195854-6d4a-48df-83ee-f5ae35a6b21c","is_oa":true,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:12195854-6d4a-48df-83ee-f5ae35a6b21c","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symplectic Elements at Oxford","raw_type":"Journal article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2573000","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2573000","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:repository.essex.ac.uk:703","is_oa":false,"landing_page_url":"https://repository.essex.ac.uk/703/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401236","display_name":"Open Access at Essex (University of Essex)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I110002522","host_organization_name":"University of Essex","host_organization_lineage":["https://openalex.org/I110002522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:researchportal.port.ac.uk:publications/70665380-4ab0-4509-807b-f2ee0a247c47","is_oa":true,"landing_page_url":"https://researchportal.port.ac.uk/portal/en/publications/a-model-of-brain-circulation-and-metabolism-nirs-signal-changes-during-physiological-challenges(70665380-4ab0-4509-807b-f2ee0a247c47).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401774","display_name":"Portsmouth Research Portal (University of Portsmouth)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I63072094","host_organization_name":"University of Portsmouth","host_organization_lineage":["https://openalex.org/I63072094"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000212","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000212","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000212&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6499999761581421,"display_name":"Affordable and clean energy","id":"https://metadata.un.org/sdg/7"}],"awards":[{"id":"https://openalex.org/G1541370587","display_name":"A complete model of oxygen consumption by mitochondrial cytochrome c oxidase","funder_award_id":"BB/D017858/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G2113131027","display_name":null,"funder_award_id":"EP/D060982/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G214365446","display_name":null,"funder_award_id":"BB/D017858/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G2459671531","display_name":"A multidisciplinary approach to non invasive optical measurements of cellular energetics in the human brain","funder_award_id":"EP/D060982/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2149152815.pdf","grobid_xml":"https://content.openalex.org/works/W2149152815.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W79191287","https://openalex.org/W107606605","https://openalex.org/W154696339","https://openalex.org/W174345320","https://openalex.org/W221088374","https://openalex.org/W585914646","https://openalex.org/W1497174676","https://openalex.org/W1559727341","https://openalex.org/W1562098826","https://openalex.org/W1583094119","https://openalex.org/W1596077691","https://openalex.org/W1755966220","https://openalex.org/W1870965654","https://openalex.org/W1946490520","https://openalex.org/W1971144058","https://openalex.org/W1973638771","https://openalex.org/W1979728048","https://openalex.org/W1981529273","https://openalex.org/W1982544435","https://openalex.org/W1988794652","https://openalex.org/W1988876580","https://openalex.org/W1992744269","https://openalex.org/W1993589568","https://openalex.org/W1995111069","https://openalex.org/W1995272538","https://openalex.org/W1996389273","https://openalex.org/W1996516846","https://openalex.org/W2011550515","https://openalex.org/W2011843627","https://openalex.org/W2015007131","https://openalex.org/W2018431813","https://openalex.org/W2021952329","https://openalex.org/W2027078803","https://openalex.org/W2030434933","https://openalex.org/W2031348767","https://openalex.org/W2039405238","https://openalex.org/W2053963261","https://openalex.org/W2061673532","https://openalex.org/W2062237318","https://openalex.org/W2063405170","https://openalex.org/W2065746243","https://openalex.org/W2068214023","https://openalex.org/W2069980876","https://openalex.org/W2073364698","https://openalex.org/W2075933944","https://openalex.org/W2083540409","https://openalex.org/W2087381888","https://openalex.org/W2091360262","https://openalex.org/W2093188448","https://openalex.org/W2094826936","https://openalex.org/W2099802623","https://openalex.org/W2129451380","https://openalex.org/W2130603606","https://openalex.org/W2133968738","https://openalex.org/W2134506141","https://openalex.org/W2137142142","https://openalex.org/W2137163826","https://openalex.org/W2141345160","https://openalex.org/W2142240863","https://openalex.org/W2144324582","https://openalex.org/W2152626368","https://openalex.org/W2162123841","https://openalex.org/W2168277699","https://openalex.org/W2175626657","https://openalex.org/W2280727632","https://openalex.org/W2405844394","https://openalex.org/W2414307385","https://openalex.org/W2428508480"],"related_works":["https://openalex.org/W83361203","https://openalex.org/W2087301946","https://openalex.org/W2071554887","https://openalex.org/W2038563802","https://openalex.org/W2033324668","https://openalex.org/W2094533929","https://openalex.org/W2051240076","https://openalex.org/W2039330812","https://openalex.org/W4390970397","https://openalex.org/W4376500474"],"abstract_inverted_index":{"We":[0,106],"construct":[1],"a":[2,28],"model":[3,11,47,110,137,142,165],"of":[4,22,30,74,136],"brain":[5],"circulation":[6,24],"and":[7,18,25,43,56,68,70,97,141,154],"energy":[8],"metabolism.":[9],"The":[10,158],"is":[12,102,166],"designed":[13],"to":[14,27,118,132,146,168,174],"explain":[15],"experimental":[16],"data":[17,148],"predict":[19],"the":[20,23,71,75,92,95,98,109,120,125,164],"response":[21,173],"metabolism":[26],"variety":[29],"stimuli,":[31],"in":[32,35,78,88,103,116,123,152,155,172],"particular,":[33,124],"changes":[34],"arterial":[36],"blood":[37,52,66],"pressure,":[38],"CO(2)":[39],"levels,":[40,42],"O(2)":[41],"functional":[44],"activation.":[45],"Significant":[46],"outputs":[48,143],"are":[49,84,139,144,160],"predictions":[50],"about":[51],"flow,":[53],"metabolic":[54],"rate,":[55],"quantities":[57,83],"measurable":[58],"noninvasively":[59],"using":[60],"near-infrared":[61],"spectroscopy":[62],"(NIRS),":[63],"including":[64],"cerebral":[65],"volume":[67],"oxygenation":[69],"redox":[72],"state":[73],"Cu(A)":[76],"centre":[77],"cytochrome":[79,126],"c":[80],"oxidase.":[81],"These":[82],"now":[85],"frequently":[86],"measured":[87],"clinical":[89],"settings;":[90],"however":[91],"relationship":[93],"between":[94],"measurements":[96],"underlying":[99],"physiological":[100],"events":[101],"general":[104],"complex.":[105],"anticipate":[107],"that":[108,163],"will":[111],"play":[112],"an":[113],"important":[114],"role":[115],"helping":[117],"understand":[119],"NIRS":[121],"signals,":[122],"signal,":[127],"which":[128],"has":[129],"been":[130],"hard":[131],"interpret.":[133],"A":[134],"range":[135],"simulations":[138],"presented,":[140],"compared":[145],"published":[147],"obtained":[149],"from":[150],"both":[151],"vivo":[153],"vitro":[156],"settings.":[157],"comparisons":[159],"encouraging,":[161],"showing":[162],"able":[167],"reproduce":[169],"observed":[170],"behaviour":[171],"various":[175],"stimuli.":[176]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":12}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
