{"id":"https://openalex.org/W1965572014","doi":"https://doi.org/10.1371/journal.pcbi.1000208","title":"The Effects of NR2 Subunit-Dependent NMDA Receptor Kinetics on Synaptic Transmission and CaMKII Activation","display_name":"The Effects of NR2 Subunit-Dependent NMDA Receptor Kinetics on Synaptic Transmission and CaMKII Activation","publication_year":2008,"publication_date":"2008-10-30","ids":{"openalex":"https://openalex.org/W1965572014","doi":"https://doi.org/10.1371/journal.pcbi.1000208","mag":"1965572014","pmid":"https://pubmed.ncbi.nlm.nih.gov/18974824"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000208","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000208","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000208&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000208&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064403574","display_name":"David M. Santucci","orcid":null},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4210153043","display_name":"Duke University Hospital","ror":"https://ror.org/04bct7p84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4210144876","https://openalex.org/I4210153043"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Santucci","raw_affiliation_strings":["Department of Neurobiology, Duke University Medical Center, Durham, NC, USA","Department of Neurobiology; Duke University Medical Center; Durham, NC USA"],"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Duke University Medical Center, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210153043","https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Department of Neurobiology; Duke University Medical Center; Durham, NC USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031978385","display_name":"Sridhar Raghavachari","orcid":null},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4210153043","display_name":"Duke University Hospital","ror":"https://ror.org/04bct7p84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4210144876","https://openalex.org/I4210153043"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sridhar Raghavachari","raw_affiliation_strings":["Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210153043","https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031978385"],"corresponding_institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298","https://openalex.org/I4210153043"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.5667,"has_fulltext":true,"cited_by_count":73,"citation_normalized_percentile":{"value":0.79201954,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"4","issue":"10","first_page":"e1000208","last_page":"e1000208"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/long-term-depression","display_name":"Long-term depression","score":0.7076557278633118},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"Synaptic plasticity","score":0.6924959421157837},{"id":"https://openalex.org/keywords/long-term-potentiation","display_name":"Long-term potentiation","score":0.6711906790733337},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.6458566188812256},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5775176882743835},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.5679483413696289},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.5674120783805847},{"id":"https://openalex.org/keywords/ion-channel-linked-receptors","display_name":"Ion channel linked receptors","score":0.4982931613922119},{"id":"https://openalex.org/keywords/glutamate-receptor","display_name":"Glutamate receptor","score":0.45111018419265747},{"id":"https://openalex.org/keywords/silent-synapse","display_name":"Silent synapse","score":0.44360584020614624},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.374409556388855},{"id":"https://openalex.org/keywords/ampa-receptor","display_name":"AMPA receptor","score":0.32109731435775757},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.20518776774406433}],"concepts":[{"id":"https://openalex.org/C73009533","wikidata":"https://www.wikidata.org/wiki/Q1517140","display_name":"Long-term depression","level":5,"score":0.7076557278633118},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.6924959421157837},{"id":"https://openalex.org/C25274449","wikidata":"https://www.wikidata.org/wiki/Q1805481","display_name":"Long-term potentiation","level":3,"score":0.6711906790733337},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.6458566188812256},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5775176882743835},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5679483413696289},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5674120783805847},{"id":"https://openalex.org/C88272193","wikidata":"https://www.wikidata.org/wiki/Q418536","display_name":"Ion channel linked receptors","level":5,"score":0.4982931613922119},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.45111018419265747},{"id":"https://openalex.org/C154559735","wikidata":"https://www.wikidata.org/wiki/Q7514768","display_name":"Silent synapse","level":5,"score":0.44360584020614624},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.374409556388855},{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.32109731435775757},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20518776774406433}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D017774","descriptor_name":"Long-Term Potentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017774","descriptor_name":"Long-Term Potentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017774","descriptor_name":"Long-Term Potentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054732","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinase Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054732","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinase Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054732","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinase Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1000208","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000208","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000208&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:18974824","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18974824","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.277.8917","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.277.8917","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/3c/9a/PLoS_Comput_Biol_2008_Oct_31_4(10)_e1000208.tar.gz","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1000208","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1000208","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:8e927ab5d4ec43f8875e3a44524b3c21","is_oa":true,"landing_page_url":"https://doaj.org/article/8e927ab5d4ec43f8875e3a44524b3c21","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 4, Iss 10, p e1000208 (2008)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2563690","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2563690","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000208","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000208","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000208&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G851205067","display_name":"Mathematical Modeling of Synaptic Transmission and Plasticity","funder_award_id":"0642000","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1965572014.pdf","grobid_xml":"https://content.openalex.org/works/W1965572014.grobid-xml"},"referenced_works_count":123,"referenced_works":["https://openalex.org/W1486852018","https://openalex.org/W1487630095","https://openalex.org/W1507029368","https://openalex.org/W1528942588","https://openalex.org/W1551756182","https://openalex.org/W1554147846","https://openalex.org/W1564150153","https://openalex.org/W1576102240","https://openalex.org/W1581543871","https://openalex.org/W1606744897","https://openalex.org/W1626546769","https://openalex.org/W1645542202","https://openalex.org/W1798313689","https://openalex.org/W1876061808","https://openalex.org/W1897919376","https://openalex.org/W1922786159","https://openalex.org/W1952831770","https://openalex.org/W1955943544","https://openalex.org/W1957331510","https://openalex.org/W1964433270","https://openalex.org/W1964694199","https://openalex.org/W1972270334","https://openalex.org/W1973436856","https://openalex.org/W1977451474","https://openalex.org/W1978121125","https://openalex.org/W1978647995","https://openalex.org/W1979586675","https://openalex.org/W1980059018","https://openalex.org/W1983284219","https://openalex.org/W1983553517","https://openalex.org/W1986246844","https://openalex.org/W1986291163","https://openalex.org/W1988900265","https://openalex.org/W1995681441","https://openalex.org/W1996208391","https://openalex.org/W2002287054","https://openalex.org/W2003701228","https://openalex.org/W2013479315","https://openalex.org/W2014408809","https://openalex.org/W2016379134","https://openalex.org/W2016575029","https://openalex.org/W2019016101","https://openalex.org/W2021235911","https://openalex.org/W2021547984","https://openalex.org/W2023654689","https://openalex.org/W2024048296","https://openalex.org/W2028236452","https://openalex.org/W2028594041","https://openalex.org/W2031779883","https://openalex.org/W2032192786","https://openalex.org/W2032596004","https://openalex.org/W2036495604","https://openalex.org/W2036869107","https://openalex.org/W2037210922","https://openalex.org/W2041024256","https://openalex.org/W2049511526","https://openalex.org/W2053980736","https://openalex.org/W2059040821","https://openalex.org/W2060941075","https://openalex.org/W2065169750","https://openalex.org/W2066871393","https://openalex.org/W2067598670","https://openalex.org/W2069362932","https://openalex.org/W2071580220","https://openalex.org/W2071908149","https://openalex.org/W2072731296","https://openalex.org/W2073224890","https://openalex.org/W2076520265","https://openalex.org/W2077306952","https://openalex.org/W2078167209","https://openalex.org/W2078366491","https://openalex.org/W2078729100","https://openalex.org/W2079133060","https://openalex.org/W2085846947","https://openalex.org/W2086543171","https://openalex.org/W2089131634","https://openalex.org/W2089184936","https://openalex.org/W2090584164","https://openalex.org/W2092045031","https://openalex.org/W2094011563","https://openalex.org/W2096551329","https://openalex.org/W2100193366","https://openalex.org/W2102365206","https://openalex.org/W2110240734","https://openalex.org/W2110724392","https://openalex.org/W2115645299","https://openalex.org/W2116635659","https://openalex.org/W2117664079","https://openalex.org/W2118064450","https://openalex.org/W2120048206","https://openalex.org/W2120264644","https://openalex.org/W2121239869","https://openalex.org/W2123609069","https://openalex.org/W2126033464","https://openalex.org/W2128156437","https://openalex.org/W2130047390","https://openalex.org/W2131270585","https://openalex.org/W2132971431","https://openalex.org/W2135163309","https://openalex.org/W2139596852","https://openalex.org/W2140439285","https://openalex.org/W2141012278","https://openalex.org/W2144874949","https://openalex.org/W2145984134","https://openalex.org/W2146521940","https://openalex.org/W2147084397","https://openalex.org/W2148923308","https://openalex.org/W2152072736","https://openalex.org/W2152402650","https://openalex.org/W2153928331","https://openalex.org/W2154178019","https://openalex.org/W2161352090","https://openalex.org/W2161448985","https://openalex.org/W2165360100","https://openalex.org/W2168159719","https://openalex.org/W2168319429","https://openalex.org/W2169154493","https://openalex.org/W2169761872","https://openalex.org/W2179166911","https://openalex.org/W2185212694","https://openalex.org/W2304854009","https://openalex.org/W2327978283","https://openalex.org/W4244876931"],"related_works":["https://openalex.org/W4256018609","https://openalex.org/W1976094901","https://openalex.org/W4230921771","https://openalex.org/W2044031472","https://openalex.org/W1985774609","https://openalex.org/W3189535008","https://openalex.org/W4246951876","https://openalex.org/W2375611933","https://openalex.org/W2161458381","https://openalex.org/W1140093318"],"abstract_inverted_index":{"N-Methyl-D-aspartic":[0],"acid":[1],"(NMDA)":[2],"receptors":[3,55,80,99,134,152,202,214,232,247,269],"are":[4,11,26,48,224],"widely":[5],"expressed":[6,28,81],"in":[7,31,40,82,135,240],"the":[8,21,32,34,128,136,165,188,211,228,243,252,255,259,265,277],"brain":[9],"and":[10,42,46,59,64,104,130,148,153,157,200,280],"critical":[12,173],"for":[13,79,174],"many":[14],"forms":[15],"of":[16,20,86,112,132,144,154,164,167,176,230,245,254,261,267],"synaptic":[17,87,177],"plasticity.":[18],"Subtypes":[19],"NMDA":[22,151,180,289],"receptor":[23,36,155,192,256,290],"NR2":[24],"subunit":[25],"differentially":[27],"during":[29],"development;":[30],"forebrain,":[33],"NR2B":[35,47],"is":[37,110,248,270],"dominant":[38],"early":[39],"development,":[41],"later":[43],"both":[44],"NR2A":[45],"expressed.":[49],"In":[50,115],"heterologous":[51],"expression":[52],"systems,":[53],"NR2A-containing":[54,98,268],"open":[56,76,125,193,286],"more":[57],"reliably":[58],"show":[60],"much":[61],"faster":[62],"opening":[63,156,206,244,266],"closing":[65,158],"kinetics":[66],"than":[67],"do":[68],"NR2B-containing":[69,201,246],"receptors.":[70],"However,":[71],"conflicting":[72,120,189],"data,":[73],"showing":[74,95,106],"similar":[75],"probabilities,":[77],"exist":[78],"neurons.":[83],"Similarly,":[84],"studies":[85],"plasticity":[88],"have":[89],"produced":[90],"divergent":[91],"results,":[92],"with":[93,198],"some":[94],"that":[96,107,187,213],"only":[97],"can":[100,195,218],"drive":[101,219],"long-term":[102,220],"potentiation":[103],"others":[105],"either":[108,216],"subtype":[109,217],"capable":[111],"driving":[113],"potentiation.":[114,221],"order":[116],"to":[117,150,226,258,275,284],"address":[118,285],"these":[119],"results":[121,185,273],"as":[122,124,159,161],"well":[123,160],"questions":[126,287],"about":[127],"number":[129,229],"location":[131,253],"functional":[133,231],"synapse,":[137],"we":[138],"constructed":[139],"a":[140,162,234],"Monte":[141],"Carlo":[142],"model":[143,163],"glutamate":[145,262],"release,":[146],"diffusion,":[147],"binding":[149],"activation":[166],"calcium-calmodulin":[168],"kinase":[169],"II,":[170],"an":[171],"enzyme":[172],"induction":[175],"plasticity,":[178],"by":[179],"receptor-mediated":[181],"calcium":[182],"influx.":[183],"Our":[184],"suggest":[186,281],"data":[190],"concerning":[191,288],"probabilities":[194],"be":[196],"resolved,":[197],"NR2A-":[199],"having":[203],"very":[204],"different":[205],"probabilities.":[207],"They":[208],"also":[209,223],"support":[210],"conclusion":[212],"containing":[215],"We":[222],"able":[225],"estimate":[227],"at":[233],"synapse":[235],"from":[236],"experimental":[237],"data.":[238],"Finally,":[239],"our":[241],"models,":[242],"highly":[249],"dependent":[250],"on":[251],"relative":[257],"site":[260],"release":[263],"whereas":[264],"not.":[271],"These":[272],"help":[274],"clarify":[276],"previous":[278],"findings":[279],"future":[282],"experiments":[283],"function.":[291]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
