{"id":"https://openalex.org/W2026980372","doi":"https://doi.org/10.1371/journal.pcbi.1000176","title":"Differentiating Protein-Coding and Noncoding RNA: Challenges and Ambiguities","display_name":"Differentiating Protein-Coding and Noncoding RNA: Challenges and Ambiguities","publication_year":2008,"publication_date":"2008-11-27","ids":{"openalex":"https://openalex.org/W2026980372","doi":"https://doi.org/10.1371/journal.pcbi.1000176","mag":"2026980372","pmid":"https://pubmed.ncbi.nlm.nih.gov/19043537"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000176","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000176","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000176&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000176&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049900685","display_name":"Marcel E. Dinger","orcid":"https://orcid.org/0000-0003-4423-934X"},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Marcel E. Dinger","raw_affiliation_strings":["ARC Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, St Lucia, Australia","Australia","ARC Special Research Centre for Functional and Applied Genomics","Institute for Molecular Bioscience, University of Queensland, St Lucia"],"affiliations":[{"raw_affiliation_string":"ARC Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, St Lucia, Australia","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"Australia","institution_ids":[]},{"raw_affiliation_string":"ARC Special Research Centre for Functional and Applied Genomics","institution_ids":[]},{"raw_affiliation_string":"Institute for Molecular Bioscience, University of Queensland, St Lucia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017713035","display_name":"Ken C. Pang","orcid":"https://orcid.org/0000-0002-6881-775X"},"institutions":[{"id":"https://openalex.org/I4210163497","display_name":"Austin Health","ror":"https://ror.org/05dbj6g52","country_code":"AU","type":"funder","lineage":["https://openalex.org/I4210163497"]},{"id":"https://openalex.org/I196064397","display_name":"Ludwig Cancer Research","ror":"https://ror.org/05923xh51","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I196064397","https://openalex.org/I4210150094"]}],"countries":["AU","BE"],"is_corresponding":false,"raw_author_name":"Ken C. Pang","raw_affiliation_strings":["T cell Laboratory, Ludwig Institute for Cancer Research, Melbourne Centre","for Clinical Sciences, Austin Health, Heidelberg, Australia"],"affiliations":[{"raw_affiliation_string":"T cell Laboratory, Ludwig Institute for Cancer Research, Melbourne Centre","institution_ids":["https://openalex.org/I196064397"]},{"raw_affiliation_string":"for Clinical Sciences, Austin Health, Heidelberg, Australia","institution_ids":["https://openalex.org/I4210163497"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089375087","display_name":"Tim R. Mercer","orcid":"https://orcid.org/0000-0001-8780-894X"},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Tim R. Mercer","raw_affiliation_strings":["ARC Special Research Centre for Functional and Applied Genomics","Australia","Institute for Molecular Bioscience, University of Queensland, St Lucia"],"affiliations":[{"raw_affiliation_string":"ARC Special Research Centre for Functional and Applied Genomics","institution_ids":[]},{"raw_affiliation_string":"Australia","institution_ids":[]},{"raw_affiliation_string":"Institute for Molecular Bioscience, University of Queensland, St Lucia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023828670","display_name":"John S. Mattick","orcid":"https://orcid.org/0000-0002-7680-7527"},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"John S. Mattick","raw_affiliation_strings":["ARC Special Research Centre for Functional and Applied Genomics","Australia","Institute for Molecular Bioscience, University of Queensland, St Lucia"],"affiliations":[{"raw_affiliation_string":"ARC Special Research Centre for Functional and Applied Genomics","institution_ids":[]},{"raw_affiliation_string":"Australia","institution_ids":[]},{"raw_affiliation_string":"Institute for Molecular Bioscience, University of Queensland, St Lucia","institution_ids":["https://openalex.org/I165143802"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5023828670"],"corresponding_institution_ids":["https://openalex.org/I165143802"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":7.4083,"has_fulltext":true,"cited_by_count":545,"citation_normalized_percentile":{"value":0.97210893,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"4","issue":"11","first_page":"e1000176","last_page":"e1000176"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6176635026931763},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.55875563621521},{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"Non-coding RNA","score":0.5506887435913086},{"id":"https://openalex.org/keywords/coding","display_name":"Coding (social sciences)","score":0.4960363805294037},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.38508015871047974},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3433731198310852},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.28726768493652344},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1223391592502594},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.10301840305328369},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.08100864291191101}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6176635026931763},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.55875563621521},{"id":"https://openalex.org/C194993378","wikidata":"https://www.wikidata.org/wiki/Q427087","display_name":"Non-coding RNA","level":4,"score":0.5506887435913086},{"id":"https://openalex.org/C179518139","wikidata":"https://www.wikidata.org/wiki/Q5140297","display_name":"Coding (social sciences)","level":2,"score":0.4960363805294037},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38508015871047974},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3433731198310852},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28726768493652344},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1223391592502594},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10301840305328369},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.08100864291191101}],"mesh":[{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016366","descriptor_name":"Open Reading Frames","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016366","descriptor_name":"Open Reading Frames","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016366","descriptor_name":"Open Reading Frames","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1000176","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000176","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000176&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:19043537","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19043537","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:93919d3375964c7b83ac10be8a57c50b","is_oa":true,"landing_page_url":"https://doaj.org/article/93919d3375964c7b83ac10be8a57c50b","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 4, Iss 11, p e1000176 (2008)","raw_type":"article"},{"id":"pmh:oai:espace.library.uq.edu.au:UQ:163427","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306402388","display_name":"Queensland's institutional digital repository (The University of Queensland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I165143802","host_organization_name":"The University of Queensland","host_organization_lineage":["https://openalex.org/I165143802"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2518207","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2518207","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000176","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000176","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000176&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","score":0.6100000143051147,"display_name":"Reduced inequalities"}],"awards":[{"id":"https://openalex.org/G5714184577","display_name":null,"funder_award_id":"Fellowship","funder_id":"https://openalex.org/F4320334704","funder_display_name":"Australian Research Council"}],"funders":[{"id":"https://openalex.org/F4320320984","display_name":"University of Queensland","ror":"https://ror.org/00rqy9422"},{"id":"https://openalex.org/F4320334704","display_name":"Australian Research Council","ror":"https://ror.org/05mmh0f86"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2026980372.pdf","grobid_xml":"https://content.openalex.org/works/W2026980372.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W151786846","https://openalex.org/W1822105579","https://openalex.org/W1968185051","https://openalex.org/W1968273294","https://openalex.org/W1969865366","https://openalex.org/W1977937947","https://openalex.org/W1979750868","https://openalex.org/W1986234964","https://openalex.org/W1991007428","https://openalex.org/W1993158258","https://openalex.org/W1994658343","https://openalex.org/W1997113958","https://openalex.org/W2007006753","https://openalex.org/W2011573728","https://openalex.org/W2012739246","https://openalex.org/W2016066165","https://openalex.org/W2016927884","https://openalex.org/W2018779765","https://openalex.org/W2020678193","https://openalex.org/W2022712317","https://openalex.org/W2023947760","https://openalex.org/W2027780439","https://openalex.org/W2029872802","https://openalex.org/W2035031476","https://openalex.org/W2035760322","https://openalex.org/W2036625331","https://openalex.org/W2040058302","https://openalex.org/W2045607906","https://openalex.org/W2050471996","https://openalex.org/W2052772529","https://openalex.org/W2053150867","https://openalex.org/W2058864686","https://openalex.org/W2059496903","https://openalex.org/W2062313490","https://openalex.org/W2066310505","https://openalex.org/W2068224181","https://openalex.org/W2070136856","https://openalex.org/W2075320162","https://openalex.org/W2075619582","https://openalex.org/W2081694107","https://openalex.org/W2085412309","https://openalex.org/W2089897307","https://openalex.org/W2092758029","https://openalex.org/W2093466316","https://openalex.org/W2098891914","https://openalex.org/W2099275700","https://openalex.org/W2099468911","https://openalex.org/W2099946731","https://openalex.org/W2102304447","https://openalex.org/W2104753410","https://openalex.org/W2105292164","https://openalex.org/W2105513224","https://openalex.org/W2105714972","https://openalex.org/W2106554405","https://openalex.org/W2112001233","https://openalex.org/W2114188442","https://openalex.org/W2123067735","https://openalex.org/W2124050695","https://openalex.org/W2129974507","https://openalex.org/W2131948930","https://openalex.org/W2136725005","https://openalex.org/W2140127479","https://openalex.org/W2140302584","https://openalex.org/W2141885858","https://openalex.org/W2142187732","https://openalex.org/W2148277388","https://openalex.org/W2149129820","https://openalex.org/W2156547523","https://openalex.org/W2158217783","https://openalex.org/W2158826174","https://openalex.org/W2167280365","https://openalex.org/W2612812586","https://openalex.org/W4210323379"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2058984380","https://openalex.org/W1988125422","https://openalex.org/W2900182103","https://openalex.org/W3183769948","https://openalex.org/W3184762873","https://openalex.org/W2010385783","https://openalex.org/W2600828970"],"abstract_inverted_index":{"The":[0,79],"assumption":[1],"that":[2,138,180,202,229],"RNA":[3,209,238,260],"can":[4,152,183,232],"be":[5,147,195,264],"readily":[6,43],"classified":[7],"into":[8],"either":[9],"protein-coding":[10,38,130,212,217],"or":[11,213],"non-protein-coding":[12,51],"categories":[13,28],"has":[14,102],"pervaded":[15],"biology":[16],"for":[17],"close":[18],"to":[19,91,106,127,146,170,206,241],"50":[20],"years.":[21],"Until":[22],"recently,":[23],"discrimination":[24],"between":[25,108,129,248],"these":[26],"two":[27],"was":[29],"relatively":[30,197],"straightforward:":[31],"most":[32],"transcripts":[33,133,220,231],"were":[34],"clearly":[35],"identifiable":[36],"as":[37,55,186,190,211],"messenger":[39],"RNAs":[40,52,182],"(mRNAs),":[41],"and":[42,58,75,85,97,110,115,131,134,164,188,218,240,250],"distinguished":[44],"from":[45],"the":[46,66,86,95,104,123,135,227,237,253,259],"small":[47],"number":[48],"of":[49,68,70,81,94,99,166,255],"well-characterized":[50],"(ncRNAs),":[53],"such":[54],"transfer,":[56],"ribosomal,":[57],"spliceosomal":[59],"RNAs.":[60],"Recent":[61],"genome-wide":[62],"studies":[63,177],"have":[64,178],"revealed":[65],"existence":[67],"thousands":[69],"noncoding":[71,132,219],"transcripts,":[72],"whose":[73],"function":[74,184,233],"significance":[76],"are":[77,139],"unclear.":[78],"discovery":[80],"this":[82,119,223],"hidden":[83],"transcriptome":[84],"implicit":[87],"challenge":[88],"it":[89,203],"presents":[90],"our":[92],"understanding":[93],"expression":[96],"regulation":[98],"genetic":[100],"information":[101],"made":[103],"need":[105],"distinguish":[107],"mRNAs":[109,187,249],"ncRNAs":[111,159],"both":[112,156,185,234],"more":[113,116],"pressing":[114],"complicated.":[117],"In":[118,225],"Review,":[120],"we":[121],"consider":[122],"diverse":[124],"strategies":[125],"employed":[126],"discriminate":[128],"fundamental":[136],"difficulties":[137],"inherent":[140],"in":[141,155],"what":[142],"may":[143,160,173,194],"superficially":[144],"appear":[145],"a":[148,196,245],"simple":[149],"problem.":[150],"Misannotations":[151],"also":[153],"run":[154],"directions:":[157],"some":[158,165,181,230],"actually":[161],"encode":[162,242],"peptides,":[163],"those":[167],"currently":[168],"thought":[169],"do":[171],"so":[172],"not.":[174],"Moreover,":[175],"recent":[176],"shown":[179],"intrinsically":[189,235],"functional":[191],"ncRNAs,":[192],"which":[193],"widespread":[198],"phenomenon.":[199],"We":[200],"conclude":[201],"is":[204],"difficult":[205],"annotate":[207],"an":[208],"unequivocally":[210],"noncoding,":[214],"with":[215],"overlapping":[216],"further":[221],"confounding":[222],"distinction.":[224],"addition,":[226],"finding":[228],"at":[236,258],"level":[239,261],"proteins":[243],"suggests":[244],"false":[246],"dichotomy":[247],"ncRNAs.":[251],"Therefore,":[252],"functionality":[254],"any":[256],"transcript":[257],"should":[262],"not":[263],"discounted.":[265]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":24},{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":26},{"year":2022,"cited_by_count":34},{"year":2021,"cited_by_count":51},{"year":2020,"cited_by_count":41},{"year":2019,"cited_by_count":36},{"year":2018,"cited_by_count":31},{"year":2017,"cited_by_count":34},{"year":2016,"cited_by_count":27},{"year":2015,"cited_by_count":48},{"year":2014,"cited_by_count":32},{"year":2013,"cited_by_count":47},{"year":2012,"cited_by_count":28}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}