{"id":"https://openalex.org/W2084920943","doi":"https://doi.org/10.1371/journal.pcbi.1000167","title":"Noise Reduction by Diffusional Dissipation in a Minimal Quorum Sensing Motif","display_name":"Noise Reduction by Diffusional Dissipation in a Minimal Quorum Sensing Motif","publication_year":2008,"publication_date":"2008-08-29","ids":{"openalex":"https://openalex.org/W2084920943","doi":"https://doi.org/10.1371/journal.pcbi.1000167","mag":"2084920943","pmid":"https://pubmed.ncbi.nlm.nih.gov/18769706"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000167","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000167","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000167&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000167&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101793017","display_name":"Yu Tanouchi","orcid":"https://orcid.org/0000-0002-6039-748X"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Tanouchi","raw_affiliation_strings":["Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014341974","display_name":"Dennis Tu","orcid":null},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis Tu","raw_affiliation_strings":["Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076476753","display_name":"Jungsang Kim","orcid":"https://orcid.org/0000-0001-9551-3826"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jungsang Kim","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Duke University, Durham, North Carolina, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Duke University, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100401842","display_name":"Lingchong You","orcid":"https://orcid.org/0000-0003-3725-4007"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lingchong You","raw_affiliation_strings":["Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America","Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100401842"],"corresponding_institution_ids":["https://openalex.org/I170897317"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.2013,"has_fulltext":true,"cited_by_count":56,"citation_normalized_percentile":{"value":0.87478024,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"4","issue":"8","first_page":"e1000167","last_page":"e1000167"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13052","display_name":"Molecular Communication and Nanonetworks","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12813","display_name":"Plant and Biological Electrophysiology Studies","score":0.9768000245094299,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quorum-sensing","display_name":"Quorum sensing","score":0.7621031403541565},{"id":"https://openalex.org/keywords/regulator","display_name":"Regulator","score":0.6605916023254395},{"id":"https://openalex.org/keywords/dissipation","display_name":"Dissipation","score":0.5708666443824768},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.5007343292236328},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.4729328453540802},{"id":"https://openalex.org/keywords/noise","display_name":"Noise (video)","score":0.4412859380245209},{"id":"https://openalex.org/keywords/intracellular","display_name":"Intracellular","score":0.4376777410507202},{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"Synthetic biology","score":0.4263022541999817},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4167470335960388},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.3781666159629822},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.30146127939224243},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.29785478115081787},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2781022787094116},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.17737415432929993},{"id":"https://openalex.org/keywords/bacteria","display_name":"Bacteria","score":0.16126462817192078},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.13713890314102173},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.12588179111480713}],"concepts":[{"id":"https://openalex.org/C118687296","wikidata":"https://www.wikidata.org/wiki/Q905754","display_name":"Quorum sensing","level":4,"score":0.7621031403541565},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.6605916023254395},{"id":"https://openalex.org/C135402231","wikidata":"https://www.wikidata.org/wiki/Q898440","display_name":"Dissipation","level":2,"score":0.5708666443824768},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5007343292236328},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4729328453540802},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.4412859380245209},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4376777410507202},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.4263022541999817},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4167470335960388},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3781666159629822},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.30146127939224243},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.29785478115081787},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2781022787094116},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17737415432929993},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.16126462817192078},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13713890314102173},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.12588179111480713},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006090","descriptor_name":"Gram-Negative Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006090","descriptor_name":"Gram-Negative Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006090","descriptor_name":"Gram-Negative Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006090","descriptor_name":"Gram-Negative Bacteria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006090","descriptor_name":"Gram-Negative Bacteria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006090","descriptor_name":"Gram-Negative Bacteria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050436","descriptor_name":"Regulatory Elements, Transcriptional","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D050436","descriptor_name":"Regulatory Elements, Transcriptional","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D050436","descriptor_name":"Regulatory Elements, Transcriptional","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053038","descriptor_name":"Quorum Sensing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053038","descriptor_name":"Quorum Sensing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053038","descriptor_name":"Quorum Sensing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1000167","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000167","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000167&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:18769706","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18769706","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:figshare.com:article/149633","is_oa":true,"landing_page_url":null,"pdf_url":"https://figshare.com/articles/dataset/Noise_Reduction_by_Diffusional_Dissipation_in_a_Minimal_Quorum_Sensing_Motif/149633","source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:RePEc:plo:pcbi00:1000167","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1000167","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:5feddce4af124dedbb1a71f0bc185e5d","is_oa":true,"landing_page_url":"https://doaj.org/article/5feddce4af124dedbb1a71f0bc185e5d","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 4, Iss 8, p e1000167 (2008)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2507755","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2507755","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000167","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000167","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000167&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2084920943.pdf","grobid_xml":"https://content.openalex.org/works/W2084920943.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1590222219","https://openalex.org/W1592652738","https://openalex.org/W1665661757","https://openalex.org/W1946177469","https://openalex.org/W1970970926","https://openalex.org/W1973435009","https://openalex.org/W1988791304","https://openalex.org/W1993009001","https://openalex.org/W1999777663","https://openalex.org/W2014761472","https://openalex.org/W2022371363","https://openalex.org/W2027896770","https://openalex.org/W2030083295","https://openalex.org/W2031822229","https://openalex.org/W2035870495","https://openalex.org/W2037298848","https://openalex.org/W2037768790","https://openalex.org/W2044692345","https://openalex.org/W2054430476","https://openalex.org/W2056498650","https://openalex.org/W2060603511","https://openalex.org/W2065833295","https://openalex.org/W2068978083","https://openalex.org/W2077023123","https://openalex.org/W2077046573","https://openalex.org/W2078193677","https://openalex.org/W2088925327","https://openalex.org/W2091198609","https://openalex.org/W2102300623","https://openalex.org/W2105057212","https://openalex.org/W2107304641","https://openalex.org/W2107342968","https://openalex.org/W2109110326","https://openalex.org/W2109117831","https://openalex.org/W2110071847","https://openalex.org/W2111870329","https://openalex.org/W2113106276","https://openalex.org/W2118274513","https://openalex.org/W2122693221","https://openalex.org/W2126922170","https://openalex.org/W2131869707","https://openalex.org/W2136294927","https://openalex.org/W2138776000","https://openalex.org/W2139374901","https://openalex.org/W2142596421","https://openalex.org/W2144150209","https://openalex.org/W2145352273","https://openalex.org/W2147745135","https://openalex.org/W2151070439","https://openalex.org/W2158905117","https://openalex.org/W2165526493","https://openalex.org/W2166860637","https://openalex.org/W2169927972","https://openalex.org/W2171280873","https://openalex.org/W2171327609","https://openalex.org/W2432517183","https://openalex.org/W2550122927","https://openalex.org/W2981264952","https://openalex.org/W3106262409","https://openalex.org/W6993211581"],"related_works":["https://openalex.org/W2169415577","https://openalex.org/W3207684964","https://openalex.org/W1980352067","https://openalex.org/W2378205681","https://openalex.org/W2059010035","https://openalex.org/W2007182598","https://openalex.org/W2389505468","https://openalex.org/W2201786346","https://openalex.org/W1822942219","https://openalex.org/W2738019715"],"abstract_inverted_index":{"Cellular":[0],"interactions":[1],"are":[2],"subject":[3],"to":[4,48,139],"random":[5],"fluctuations":[6],"(noise)":[7],"in":[8,106,177],"quantities":[9],"of":[10,22,57,92,114,122,129,143,161,167,191],"interacting":[11],"molecules.":[12],"Noise":[13],"presents":[14],"a":[15,45,58,81,97,102,159,162,178],"major":[16],"challenge":[17],"for":[18,188],"the":[19,37,55,115,141],"robust":[20,50],"function":[21],"natural":[23],"and":[24,63,90],"engineered":[25],"cellular":[26],"networks.":[27],"Past":[28],"studies":[29],"have":[30,73],"analyzed":[31],"how":[32],"noise":[33,75,156],"is":[34,158,170],"regulated":[35],"at":[36],"intracellular":[38],"level.":[39],"Cell-cell":[40],"communication,":[41],"however,":[42],"may":[43,185],"provide":[44],"complementary":[46],"strategy":[47],"achieve":[49],"gene":[51],"expression":[52,190],"by":[53,77,83,149],"enabling":[54],"coupling":[56],"cell":[59],"with":[60,119],"its":[61,123],"environment":[62],"other":[64],"cells.":[65],"To":[66],"gain":[67],"insight":[68],"into":[69],"this":[70,134,155],"issue,":[71],"we":[72,100],"examined":[74],"regulation":[76],"quorum":[78],"sensing":[79,91],"(QS),":[80],"mechanism":[82,136],"which":[84,168],"many":[85],"bacteria":[86],"communicate":[87],"through":[88],"production":[89],"small":[93],"diffusible":[94],"signals.":[95],"Using":[96],"stochastic":[98],"model,":[99],"analyze":[101],"minimal":[103],"QS":[104,116,169,179],"motif":[105],"Gram-negative":[107],"bacteria.":[108],"Our":[109,173],"analysis":[110],"shows":[111],"that":[112,154,194],"diffusion":[113],"signal,":[117],"together":[118],"fast":[120,144],"turnover":[121,146],"transcriptional":[124,183],"regulator,":[125],"attenuates":[126],"low-frequency":[127],"components":[128],"extrinsic":[130],"noise.":[131],"We":[132,151],"term":[133],"unique":[135],"\"diffusional":[137],"dissipation\"":[138],"emphasize":[140],"importance":[142],"signal":[145],"(or":[147],"dissipation)":[148],"diffusion.":[150],"further":[152],"show":[153],"attenuation":[157],"property":[160],"more":[163],"generic":[164],"regulatory":[165],"motif,":[166],"an":[171,181],"implementation.":[172],"results":[174],"suggest":[175],"that,":[176],"system,":[180],"unstable":[182],"regulator":[184],"be":[186],"favored":[187],"regulating":[189],"costly":[192],"proteins":[193],"generate":[195],"public":[196],"goods.":[197]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-03-10T16:38:18.471706","created_date":"2025-10-10T00:00:00"}