{"id":"https://openalex.org/W1964542367","doi":"https://doi.org/10.1371/journal.pcbi.1000165","title":"A Genomewide Functional Network for the Laboratory Mouse","display_name":"A Genomewide Functional Network for the Laboratory Mouse","publication_year":2008,"publication_date":"2008-09-25","ids":{"openalex":"https://openalex.org/W1964542367","doi":"https://doi.org/10.1371/journal.pcbi.1000165","mag":"1964542367","pmid":"https://pubmed.ncbi.nlm.nih.gov/18818725"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000165","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000165","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000165&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000165&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011032655","display_name":"Yuanfang Guan","orcid":"https://orcid.org/0000-0001-8275-2852"},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuanfang Guan","raw_affiliation_strings":["Lewis-Sigler Institute for Integrative Genomics, Carl Icahn Laboratory, Princeton University, Princeton, New Jersey, United States of America","Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America"],"affiliations":[{"raw_affiliation_string":"Lewis-Sigler Institute for Integrative Genomics, Carl Icahn Laboratory, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022226374","display_name":"Chad L. Myers","orcid":"https://orcid.org/0000-0002-1026-5972"},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chad L. Myers","raw_affiliation_strings":["Department of Computer Science, Princeton University, Princeton, New Jersey, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060825554","display_name":"Rong Lu","orcid":"https://orcid.org/0000-0002-5151-9246"},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rong Lu","raw_affiliation_strings":["Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112240982","display_name":"Ihor R. Lemischka","orcid":null},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ihor R. Lemischka","raw_affiliation_strings":["Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028990206","display_name":"Carol J. Bult","orcid":"https://orcid.org/0000-0001-9433-210X"},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol J. Bult","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, Maine, United States of America"],"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, Maine, United States of America","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025250742","display_name":"Olga G. Troyanskaya","orcid":"https://orcid.org/0000-0002-5676-5737"},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Olga G. Troyanskaya","raw_affiliation_strings":["Department of Computer Science, Princeton University, Princeton, New Jersey, United States of America","Lewis-Sigler Institute for Integrative Genomics, Carl Icahn Laboratory, Princeton University, Princeton, New Jersey, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Lewis-Sigler Institute for Integrative Genomics, Carl Icahn Laboratory, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5025250742"],"corresponding_institution_ids":["https://openalex.org/I20089843"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":5.5324,"has_fulltext":true,"cited_by_count":111,"citation_normalized_percentile":{"value":0.96575872,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"4","issue":"9","first_page":"e1000165","last_page":"e1000165"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9922999739646912,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6981156468391418},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6702533960342407},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.6689706444740295},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.6393972635269165},{"id":"https://openalex.org/keywords/functional-genomics","display_name":"Functional genomics","score":0.5414557456970215},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.5392699241638184},{"id":"https://openalex.org/keywords/interactome","display_name":"Interactome","score":0.49372395873069763},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.46723324060440063},{"id":"https://openalex.org/keywords/interaction-network","display_name":"Interaction network","score":0.46118858456611633},{"id":"https://openalex.org/keywords/network-analysis","display_name":"Network analysis","score":0.45161157846450806},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.4348064959049225},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.42906254529953003},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3660905361175537},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.3344990015029907},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.20219632983207703},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.11075916886329651}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6981156468391418},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6702533960342407},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.6689706444740295},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.6393972635269165},{"id":"https://openalex.org/C161078062","wikidata":"https://www.wikidata.org/wiki/Q1068690","display_name":"Functional genomics","level":5,"score":0.5414557456970215},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5392699241638184},{"id":"https://openalex.org/C9760119","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interactome","level":3,"score":0.49372395873069763},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.46723324060440063},{"id":"https://openalex.org/C55105296","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interaction network","level":3,"score":0.46118858456611633},{"id":"https://openalex.org/C32946077","wikidata":"https://www.wikidata.org/wiki/Q618079","display_name":"Network analysis","level":2,"score":0.45161157846450806},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4348064959049225},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42906254529953003},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3660905361175537},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.3344990015029907},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.20219632983207703},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.11075916886329651},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000071317","descriptor_name":"Nanog Homeobox Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071317","descriptor_name":"Nanog Homeobox Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071317","descriptor_name":"Nanog Homeobox Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003628","descriptor_name":"Database Management Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003628","descriptor_name":"Database Management Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003628","descriptor_name":"Database Management Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pcbi.1000165","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000165","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000165&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:18818725","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18818725","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pure.atira.dk:publications/e45ed64c-1d1e-4c77-995c-1e1f78c8ba7e","is_oa":true,"landing_page_url":null,"pdf_url":"https://www.research.manchester.ac.uk/portal/en/publications/a-genomewide-functional-network-for-the-laboratory-mouse(e45ed64c-1d1e-4c77-995c-1e1f78c8ba7e).html","source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""},{"id":"pmh:oai:pure.atira.dk:publications/e45ed64c-1d1e-4c77-995c-1e1f78c8ba7e","is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/publications/e45ed64c-1d1e-4c77-995c-1e1f78c8ba7e","pdf_url":"https://www.research.manchester.ac.uk/portal/en/publications/a-genomewide-functional-network-for-the-laboratory-mouse(e45ed64c-1d1e-4c77-995c-1e1f78c8ba7e).html","source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Guan, Y, Myers, C L, Lu, R, Lemischka, I R, Bult, C J & Troyanskaya, O G 2008, 'A genomewide functional network for the laboratory mouse', PL o S Computational Biology, vol. 4, no. 9, e1000165. https://doi.org/10.1371/journal.pcbi.1000165","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.275.6904","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.275.6904","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/3d/33/PLoS_Comput_Biol_2008_Sep_26_4(9)_e1000165.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:a646d295f96146ceb7ca162c3cfdbd3f","is_oa":true,"landing_page_url":"https://doaj.org/article/a646d295f96146ceb7ca162c3cfdbd3f","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 4, Iss 9, p e1000165 (2008)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/149540","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/A_Genomewide_Functional_Network_for_the_Laboratory_Mouse/149540","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:mouseion.jax.org:stfb2000_2009-2823","is_oa":true,"landing_page_url":"http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1000165","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Research 2000 - 2009","raw_type":"text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2527685","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2527685","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000165","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000165","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000165&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1011064577","display_name":null,"funder_award_id":"P50 GM071508","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2271306371","display_name":null,"funder_award_id":"GM071508","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2994491871","display_name":null,"funder_award_id":"GM071508","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4170014715","display_name":"SEI (BIO): Integrated analysis of heterogeneous genomic data for accurate prediction of gene function and interactions between proteins","funder_award_id":"0513552","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4950152500","display_name":null,"funder_award_id":"DBI-0546275","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5288662233","display_name":null,"funder_award_id":"GM071966","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5910422865","display_name":null,"funder_award_id":"P50 GM071508","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6567509300","display_name":null,"funder_award_id":"P50 GM071508","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6671297155","display_name":null,"funder_award_id":"CAREER","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7105370156","display_name":null,"funder_award_id":"R01 GM071966","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7411829897","display_name":null,"funder_award_id":"R01 GM","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7588032409","display_name":"CAREER: An Integrated Approach to the Study of Biological Process Specific Networks","funder_award_id":"0546275","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7844601725","display_name":null,"funder_award_id":"GM071966","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8725729182","display_name":null,"funder_award_id":"P50 GM07150","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1964542367.pdf"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1492851286","https://openalex.org/W1811927564","https://openalex.org/W1872489737","https://openalex.org/W1975200987","https://openalex.org/W1976386441","https://openalex.org/W1984249061","https://openalex.org/W1999154602","https://openalex.org/W2008403314","https://openalex.org/W2015721745","https://openalex.org/W2017994420","https://openalex.org/W2038303935","https://openalex.org/W2043842514","https://openalex.org/W2046618236","https://openalex.org/W2049342816","https://openalex.org/W2052815101","https://openalex.org/W2055226243","https://openalex.org/W2059682917","https://openalex.org/W2070412833","https://openalex.org/W2078222204","https://openalex.org/W2083045667","https://openalex.org/W2095387858","https://openalex.org/W2096373458","https://openalex.org/W2098170619","https://openalex.org/W2101674614","https://openalex.org/W2103017472","https://openalex.org/W2104080300","https://openalex.org/W2104878392","https://openalex.org/W2107575419","https://openalex.org/W2110015307","https://openalex.org/W2112090702","https://openalex.org/W2112928083","https://openalex.org/W2119043225","https://openalex.org/W2122686681","https://openalex.org/W2123828448","https://openalex.org/W2126851387","https://openalex.org/W2130687290","https://openalex.org/W2130790725","https://openalex.org/W2134711219","https://openalex.org/W2137464714","https://openalex.org/W2143537765","https://openalex.org/W2144014661","https://openalex.org/W2145825942","https://openalex.org/W2147461734","https://openalex.org/W2149310258","https://openalex.org/W2150163104","https://openalex.org/W2151875636","https://openalex.org/W2152360905","https://openalex.org/W2152653671","https://openalex.org/W2153577994","https://openalex.org/W2153932080","https://openalex.org/W2157305748","https://openalex.org/W2162142896","https://openalex.org/W2164683872","https://openalex.org/W2165674132","https://openalex.org/W2166574880","https://openalex.org/W2171281715","https://openalex.org/W4247236552"],"related_works":["https://openalex.org/W2063905494","https://openalex.org/W2101998831","https://openalex.org/W2158714033","https://openalex.org/W1922372990","https://openalex.org/W2032694615","https://openalex.org/W2153577994","https://openalex.org/W4386628104","https://openalex.org/W2043924719","https://openalex.org/W2092868481","https://openalex.org/W2127864418"],"abstract_inverted_index":{"Establishing":[0],"a":[1,22,34,43,89,126,149,156,187,201],"functional":[2,35,50,58,73,107,153,161,177],"network":[3,36,55,68,76,108,178,218],"is":[4],"invaluable":[5],"to":[6,85,168,171],"our":[7,175],"understanding":[8],"of":[9,16,46,100,104,115,129,152,163,210,216],"gene":[10,91,232],"function,":[11],"pathways,":[12],"and":[13,19,49,75,78,145,194,207,230],"systems-level":[14,113,205],"properties":[15],"an":[17,235],"organism":[18],"can":[20,69],"be":[21],"powerful":[23],"resource":[24,189],"in":[25,92,228],"directing":[26],"targeted":[27],"experiments.":[28],"In":[29,147],"this":[30,67,217],"study,":[31],"we":[32,120,224],"present":[33,79],"for":[37,82,179,190,203],"the":[38,101,105,116,122,180,184,220],"laboratory":[39,181],"mouse":[40,93,106,117,182],"based":[41],"on":[42,155],"Bayesian":[44],"integration":[45],"diverse":[47,134],"genetic":[48],"genomic":[51,157],"data.":[52],"The":[53],"resulting":[54],"includes":[56],"probabilistic":[57],"linkages":[59],"among":[60],"20,581":[61],"protein-coding":[62],"genes.":[63],"We":[64],"show":[65],"that":[66,132],"accurately":[70],"predict":[71],"novel":[72,195],"assignments":[74],"components":[77,197],"experimental":[80],"evidence":[81],"predictions":[83],"related":[84],"Nanog":[86],"homeobox":[87],"(Nanog),":[88],"critical":[90,127],"embryonic":[94],"stem":[95],"cell":[96],"pluripotency.":[97],"An":[98],"analysis":[99],"global":[102,176],"topology":[103],"reveals":[109],"multiple":[110],"biologically":[111],"relevant":[112],"features":[114,209],"proteome.":[118],"Specifically,":[119],"identify":[121],"clustering":[123],"coefficient":[124],"as":[125,136,138,166,198,200],"characteristic":[128],"central":[130],"modulators":[131],"affect":[133],"pathways":[135],"well":[137,199],"genes":[139],"associated":[140],"with":[141,186],"different":[142],"phenotype":[143],"traits":[144],"diseases.":[146],"addition,":[148],"cross-species":[150],"comparison":[151],"interactomes":[154],"scale":[158],"revealed":[159],"distinct":[160],"characteristics":[162],"conserved":[164],"neighborhoods":[165],"compared":[167],"subnetworks":[169],"specific":[170],"higher":[172],"organisms.":[173],"Thus,":[174],"provides":[183],"community":[185],"key":[188],"discovering":[191],"protein":[192],"functions":[193],"pathway":[196],"tool":[202],"exploring":[204],"topological":[206],"evolutionary":[208],"cellular":[211],"interactomes.":[212],"To":[213],"facilitate":[214],"exploration":[215],"by":[219],"biomedical":[221],"research":[222],"community,":[223],"illustrate":[225],"its":[226],"application":[227],"function":[229],"disease":[231],"discovery":[233],"through":[234],"interactive,":[236],"Web-based,":[237],"publicly":[238],"available":[239],"interface":[240],"at":[241],"http://mouseNET.princeton.edu.":[242]},"counts_by_year":[{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":11}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}