{"id":"https://openalex.org/W18725924","doi":"https://doi.org/10.1371/journal.pcbi.1000155","title":"Champions league 2008 2009: analisi tecnico tattica delle partite del Chelsea","display_name":"Champions league 2008 2009: analisi tecnico tattica delle partite del Chelsea","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W18725924","doi":"https://doi.org/10.1371/journal.pcbi.1000155","mag":"18725924"},"language":"en","primary_location":{"id":"mag:18725924","is_oa":true,"landing_page_url":"http://biblioteca.figc.it/3242/","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},"type":"dissertation","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://biblioteca.figc.it/3242/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091440291","display_name":"Lorenzo Pier Paolo Amoruso","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lorenzo Pier Paolo Amoruso","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5091440291"],"corresponding_institution_ids":[],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"8","first_page":"e1000155","last_page":"e1000155"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13752","display_name":"Mechanics and Biomechanics Studies","score":0.947700023651123,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13752","display_name":"Mechanics and Biomechanics Studies","score":0.947700023651123,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/league","display_name":"League","score":0.8218458890914917},{"id":"https://openalex.org/keywords/political-science","display_name":"Political science","score":0.4080219864845276},{"id":"https://openalex.org/keywords/humanities","display_name":"Humanities","score":0.36325594782829285},{"id":"https://openalex.org/keywords/art","display_name":"Art","score":0.19299107789993286},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.05811753869056702}],"concepts":[{"id":"https://openalex.org/C207456731","wikidata":"https://www.wikidata.org/wiki/Q660818","display_name":"League","level":2,"score":0.8218458890914917},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.4080219864845276},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.36325594782829285},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.19299107789993286},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.05811753869056702},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:18725924","is_oa":true,"landing_page_url":"http://biblioteca.figc.it/3242/","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null}],"best_oa_location":{"id":"mag:18725924","is_oa":true,"landing_page_url":"http://biblioteca.figc.it/3242/","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Tau":[0],"is":[1,83,172],"a":[2,30,54,71,91,102,112,168,218,273],"natively":[3,37,55],"unfolded":[4,38,56,97],"protein":[5,57],"that":[6,67,84,94,126,141,185,193,213,225],"forms":[7,176],"intracellular":[8],"aggregates":[9],"in":[10,129,163,174,202,221,239],"the":[11,20,23,81,96,132,157,194,204,244,256,262,280],"brains":[12],"of":[13,25,36,51,74,80,104,108,115,131,177,227,246,258,264,282],"patients":[14],"with":[15,70,111,144],"Alzheimer's":[16],"disease.":[17],"To":[18],"decipher":[19],"mechanism":[21],"underlying":[22],"formation":[24,281],"tau":[26,150,166,283],"aggregates,":[27],"we":[28,100,138,191,211],"developed":[29],"novel":[31],"approach":[32],"for":[33,156,252],"constructing":[34],"models":[35,153],"proteins.":[39],"The":[40],"method,":[41],"energy-minima":[42],"mapping":[43],"and":[44,58,118,167,206,224],"weighting":[45],"(EMW),":[46],"samples":[47],"local":[48,123],"energy":[49],"minima":[50],"subsequences":[52],"within":[53],"then":[59],"constructs":[60],"ensembles":[61,140],"from":[62,267],"these":[63,269],"energetically":[64],"favorable":[65],"conformations":[66,242],"are":[68,127,142,186],"consistent":[69,143],"given":[72,113],"set":[73,114],"experimental":[75,116],"data.":[76],"A":[77],"unique":[78],"feature":[79],"method":[82],"it":[85],"does":[86],"not":[87],"strive":[88],"to":[89,236],"generate":[90],"single":[92],"ensemble":[93],"represents":[95],"state.":[98],"Instead":[99],"construct":[101],"number":[103],"candidate":[105],"ensembles,":[106,190],"each":[107],"which":[109,171,230],"agrees":[110],"constraints,":[117],"focus":[119],"our":[120],"analysis":[121],"on":[122,149,182],"structural":[124,183],"features":[125,184],"present":[128],"all":[130,189],"independently":[133],"generated":[134,139],"ensembles.":[135],"Using":[136],"EMW":[137],"chemical":[145],"shift":[146],"measurements":[147],"obtained":[148],"constructs.":[151],"Thirty":[152],"were":[154],"constructed":[155],"second":[158],"microtubule":[159],"binding":[160],"repeat":[161],"(MTBR2)":[162],"wild-type":[164],"(WT)":[165],"DeltaK280":[169,207],"mutant,":[170],"found":[173],"some":[175],"frontotemporal":[178],"dementia.":[179],"By":[180],"focusing":[181],"preserved":[187],"across":[188],"find":[192,212],"aggregation-initiating":[195],"sequence,":[196],"PHF6*,":[197,268],"prefers":[198],"an":[199,237,249],"extended":[200,241,253],"conformation":[201,220],"both":[203],"WT":[205,222],"sequences.":[208],"In":[209],"addition,":[210],"residue":[214],"K280":[215],"can":[216,231,278],"adopt":[217,232],"loop/turn":[219],"MTBR2":[223],"deletion":[226,274],"this":[228],"residue,":[229],"nonextended":[233],"states,":[234],"leads":[235],"increase":[238],"locally":[240],"near":[243,255],"C-terminus":[245,257],"PHF6*.":[247],"As":[248],"increased":[250],"preference":[251],"states":[254],"PHF6*":[259],"may":[260],"facilitate":[261],"propagation":[263],"beta-structure":[265],"downstream":[266],"results":[270],"explain":[271],"how":[272],"at":[275],"position":[276],"280":[277],"promote":[279],"aggregates.":[284]},"counts_by_year":[],"updated_date":"2025-07-23T07:01:51.661072","created_date":"2016-06-24T00:00:00"}