{"id":"https://openalex.org/W2043366372","doi":"https://doi.org/10.1371/journal.pcbi.1000148","title":"Coordinate Regulation of G Protein Signaling via Dynamic Interactions of Receptor and GAP","display_name":"Coordinate Regulation of G Protein Signaling via Dynamic Interactions of Receptor and GAP","publication_year":2008,"publication_date":"2008-08-14","ids":{"openalex":"https://openalex.org/W2043366372","doi":"https://doi.org/10.1371/journal.pcbi.1000148","mag":"2043366372","pmid":"https://pubmed.ncbi.nlm.nih.gov/18716678"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000148","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000148","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000148&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000148&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107208839","display_name":"Marc Turcotte","orcid":"https://orcid.org/0000-0003-3222-5856"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"education","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc Turcotte","raw_affiliation_strings":["Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, USA","Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013607512","display_name":"Wei\u2010Jen Tang","orcid":"https://orcid.org/0000-0002-8267-8995"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"education","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Tang","raw_affiliation_strings":["Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America","Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036589276","display_name":"Elliott M. Ross","orcid":"https://orcid.org/0000-0002-0252-8197"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"education","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elliott M. Ross","raw_affiliation_strings":["Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5036589276"],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.9044,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.90983497,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"4","issue":"8","first_page":"e1000148","last_page":"e1000148"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gtpase-activating-protein","display_name":"GTPase-activating protein","score":0.8037928342819214},{"id":"https://openalex.org/keywords/gtpase","display_name":"GTPase","score":0.7245125770568848},{"id":"https://openalex.org/keywords/effector","display_name":"Effector","score":0.6697136163711548},{"id":"https://openalex.org/keywords/g-protein","display_name":"G protein","score":0.6568397283554077},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.5267719030380249},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor","display_name":"G protein-coupled receptor","score":0.4759880304336548},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.4673740267753601},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.43567103147506714},{"id":"https://openalex.org/keywords/gtp-binding-protein-regulators","display_name":"GTP-binding protein regulators","score":0.4332329034805298},{"id":"https://openalex.org/keywords/phospholipase-c","display_name":"Phospholipase C","score":0.4325621426105499},{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"Allosteric regulation","score":0.42691484093666077},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.4235367178916931},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3917819857597351},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3590371012687683},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.3292314410209656}],"concepts":[{"id":"https://openalex.org/C163181125","wikidata":"https://www.wikidata.org/wiki/Q408592","display_name":"GTPase-activating protein","level":4,"score":0.8037928342819214},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.7245125770568848},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.6697136163711548},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.6568397283554077},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5267719030380249},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.4759880304336548},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4673740267753601},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43567103147506714},{"id":"https://openalex.org/C85771745","wikidata":"https://www.wikidata.org/wiki/Q5514732","display_name":"GTP-binding protein regulators","level":4,"score":0.4332329034805298},{"id":"https://openalex.org/C2778597717","wikidata":"https://www.wikidata.org/wiki/Q420248","display_name":"Phospholipase C","level":3,"score":0.4325621426105499},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.42691484093666077},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4235367178916931},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3917819857597351},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3590371012687683},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3292314410209656}],"mesh":[{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006153","descriptor_name":"Guanosine Diphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006153","descriptor_name":"Guanosine Diphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006153","descriptor_name":"Guanosine Diphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006153","descriptor_name":"Guanosine Diphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016018","descriptor_name":"Least-Squares Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016018","descriptor_name":"Least-Squares Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016018","descriptor_name":"Least-Squares Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016018","descriptor_name":"Least-Squares Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020690","descriptor_name":"GTPase-Activating Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020690","descriptor_name":"GTPase-Activating Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020690","descriptor_name":"GTPase-Activating Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020690","descriptor_name":"GTPase-Activating Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053835","descriptor_name":"Unilamellar Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053835","descriptor_name":"Unilamellar Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053835","descriptor_name":"Unilamellar Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053835","descriptor_name":"Unilamellar Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054799","descriptor_name":"Phospholipase C beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054799","descriptor_name":"Phospholipase C beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054799","descriptor_name":"Phospholipase C beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054799","descriptor_name":"Phospholipase C beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1000148","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000148","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000148&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:18716678","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18716678","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.275.1557","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.275.1557","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/d5/92/PLoS_Comput_Biol_2008_Aug_15_4(8)_e1000148.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:b2c264d455ba4cd387bbbaca28735511","is_oa":true,"landing_page_url":"https://doaj.org/article/b2c264d455ba4cd387bbbaca28735511","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 4, Iss 8, p e1000148 (2008)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:1932209","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2518520","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/149798","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Coordinate_Regulation_of_G_Protein_Signaling_via_Dynamic_Interactions_of_Receptor_and_GAP/149798","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000148","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000148","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000148&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/8","display_name":"Decent work and economic growth","score":0.6399999856948853}],"awards":[{"id":"https://openalex.org/G1086607988","display_name":null,"funder_award_id":"GM07197","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2278667889","display_name":null,"funder_award_id":"I-098","funder_id":"https://openalex.org/F4320306196","funder_display_name":"Welch Foundation"}],"funders":[{"id":"https://openalex.org/F4320306196","display_name":"Welch Foundation","ror":"https://ror.org/00np6vq88"},{"id":"https://openalex.org/F4320310169","display_name":"University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2043366372.pdf","grobid_xml":"https://content.openalex.org/works/W2043366372.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1518153787","https://openalex.org/W1534683572","https://openalex.org/W1545819790","https://openalex.org/W1666636243","https://openalex.org/W1871134734","https://openalex.org/W1953109900","https://openalex.org/W1965926793","https://openalex.org/W1972657716","https://openalex.org/W1974229569","https://openalex.org/W1974770940","https://openalex.org/W1985706424","https://openalex.org/W1991091877","https://openalex.org/W1993735775","https://openalex.org/W1995682111","https://openalex.org/W1996356699","https://openalex.org/W2000151769","https://openalex.org/W2004125744","https://openalex.org/W2008184881","https://openalex.org/W2013412105","https://openalex.org/W2027764322","https://openalex.org/W2029445497","https://openalex.org/W2034983225","https://openalex.org/W2040689106","https://openalex.org/W2043276874","https://openalex.org/W2045074917","https://openalex.org/W2053217010","https://openalex.org/W2058089380","https://openalex.org/W2064746296","https://openalex.org/W2064792414","https://openalex.org/W2075869274","https://openalex.org/W2076148711","https://openalex.org/W2081346423","https://openalex.org/W2081963773","https://openalex.org/W2085229836","https://openalex.org/W2090774157","https://openalex.org/W2090882698","https://openalex.org/W2093638721","https://openalex.org/W2095202899","https://openalex.org/W2102492042","https://openalex.org/W2104519586","https://openalex.org/W2105149671","https://openalex.org/W2114460420","https://openalex.org/W2118656164","https://openalex.org/W2119965520","https://openalex.org/W2126463310","https://openalex.org/W2131740293","https://openalex.org/W2134704464","https://openalex.org/W2154653890","https://openalex.org/W2156343284","https://openalex.org/W2165888364","https://openalex.org/W2166384691","https://openalex.org/W2168808956","https://openalex.org/W2171776966","https://openalex.org/W2172659222","https://openalex.org/W2593239890","https://openalex.org/W2888848023","https://openalex.org/W3047194857","https://openalex.org/W4229518981","https://openalex.org/W4235083685","https://openalex.org/W4239951588","https://openalex.org/W4300765115","https://openalex.org/W4302422232"],"related_works":["https://openalex.org/W2029445497","https://openalex.org/W2149683244","https://openalex.org/W1997652486","https://openalex.org/W2095013577","https://openalex.org/W1953109900","https://openalex.org/W1614895539","https://openalex.org/W2083195970","https://openalex.org/W338648647","https://openalex.org/W4251729199","https://openalex.org/W3047194857"],"abstract_inverted_index":{"Signal":[0],"output":[1,44,337],"from":[2,199],"receptor-G-protein-effector":[3],"modules":[4],"is":[5,48,61,195,230,251,341],"a":[6,120,161,365],"dynamic":[7],"function":[8],"of":[9,14,20,39,85,107,130,147,164,216,227,234,271,313,330,344,354,364,408,416],"the":[10,15,17,46,73,103,148,190,200,212,217,228,268,301,339,362,367,375,384,396,406],"nucleotide":[11,297],"exchange":[12,214,225,290],"activity":[13,19,215,220,226,323],"receptor,":[16,218],"GTPase-accelerating":[18],"GTPase-activating":[21],"proteins":[22,71],"(GAPs),":[23],"and":[24,59,88,111,133,138,142,152,240,262,285,351,378,392],"their":[25],"interactions.":[26],"GAPs":[27],"may":[28,33],"inhibit":[29],"steady-state":[30,165,277],"signaling":[31,126,414],"but":[32,304,332],"also":[34,404],"accelerate":[35,78,325],"deactivation":[36,326],"upon":[37,328],"removal":[38,329],"stimulus":[40],"without":[41],"significantly":[42],"inhibiting":[43],"when":[45,248],"receptor":[47,141,229,239,272,283,287,340,368],"active.":[49,342],"Further,":[50],"some":[51],"effectors":[52,65],"(e.g.,":[53],"phospholipase":[54],"C-beta)":[55],"are":[56,112],"themselves":[57],"GAPs,":[58],"it":[60],"unclear":[62],"how":[63,321],"such":[64,94],"can":[66,324],"be":[67],"stimulated":[68],"by":[69,140,156,181,236,292],"G":[70,79,124,135,243,249,274,302,314,372],"at":[72],"same":[74],"time":[75],"as":[76],"they":[77],"protein":[80,125,136,244,250,275,303,315,373],"deactivation.":[81],"The":[82,387,402],"multiple":[83,186],"combinations":[84],"protein-protein":[86],"associations":[87],"interacting":[89],"regulatory":[90,398],"effects":[91],"that":[92,127,208,379],"allow":[93,334],"complex":[95],"behaviors":[96,391],"in":[97,168,175,361],"this":[98,417],"system":[99],"do":[100],"not":[101],"permit":[102],"usual":[104],"simplifying":[105],"assumptions":[106],"traditional":[108],"enzyme":[109],"kinetics":[110],"uniquely":[113],"subject":[114],"to":[115,160,188,253,273,371,395,413],"systems-level":[116],"analysis.":[117],"We":[118,144,184],"developed":[119],"kinetic":[121,204],"model":[122,149],"for":[123,316],"permits":[128],"analysis":[129,388,412],"both":[131],"interactive":[132],"independent":[134],"binding":[137,261,270,298],"regulation":[139],"GAP.":[143],"evaluated":[145],"parameters":[146],"(all":[150],"forward":[151],"reverse":[153],"rate":[154],"constants)":[155],"global":[157],"least-squares":[158],"fitting":[159],"diverse":[162],"set":[163],"GTPase":[166,177,278,345,356,376],"measurements":[167],"an":[169,219,294],"m1":[170],"muscarinic":[171],"receptor-G(q)-phospholipase":[172],"C-beta1":[173],"module":[174],"which":[176,194],"activities":[178],"were":[179],"varied":[180],"approximately":[182],"10(4)-fold.":[183],"provide":[185],"tests":[187],"validate":[189],"fitted":[191],"parameter":[192],"set,":[193],"consistent":[196],"with":[197,245],"results":[198],"few":[201],"previous":[202],"pre-steady-state":[203],"measurements.":[205],"Results":[206],"indicate":[207,359],"(1)":[209],"GAP":[210,241,260,265,322,380],"potentiates":[211],"GDP/GTP":[213,289],"never":[221],"before":[222],"reported;":[223],"(2)":[224],"biased":[231],"toward":[232],"replacement":[233],"GDP":[235],"GTP;":[237],"(3)":[238],"bind":[242],"negative":[246],"cooperativity":[247],"bound":[252,370],"either":[254],"GTP":[255],"or":[256],"GDP,":[257],"promoting":[258],"rapid":[259],"dissociation;":[263],"(4)":[264],"indirectly":[266],"stabilizes":[267],"continuous":[269],"during":[276,383],"hydrolysis,":[279],"thus":[280],"further":[281],"enhancing":[282],"activity;":[284],"(5)":[286],"accelerates":[288],"primarily":[291,382],"opening":[293],"otherwise":[295],"closed":[296],"site":[299],"on":[300,308],"has":[305],"minimal":[306],"effect":[307],"affinity":[309],"(K(assoc)":[310],"=":[311],"k(assoc)/k(dissoc))":[312],"nucleotide.":[317],"Model-based":[318],"simulation":[319],"explains":[320,389],">10-fold":[327],"agonist":[331],"still":[333],"high":[335],"signal":[336],"while":[338],"Analysis":[343],"flux":[346],"through":[347],"distinct":[348],"reaction":[349],"pathways":[350],"consequent":[352],"accumulation":[353],"specific":[355,397],"cycle":[357,377],"intermediates":[358],"that,":[360],"presence":[363],"GAP,":[366],"remains":[369],"throughout":[374],"binds":[381],"GTP-bound":[385],"phase.":[386],"these":[390],"relates":[393],"them":[394],"phenomena":[399],"described":[400],"above.":[401],"work":[403],"demonstrates":[405],"applicability":[407],"appropriately":[409],"data-constrained":[410],"system-level":[411],"networks":[415],"scale.":[418]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}