{"id":"https://openalex.org/W2043002375","doi":"https://doi.org/10.1371/journal.pcbi.1000145","title":"Intramolecular Cohesion of Coils Mediated by Phenylalanine\u2013Glycine Motifs in the Natively Unfolded Domain of a Nucleoporin","display_name":"Intramolecular Cohesion of Coils Mediated by Phenylalanine\u2013Glycine Motifs in the Natively Unfolded Domain of a Nucleoporin","publication_year":2008,"publication_date":"2008-08-07","ids":{"openalex":"https://openalex.org/W2043002375","doi":"https://doi.org/10.1371/journal.pcbi.1000145","mag":"2043002375","pmid":"https://pubmed.ncbi.nlm.nih.gov/18688269"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000145","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000145","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000145&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000145&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113785712","display_name":"V. V. Krishnan","orcid":null},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]},{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]},{"id":"https://openalex.org/I67328108","display_name":"California State University, Fresno","ror":"https://ror.org/03enmdz06","country_code":"US","type":"education","lineage":["https://openalex.org/I67328108"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"V. V. Krishnan","raw_affiliation_strings":["Department of Applied Science, University of California Davis, Davis, California, United States of America","Department of Chemistry, California State University Fresno, Fresno, California, United States of America","Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Applied Science, University of California Davis, Davis, California, United States of America","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Chemistry, California State University Fresno, Fresno, California, United States of America","institution_ids":["https://openalex.org/I67328108"]},{"raw_affiliation_string":"Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016987266","display_name":"Edmond Y. Lau","orcid":"https://orcid.org/0000-0003-0619-7249"},"institutions":[{"id":"https://openalex.org/I1282311441","display_name":"Lawrence Livermore National Laboratory","ror":"https://ror.org/041nk4h53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282311441","https://openalex.org/I1330989302","https://openalex.org/I198811213","https://openalex.org/I4210138311"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Edmond Y. Lau","raw_affiliation_strings":["Chemistry, Materials, Earth and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California, United States of America,","Chemistry, Materials, Earth and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Chemistry, Materials, Earth and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California, United States of America,","institution_ids":["https://openalex.org/I1282311441"]},{"raw_affiliation_string":"Chemistry, Materials, Earth and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California, United States of America","institution_ids":["https://openalex.org/I1282311441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036098177","display_name":"Justin Yamada","orcid":"https://orcid.org/0000-0003-1933-3721"},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Justin Yamada","raw_affiliation_strings":["Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America,","Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America,","institution_ids":["https://openalex.org/I185103710"]},{"raw_affiliation_string":"Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048465477","display_name":"Daniel P. Denning","orcid":"https://orcid.org/0000-0001-5667-3480"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniel P. Denning","raw_affiliation_strings":["Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America,","Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America,","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002654927","display_name":"Samir S. Patel","orcid":"https://orcid.org/0000-0002-9489-5516"},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Samir S. Patel","raw_affiliation_strings":["Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America,","Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America,","institution_ids":["https://openalex.org/I185103710"]},{"raw_affiliation_string":"Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060594038","display_name":"Michael E. Colvin","orcid":"https://orcid.org/0000-0002-6581-4764"},"institutions":[{"id":"https://openalex.org/I156087764","display_name":"University of California, Merced","ror":"https://ror.org/00d9ah105","country_code":"US","type":"education","lineage":["https://openalex.org/I156087764"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael E. Colvin","raw_affiliation_strings":["Center for Computational Biology,","School of Natural Sciences, University of California Merced, Merced, California, United States of America","Center for Computational Biology, School of Natural Sciences, University of California Merced, Merced, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Center for Computational Biology,","institution_ids":[]},{"raw_affiliation_string":"School of Natural Sciences, University of California Merced, Merced, California, United States of America","institution_ids":["https://openalex.org/I156087764"]},{"raw_affiliation_string":"Center for Computational Biology, School of Natural Sciences, University of California Merced, Merced, California, United States of America","institution_ids":["https://openalex.org/I156087764"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065057275","display_name":"Michael Rexach","orcid":null},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael F. Rexach","raw_affiliation_strings":["Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America,","Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America,","institution_ids":["https://openalex.org/I185103710"]},{"raw_affiliation_string":"Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America","institution_ids":["https://openalex.org/I185103710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5002654927","https://openalex.org/A5016987266","https://openalex.org/A5036098177","https://openalex.org/A5048465477","https://openalex.org/A5060594038","https://openalex.org/A5065057275","https://openalex.org/A5113785712"],"corresponding_institution_ids":["https://openalex.org/I1282311441","https://openalex.org/I156087764","https://openalex.org/I185103710","https://openalex.org/I63966007","https://openalex.org/I67328108","https://openalex.org/I84218800"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.7662,"has_fulltext":true,"cited_by_count":53,"citation_normalized_percentile":{"value":0.9038711,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"4","issue":"8","first_page":"e1000145","last_page":"e1000145"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nucleoporin","display_name":"Nucleoporin","score":0.9448162317276001},{"id":"https://openalex.org/keywords/nuclear-pore","display_name":"Nuclear pore","score":0.8336831331253052},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.5999269485473633},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5485544800758362},{"id":"https://openalex.org/keywords/intrinsically-disordered-proteins","display_name":"Intrinsically disordered proteins","score":0.49449726939201355},{"id":"https://openalex.org/keywords/cytoplasm","display_name":"Cytoplasm","score":0.4560331106185913},{"id":"https://openalex.org/keywords/crystallography","display_name":"Crystallography","score":0.4452032744884491},{"id":"https://openalex.org/keywords/nuclear-transport","display_name":"Nuclear transport","score":0.42279624938964844},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2867922782897949},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.23601305484771729},{"id":"https://openalex.org/keywords/cell-nucleus","display_name":"Cell nucleus","score":0.15408650040626526}],"concepts":[{"id":"https://openalex.org/C68556195","wikidata":"https://www.wikidata.org/wiki/Q3571630","display_name":"Nucleoporin","level":5,"score":0.9448162317276001},{"id":"https://openalex.org/C126725582","wikidata":"https://www.wikidata.org/wiki/Q30679","display_name":"Nuclear pore","level":3,"score":0.8336831331253052},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5999269485473633},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5485544800758362},{"id":"https://openalex.org/C2778815515","wikidata":"https://www.wikidata.org/wiki/Q3408242","display_name":"Intrinsically disordered proteins","level":2,"score":0.49449726939201355},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.4560331106185913},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.4452032744884491},{"id":"https://openalex.org/C59157529","wikidata":"https://www.wikidata.org/wiki/Q994741","display_name":"Nuclear transport","level":4,"score":0.42279624938964844},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2867922782897949},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23601305484771729},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.15408650040626526}],"mesh":[{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020449","descriptor_name":"Repetitive Sequences, Amino Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020449","descriptor_name":"Repetitive Sequences, Amino Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020449","descriptor_name":"Repetitive Sequences, Amino Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021581","descriptor_name":"Active Transport, Cell Nucleus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D021581","descriptor_name":"Active Transport, Cell Nucleus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D021581","descriptor_name":"Active Transport, Cell Nucleus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D022022","descriptor_name":"Nuclear Pore","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022022","descriptor_name":"Nuclear Pore","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022022","descriptor_name":"Nuclear Pore","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022022","descriptor_name":"Nuclear Pore","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D022022","descriptor_name":"Nuclear Pore","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D022022","descriptor_name":"Nuclear Pore","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D022022","descriptor_name":"Nuclear Pore","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D022022","descriptor_name":"Nuclear Pore","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D022022","descriptor_name":"Nuclear Pore","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D028861","descriptor_name":"Nuclear Pore Complex Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D028861","descriptor_name":"Nuclear Pore Complex Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D028861","descriptor_name":"Nuclear Pore Complex Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D028861","descriptor_name":"Nuclear Pore Complex Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D028861","descriptor_name":"Nuclear Pore Complex Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D028861","descriptor_name":"Nuclear Pore Complex Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D028861","descriptor_name":"Nuclear Pore Complex Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D028861","descriptor_name":"Nuclear Pore Complex Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D028861","descriptor_name":"Nuclear Pore Complex Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":11,"locations":[{"id":"doi:10.1371/journal.pcbi.1000145","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000145","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000145&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:18688269","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18688269","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:osti.gov:1627187","is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1627187","pdf_url":"https://www.osti.gov/servlets/purl/1627187","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:info:ark/67531/metadc895628","is_oa":false,"landing_page_url":"https://digital.library.unt.edu/ark:/67531/metadc895628/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400792","display_name":"University of North Texas Digital Library (University of North Texas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I123534392","host_organization_name":"University of North Texas","host_organization_lineage":["https://openalex.org/I123534392"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, vol. 4, no. 8, August 8, 2008, e1000145","raw_type":"Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.275.8317","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.275.8317","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/49/70/PLoS_Comput_Biol_2008_Aug_8_4(8)_e1000145.tar.gz","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1000145","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1000145","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:ceb5cd69ae3b4926bf29d2d110d8e741","is_oa":true,"landing_page_url":"https://doaj.org/article/ceb5cd69ae3b4926bf29d2d110d8e741","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 4, Iss 8, p e1000145 (2008)","raw_type":"article"},{"id":"pmh:oai:dspace.calstate.edu:10211.3/200452","is_oa":false,"landing_page_url":"http://hdl.handle.net/10211.3/200452","pdf_url":null,"source":{"id":"https://openalex.org/S4306402638","display_name":"CSUN ScholarWorks (California State University, Northridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I157638225","host_organization_name":"California State University, Northridge","host_organization_lineage":["https://openalex.org/I157638225"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""},{"id":"pmh:oai:figshare.com:article/149952","is_oa":true,"landing_page_url":"https://figshare.com/articles/Intramolecular_Cohesion_of_Coils_Mediated_by_Phenylalanine_Glycine_Motifs_in_the_Natively_Unfolded_Domain_of_a_Nucleoporin/149952","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:osti.gov:940865","is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/940865","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:2475668","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2475668","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000145","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000145","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000145&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/14","score":0.5400000214576721,"display_name":"Life below water"}],"awards":[{"id":"https://openalex.org/G1702950523","display_name":null,"funder_award_id":"W-7405","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G6988745498","display_name":null,"funder_award_id":"GM07752","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7451160165","display_name":null,"funder_award_id":"W-7405-ENG-48","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G7531008850","display_name":null,"funder_award_id":"W-7405-ENG-48","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"},{"id":"https://openalex.org/F4320333031","display_name":"University of California Merced","ror":"https://ror.org/00d9ah105"},{"id":"https://openalex.org/F4320337506","display_name":"Advanced Scientific Computing Research","ror":"https://ror.org/0012c7r22"},{"id":"https://openalex.org/F4320338286","display_name":"Lawrence Livermore National Laboratory","ror":"https://ror.org/041nk4h53"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2043002375.pdf","grobid_xml":"https://content.openalex.org/works/W2043002375.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W131973759","https://openalex.org/W1505062366","https://openalex.org/W1965529594","https://openalex.org/W1968975193","https://openalex.org/W1969644422","https://openalex.org/W1972459558","https://openalex.org/W1972961211","https://openalex.org/W1982383324","https://openalex.org/W1982413468","https://openalex.org/W1982515690","https://openalex.org/W1984627474","https://openalex.org/W1991877201","https://openalex.org/W2004291898","https://openalex.org/W2004461664","https://openalex.org/W2006192061","https://openalex.org/W2007016963","https://openalex.org/W2008708467","https://openalex.org/W2011052397","https://openalex.org/W2017908238","https://openalex.org/W2019057425","https://openalex.org/W2020308015","https://openalex.org/W2020415369","https://openalex.org/W2020541498","https://openalex.org/W2022506021","https://openalex.org/W2025880126","https://openalex.org/W2028170230","https://openalex.org/W2029208937","https://openalex.org/W2034809225","https://openalex.org/W2040840183","https://openalex.org/W2046997182","https://openalex.org/W2047167799","https://openalex.org/W2056236390","https://openalex.org/W2058238447","https://openalex.org/W2059150886","https://openalex.org/W2059512804","https://openalex.org/W2059569036","https://openalex.org/W2061040254","https://openalex.org/W2070821144","https://openalex.org/W2073486807","https://openalex.org/W2076279192","https://openalex.org/W2076870182","https://openalex.org/W2080978882","https://openalex.org/W2089618587","https://openalex.org/W2089847528","https://openalex.org/W2092006899","https://openalex.org/W2094186244","https://openalex.org/W2103050418","https://openalex.org/W2105657024","https://openalex.org/W2110110505","https://openalex.org/W2118233996","https://openalex.org/W2119693327","https://openalex.org/W2122823449","https://openalex.org/W2131288855","https://openalex.org/W2133201628","https://openalex.org/W2137220407","https://openalex.org/W2140788063","https://openalex.org/W2147752484","https://openalex.org/W2147993766","https://openalex.org/W2149472608","https://openalex.org/W2150359450","https://openalex.org/W2153347073","https://openalex.org/W2158869723","https://openalex.org/W2160007141","https://openalex.org/W2163503448","https://openalex.org/W2419271322"],"related_works":["https://openalex.org/W2060136033","https://openalex.org/W2891879415","https://openalex.org/W2076213038","https://openalex.org/W2237013109","https://openalex.org/W4220972152","https://openalex.org/W2172097982","https://openalex.org/W2131175278","https://openalex.org/W2152653460","https://openalex.org/W2013284012","https://openalex.org/W2795117887"],"abstract_inverted_index":{"The":[0,92],"nuclear":[1],"pore":[2],"complex":[3],"(NPC)":[4],"provides":[5],"the":[6,14,17,55,77,88,108,123,125,157,170,177],"sole":[7],"aqueous":[8],"conduit":[9,23,179],"for":[10],"macromolecular":[11],"exchange":[12],"between":[13,161],"nucleus":[15],"and":[16,72,111,163,172,189],"cytoplasm":[18],"of":[19,32,48,80,82,115,128,149,186],"cells.":[20],"Its":[21],"diffusion":[22],"contains":[24],"a":[25,30,83,142,194],"size-selective":[26,195],"gate":[27,196],"formed":[28],"by":[29],"family":[31],"NPC":[33,56,178],"proteins":[34],"that":[35,95,104],"feature":[36],"large,":[37],"natively":[38],"unfolded":[39],"domains":[40,47],"with":[41],"phenylalanine-glycine":[42],"repeats":[43],"(FG":[44],"domains).":[45],"These":[46],"nucleoporins":[49,129],"play":[50],"key":[51],"roles":[52],"in":[53,156],"establishing":[54],"permeability":[57],"barrier,":[58],"but":[59],"little":[60],"is":[61],"known":[62],"about":[63],"their":[64],"dynamic":[65,78],"structure.":[66],"Here":[67],"we":[68],"used":[69],"molecular":[70],"modeling":[71],"biophysical":[73],"techniques":[74],"to":[75,107,140,181],"characterize":[76],"ensemble":[79,114],"structures":[81,116],"representative":[84],"FG":[85,97,109,126,165],"domain":[86,110],"from":[87],"yeast":[89],"nucleoporin":[90],"Nup116.":[91],"results":[93],"showed":[94],"its":[96,113],"motifs":[98,127],"function":[99],"as":[100,136,138],"intramolecular":[101],"cohesion":[102],"elements":[103],"impart":[105],"order":[106],"compact":[112],"into":[117],"native":[118],"premolten":[119],"globular":[120],"configurations.":[121],"At":[122],"NPC,":[124],"may":[130],"exert":[131],"this":[132],"cohesive":[133,145],"effect":[134],"intermolecularly":[135],"well":[137],"intramolecularly":[139],"form":[141],"malleable":[143],"yet":[144],"quaternary":[146],"structure":[147],"composed":[148],"highly":[150],"flexible":[151],"polypeptide":[152],"chains.":[153],"Dynamic":[154],"shifts":[155],"equilibrium":[158],"or":[159],"competition":[160],"intra-":[162],"intermolecular":[164],"motif":[166],"interactions":[167],"could":[168],"facilitate":[169],"rapid":[171],"reversible":[173],"structural":[174],"transitions":[175],"at":[176],"needed":[180],"accommodate":[182],"passing":[183],"karyopherin-cargo":[184],"complexes":[185],"various":[187],"shapes":[188],"sizes":[190],"while":[191],"simultaneously":[192],"maintaining":[193],"against":[197],"protein":[198],"diffusion.":[199]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
