{"id":"https://openalex.org/W2152285853","doi":"https://doi.org/10.1371/journal.pcbi.1000140","title":"Why Do Hubs in the Yeast Protein Interaction Network Tend To Be Essential: Reexamining the Connection between the Network Topology and Essentiality","display_name":"Why Do Hubs in the Yeast Protein Interaction Network Tend To Be Essential: Reexamining the Connection between the Network Topology and Essentiality","publication_year":2008,"publication_date":"2008-07-31","ids":{"openalex":"https://openalex.org/W2152285853","doi":"https://doi.org/10.1371/journal.pcbi.1000140","mag":"2152285853"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000140","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000140","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000140&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000140&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017777700","display_name":"Elena Zotenko","orcid":"https://orcid.org/0000-0002-0256-3195"},"institutions":[{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Elena Zotenko","raw_affiliation_strings":["Max-Planck Institute for Informatics, Saarbruecken, Germany"],"affiliations":[{"raw_affiliation_string":"Max-Planck Institute for Informatics, Saarbruecken, Germany","institution_ids":["https://openalex.org/I4210109712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007528822","display_name":"Juli\u00e1n Mestre","orcid":"https://orcid.org/0000-0003-4948-2998"},"institutions":[{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julian Mestre","raw_affiliation_strings":["Max-Planck Institute for Informatics, Saarbruecken, Germany"],"affiliations":[{"raw_affiliation_string":"Max-Planck Institute for Informatics, Saarbruecken, Germany","institution_ids":["https://openalex.org/I4210109712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062480442","display_name":"Dianne P. O\u2019Leary","orcid":"https://orcid.org/0000-0001-9809-5180"},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dianne P. O'Leary","raw_affiliation_strings":["Department of Computer Science, University of Maryland, College Park, Maryland, United States of America","Institute for Advanced Computer Studies, University of Maryland, College Park, Maryland, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Maryland, College Park, Maryland, United States of America","institution_ids":["https://openalex.org/I66946132"]},{"raw_affiliation_string":"Institute for Advanced Computer Studies, University of Maryland, College Park, Maryland, United States of America","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089548776","display_name":"Teresa M. Przytycka","orcid":"https://orcid.org/0000-0002-6261-277X"},"institutions":[{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Teresa M. Przytycka","raw_affiliation_strings":["National Center of Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, United States of America"],"affiliations":[{"raw_affiliation_string":"National Center of Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I4210109390","https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5089548776"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210109390"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":10.9261,"has_fulltext":true,"cited_by_count":416,"citation_normalized_percentile":{"value":0.98974484,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"4","issue":"8","first_page":"e1000140","last_page":"e1000140"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9922999739646912,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/centrality","display_name":"Centrality","score":0.8671326637268066},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.6050827503204346},{"id":"https://openalex.org/keywords/interaction-network","display_name":"Interaction network","score":0.5913317203521729},{"id":"https://openalex.org/keywords/network-topology","display_name":"Network topology","score":0.5443929433822632},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5395057201385498},{"id":"https://openalex.org/keywords/protein-interaction-networks","display_name":"Protein Interaction Networks","score":0.5378953218460083},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.5224284529685974},{"id":"https://openalex.org/keywords/protein\u2013protein-interaction","display_name":"Protein\u2013protein interaction","score":0.5173389315605164},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5082914233207703},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.43538686633110046},{"id":"https://openalex.org/keywords/connection","display_name":"Connection (principal bundle)","score":0.4227219820022583},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.41645729541778564},{"id":"https://openalex.org/keywords/network-analysis","display_name":"Network analysis","score":0.41410544514656067},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3888952136039734},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2690597474575043},{"id":"https://openalex.org/keywords/yeast","display_name":"Yeast","score":0.19123134016990662},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.17682147026062012},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.13168346881866455},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.1262315809726715},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.1011374294757843},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.08637309074401855}],"concepts":[{"id":"https://openalex.org/C53811970","wikidata":"https://www.wikidata.org/wiki/Q5062194","display_name":"Centrality","level":2,"score":0.8671326637268066},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.6050827503204346},{"id":"https://openalex.org/C55105296","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interaction network","level":3,"score":0.5913317203521729},{"id":"https://openalex.org/C199845137","wikidata":"https://www.wikidata.org/wiki/Q145490","display_name":"Network topology","level":2,"score":0.5443929433822632},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5395057201385498},{"id":"https://openalex.org/C2909613950","wikidata":"https://www.wikidata.org/wiki/Q158695","display_name":"Protein Interaction Networks","level":3,"score":0.5378953218460083},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.5224284529685974},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.5173389315605164},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5082914233207703},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.43538686633110046},{"id":"https://openalex.org/C13355873","wikidata":"https://www.wikidata.org/wiki/Q2920850","display_name":"Connection (principal bundle)","level":2,"score":0.4227219820022583},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.41645729541778564},{"id":"https://openalex.org/C32946077","wikidata":"https://www.wikidata.org/wiki/Q618079","display_name":"Network analysis","level":2,"score":0.41410544514656067},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3888952136039734},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2690597474575043},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.19123134016990662},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.17682147026062012},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13168346881866455},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1262315809726715},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.1011374294757843},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.08637309074401855},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1000140","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000140","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000140&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.148.3586","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.148.3586","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.cs.umd.edu/users/oleary/reprints/j88.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:1dfc41e3c4764ca69958bda9fabf7220","is_oa":true,"landing_page_url":"https://doaj.org/article/1dfc41e3c4764ca69958bda9fabf7220","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 4, Iss 8, p e1000140 (2008)","raw_type":"article"},{"id":"pmh:oai:edoc.mpg.de:428291","is_oa":false,"landing_page_url":"http://edoc.mpg.de/428291","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, v.4, e1000140.1-16 (2008)","raw_type":"Article"},{"id":"pmh:oai:europepmc.org:1217861","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2467474","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/149995","is_oa":true,"landing_page_url":"https://figshare.com/articles/Why_Do_Hubs_in_the_Yeast_Protein_Interaction_Network_Tend_To_Be_Essential_Reexamining_the_Connection_between_the_Network_Topology_and_Essentiality/149995","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pure.mpg.de:item_1325766","is_oa":false,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-000F-1D62-B","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000140","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000140","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000140&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G879861350","display_name":"Computations with Unitary Matrices","funder_award_id":"0514213","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2152285853.pdf","grobid_xml":"https://content.openalex.org/works/W2152285853.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W212244014","https://openalex.org/W1766157213","https://openalex.org/W1970913835","https://openalex.org/W1971937094","https://openalex.org/W1980800453","https://openalex.org/W1990435776","https://openalex.org/W2006683252","https://openalex.org/W2010000580","https://openalex.org/W2012852001","https://openalex.org/W2024839376","https://openalex.org/W2037036397","https://openalex.org/W2050721857","https://openalex.org/W2065304353","https://openalex.org/W2065769502","https://openalex.org/W2074443723","https://openalex.org/W2077159940","https://openalex.org/W2084619201","https://openalex.org/W2089125183","https://openalex.org/W2096248890","https://openalex.org/W2113654464","https://openalex.org/W2116117181","https://openalex.org/W2116447934","https://openalex.org/W2124379907","https://openalex.org/W2127201083","https://openalex.org/W2130790725","https://openalex.org/W2142437744","https://openalex.org/W2143537765","https://openalex.org/W2149310258","https://openalex.org/W2150318080","https://openalex.org/W2152336513","https://openalex.org/W2152360905","https://openalex.org/W2154600255","https://openalex.org/W2154897810","https://openalex.org/W2164928285","https://openalex.org/W2166558964","https://openalex.org/W2167869241","https://openalex.org/W2172049947","https://openalex.org/W3103071483","https://openalex.org/W4245546812","https://openalex.org/W4301891957"],"related_works":["https://openalex.org/W4229728790","https://openalex.org/W2800059693","https://openalex.org/W1987705964","https://openalex.org/W2099913238","https://openalex.org/W4377086792","https://openalex.org/W2414873431","https://openalex.org/W2949751838","https://openalex.org/W2145100112","https://openalex.org/W4384303460","https://openalex.org/W2137238644"],"abstract_inverted_index":{"The":[0],"centrality-lethality":[1,186],"rule,":[2,187],"which":[3],"notes":[4],"that":[5,18,22,145,171],"high-degree":[6],"nodes":[7],"in":[8,29,156,174,197],"a":[9,27,30,36,110,124,161],"protein":[10,28,31,96,133,210],"interaction":[11,32,78,97,134],"network":[12,33,118,135,200],"tend":[13],"to":[14,16,108,153,194],"correspond":[15],"proteins":[17,166],"are":[19,89,150,172],"essential,":[20],"suggests":[21],"the":[23,45,57,74,93,101,114,117,131,146,185,190,198,206],"topological":[24,103],"prominence":[25],"of":[26,39,71,76,95,105,127,130,148,163,192],"may":[34],"be":[35],"good":[37],"predictor":[38],"its":[40],"biological":[41,111,169],"importance.":[42],"Even":[43],"though":[44],"correlation":[46,61],"between":[47,69,116],"degree":[48],"and":[49,73,107,120,202],"essentiality":[50,70,106,191],"was":[51],"confirmed":[52],"by":[53,92],"many":[54],"independent":[55],"studies,":[56],"reason":[58],"for":[59,113,136,184],"this":[60],"remains":[62],"illusive.":[63],"Several":[64],"hypotheses":[65],"about":[66],"putative":[67],"connections":[68],"hubs":[72,149,193],"topology":[75,119],"protein-protein":[77],"networks":[79],"have":[80],"been":[81],"proposed,":[82],"but":[83],"as":[84],"we":[85,122,178],"demonstrate,":[86],"these":[87],"explanations":[88,183],"not":[90],"supported":[91],"properties":[94],"networks.":[98],"To":[99],"identify":[100],"main":[102],"determinant":[104],"provide":[109],"explanation":[112],"connection":[115],"essentiality,":[121],"performed":[123],"rigorous":[125],"analysis":[126],"six":[128],"variants":[129],"genomewide":[132],"Saccharomyces":[137],"cerevisiae":[138],"obtained":[139],"using":[140],"different":[141],"techniques.":[142],"We":[143],"demonstrated":[144],"majority":[147],"essential":[151,175,209],"due":[152],"their":[154,195],"involvement":[155],"Essential":[157],"Complex":[158],"Biological":[159],"Modules,":[160],"group":[162],"densely":[164],"connected":[165],"with":[167],"shared":[168],"function":[170],"enriched":[173],"proteins.":[176],"Moreover,":[177],"rejected":[179],"two":[180],"previously":[181],"proposed":[182],"one":[188],"relating":[189],"role":[196],"overall":[199],"connectivity":[201],"another":[203],"relying":[204],"on":[205],"recently":[207],"published":[208],"interactions":[211],"model.":[212]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":23},{"year":2021,"cited_by_count":25},{"year":2020,"cited_by_count":24},{"year":2019,"cited_by_count":22},{"year":2018,"cited_by_count":21},{"year":2017,"cited_by_count":24},{"year":2016,"cited_by_count":27},{"year":2015,"cited_by_count":25},{"year":2014,"cited_by_count":35},{"year":2013,"cited_by_count":35},{"year":2012,"cited_by_count":39}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
