{"id":"https://openalex.org/W1965219597","doi":"https://doi.org/10.1371/journal.pcbi.1000138","title":"Identification and Rational Redesign of Peptide Ligands to CRIP1, A Novel Biomarker for Cancers","display_name":"Identification and Rational Redesign of Peptide Ligands to CRIP1, A Novel Biomarker for Cancers","publication_year":2008,"publication_date":"2008-07-31","ids":{"openalex":"https://openalex.org/W1965219597","doi":"https://doi.org/10.1371/journal.pcbi.1000138","mag":"1965219597","pmid":"https://pubmed.ncbi.nlm.nih.gov/18670594"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000138","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000138","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000138&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000138&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091033395","display_name":"Jihua Hao","orcid":"https://orcid.org/0000-0003-3657-050X"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jihua Hao","raw_affiliation_strings":["Department of Radiology, Case Western Reserve University, Cleveland, Ohio, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, Case Western Reserve University, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038098410","display_name":"Adrian W.R. Serohijos","orcid":"https://orcid.org/0000-0001-8369-982X"},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adrian W. R. Serohijos","raw_affiliation_strings":["Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","Department of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042607315","display_name":"Gail Newton","orcid":null},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gail Newton","raw_affiliation_strings":["Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072748231","display_name":"Gina Tassone","orcid":null},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gina Tassone","raw_affiliation_strings":["Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076146558","display_name":"Zuncai Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zuncai Wang","raw_affiliation_strings":["Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034256147","display_name":"Dennis C. Sgroi","orcid":"https://orcid.org/0000-0003-4052-6659"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis C. Sgroi","raw_affiliation_strings":["Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033490428","display_name":"Nikolay V. Dokholyan","orcid":"https://orcid.org/0000-0002-8225-4025"},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nikolay V. Dokholyan","raw_affiliation_strings":["Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067133924","display_name":"James P. Basilion","orcid":null},"institutions":[{"id":"https://openalex.org/I21182828","display_name":"National Foundation for Cancer Research","ror":"https://ror.org/04v83ky93","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I21182828"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James P. Basilion","raw_affiliation_strings":["Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States of America","Department of Radiology, Case Western Reserve University, Cleveland, Ohio, United States of America","National Foundation for Cancer Research Center for Molecular Imaging, Case Western Reserve University, Cleveland, Ohio, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Radiology, Case Western Reserve University, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"National Foundation for Cancer Research Center for Molecular Imaging, Case Western Reserve University, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I58956616","https://openalex.org/I21182828"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5033490428","https://openalex.org/A5067133924"],"corresponding_institution_ids":["https://openalex.org/I114027177","https://openalex.org/I21182828","https://openalex.org/I58956616"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":3.7326,"has_fulltext":true,"cited_by_count":62,"citation_normalized_percentile":{"value":0.92290974,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"4","issue":"8","first_page":"e1000138","last_page":"e1000138"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phage-display","display_name":"Phage display","score":0.8298137187957764},{"id":"https://openalex.org/keywords/peptide","display_name":"Peptide","score":0.7773216962814331},{"id":"https://openalex.org/keywords/panning","display_name":"Panning (audio)","score":0.6293782591819763},{"id":"https://openalex.org/keywords/peptide-library","display_name":"Peptide library","score":0.6258050799369812},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5845233798027039},{"id":"https://openalex.org/keywords/affinities","display_name":"Affinities","score":0.4776146113872528},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4496144652366638},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.44950640201568604},{"id":"https://openalex.org/keywords/ligand","display_name":"Ligand (biochemistry)","score":0.440904825925827},{"id":"https://openalex.org/keywords/competitive-binding","display_name":"Competitive binding","score":0.41881877183914185},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.417390912771225},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.40771931409835815},{"id":"https://openalex.org/keywords/molecular-biology","display_name":"Molecular biology","score":0.3662828803062439},{"id":"https://openalex.org/keywords/combinatorial-chemistry","display_name":"Combinatorial chemistry","score":0.3257754445075989},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.11017027497291565},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.10298487544059753}],"concepts":[{"id":"https://openalex.org/C186268636","wikidata":"https://www.wikidata.org/wiki/Q896217","display_name":"Phage display","level":3,"score":0.8298137187957764},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.7773216962814331},{"id":"https://openalex.org/C108944566","wikidata":"https://www.wikidata.org/wiki/Q1524510","display_name":"Panning (audio)","level":4,"score":0.6293782591819763},{"id":"https://openalex.org/C2776471321","wikidata":"https://www.wikidata.org/wiki/Q7166526","display_name":"Peptide library","level":4,"score":0.6258050799369812},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5845233798027039},{"id":"https://openalex.org/C2780283098","wikidata":"https://www.wikidata.org/wiki/Q4688960","display_name":"Affinities","level":2,"score":0.4776146113872528},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4496144652366638},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.44950640201568604},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.440904825925827},{"id":"https://openalex.org/C3019856697","wikidata":"https://www.wikidata.org/wiki/Q912894","display_name":"Competitive binding","level":3,"score":0.41881877183914185},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.417390912771225},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40771931409835815},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3662828803062439},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3257754445075989},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11017027497291565},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10298487544059753},{"id":"https://openalex.org/C124913957","wikidata":"https://www.wikidata.org/wiki/Q1232548","display_name":"Zoom","level":3,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C15336307","wikidata":"https://www.wikidata.org/wiki/Q1766051","display_name":"Lens (geology)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D003090","descriptor_name":"Coliphages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003090","descriptor_name":"Coliphages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003090","descriptor_name":"Coliphages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019151","descriptor_name":"Peptide Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019151","descriptor_name":"Peptide Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019151","descriptor_name":"Peptide Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060588","descriptor_name":"LIM Domain Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060588","descriptor_name":"LIM Domain Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060588","descriptor_name":"LIM Domain Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1000138","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000138","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000138&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:18670594","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18670594","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:dash.harvard.edu:1/4622131","is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:4622131","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:0b4fda914f8842a8b47ba811bd8ac487","is_oa":true,"landing_page_url":"https://doaj.org/article/0b4fda914f8842a8b47ba811bd8ac487","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 4, Iss 8, p e1000138 (2008)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/149921","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Identification_and_Rational_Redesign_of_Peptide_Ligands_to_CRIP1_A_Novel_Biomarker_for_Cancers/149921","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:2453235","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2453235","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000138","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000138","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000138&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5899999737739563,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G3611247453","display_name":null,"funder_award_id":"R01GM","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5609243208","display_name":null,"funder_award_id":"R01GM080742","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7769797363","display_name":null,"funder_award_id":"GM080742","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320306777","display_name":"National Foundation for Cancer Research","ror":"https://ror.org/04v83ky93"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1965219597.pdf","grobid_xml":"https://content.openalex.org/works/W1965219597.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1545934872","https://openalex.org/W1657231595","https://openalex.org/W1963896702","https://openalex.org/W1979365559","https://openalex.org/W1981021420","https://openalex.org/W1982162547","https://openalex.org/W1983102499","https://openalex.org/W1985006546","https://openalex.org/W1987888718","https://openalex.org/W1992818397","https://openalex.org/W1995485155","https://openalex.org/W1995514580","https://openalex.org/W1998024235","https://openalex.org/W2001012906","https://openalex.org/W2004182520","https://openalex.org/W2010610489","https://openalex.org/W2016626477","https://openalex.org/W2018954741","https://openalex.org/W2022160931","https://openalex.org/W2023389323","https://openalex.org/W2029999655","https://openalex.org/W2030860488","https://openalex.org/W2032746478","https://openalex.org/W2035266068","https://openalex.org/W2037511678","https://openalex.org/W2046800939","https://openalex.org/W2051294170","https://openalex.org/W2051381895","https://openalex.org/W2060335815","https://openalex.org/W2067041186","https://openalex.org/W2072917371","https://openalex.org/W2083978969","https://openalex.org/W2084429764","https://openalex.org/W2085108537","https://openalex.org/W2103543394","https://openalex.org/W2103945336","https://openalex.org/W2112919985","https://openalex.org/W2119349031","https://openalex.org/W2119367395","https://openalex.org/W2123768693","https://openalex.org/W2128572087","https://openalex.org/W2128635872","https://openalex.org/W2131050216","https://openalex.org/W2133712572","https://openalex.org/W2139898710","https://openalex.org/W2144482528","https://openalex.org/W2146336125","https://openalex.org/W2149121581","https://openalex.org/W2151617129","https://openalex.org/W2159487740","https://openalex.org/W2160077085","https://openalex.org/W2165594346","https://openalex.org/W2167454422","https://openalex.org/W2189093937","https://openalex.org/W4252571607","https://openalex.org/W4293247451","https://openalex.org/W4388251328"],"related_works":["https://openalex.org/W2066892610","https://openalex.org/W2152440849","https://openalex.org/W3136489676","https://openalex.org/W2389347183","https://openalex.org/W2090059339","https://openalex.org/W2959190208","https://openalex.org/W2043061837","https://openalex.org/W3190042041","https://openalex.org/W2056665457","https://openalex.org/W2610098014"],"abstract_inverted_index":{"Cysteine-rich":[0],"intestinal":[1],"protein":[2],"1":[3],"(CRIP1)":[4],"has":[5],"been":[6],"identified":[7],"as":[8],"a":[9,33,41,92,116],"novel":[10,93,142],"marker":[11],"for":[12,36,67,71],"early":[13],"detection":[14],"of":[15,23,82,105,122,127,141],"cancers.":[16],"Here":[17],"we":[18],"report":[19],"on":[20],"the":[21,64,79,84,106,120,139],"use":[22],"phage":[24,44],"display":[25],"in":[26,119],"combination":[27],"with":[28,50],"molecular":[29],"modeling":[30],"to":[31,54,100,125,138],"identify":[32],"high-affinity":[34],"ligand":[35,143],"CRIP1.":[37,56],"Panning":[38],"experiments":[39],"using":[40],"circularized":[42],"C7C":[43],"library":[45],"yielded":[46],"several":[47],"consensus":[48],"sequences":[49],"modest":[51],"binding":[52,112],"affinities":[53,66],"purified":[55],"Two":[57],"sequence":[58],"motifs,":[59],"A1":[60,86,129],"and":[61,78,108,110],"B5,":[62],"having":[63],"highest":[65],"CRIP1,":[68,83],"were":[69],"chosen":[70],"further":[72],"study.":[73],"With":[74],"peptide":[75,87,107],"structure":[76,81],"information":[77],"NMR":[80],"higher-affinity":[85],"was":[88,98],"computationally":[89],"redesigned,":[90],"yielding":[91],"peptide,":[94],"A1M,":[95],"whose":[96],"affinity":[97,121],"predicted":[99],"be":[101],"much":[102],"improved.":[103],"Synthesis":[104],"saturation":[109],"competitive":[111],"studies":[113],"demonstrated":[114],"approximately":[115],"10-28-fold":[117],"improvement":[118],"A1M":[123],"compared":[124],"that":[126],"either":[128],"or":[130],"B5":[131],"peptide.":[132],"These":[133],"techniques":[134],"have":[135],"broad":[136],"application":[137],"design":[140],"peptides.":[144]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
