{"id":"https://openalex.org/W1986363856","doi":"https://doi.org/10.1371/journal.pcbi.1000127","title":"The Spatiotemporal Pattern of Src Activation at Lipid Rafts Revealed by Diffusion-Corrected FRET Imaging","display_name":"The Spatiotemporal Pattern of Src Activation at Lipid Rafts Revealed by Diffusion-Corrected FRET Imaging","publication_year":2008,"publication_date":"2008-07-24","ids":{"openalex":"https://openalex.org/W1986363856","doi":"https://doi.org/10.1371/journal.pcbi.1000127","mag":"1986363856","pmid":"https://pubmed.ncbi.nlm.nih.gov/18711637"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000127","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000127","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000127&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000127&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101494356","display_name":"Shaoying Lu","orcid":"https://orcid.org/0000-0001-8289-2177"},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shaoying Lu","raw_affiliation_strings":["Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA","Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055049278","display_name":"Mingxing Ouyang","orcid":"https://orcid.org/0000-0002-2910-0713"},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mingxing Ouyang","raw_affiliation_strings":["Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026656606","display_name":"Jihye Seong","orcid":"https://orcid.org/0000-0001-8450-3315"},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jihye Seong","raw_affiliation_strings":["Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America"],"affiliations":[{"raw_affiliation_string":"Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100405907","display_name":"Jin Zhang","orcid":"https://orcid.org/0000-0001-7145-7823"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jin Zhang","raw_affiliation_strings":["Department of Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, Maryland, United States of America","Solomon H. Snyder Department of Neuroscience and Department of Oncology, Johns Hopkins University, Baltimore, Maryland, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Solomon H. Snyder Department of Neuroscience and Department of Oncology, Johns Hopkins University, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068335042","display_name":"Shu Chien","orcid":"https://orcid.org/0000-0003-0332-285X"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shu Chien","raw_affiliation_strings":["Department of Bioengineering, University of California at San Diego, San Diego, California, United States of America","Department of Medicine, University of California at San Diego, San Diego, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California at San Diego, San Diego, California, United States of America","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine, University of California at San Diego, San Diego, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066337260","display_name":"Yingxiao Wang","orcid":"https://orcid.org/0000-0003-0265-326X"},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yingxiao Wang","raw_affiliation_strings":["Beckman Institute for Advanced Science and Technology, Department of Molecular and Integrative Physiology and Center of Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America","Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America","Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America"],"affiliations":[{"raw_affiliation_string":"Beckman Institute for Advanced Science and Technology, Department of Molecular and Integrative Physiology and Center of Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America","institution_ids":["https://openalex.org/I157725225"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5066337260"],"corresponding_institution_ids":["https://openalex.org/I157725225"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":5.2084,"has_fulltext":true,"cited_by_count":63,"citation_normalized_percentile":{"value":0.947156,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"4","issue":"7","first_page":"e1000127","last_page":"e1000127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/f\u00f6rster-resonance-energy-transfer","display_name":"F\u00f6rster resonance energy transfer","score":0.9337117671966553},{"id":"https://openalex.org/keywords/fluorescence-recovery-after-photobleaching","display_name":"Fluorescence recovery after photobleaching","score":0.8993188738822937},{"id":"https://openalex.org/keywords/lipid-raft","display_name":"Lipid raft","score":0.8316932320594788},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.6395098567008972},{"id":"https://openalex.org/keywords/photobleaching","display_name":"Photobleaching","score":0.62388676404953},{"id":"https://openalex.org/keywords/biosensor","display_name":"Biosensor","score":0.5850282311439514},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5159916877746582},{"id":"https://openalex.org/keywords/raft","display_name":"Raft","score":0.515698254108429},{"id":"https://openalex.org/keywords/cytoplasm","display_name":"Cytoplasm","score":0.5052884221076965},{"id":"https://openalex.org/keywords/mass-diffusivity","display_name":"Mass diffusivity","score":0.47682422399520874},{"id":"https://openalex.org/keywords/live-cell-imaging","display_name":"Live cell imaging","score":0.46452128887176514},{"id":"https://openalex.org/keywords/fluorescence-lifetime-imaging-microscopy","display_name":"Fluorescence-lifetime imaging microscopy","score":0.4399886727333069},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3892107307910919},{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.35467708110809326},{"id":"https://openalex.org/keywords/fluorescence","display_name":"Fluorescence","score":0.3098704516887665},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.23669764399528503},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22926652431488037},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.1990259885787964}],"concepts":[{"id":"https://openalex.org/C96305047","wikidata":"https://www.wikidata.org/wiki/Q367473","display_name":"F\u00f6rster resonance energy transfer","level":3,"score":0.9337117671966553},{"id":"https://openalex.org/C26659971","wikidata":"https://www.wikidata.org/wiki/Q729923","display_name":"Fluorescence recovery after photobleaching","level":3,"score":0.8993188738822937},{"id":"https://openalex.org/C79266657","wikidata":"https://www.wikidata.org/wiki/Q424178","display_name":"Lipid raft","level":3,"score":0.8316932320594788},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6395098567008972},{"id":"https://openalex.org/C31332276","wikidata":"https://www.wikidata.org/wiki/Q899750","display_name":"Photobleaching","level":3,"score":0.62388676404953},{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.5850282311439514},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5159916877746582},{"id":"https://openalex.org/C9132879","wikidata":"https://www.wikidata.org/wiki/Q17100313","display_name":"Raft","level":4,"score":0.515698254108429},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.5052884221076965},{"id":"https://openalex.org/C203496682","wikidata":"https://www.wikidata.org/wiki/Q604008","display_name":"Mass diffusivity","level":3,"score":0.47682422399520874},{"id":"https://openalex.org/C15526883","wikidata":"https://www.wikidata.org/wiki/Q6657126","display_name":"Live cell imaging","level":3,"score":0.46452128887176514},{"id":"https://openalex.org/C57477423","wikidata":"https://www.wikidata.org/wiki/Q1434196","display_name":"Fluorescence-lifetime imaging microscopy","level":3,"score":0.4399886727333069},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3892107307910919},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.35467708110809326},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.3098704516887665},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23669764399528503},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22926652431488037},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.1990259885787964},{"id":"https://openalex.org/C37668627","wikidata":"https://www.wikidata.org/wiki/Q3381809","display_name":"Thermal diffusivity","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016392","descriptor_name":"Proto-Oncogene Proteins pp60(c-src)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016392","descriptor_name":"Proto-Oncogene Proteins pp60(c-src)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016392","descriptor_name":"Proto-Oncogene Proteins pp60(c-src)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D031541","descriptor_name":"Fluorescence Resonance Energy Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D031541","descriptor_name":"Fluorescence Resonance Energy Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D031541","descriptor_name":"Fluorescence Resonance Energy Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1000127","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000127","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000127&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:18711637","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18711637","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.275.4639","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.275.4639","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/63/7f/PLoS_Comput_Biol_2008_Jul_25_4(7)_e1000127.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:1b5c1869ac444caaa3cb126802882f68","is_oa":true,"landing_page_url":"https://doaj.org/article/1b5c1869ac444caaa3cb126802882f68","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 4, Iss 7, p e1000127 (2008)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/150176","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/The_Spatiotemporal_Pattern_of_Src_Activation_at_Lipid_Rafts_Revealed_by_Diffusion_Corrected_FRET_Imaging/150176","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:2517613","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2517613","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000127","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000127","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000127&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/7","score":0.9100000262260437,"display_name":"Affordable and clean energy"}],"awards":[{"id":"https://openalex.org/G2803336209","display_name":null,"funder_award_id":"DK073368","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4299178011","display_name":null,"funder_award_id":"HL080518","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7729069409","display_name":null,"funder_award_id":"HL0851","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320306300","display_name":"Wallace H. Coulter Foundation","ror":"https://ror.org/04cmszv87"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332222","display_name":"University of Illinois at Urbana-Champaign","ror":"https://ror.org/047426m28"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1986363856.pdf","grobid_xml":"https://content.openalex.org/works/W1986363856.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W85002878","https://openalex.org/W180669350","https://openalex.org/W1522989648","https://openalex.org/W1530872699","https://openalex.org/W1541162015","https://openalex.org/W1635552303","https://openalex.org/W1854123316","https://openalex.org/W1948870077","https://openalex.org/W1965408398","https://openalex.org/W1965878299","https://openalex.org/W1967265143","https://openalex.org/W1968831085","https://openalex.org/W1969485865","https://openalex.org/W1972145067","https://openalex.org/W1972765924","https://openalex.org/W1977930114","https://openalex.org/W1984521949","https://openalex.org/W1989658262","https://openalex.org/W1990524685","https://openalex.org/W1998039328","https://openalex.org/W1998547458","https://openalex.org/W2003698382","https://openalex.org/W2004122633","https://openalex.org/W2004296371","https://openalex.org/W2007811014","https://openalex.org/W2011615540","https://openalex.org/W2013412105","https://openalex.org/W2014286995","https://openalex.org/W2016397660","https://openalex.org/W2017934591","https://openalex.org/W2025646685","https://openalex.org/W2028986871","https://openalex.org/W2029922958","https://openalex.org/W2034385303","https://openalex.org/W2045922393","https://openalex.org/W2051979309","https://openalex.org/W2055864348","https://openalex.org/W2059552745","https://openalex.org/W2063107082","https://openalex.org/W2063260609","https://openalex.org/W2065215105","https://openalex.org/W2069496952","https://openalex.org/W2076086205","https://openalex.org/W2078692950","https://openalex.org/W2080544485","https://openalex.org/W2090109575","https://openalex.org/W2093210578","https://openalex.org/W2101257013","https://openalex.org/W2110193578","https://openalex.org/W2115674731","https://openalex.org/W2116435209","https://openalex.org/W2117457196","https://openalex.org/W2118060829","https://openalex.org/W2119679162","https://openalex.org/W2122925019","https://openalex.org/W2127068865","https://openalex.org/W2129223724","https://openalex.org/W2129251085","https://openalex.org/W2130547757","https://openalex.org/W2133699333","https://openalex.org/W2135371328","https://openalex.org/W2139107515","https://openalex.org/W2142083551","https://openalex.org/W2142364395","https://openalex.org/W2148025008","https://openalex.org/W2156480395","https://openalex.org/W2157391644","https://openalex.org/W2158337917","https://openalex.org/W2162997245","https://openalex.org/W2163614199","https://openalex.org/W2169084894","https://openalex.org/W2170805761","https://openalex.org/W2172159758","https://openalex.org/W2432517183","https://openalex.org/W2898519191","https://openalex.org/W2981264952","https://openalex.org/W6631554681","https://openalex.org/W6993211581"],"related_works":["https://openalex.org/W1518240974","https://openalex.org/W2410074698","https://openalex.org/W113297786","https://openalex.org/W1997452518","https://openalex.org/W1978769331","https://openalex.org/W2140320154","https://openalex.org/W1976055993","https://openalex.org/W2143611296","https://openalex.org/W2789311093","https://openalex.org/W1574396544"],"abstract_inverted_index":{"Genetically":[0],"encoded":[1],"biosensors":[2,82],"based":[3],"on":[4,44,112],"fluorescence":[5,45],"resonance":[6],"energy":[7],"transfer":[8],"(FRET)":[9],"have":[10,52],"been":[11,73],"widely":[12],"applied":[13,74],"to":[14,59,75,84,171],"visualize":[15],"the":[16,27,38,64,77,96,101,155,172,218],"molecular":[17,40,214],"activity":[18,161],"in":[19,89,100,115,225],"live":[20,90,226],"cells":[21],"with":[22,197],"high":[23,159],"spatiotemporal":[24,199,219],"resolution.":[25],"However,":[26],"rapid":[28],"diffusion":[29,65,150],"of":[30,37,67,79,129,139,209,222],"biosensor":[31,98,130],"proteins":[32],"hinders":[33],"a":[34,54,191],"precise":[35],"reconstruction":[36],"actual":[39],"activation":[41,193,220],"map.":[42],"Based":[43],"recovery":[46],"after":[47],"photobleaching":[48],"(FRAP)":[49],"experiments,":[50],"we":[51],"developed":[53],"finite":[55],"element":[56],"(FE)":[57],"method":[58,71,203],"analyze,":[60],"simulate,":[61],"and":[62,123,142,216],"subtract":[63],"effect":[66,151],"mobile":[68],"biosensors.":[69],"This":[70,185],"has":[72],"analyze":[76],"mobility":[78,128,215],"Src":[80,97,160,192],"FRET":[81,156],"engineered":[83],"reside":[85],"at":[86,131,162,167,194],"different":[87,113],"subcompartments":[88],"cells.":[91,227],"The":[92,127],"results":[93],"indicate":[94],"that":[95,137,188],"located":[99],"cytoplasm":[102],"moves":[103],"4-8":[104],"folds":[105],"faster":[106],"(0.93+/-0.06":[107],"microm(2)/sec)":[108],"than":[109,136],"those":[110],"anchored":[111],"compartments":[114],"plasma":[116],"membrane":[117],"(at":[118],"lipid":[119,132,140,163,195],"raft:":[120],"0.11+/-0.01":[121],"microm(2)/sec":[122],"outside:":[124],"0.18+/-0.02":[125],"microm(2)/sec).":[126],"rafts":[133,141,164,196],"is":[134,143],"slower":[135],"outside":[138],"dominated":[144],"by":[145],"two-dimensional":[146],"diffusion.":[147],"When":[148],"this":[149],"was":[152,165],"subtracted":[153],"from":[154],"ratio":[157],"images,":[158],"observed":[166],"clustered":[168],"regions":[169],"proximal":[170],"cell":[173],"periphery,":[174],"which":[175],"remained":[176],"relatively":[177],"stationary":[178],"upon":[179],"epidermal":[180],"growth":[181],"factor":[182],"(EGF)":[183],"stimulation.":[184],"result":[186],"suggests":[187],"EGF":[189],"induced":[190],"well-coordinated":[198],"patterns.":[200],"Our":[201],"FE-based":[202],"also":[204],"provides":[205],"an":[206],"integrated":[207],"platform":[208],"image":[210],"analysis":[211],"for":[212],"studying":[213],"reconstructing":[217],"maps":[221],"signaling":[223],"molecules":[224]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
