{"id":"https://openalex.org/W2035604667","doi":"https://doi.org/10.1371/journal.pcbi.1000084","title":"Evolution of Taxis Responses in Virtual Bacteria: Non-Adaptive Dynamics","display_name":"Evolution of Taxis Responses in Virtual Bacteria: Non-Adaptive Dynamics","publication_year":2008,"publication_date":"2008-05-22","ids":{"openalex":"https://openalex.org/W2035604667","doi":"https://doi.org/10.1371/journal.pcbi.1000084","mag":"2035604667","pmid":"https://pubmed.ncbi.nlm.nih.gov/18483577"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000084","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000084","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000084&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000084&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040571548","display_name":"Richard A. Goldstein","orcid":"https://orcid.org/0000-0001-5148-4672"},"institutions":[{"id":"https://openalex.org/I4210164902","display_name":"National Institute for Medical Research","ror":"https://ror.org/05fjs7w98","country_code":"TZ","type":"facility","lineage":["https://openalex.org/I2801810276","https://openalex.org/I4210164902"]},{"id":"https://openalex.org/I34931013","display_name":"National Institute for Health Research","ror":"https://ror.org/0187kwz08","country_code":"GB","type":"funder","lineage":["https://openalex.org/I34931013"]}],"countries":["GB","TZ"],"is_corresponding":true,"raw_author_name":"Richard A. Goldstein","raw_affiliation_strings":["Mathematical Biology, National Institute for Medical Research, London, United Kingdom. rgoldst@nimr.mrc.ac.uk","Mathematical Biology, National Institute for Medical Research, London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Mathematical Biology, National Institute for Medical Research, London, United Kingdom. rgoldst@nimr.mrc.ac.uk","institution_ids":["https://openalex.org/I4210164902"]},{"raw_affiliation_string":"Mathematical Biology, National Institute for Medical Research, London, United Kingdom","institution_ids":["https://openalex.org/I34931013"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013739050","display_name":"Orkun S. Soyer","orcid":"https://orcid.org/0000-0002-9504-3796"},"institutions":[{"id":"https://openalex.org/I193223587","display_name":"University of Trento","ror":"https://ror.org/05trd4x28","country_code":"IT","type":"education","lineage":["https://openalex.org/I193223587"]},{"id":"https://openalex.org/I2802934434","display_name":"The Microsoft Research - University of Trento Centre for Computational and Systems Biology","ror":"https://ror.org/04kcgyj43","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I1290206253","https://openalex.org/I193223587","https://openalex.org/I2802934434","https://openalex.org/I4210164937"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Orkun S. Soyer","raw_affiliation_strings":["The Microsoft Research\u2013University of Trento Centre for Computational and Systems Biology (CoSBi), Trento, Italy"],"affiliations":[{"raw_affiliation_string":"The Microsoft Research\u2013University of Trento Centre for Computational and Systems Biology (CoSBi), Trento, Italy","institution_ids":["https://openalex.org/I2802934434","https://openalex.org/I193223587"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5040571548"],"corresponding_institution_ids":["https://openalex.org/I34931013","https://openalex.org/I4210164902"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":3.0565,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.91549737,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"4","issue":"5","first_page":"e1000084","last_page":"e1000084"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/taxis","display_name":"Taxis","score":0.6925400495529175},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"Chemotaxis","score":0.6172152757644653},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5358980894088745},{"id":"https://openalex.org/keywords/stimulus","display_name":"Stimulus (psychology)","score":0.5200602412223816},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.4879257380962372},{"id":"https://openalex.org/keywords/evolutionary-dynamics","display_name":"Evolutionary dynamics","score":0.4755522906780243},{"id":"https://openalex.org/keywords/adaptive-response","display_name":"Adaptive response","score":0.4521671533584595},{"id":"https://openalex.org/keywords/dynamics","display_name":"Dynamics (music)","score":0.44925978779792786},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.4363386631011963},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.17347532510757446},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.1311279833316803},{"id":"https://openalex.org/keywords/cognitive-psychology","display_name":"Cognitive psychology","score":0.08027738332748413}],"concepts":[{"id":"https://openalex.org/C183373512","wikidata":"https://www.wikidata.org/wiki/Q949618","display_name":"Taxis","level":2,"score":0.6925400495529175},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.6172152757644653},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5358980894088745},{"id":"https://openalex.org/C2779918689","wikidata":"https://www.wikidata.org/wiki/Q3771842","display_name":"Stimulus (psychology)","level":2,"score":0.5200602412223816},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4879257380962372},{"id":"https://openalex.org/C171578705","wikidata":"https://www.wikidata.org/wiki/Q5418700","display_name":"Evolutionary dynamics","level":3,"score":0.4755522906780243},{"id":"https://openalex.org/C33507282","wikidata":"https://www.wikidata.org/wiki/Q4680759","display_name":"Adaptive response","level":2,"score":0.4521671533584595},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.44925978779792786},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4363386631011963},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17347532510757446},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1311279833316803},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.08027738332748413},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018407","descriptor_name":"Bacterial Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018407","descriptor_name":"Bacterial Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018407","descriptor_name":"Bacterial Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018407","descriptor_name":"Bacterial Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pcbi.1000084","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000084","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000084&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:18483577","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18483577","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.274.9809","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.274.9809","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/66/44/PLoS_Comput_Biol_2008_May_23_4(5)_e1000084.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:14de69a1649d425ca5e1605bff349e82","is_oa":true,"landing_page_url":"https://doaj.org/article/14de69a1649d425ca5e1605bff349e82","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 4, Iss 5, p e1000084 (2008)","raw_type":"article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1396079","is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1396079/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"   PLOS COMPUTATIONAL BIOLOGY , 4  (5)     (2008)      ","raw_type":"Article"},{"id":"pmh:oai:figshare.com:article/150381","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Evolution_of_Taxis_Responses_in_Virtual_Bacteria_Non_Adaptive_Dynamics/150381","pdf_url":null,"source":{"id":"https://openalex.org/S4306400572","display_name":"OPAL (Open@LaTrobe) (La Trobe University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I196829312","host_organization_name":"La Trobe University","host_organization_lineage":["https://openalex.org/I196829312"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},{"id":"pmh:oai:figshare.com:article/29686640","is_oa":true,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal contribution"},{"id":"pmh:oai:ore.exeter.ac.uk:10036/3798","is_oa":false,"landing_page_url":"http://hdl.handle.net/10036/3798","pdf_url":null,"source":{"id":"https://openalex.org/S4306401998","display_name":"Open Research Exeter (University of Exeter)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I23923803","host_organization_name":"University of Exeter","host_organization_lineage":["https://openalex.org/I23923803"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2386285","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2386285","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000084","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000084","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000084&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/14","score":0.5699999928474426,"display_name":"Life below water"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2035604667.pdf","grobid_xml":"https://content.openalex.org/works/W2035604667.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1501226516","https://openalex.org/W1602756817","https://openalex.org/W1747947604","https://openalex.org/W1920238277","https://openalex.org/W1967728742","https://openalex.org/W1981047637","https://openalex.org/W1984370729","https://openalex.org/W2000329555","https://openalex.org/W2003868351","https://openalex.org/W2033118095","https://openalex.org/W2038503726","https://openalex.org/W2061654838","https://openalex.org/W2064441783","https://openalex.org/W2071082661","https://openalex.org/W2074759798","https://openalex.org/W2093755071","https://openalex.org/W2101499441","https://openalex.org/W2111361043","https://openalex.org/W2117056464","https://openalex.org/W2118753015","https://openalex.org/W2128481036","https://openalex.org/W2134864306","https://openalex.org/W2145275570","https://openalex.org/W2154370940","https://openalex.org/W2164965612"],"related_works":["https://openalex.org/W2731640799","https://openalex.org/W3145095895","https://openalex.org/W2978498151","https://openalex.org/W2782837293","https://openalex.org/W2388377527","https://openalex.org/W565532978","https://openalex.org/W1946755446","https://openalex.org/W2376563300","https://openalex.org/W2594548639","https://openalex.org/W4387544810"],"abstract_inverted_index":{"Bacteria":[0],"are":[1,46,218],"able":[2,175],"to":[3,7,19,24,60,64,68,86,113,166,176,213],"sense":[4],"and":[5,21,39,103,105,118,171,197,248,262,309,333,344,378,390,402],"respond":[6],"a":[8,88,95,129,141,149,182,188,221,335,357,370],"variety":[9],"of":[10,42,98,132,135,143,156,210,224,232,272,306,341,350,360,388,399,410],"external":[11],"stimuli,":[12],"with":[13,140,178,284,319],"responses":[14,63,82,124,295,364],"that":[15,79,120,146,187,217,245,257,277,314,324,406],"vary":[16],"from":[17,22,83],"stimuli":[18,20,66,85,268],"species":[23],"species.":[25,72],"The":[26,290,348],"best-understood":[27],"is":[28,50,75,109],"chemotaxis":[29,230],"in":[30,70,125,148,168,228,238,253,260,303,310,328],"the":[31,37,40,43,99,133,154,157,211,229,338,342,345,394],"model":[32,195],"organism":[33],"Escherichia":[34],"coli,":[35,234],"where":[36],"dynamics":[38,104,119,155,190,256,264,280,292,326,354,411],"structure":[41,170],"underlying":[44],"pathway":[45,101,116,169,231,255,274,380,396],"well":[47,55,332],"characterised.":[48],"It":[49],"not":[51,236,316],"clear,":[52],"however,":[53],"how":[54,106],"this":[56,107],"detailed":[57],"knowledge":[58],"applies":[59],"mechanisms":[61,351],"mediating":[62,293,352],"other":[65,71,329],"or":[67],"pathways":[69,160],"Furthermore,":[73],"there":[74],"increasing":[76,214],"experimental":[77,300],"evidence":[78],"bacteria":[80,145,173,330],"integrate":[81],"different":[84,100,115,194,414],"generate":[87],"coherent":[89],"taxis":[90,123,279,294,346,363],"response.":[91,347],"We":[92,185,322],"currently":[93],"lack":[94],"full":[96],"understanding":[97],"structures":[102,117,275],"integration":[108],"achieved.":[110],"In":[111],"order":[112],"explore":[114],"can":[121,281,412],"underlie":[122],"bacteria,":[126],"we":[127,202,243],"perform":[128],"computational":[130],"simulation":[131],"evolution":[134,251,377,383],"taxis.":[136],"This":[137,367],"approach":[138],"starts":[139],"population":[142],"virtual":[144,150],"move":[147],"environment":[151],"based":[152],"on":[153,266],"simple":[158],"biochemical":[159],"they":[161],"harbour.":[162],"As":[163],"mutations":[164],"lead":[165],"changes":[167],"dynamics,":[172,200,205,404],"better":[174],"localise":[177],"favourable":[179],"conditions":[180,375,387],"gain":[181],"selective":[183],"advantage.":[184],"find":[186,244],"certain":[189],"evolves":[191],"consistently":[192],"under":[193,220,386,416],"assumptions":[196],"environments.":[198],"These":[199],"which":[201],"call":[203],"non-adaptive":[204,263,291,403],"directly":[206],"couple":[207],"tumbling":[208],"probability":[209],"cell":[212,343],"stimuli.":[215],"Dynamics":[216],"adaptive":[219,261,401],"wide":[222],"range":[223],"conditions,":[225,393],"as":[226,285,287,331],"seen":[227],"E.":[233,307],"do":[235],"evolve":[237],"these":[239,407],"evolutionary":[240],"simulations.":[241],"However,":[242],"stimulus":[246,374,392],"scarcity":[247],"fluctuations":[249],"during":[250,376],"results":[252],"complex":[254,362],"result":[258],"both":[259,400],"depending":[265],"basal":[267],"levels.":[269],"Further":[270],"analyses":[271],"evolved":[273,379,395],"show":[276],"effective":[278],"be":[282,317],"mediated":[283],"few":[286],"two":[288,408],"components.":[289],"provide":[296],"an":[297],"explanation":[298],"for":[299],"observations":[301],"made":[302],"mutant":[304],"strains":[305],"coli":[308],"wild-type":[311],"Rhodobacter":[312],"sphaeroides":[313],"could":[315],"explained":[318],"standard":[320],"models.":[321],"speculate":[323],"such":[325,353],"exist":[327],"play":[334],"role":[336],"linking":[337],"metabolic":[339],"state":[340],"simplicity":[349],"makes":[355],"them":[356],"candidate":[358],"precursor":[359],"more":[361],"involving":[365],"adaptation.":[366],"study":[368],"suggests":[369],"strong":[371],"link":[372],"between":[373],"dynamics.":[381],"When":[382],"was":[384],"simulated":[385],"scarce":[389],"fluctuating":[391],"contained":[397],"features":[398],"suggesting":[405],"types":[409],"have":[413],"advantages":[415],"distinct":[417],"environmental":[418],"circumstances.":[419]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}