{"id":"https://openalex.org/W2063080802","doi":"https://doi.org/10.1371/journal.pcbi.1000041","title":"A Hidden Feedback in Signaling Cascades Is Revealed","display_name":"A Hidden Feedback in Signaling Cascades Is Revealed","publication_year":2008,"publication_date":"2008-03-20","ids":{"openalex":"https://openalex.org/W2063080802","doi":"https://doi.org/10.1371/journal.pcbi.1000041","mag":"2063080802","pmid":"https://pubmed.ncbi.nlm.nih.gov/18369431"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000041","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000041","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000041&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000041&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003045715","display_name":"Alejandra C. Ventura","orcid":"https://orcid.org/0000-0002-5275-3827"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alejandra C. Ventura","raw_affiliation_strings":["Department of Internal Medicine, Division of Hematology and Oncology and Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Hematology and Oncology and Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107309748","display_name":"Jacques-A. Sepulchre","orcid":null},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I201841394","display_name":"Universit\u00e9 C\u00f4te d'Azur","ror":"https://ror.org/019tgvf94","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Jacques-A. Sepulchre","raw_affiliation_strings":["Institut Non Lin\u00e9aire de Nice, Universit\u00e9 de Nice Sophia-Antipolis, CNRS, Valbonne, France","Institut Non Lin\u00e9aire de Nice, Universit\u00e9 de Nice-Sophia Antipolis, CNRS, Valbonne, France"],"affiliations":[{"raw_affiliation_string":"Institut Non Lin\u00e9aire de Nice, Universit\u00e9 de Nice Sophia-Antipolis, CNRS, Valbonne, France","institution_ids":["https://openalex.org/I201841394","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Institut Non Lin\u00e9aire de Nice, Universit\u00e9 de Nice-Sophia Antipolis, CNRS, Valbonne, France","institution_ids":["https://openalex.org/I201841394","https://openalex.org/I1294671590"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071608210","display_name":"Sof\u00eda D. Merajver","orcid":"https://orcid.org/0000-0002-6823-7130"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sof\u00eda D. Merajver","raw_affiliation_strings":["Department of Internal Medicine, Division of Hematology and Oncology and Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Hematology and Oncology and Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5107309748"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I201841394"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":5.9474,"has_fulltext":true,"cited_by_count":104,"citation_normalized_percentile":{"value":0.97016143,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"4","issue":"3","first_page":"e1000041","last_page":"e1000041"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9871000051498413,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cascade","display_name":"Cascade","score":0.7321493625640869},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4444512724876404},{"id":"https://openalex.org/keywords/negative-feedback","display_name":"Negative feedback","score":0.43160736560821533},{"id":"https://openalex.org/keywords/phenomenological-model","display_name":"Phenomenological model","score":0.41179633140563965},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.32677245140075684},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.28797292709350586},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.21440520882606506},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.18749839067459106}],"concepts":[{"id":"https://openalex.org/C34146451","wikidata":"https://www.wikidata.org/wiki/Q5048094","display_name":"Cascade","level":2,"score":0.7321493625640869},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4444512724876404},{"id":"https://openalex.org/C93586867","wikidata":"https://www.wikidata.org/wiki/Q62527","display_name":"Negative feedback","level":3,"score":0.43160736560821533},{"id":"https://openalex.org/C2779569378","wikidata":"https://www.wikidata.org/wiki/Q25303768","display_name":"Phenomenological model","level":2,"score":0.41179633140563965},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.32677245140075684},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.28797292709350586},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21440520882606506},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18749839067459106},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1000041","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000041","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000041&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:18369431","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18369431","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:33c9b3c61dfc4455bca7bcb92a3e73d5","is_oa":true,"landing_page_url":"https://doaj.org/article/33c9b3c61dfc4455bca7bcb92a3e73d5","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 4, Iss 3, p e1000041 (2008)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/150781","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/A_Hidden_Feedback_in_Signaling_Cascades_Is_Revealed/150781","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:2265423","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2265423","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000041","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000041","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000041&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G6850104026","display_name":null,"funder_award_id":"CA77612","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306133","display_name":"Burroughs Wellcome Fund","ror":"https://ror.org/01d35cw23"},{"id":"https://openalex.org/F4320306260","display_name":"Breast Cancer Research Foundation","ror":"https://ror.org/0348ff195"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2063080802.pdf","grobid_xml":"https://content.openalex.org/works/W2063080802.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1517356485","https://openalex.org/W1544401280","https://openalex.org/W1576664335","https://openalex.org/W1970661255","https://openalex.org/W1974020517","https://openalex.org/W1980396134","https://openalex.org/W1989712725","https://openalex.org/W1993459930","https://openalex.org/W1994500037","https://openalex.org/W1994780544","https://openalex.org/W2000619385","https://openalex.org/W2003179536","https://openalex.org/W2007415331","https://openalex.org/W2015869454","https://openalex.org/W2020651752","https://openalex.org/W2031533876","https://openalex.org/W2034188706","https://openalex.org/W2041603328","https://openalex.org/W2047575710","https://openalex.org/W2065151681","https://openalex.org/W2067160012","https://openalex.org/W2067620337","https://openalex.org/W2069076431","https://openalex.org/W2070658593","https://openalex.org/W2096248361","https://openalex.org/W2107940486","https://openalex.org/W2126483190","https://openalex.org/W2126538490","https://openalex.org/W2133667940","https://openalex.org/W2135535700","https://openalex.org/W2139439234","https://openalex.org/W2139546509","https://openalex.org/W2145225614","https://openalex.org/W2157989234","https://openalex.org/W2160214128","https://openalex.org/W2164925597"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2153719181","https://openalex.org/W1971748923","https://openalex.org/W1566155057","https://openalex.org/W2060986072","https://openalex.org/W2052574922","https://openalex.org/W64588465","https://openalex.org/W3120641340","https://openalex.org/W2117825986"],"abstract_inverted_index":{"Cycles":[0],"involving":[1],"covalent":[2],"modification":[3],"of":[4,9,18,22,37,55,90,123,138,159,162,168,216,223,251],"proteins":[5],"are":[6,228,233],"key":[7,166],"components":[8],"the":[10,46,53,56,60,84,91,105,113,124,135,191,213,236],"intracellular":[11],"signaling":[12,28,163,219,252],"machinery.":[13],"Each":[14],"cycle":[15,39,51,182],"is":[16,30,102,119,172],"comprised":[17],"two":[19],"interconvertable":[20],"forms":[21],"a":[23,33,43,67,73,87,120,144,174],"particular":[24],"protein.":[25],"A":[26,165],"classic":[27],"pathway":[29],"structured":[31],"by":[32,235,246],"chain":[34,92],"or":[35],"cascade":[36],"basic":[38],"units":[40],"in":[41,49,59,110,112,150,218],"such":[42],"way":[44],"that":[45,107,173],"activated":[47],"protein":[48,58],"one":[50,94,106],"promotes":[52],"activation":[54],"next":[57],"chain,":[61],"and":[62,71,183,207,240],"so":[63],"on.":[64],"Starting":[65],"from":[66,104],"mechanistic":[68,238],"kinetic":[69],"description":[70,239],"using":[72],"careful":[74],"perturbation":[75],"analysis,":[76],"we":[77,100,153],"have":[78,154],"derived,":[79],"to":[80,187,225],"our":[81,141,169,241],"knowledge":[82],"for":[83,115],"first":[85],"time,":[86],"consistent":[88],"approximation":[89],"with":[93],"variable":[95],"per":[96],"cycle.":[97],"The":[98],"model":[99,171],"derive":[101],"distinct":[103],"has":[108,131],"been":[109,132],"use":[111],"literature":[114],"several":[116],"years,":[117],"which":[118],"phenomenological":[121,249],"extension":[122],"Goldbeter-Koshland":[125],"biochemical":[126],"switch.":[127],"Even":[128],"though":[129],"much":[130],"done":[133],"regarding":[134],"mathematical":[136],"modeling":[137],"these":[139,231],"systems,":[140],"contribution":[142],"fills":[143],"gap":[145],"between":[146,180],"existing":[147],"models":[148,250],"and,":[149,200],"doing":[151],"so,":[152],"unveiled":[155],"critical":[156],"new":[157,170],"properties":[158,232],"this":[160,188],"type":[161],"cascades.":[164,220,253],"feature":[167],"negative":[175,189],"feedback":[176],"emerges":[177],"naturally,":[178],"exerted":[179],"each":[181],"its":[184],"predecessor.":[185],"Due":[186],"feedback,":[190],"system":[192],"displays":[193],"damped":[194],"temporal":[195],"oscillations":[196],"under":[197],"constant":[198],"stimulation":[199],"most":[201],"important,":[202],"propagates":[203],"perturbations":[204],"both":[205],"forwards":[206],"backwards.":[208],"This":[209],"last":[210],"attribute":[211],"challenges":[212],"widespread":[214],"notion":[215],"unidirectionality":[217],"Concrete":[221],"examples":[222],"applications":[224],"MAPK":[226],"cascades":[227],"discussed.":[229],"All":[230],"shared":[234],"complete":[237],"simplified":[242],"model,":[243],"but":[244],"not":[245],"previously":[247],"derived":[248]},"counts_by_year":[{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":8}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
