{"id":"https://openalex.org/W2159532448","doi":"https://doi.org/10.1371/journal.pcbi.1000014","title":"Translational Systems Biology of Inflammation","display_name":"Translational Systems Biology of Inflammation","publication_year":2008,"publication_date":"2008-04-24","ids":{"openalex":"https://openalex.org/W2159532448","doi":"https://doi.org/10.1371/journal.pcbi.1000014","mag":"2159532448","pmid":"https://pubmed.ncbi.nlm.nih.gov/18437239"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000014","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000014","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000014&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000014&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073022985","display_name":"Yoram Vodovotz","orcid":"https://orcid.org/0000-0002-4389-8768"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]},{"id":"https://openalex.org/I4210155891","display_name":"McGowan Institute for Regenerative Medicine","ror":"https://ror.org/04js6xx21","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210098814","https://openalex.org/I4210134769","https://openalex.org/I4210155891"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yoram Vodovotz","raw_affiliation_strings":["Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America. vodovotzy@upmc.edu","Center for Inflammation and Regenerative Modeling, McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America. vodovotzy@upmc.edu","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210134769"]},{"raw_affiliation_string":"Center for Inflammation and Regenerative Modeling, McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210155891"]},{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030934220","display_name":"Marie Csete","orcid":"https://orcid.org/0000-0003-4591-0510"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marie Csete","raw_affiliation_strings":["Department of Anesthesiology, Emory University School of Medicine, Atlanta, Georgia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Emory University School of Medicine, Atlanta, Georgia, United States of America","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103415986","display_name":"John Bartels","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Bartels","raw_affiliation_strings":["Immunetrics Corporation, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunetrics Corporation, Pittsburgh, Pennsylvania, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012536911","display_name":"Steven C. Chang","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven Chang","raw_affiliation_strings":["Immunetrics Corporation, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunetrics Corporation, Pittsburgh, Pennsylvania, United States of America","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042696510","display_name":"Gary An","orcid":"https://orcid.org/0000-0003-4549-9004"},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210155891","display_name":"McGowan Institute for Regenerative Medicine","ror":"https://ror.org/04js6xx21","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210098814","https://openalex.org/I4210134769","https://openalex.org/I4210155891"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary An","raw_affiliation_strings":["Center for Inflammation and Regenerative Modeling, McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","Department of Surgery, Northwestern University, Chicago, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Inflammation and Regenerative Modeling, McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210155891"]},{"raw_affiliation_string":"Department of Surgery, Northwestern University, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5073022985"],"corresponding_institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210134769","https://openalex.org/I4210155891"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":8.0605,"has_fulltext":true,"cited_by_count":229,"citation_normalized_percentile":{"value":0.98321298,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"4","issue":"4","first_page":"e1000014","last_page":"e1000014"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9290000200271606,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9290000200271606,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9178000092506409,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.8001147508621216},{"id":"https://openalex.org/keywords/translational-research","display_name":"Translational research","score":0.6091427803039551},{"id":"https://openalex.org/keywords/translational-science","display_name":"Translational science","score":0.4916687607765198},{"id":"https://openalex.org/keywords/modelling-biological-systems","display_name":"Modelling biological systems","score":0.47571948170661926},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.46349096298217773},{"id":"https://openalex.org/keywords/systems-medicine","display_name":"Systems medicine","score":0.4406881034374237},{"id":"https://openalex.org/keywords/multidisciplinary-approach","display_name":"Multidisciplinary approach","score":0.43881574273109436},{"id":"https://openalex.org/keywords/organism","display_name":"Organism","score":0.43157482147216797},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4310452342033386},{"id":"https://openalex.org/keywords/inflammation","display_name":"Inflammation","score":0.41767412424087524},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3908311426639557},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3742942810058594},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2666419446468353},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.2001950740814209},{"id":"https://openalex.org/keywords/biotechnology","display_name":"Biotechnology","score":0.12731677293777466},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.11068743467330933}],"concepts":[{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.8001147508621216},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.6091427803039551},{"id":"https://openalex.org/C57634137","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational science","level":2,"score":0.4916687607765198},{"id":"https://openalex.org/C137866125","wikidata":"https://www.wikidata.org/wiki/Q4299308","display_name":"Modelling biological systems","level":3,"score":0.47571948170661926},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.46349096298217773},{"id":"https://openalex.org/C36415437","wikidata":"https://www.wikidata.org/wiki/Q7663871","display_name":"Systems medicine","level":3,"score":0.4406881034374237},{"id":"https://openalex.org/C22467394","wikidata":"https://www.wikidata.org/wiki/Q849359","display_name":"Multidisciplinary approach","level":2,"score":0.43881574273109436},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.43157482147216797},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4310452342033386},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.41767412424087524},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3908311426639557},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3742942810058594},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2666419446468353},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2001950740814209},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.12731677293777466},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11068743467330933},{"id":"https://openalex.org/C36289849","wikidata":"https://www.wikidata.org/wiki/Q34749","display_name":"Social science","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1000014","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000014","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000014&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:18437239","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18437239","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:d-scholarship.pitt.edu:12953","is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/12953/8/licence.txt","pdf_url":null,"source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:europepmc.org:1379909","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2329781","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1000014","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1000014","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:d5fc7385c95347be9e3909ed9a86396a","is_oa":true,"landing_page_url":"https://doaj.org/article/d5fc7385c95347be9e3909ed9a86396a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 4, Iss 4, p e1000014 (2008)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000014","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000014","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000014&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1040947475","display_name":null,"funder_award_id":"R01-HL-080926","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1934434356","display_name":null,"funder_award_id":"R01-HL080926-01","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2242382121","display_name":"Metabolic-Inflammatory Systems in Irreversible Shock","funder_award_id":"5r01hl076157-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3158406084","display_name":null,"funder_award_id":"R01 GM 67240-02","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G34028528","display_name":null,"funder_award_id":"R01-HL-76157-02","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3631662173","display_name":null,"funder_award_id":"H133E070024","funder_id":"https://openalex.org/F4320337112","funder_display_name":"National Institute on Disability and Rehabilitation Research"},{"id":"https://openalex.org/G3746577913","display_name":null,"funder_award_id":"R01 HL076157","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G507032350","display_name":"Molecular Biology of Hemorrhagic Shock","funder_award_id":"5p50gm053789-14","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5945718041","display_name":null,"funder_award_id":"R01 GM067240","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6590623284","display_name":null,"funder_award_id":"H133E070024","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G7405967469","display_name":"Systems Engineering of Pheresis Intervention for Sepsis","funder_award_id":"5r01hl080926-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G771770300","display_name":null,"funder_award_id":"P50GM053789","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8068000329","display_name":null,"funder_award_id":"H133E070024","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8249080979","display_name":"Modeling the acute inflammatory response","funder_award_id":"5r01gm067240-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G884576999","display_name":null,"funder_award_id":"P50 GM 53789-08","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320309381","display_name":"Emory University","ror":"https://ror.org/03czfpz43"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337112","display_name":"National Institute on Disability and Rehabilitation Research","ror":"https://ror.org/021adze67"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2159532448.pdf","grobid_xml":"https://content.openalex.org/works/W2159532448.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W44245397","https://openalex.org/W202929248","https://openalex.org/W631732704","https://openalex.org/W1762585791","https://openalex.org/W1835595562","https://openalex.org/W1904529686","https://openalex.org/W1970940391","https://openalex.org/W1973065632","https://openalex.org/W1975631908","https://openalex.org/W1977523316","https://openalex.org/W1978486653","https://openalex.org/W1978746538","https://openalex.org/W1985240742","https://openalex.org/W1985264236","https://openalex.org/W1985546006","https://openalex.org/W1992033406","https://openalex.org/W1992585458","https://openalex.org/W1993401546","https://openalex.org/W1996449803","https://openalex.org/W1997896661","https://openalex.org/W2005229991","https://openalex.org/W2008760760","https://openalex.org/W2014579166","https://openalex.org/W2017172862","https://openalex.org/W2022140268","https://openalex.org/W2023447635","https://openalex.org/W2030006245","https://openalex.org/W2031827679","https://openalex.org/W2034900742","https://openalex.org/W2035407279","https://openalex.org/W2035431664","https://openalex.org/W2040726163","https://openalex.org/W2041042514","https://openalex.org/W2046923162","https://openalex.org/W2049655700","https://openalex.org/W2051837736","https://openalex.org/W2053033670","https://openalex.org/W2054519334","https://openalex.org/W2060422880","https://openalex.org/W2061750802","https://openalex.org/W2064491404","https://openalex.org/W2065619992","https://openalex.org/W2077783099","https://openalex.org/W2084595614","https://openalex.org/W2086970540","https://openalex.org/W2088519259","https://openalex.org/W2089323578","https://openalex.org/W2097050934","https://openalex.org/W2100953664","https://openalex.org/W2104688931","https://openalex.org/W2109343049","https://openalex.org/W2112234220","https://openalex.org/W2123770403","https://openalex.org/W2124524536","https://openalex.org/W2125590226","https://openalex.org/W2127857142","https://openalex.org/W2128084205","https://openalex.org/W2128977013","https://openalex.org/W2128988773","https://openalex.org/W2130929414","https://openalex.org/W2134573759","https://openalex.org/W2137082708","https://openalex.org/W2141133391","https://openalex.org/W2142605112","https://openalex.org/W2145221987","https://openalex.org/W2151508309","https://openalex.org/W2151673904","https://openalex.org/W2155829013","https://openalex.org/W2156661166","https://openalex.org/W2183236591","https://openalex.org/W2494703032","https://openalex.org/W4246350887","https://openalex.org/W4248422090","https://openalex.org/W4255777804"],"related_works":["https://openalex.org/W4386563820","https://openalex.org/W2169478906","https://openalex.org/W2185904291","https://openalex.org/W4233388905","https://openalex.org/W2140327348","https://openalex.org/W2034718166","https://openalex.org/W2057769265","https://openalex.org/W3199870583","https://openalex.org/W1511119527","https://openalex.org/W4232208290"],"abstract_inverted_index":{"Inflammation":[0],"is":[1,10,71,89],"a":[2,65,90,112],"complex,":[3],"multi-scale":[4],"biologic":[5,113,137],"response":[6],"to":[7,99,116,118,136,151,156,161],"stress":[8],"that":[9,92],"also":[11],"required":[12],"for":[13,63,127],"repair":[14],"and":[15,28,61,69,109,133,199,209],"regeneration":[16],"after":[17],"injury.":[18],"Despite":[19],"the":[20,26,47,55,83,102,105,122,128,140,149,165,180,202],"repository":[21],"of":[22,37,51,67,78,85,104,111,130,143,167,182,201],"detailed":[23],"data":[24],"about":[25],"cellular":[27],"molecular":[29],"processes":[30],"involved":[31],"in":[32,45,76,101,171,188],"inflammation,":[33],"including":[34],"some":[35],"understanding":[36,103,172,189],"its":[38],"pathophysiology,":[39],"little":[40],"progress":[41],"has":[42],"been":[43],"made":[44],"treating":[46],"severe":[48],"inflammatory":[49],"syndrome":[50],"sepsis.":[52],"To":[53],"address":[54],"gap":[56],"between":[57],"basic":[58,80],"science":[59],"knowledge":[60],"therapy":[62],"sepsis,":[64],"community":[66,206],"biologists":[68,208],"physicians":[70],"using":[72,174],"systems":[73,125,138,154,176,204],"biology":[74,84,126,155,177,205],"approaches":[75],"hopes":[77],"yielding":[79],"insights":[81],"into":[82,164],"inflammation.":[86,169],"\"Systems":[87],"biology\"":[88],"discipline":[91],"combines":[93],"experimental":[94],"discovery":[95],"with":[96,139,207],"mathematical":[97],"modeling":[98],"aid":[100],"dynamic":[106],"global":[107],"organization":[108],"function":[110],"system":[114],"(cell":[115],"organ":[117],"organism).":[119],"We":[120,147],"propose":[121],"term":[123],"translational":[124,153,175],"application":[129],"similar":[131],"tools":[132,178],"engineering":[134],"principles":[135],"primary":[141],"goal":[142],"optimizing":[144],"clinical":[145],"practice.":[146],"describe":[148],"efforts":[150],"use":[152],"develop":[157],"an":[158],"integrated":[159],"framework":[160],"gain":[162],"insight":[163],"problem":[166],"acute":[168],"Progress":[170],"inflammation":[173],"highlights":[179],"promise":[181],"this":[183],"multidisciplinary":[184],"field.":[185],"Future":[186],"advances":[187,198],"complex":[190],"medical":[191],"problems":[192],"are":[193],"highly":[194],"dependent":[195],"on":[196],"methodological":[197],"integration":[200],"computational":[203],"clinicians.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":26},{"year":2013,"cited_by_count":26},{"year":2012,"cited_by_count":24}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}
