{"id":"https://openalex.org/W2002354671","doi":"https://doi.org/10.1371/journal.pcbi.1000011","title":"Entropy Measures Quantify Global Splicing Disorders in Cancer","display_name":"Entropy Measures Quantify Global Splicing Disorders in Cancer","publication_year":2008,"publication_date":"2008-03-13","ids":{"openalex":"https://openalex.org/W2002354671","doi":"https://doi.org/10.1371/journal.pcbi.1000011","mag":"2002354671","pmid":"https://pubmed.ncbi.nlm.nih.gov/18369415"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000011","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000011","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000011&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000011&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083670919","display_name":"William Ritchie","orcid":"https://orcid.org/0000-0001-8162-1439"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William Ritchie","raw_affiliation_strings":["Universit\u00e9 de M\u00e9diterran\u00e9e, INSERM ERM 206, Technologies Avanc\u00e9es pour le G\u00e9nome et Clinique, Marseille, France"],"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de M\u00e9diterran\u00e9e, INSERM ERM 206, Technologies Avanc\u00e9es pour le G\u00e9nome et Clinique, Marseille, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030421016","display_name":"Samuel Granjeaud","orcid":"https://orcid.org/0000-0001-9245-1535"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Samuel Granjeaud","raw_affiliation_strings":["Universit\u00e9 de la M\u00e9diterran\u00e9e, INSERM ERM 206, Technologies Avanc\u00e9es pour le G\u00e9nome et la Clinique, Marseille, France"],"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de la M\u00e9diterran\u00e9e, INSERM ERM 206, Technologies Avanc\u00e9es pour le G\u00e9nome et la Clinique, Marseille, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049857580","display_name":"Denis Puthier","orcid":"https://orcid.org/0000-0002-7240-5280"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Denis Puthier","raw_affiliation_strings":["Universit\u00e9 de la M\u00e9diterran\u00e9e, INSERM ERM 206, Technologies Avanc\u00e9es pour le G\u00e9nome et la Clinique, Marseille, France"],"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de la M\u00e9diterran\u00e9e, INSERM ERM 206, Technologies Avanc\u00e9es pour le G\u00e9nome et la Clinique, Marseille, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042025248","display_name":"Daniel Gautheret","orcid":"https://orcid.org/0000-0002-1508-8469"},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Daniel Gautheret","raw_affiliation_strings":["Universit\u00e9 Paris-Sud 11, CNRS UMR 8621, Institut de G\u00e9n\u00e9tique et Microbiologie, Orsay, France","Universit\u00e9 Paris Sud-11, CNRS UMR 8621, Institut de G\u00e9n\u00e9tique et Microbiologie, Orsay, France"],"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Sud 11, CNRS UMR 8621, Institut de G\u00e9n\u00e9tique et Microbiologie, Orsay, France","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Universit\u00e9 Paris Sud-11, CNRS UMR 8621, Institut de G\u00e9n\u00e9tique et Microbiologie, Orsay, France","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I1294671590"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5042025248"],"corresponding_institution_ids":["https://openalex.org/I102197404","https://openalex.org/I1294671590"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.213,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.87156019,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"4","issue":"3","first_page":"e1000011","last_page":"e1000011"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"Alternative splicing","score":0.8559131622314453},{"id":"https://openalex.org/keywords/rna-splicing","display_name":"RNA splicing","score":0.7897953391075134},{"id":"https://openalex.org/keywords/polyadenylation","display_name":"Polyadenylation","score":0.6817845106124878},{"id":"https://openalex.org/keywords/splice","display_name":"splice","score":0.6719529628753662},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6386469006538391},{"id":"https://openalex.org/keywords/gene-isoform","display_name":"Gene isoform","score":0.5182921290397644},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.49314063787460327},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4775731861591339},{"id":"https://openalex.org/keywords/splicing-factor","display_name":"Splicing factor","score":0.42153623700141907},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.40690088272094727},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.3688622713088989},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.25400012731552124}],"concepts":[{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.8559131622314453},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.7897953391075134},{"id":"https://openalex.org/C142575336","wikidata":"https://www.wikidata.org/wiki/Q412148","display_name":"Polyadenylation","level":4,"score":0.6817845106124878},{"id":"https://openalex.org/C2780989783","wikidata":"https://www.wikidata.org/wiki/Q7578557","display_name":"splice","level":3,"score":0.6719529628753662},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6386469006538391},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.5182921290397644},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.49314063787460327},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4775731861591339},{"id":"https://openalex.org/C73758832","wikidata":"https://www.wikidata.org/wiki/Q7578564","display_name":"Splicing factor","level":5,"score":0.42153623700141907},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.40690088272094727},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3688622713088989},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.25400012731552124}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018390","descriptor_name":"Gene Targeting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018390","descriptor_name":"Gene Targeting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018390","descriptor_name":"Gene Targeting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019154","descriptor_name":"Protein Splicing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019154","descriptor_name":"Protein Splicing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019154","descriptor_name":"Protein Splicing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1000011","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000011","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000011&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:18369415","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18369415","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.282.9710","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.282.9710","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/39/68/PLoS_Comput_Biol_2008_Mar_14_4(3)_e1000011.tar.gz","raw_type":"text"},{"id":"pmh:oai:HAL:hal-00286322v1","is_oa":true,"landing_page_url":"https://hal.science/hal-00286322","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 2008, 4 (3), pp.e1000011. &#x27E8;10.1371/journal.pcbi.1000011&#x27E9;","raw_type":"Journal articles"},{"id":"pmh:oai:doaj.org/article:d886706782b84fa8b4c3d3b123862386","is_oa":true,"landing_page_url":"https://doaj.org/article/d886706782b84fa8b4c3d3b123862386","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 4, Iss 3, p e1000011 (2008)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/150822","is_oa":true,"landing_page_url":"https://figshare.com/articles/Entropy_Measures_Quantify_Global_Splicing_Disorders_in_Cancer/150822","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:2268240","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2268240","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000011","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000011","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000011&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5899999737739563,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320323807","display_name":"Institut National Du Cancer","ror":"https://ror.org/03m8vkq32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2002354671.pdf","grobid_xml":"https://content.openalex.org/works/W2002354671.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1489421422","https://openalex.org/W1857325778","https://openalex.org/W1946500467","https://openalex.org/W1970108031","https://openalex.org/W1971363517","https://openalex.org/W1971846931","https://openalex.org/W1986113553","https://openalex.org/W1995048208","https://openalex.org/W2010852376","https://openalex.org/W2012640439","https://openalex.org/W2022129227","https://openalex.org/W2038617558","https://openalex.org/W2041380439","https://openalex.org/W2046002852","https://openalex.org/W2063559465","https://openalex.org/W2070564797","https://openalex.org/W2074403146","https://openalex.org/W2092129813","https://openalex.org/W2096940705","https://openalex.org/W2099468911","https://openalex.org/W2102711634","https://openalex.org/W2103017472","https://openalex.org/W2107881958","https://openalex.org/W2109063364","https://openalex.org/W2126705594","https://openalex.org/W2128012941","https://openalex.org/W2129441720","https://openalex.org/W2130962401","https://openalex.org/W2133932782","https://openalex.org/W2134208113","https://openalex.org/W2152545090","https://openalex.org/W2157338021","https://openalex.org/W2158463967","https://openalex.org/W2162142896","https://openalex.org/W2164971856","https://openalex.org/W2165090547","https://openalex.org/W2171791048","https://openalex.org/W2321791250"],"related_works":["https://openalex.org/W2001319824","https://openalex.org/W2067501355","https://openalex.org/W2116965031","https://openalex.org/W1959417209","https://openalex.org/W2008389025","https://openalex.org/W2140894105","https://openalex.org/W2014791263","https://openalex.org/W2321791250","https://openalex.org/W2060213717","https://openalex.org/W1929261690"],"abstract_inverted_index":{"Most":[0,34],"mammalian":[1],"genes":[2,167],"are":[3,174],"able":[4],"to":[5,27,154],"express":[6],"several":[7],"splice":[8,32,47,195,225],"variants":[9,48,196],"in":[10,23,82,144,161,176,189,202,218,223,228],"a":[11,70,142],"phenomenon":[12],"known":[13],"as":[14,49],"alternative":[15,20,37,98,105,122],"splicing.":[16],"Serious":[17],"alterations":[18],"of":[19,29,36,45,59,67,72,95,115,131,148,157,186,193,206],"splicing":[21,38,123,177,187,214,221],"occur":[22],"cancer":[24,85,120,163],"tissues,":[25,121],"leading":[26],"expression":[28,80,146,192],"multiple":[30,232],"aberrant":[31],"forms.":[33],"studies":[35],"defects":[39],"have":[40],"focused":[41],"on":[42],"the":[43,57,88,132,145,155,162,166,170,182,207],"identification":[44],"cancer-specific":[46],"potential":[50],"therapeutic":[51],"targets.":[52],"Here,":[53],"we":[54],"examine":[55],"instead":[56],"bulk":[58],"non-specific":[60],"transcript":[61,96],"isoforms":[62,150],"and":[63,84,101,107,119,151,199],"analyze":[64],"their":[65],"level":[66,156],"disorder":[68],"using":[69],"measure":[71],"uncertainty":[73],"called":[74],"Shannon's":[75],"entropy.":[76],"We":[77,179,210],"compare":[78],"isoform":[79],"entropy":[81,116,127,137,172],"normal":[83,118,149,194],"tissues":[86],"from":[87,220],"same":[89],"anatomical":[90],"site":[91],"for":[92,129],"different":[93],"classes":[94],"variations:":[97],"splicing,":[99],"polyadenylation,":[100],"transcription":[102],"initiation.":[103],"Whereas":[104],"initiation":[106],"polyadenylation":[108],"show":[109],"no":[110],"significant":[111,126],"gain":[112,138,173],"or":[113],"loss":[114],"between":[117],"shows":[124],"highly":[125],"gains":[128],"13":[130],"27":[133],"cancers":[134,208],"studied.":[135,209],"This":[136],"is":[139,152,197],"characterized":[140],"by":[141],"flattening":[143],"profile":[147],"correlated":[153],"estimated":[158],"cellular":[159],"proliferation":[160],"tissue.":[164],"Interestingly,":[165],"that":[168,212],"present":[169],"highest":[171],"enriched":[175],"factors.":[178],"provide":[180],"here":[181],"first":[183],"quantitative":[184],"estimate":[185],"disruption":[188],"cancer.":[190],"The":[191],"widely":[198],"significantly":[200,230],"disrupted":[201],"at":[203],"least":[204],"half":[205],"postulate":[211],"such":[213],"disorders":[215],"may":[216],"develop":[217],"part":[219],"alteration":[222],"key":[224],"factors,":[226],"which":[227],"turn":[229],"impact":[231],"target":[233],"genes.":[234]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
