{"id":"https://openalex.org/W1993402893","doi":"https://doi.org/10.1371/journal.pcbi.0040043","title":"Accurate Structural Correlations from Maximum Likelihood Superpositions","display_name":"Accurate Structural Correlations from Maximum Likelihood Superpositions","publication_year":2008,"publication_date":"2008-02-12","ids":{"openalex":"https://openalex.org/W1993402893","doi":"https://doi.org/10.1371/journal.pcbi.0040043","mag":"1993402893","pmid":"https://pubmed.ncbi.nlm.nih.gov/18282091"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.0040043","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0040043","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0040043&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0040043&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046700536","display_name":"Douglas L. Theobald","orcid":"https://orcid.org/0000-0002-2695-8343"},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Douglas L Theobald","raw_affiliation_strings":["Department of Biochemistry, Brandeis University, Waltham, Massachusetts, USA. dtheobald@brandeis.edu","Department of Biochemistry, Brandeis University, Waltham, Massachusetts, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Brandeis University, Waltham, Massachusetts, USA. dtheobald@brandeis.edu","institution_ids":["https://openalex.org/I6902469"]},{"raw_affiliation_string":"Department of Biochemistry, Brandeis University, Waltham, Massachusetts, USA","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031343617","display_name":"Deborah S. Wuttke","orcid":"https://orcid.org/0000-0002-8158-8795"},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deborah S Wuttke","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, Colorado, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, Colorado, United States of America","institution_ids":["https://openalex.org/I188538660"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5046700536"],"corresponding_institution_ids":["https://openalex.org/I6902469"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.4501,"has_fulltext":true,"cited_by_count":97,"citation_normalized_percentile":{"value":0.89018029,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"4","issue":"2","first_page":"e43","last_page":"e43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9024999737739563,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/maximum-likelihood","display_name":"Maximum likelihood","score":0.6191866397857666},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.49481672048568726},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.4273388385772705},{"id":"https://openalex.org/keywords/econometrics","display_name":"Econometrics","score":0.40480566024780273},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.36210745573043823},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.34120962023735046},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3222620487213135},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.3101809620857239}],"concepts":[{"id":"https://openalex.org/C49781872","wikidata":"https://www.wikidata.org/wiki/Q1045555","display_name":"Maximum likelihood","level":2,"score":0.6191866397857666},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.49481672048568726},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.4273388385772705},{"id":"https://openalex.org/C149782125","wikidata":"https://www.wikidata.org/wiki/Q160039","display_name":"Econometrics","level":1,"score":0.40480566024780273},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.36210745573043823},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34120962023735046},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3222620487213135},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3101809620857239}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003461","descriptor_name":"Crystallography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003461","descriptor_name":"Crystallography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003461","descriptor_name":"Crystallography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016013","descriptor_name":"Likelihood Functions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016013","descriptor_name":"Likelihood Functions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016013","descriptor_name":"Likelihood Functions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.0040043","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0040043","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0040043&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:18282091","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18282091","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.282.8883","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.282.8883","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/57/73/PLoS_Comput_Biol_2008_Feb_15_4(2)_e43.tar.gz","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:0040043","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.0040043","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:a3a9bd982faf4ddd8b69065889cd8419","is_oa":true,"landing_page_url":"https://doaj.org/article/a3a9bd982faf4ddd8b69065889cd8419","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 4, Iss 2, p e43 (2008)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2622561","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC2242818","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2242818","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2242818","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.0040043","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0040043","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0040043&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1993402893.pdf","grobid_xml":"https://content.openalex.org/works/W1993402893.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W33507944","https://openalex.org/W1490229695","https://openalex.org/W1535832174","https://openalex.org/W1553860573","https://openalex.org/W1964083898","https://openalex.org/W1967986998","https://openalex.org/W1970769480","https://openalex.org/W1974225312","https://openalex.org/W1978517242","https://openalex.org/W1983534198","https://openalex.org/W1995808589","https://openalex.org/W1998412941","https://openalex.org/W2026258231","https://openalex.org/W2028034301","https://openalex.org/W2028231353","https://openalex.org/W2037760012","https://openalex.org/W2047580257","https://openalex.org/W2049633694","https://openalex.org/W2051317301","https://openalex.org/W2053684353","https://openalex.org/W2055530511","https://openalex.org/W2060999146","https://openalex.org/W2067129729","https://openalex.org/W2069684779","https://openalex.org/W2078248419","https://openalex.org/W2078537874","https://openalex.org/W2079942516","https://openalex.org/W2080627708","https://openalex.org/W2102162967","https://openalex.org/W2103956655","https://openalex.org/W2110003471","https://openalex.org/W2130479394","https://openalex.org/W2131529311","https://openalex.org/W2132589721","https://openalex.org/W2133956643","https://openalex.org/W2146598193","https://openalex.org/W2159544267","https://openalex.org/W2160451368","https://openalex.org/W2165969670","https://openalex.org/W2171170345","https://openalex.org/W2171810840","https://openalex.org/W2334826812","https://openalex.org/W2433700685","https://openalex.org/W2489605225","https://openalex.org/W3015240874","https://openalex.org/W4388322985"],"related_works":["https://openalex.org/W1922851888","https://openalex.org/W2406961220","https://openalex.org/W2046260256","https://openalex.org/W4232468313","https://openalex.org/W3214485701","https://openalex.org/W4391677502","https://openalex.org/W4242249046","https://openalex.org/W4240106746","https://openalex.org/W3162882601","https://openalex.org/W4230369419"],"abstract_inverted_index":{"The":[0,133],"cores":[1],"of":[2,12,29,34,62,71,73,83,88,97,103,114,124,129,140,176,193,201],"globular":[3],"proteins":[4],"are":[5,117,137],"densely":[6],"packed,":[7],"resulting":[8],"in":[9,17,65,198],"complicated":[10],"networks":[11],"structural":[13,23,63,101,115,150,177,181,195,202],"interactions.":[14],"These":[15],"interactions":[16],"turn":[18],"give":[19],"rise":[20],"to":[21,48,80],"dynamic":[22,145,194],"correlations":[24,37,134,165,196],"over":[25],"a":[26,53,98,170],"wide":[27],"range":[28],"time":[30],"scales.":[31],"Accurate":[32],"analysis":[33,70,122],"these":[35,163],"complex":[36],"is":[38,77],"crucial":[39],"for":[40,45,57,161],"understanding":[41],"biomolecular":[42],"mechanisms":[43],"and":[44,100,144,179],"relating":[46],"structure":[47],"function.":[49],"Here":[50],"we":[51,135],"report":[52],"highly":[54],"accurate":[55,191],"technique":[56],"inferring":[58],"the":[59,125,130,141,149,180,186,190],"major":[60],"modes":[61,113],"correlation":[64,116,131],"macromolecules":[66],"using":[67,119],"likelihood-based":[68],"statistical":[69,142],"sets":[72],"structures.":[74],"This":[75],"method":[76,158],"generally":[78],"applicable":[79],"any":[81],"ensemble":[82],"related":[84],"molecules,":[85],"including":[86],"families":[87],"nuclear":[89],"magnetic":[90],"resonance":[91],"(NMR)":[92],"models,":[93],"different":[94],"crystal":[95],"forms":[96],"protein,":[99],"alignments":[102],"homologous":[104],"proteins,":[105],"as":[106,108],"well":[107],"molecular":[109],"dynamics":[110],"trajectories.":[111],"Dominant":[112],"determined":[118],"principal":[120],"components":[121],"(PCA)":[123],"maximum":[126],"likelihood":[127,174],"estimate":[128],"matrix.":[132],"identify":[136],"inherently":[138],"independent":[139],"uncertainty":[143],"heterogeneity":[146],"associated":[147],"with":[148],"coordinates.":[151],"We":[152],"additionally":[153],"present":[154],"an":[155],"easily":[156],"interpretable":[157],"(\"PCA":[159],"plots\")":[160],"displaying":[162],"positional":[164],"by":[166],"color-coding":[167],"them":[168],"onto":[169],"macromolecular":[171],"structure.":[172],"Maximum":[173],"PCA":[175,182],"superpositions,":[178],"plots":[183],"that":[184],"illustrate":[185],"results,":[187],"will":[188],"facilitate":[189],"determination":[192],"analyzed":[197],"diverse":[199],"fields":[200],"biology.":[203]},"counts_by_year":[{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":5}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}