{"id":"https://openalex.org/W1979262621","doi":"https://doi.org/10.1371/journal.pcbi.0040021","title":"Strategies for Identifying RNA Splicing Regulatory Motifs and Predicting Alternative Splicing Events","display_name":"Strategies for Identifying RNA Splicing Regulatory Motifs and Predicting Alternative Splicing Events","publication_year":2008,"publication_date":"2008-01-22","ids":{"openalex":"https://openalex.org/W1979262621","doi":"https://doi.org/10.1371/journal.pcbi.0040021","mag":"1979262621","pmid":"https://pubmed.ncbi.nlm.nih.gov/18225947"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.0040021","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0040021","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0040021&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0040021&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036949377","display_name":"Dirk Holste","orcid":null},"institutions":[{"id":"https://openalex.org/I138211613","display_name":"Austrian Academy of Sciences","ror":"https://ror.org/03anc3s24","country_code":"AT","type":"funder","lineage":["https://openalex.org/I138211613"]},{"id":"https://openalex.org/I195525897","display_name":"Research Institute of Molecular Pathology","ror":"https://ror.org/02c5jsm26","country_code":"AT","type":"facility","lineage":["https://openalex.org/I195525897"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Dirk Holste","raw_affiliation_strings":["Research Institute of Molecular Pathology, Austrian Academy of Sciences, Vienna, Austria. holste@imp.ac.at","Research Institute of Molecular Pathology, Austrian Academy of Sciences, Vienna, Austria"],"affiliations":[{"raw_affiliation_string":"Research Institute of Molecular Pathology, Austrian Academy of Sciences, Vienna, Austria. holste@imp.ac.at","institution_ids":["https://openalex.org/I195525897","https://openalex.org/I138211613"]},{"raw_affiliation_string":"Research Institute of Molecular Pathology, Austrian Academy of Sciences, Vienna, Austria","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000077668","display_name":"Uwe Ohler","orcid":"https://orcid.org/0000-0002-0881-3116"},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Uwe Ohler","raw_affiliation_strings":["Fran Lewitter, Whitehead Institute, United States of America","Research Institute of Molecular Pathology and the Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria","Institute for Genome Sciences & Policy, Department of Biostatistics & Bioinformatics, Department of Computer Science, Duke University, Durham, North Carolina, United States of America"],"affiliations":[{"raw_affiliation_string":"Fran Lewitter, Whitehead Institute, United States of America","institution_ids":["https://openalex.org/I4210157710"]},{"raw_affiliation_string":"Research Institute of Molecular Pathology and the Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria","institution_ids":[]},{"raw_affiliation_string":"Institute for Genome Sciences & Policy, Department of Biostatistics & Bioinformatics, Department of Computer Science, Duke University, Durham, North Carolina, United States of America","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5036949377"],"corresponding_institution_ids":["https://openalex.org/I138211613","https://openalex.org/I195525897"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.3831,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.79458278,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"4","issue":"1","first_page":"e21","last_page":"e21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-splicing","display_name":"RNA splicing","score":0.7478413581848145},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"Alternative splicing","score":0.6651049256324768},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.645214855670929},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.47452986240386963},{"id":"https://openalex.org/keywords/rna-binding-protein","display_name":"RNA-binding protein","score":0.42990145087242126},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.40037429332733154},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3793759346008301},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2840999960899353},{"id":"https://openalex.org/keywords/exon","display_name":"Exon","score":0.18580159544944763}],"concepts":[{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.7478413581848145},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.6651049256324768},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.645214855670929},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47452986240386963},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.42990145087242126},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.40037429332733154},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3793759346008301},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2840999960899353},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.18580159544944763}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018511","descriptor_name":"Systems Integration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018511","descriptor_name":"Systems Integration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018511","descriptor_name":"Systems Integration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020506","descriptor_name":"Untranslated Regions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020506","descriptor_name":"Untranslated Regions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020506","descriptor_name":"Untranslated Regions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D022821","descriptor_name":"RNA Splice Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D022821","descriptor_name":"RNA Splice Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D022821","descriptor_name":"RNA Splice Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D038621","descriptor_name":"Regulatory Sequences, Ribonucleic Acid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D038621","descriptor_name":"Regulatory Sequences, Ribonucleic Acid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D038621","descriptor_name":"Regulatory Sequences, Ribonucleic Acid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.0040021","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0040021","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0040021&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:18225947","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18225947","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:45e4a7fd1443422885cdf8b652c23971","is_oa":true,"landing_page_url":"https://doaj.org/article/45e4a7fd1443422885cdf8b652c23971","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 4, Iss 1, p e21 (2008)","raw_type":"article"},{"id":"pmh:oai:edoc.mdc-berlin.de:12587","is_oa":false,"landing_page_url":"https://edoc.mdc-berlin.de/12587/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400224","display_name":"MDC Repository (Max-Delbrueck-Center for Molecular Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:figshare.com:article/151160","is_oa":true,"landing_page_url":"https://figshare.com/articles/Strategies_for_Identifying_RNA_Splicing_Regulatory_Motifs_and_Predicting_Alternative_Splicing_Events/151160","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:2217580","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2217580","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.0040021","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0040021","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0040021&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5905734738","display_name":null,"funder_award_id":"PHY05-51164","funder_id":"https://openalex.org/F4320337427","funder_display_name":"Kavli Institute for Theoretical Physics, University of California, Santa Barbara"},{"id":"https://openalex.org/G7975596127","display_name":null,"funder_award_id":"PHY05-51164","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320337427","display_name":"Kavli Institute for Theoretical Physics, University of California, Santa Barbara","ror":"https://ror.org/02t274463"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1979262621.pdf","grobid_xml":"https://content.openalex.org/works/W1979262621.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W1913751664","https://openalex.org/W1964906901","https://openalex.org/W1967061818","https://openalex.org/W1967205151","https://openalex.org/W1970774008","https://openalex.org/W1971158461","https://openalex.org/W1971278266","https://openalex.org/W1972067938","https://openalex.org/W1975972631","https://openalex.org/W1985991078","https://openalex.org/W1988692621","https://openalex.org/W1991703748","https://openalex.org/W1992451058","https://openalex.org/W1994025422","https://openalex.org/W1997182337","https://openalex.org/W2002969314","https://openalex.org/W2003605043","https://openalex.org/W2006931677","https://openalex.org/W2009570821","https://openalex.org/W2013235753","https://openalex.org/W2013340095","https://openalex.org/W2017304814","https://openalex.org/W2021018226","https://openalex.org/W2023340322","https://openalex.org/W2023648355","https://openalex.org/W2024553562","https://openalex.org/W2028279880","https://openalex.org/W2029760674","https://openalex.org/W2033310094","https://openalex.org/W2038921819","https://openalex.org/W2041998806","https://openalex.org/W2043099927","https://openalex.org/W2045131720","https://openalex.org/W2051631967","https://openalex.org/W2058819116","https://openalex.org/W2061047696","https://openalex.org/W2063318299","https://openalex.org/W2064664075","https://openalex.org/W2069696438","https://openalex.org/W2072088482","https://openalex.org/W2073654740","https://openalex.org/W2075675982","https://openalex.org/W2085385454","https://openalex.org/W2088440342","https://openalex.org/W2089465951","https://openalex.org/W2093506762","https://openalex.org/W2102337459","https://openalex.org/W2105402655","https://openalex.org/W2108876548","https://openalex.org/W2109936378","https://openalex.org/W2111765516","https://openalex.org/W2111796265","https://openalex.org/W2112875226","https://openalex.org/W2113322429","https://openalex.org/W2114858580","https://openalex.org/W2118301659","https://openalex.org/W2121006508","https://openalex.org/W2123759220","https://openalex.org/W2124288620","https://openalex.org/W2129623502","https://openalex.org/W2129682060","https://openalex.org/W2130368032","https://openalex.org/W2130395351","https://openalex.org/W2132340288","https://openalex.org/W2145070407","https://openalex.org/W2151100808","https://openalex.org/W2151949149","https://openalex.org/W2158020008","https://openalex.org/W2160075393","https://openalex.org/W2160286042","https://openalex.org/W2166336598","https://openalex.org/W2168909179","https://openalex.org/W2169361401","https://openalex.org/W2169685494","https://openalex.org/W3041019241"],"related_works":["https://openalex.org/W2321791250","https://openalex.org/W4213427798","https://openalex.org/W2023199111","https://openalex.org/W2564462691","https://openalex.org/W2065030615","https://openalex.org/W2885403345","https://openalex.org/W2052498125","https://openalex.org/W4387768639","https://openalex.org/W2094867951","https://openalex.org/W1535548930"],"abstract_inverted_index":{"Strategies":[0],"for":[1],"Identifying":[2],"RNA":[3],"Splicing":[4,10],"Regulatory":[5],"Motifs":[6],"and":[7],"Predicting":[8],"Alternative":[9],"Events":[11]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}